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The map label for this gene is nqo6

Identifier: 55980054

GI number: 55980054

Start: 84115

End: 84660

Strand: Direct

Name: nqo6

Synonym: TTHA0085

Alternate gene names: 55980054

Gene position: 84115-84660 (Clockwise)

Preceding gene: 55980053

Following gene: 55980055

Centisome position: 4.55

GC content: 67.58

Gene sequence:

>546_bases
GTGGCACTGAAGGACCTTTTTGAGCGGGACGTCCAGGAGCTGGAACGGGAGGGGATCCTCTTCACCACCTTGGAGAAGCT
CGTGGCCTGGGGGCGGAGCAACTCCCTGTGGCCCGCCACCTTCGGCCTCGCCTGCTGCGCCATTGAGATGATGGCCTCCA
CGGACGCCCGCAACGACCTGGCCCGCTTCGGCAGCGAGGTCTTCCGCGCAAGCCCCCGCCAGGCGGACGTGATGATCGTG
GCCGGGAGGCTTTCCAAGAAAATGGCCCCGGTGATGCGCCGGGTCTGGGAGCAGATGCCCGACCCCAAGTGGGTGATCTC
CATGGGGGCCTGCGCGAGCTCGGGCGGGATGTTCAACAACTACGCCATCGTGCAGAACGTGGACTCGGTGGTGCCCGTGG
ACGTCTACGTCCCCGGCTGCCCCCCCAGGCCCGAGGCCCTGATCTACGCGGTGATGCAGCTGCAGAAGAAGGTGCGGGGC
CAGGCCTACAACGAGCGGGGAGAGAGGCTTCCCCCGGTGGCGGCCTGGAAGCGGACGAGGGGGTGA

Upstream 100 bases:

>100_bases
GCGCGGGCGGGCTTGGCCTCTATGGCTTCCTCGGGGTCCTCGCCTTCACCCTCCTCCTCTTCGTGGGCTTCCTCTACGAG
TGGTGGAAGGGGGTGATGCG

Downstream 100 bases:

>100_bases
GGTATGCGGCTTGAGCGCGTCCTGGAAGAGGCCCGGGCCAAGGGCTACCCCATAGAGGACAACGGCCTCGGCAACCTCTG
GGTGGTCCTGCCCAGGGAGC

Product: NADH dehydrogenase subunit B

Products: NA

Alternate protein names: NADH dehydrogenase I subunit 6; NDH-1 subunit 6

Number of amino acids: Translated: 181; Mature: 180

Protein sequence:

>181_residues
MALKDLFERDVQELEREGILFTTLEKLVAWGRSNSLWPATFGLACCAIEMMASTDARNDLARFGSEVFRASPRQADVMIV
AGRLSKKMAPVMRRVWEQMPDPKWVISMGACASSGGMFNNYAIVQNVDSVVPVDVYVPGCPPRPEALIYAVMQLQKKVRG
QAYNERGERLPPVAAWKRTRG

Sequences:

>Translated_181_residues
MALKDLFERDVQELEREGILFTTLEKLVAWGRSNSLWPATFGLACCAIEMMASTDARNDLARFGSEVFRASPRQADVMIV
AGRLSKKMAPVMRRVWEQMPDPKWVISMGACASSGGMFNNYAIVQNVDSVVPVDVYVPGCPPRPEALIYAVMQLQKKVRG
QAYNERGERLPPVAAWKRTRG
>Mature_180_residues
ALKDLFERDVQELEREGILFTTLEKLVAWGRSNSLWPATFGLACCAIEMMASTDARNDLARFGSEVFRASPRQADVMIVA
GRLSKKMAPVMRRVWEQMPDPKWVISMGACASSGGMFNNYAIVQNVDSVVPVDVYVPGCPPRPEALIYAVMQLQKKVRGQ
AYNERGERLPPVAAWKRTRG

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is menaquinone. Couples the redox reaction to proton translocation (for every

COG id: COG0377

COG function: function code C; NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 20 kDa subunit family

Homologues:

Organism=Homo sapiens, GI187281616, Length=146, Percent_Identity=55.4794520547945, Blast_Score=183, Evalue=9e-47,
Organism=Escherichia coli, GI1788624, Length=156, Percent_Identity=55.1282051282051, Blast_Score=192, Evalue=1e-50,
Organism=Escherichia coli, GI1789074, Length=133, Percent_Identity=39.8496240601504, Blast_Score=103, Evalue=9e-24,
Organism=Escherichia coli, GI1788834, Length=129, Percent_Identity=37.2093023255814, Blast_Score=94, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17509685, Length=137, Percent_Identity=54.7445255474453, Blast_Score=171, Evalue=3e-43,
Organism=Drosophila melanogaster, GI18859983, Length=137, Percent_Identity=60.5839416058394, Blast_Score=187, Evalue=5e-48,
Organism=Drosophila melanogaster, GI24642371, Length=137, Percent_Identity=60.5839416058394, Blast_Score=187, Evalue=5e-48,
Organism=Drosophila melanogaster, GI24651058, Length=137, Percent_Identity=60.5839416058394, Blast_Score=184, Evalue=2e-47,

Paralogues:

None

Copy number: 520 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NQO6_THET8 (Q56218)

Other databases:

- EMBL:   U52917
- EMBL:   AP008226
- PIR:   T11899
- RefSeq:   YP_143351.1
- PDB:   2FUG
- PDB:   3I9V
- PDB:   3IAM
- PDB:   3IAS
- PDB:   3M9S
- PDBsum:   2FUG
- PDBsum:   3I9V
- PDBsum:   3IAM
- PDBsum:   3IAS
- PDBsum:   3M9S
- ProteinModelPortal:   Q56218
- SMR:   Q56218
- STRING:   Q56218
- GeneID:   3168381
- GenomeReviews:   AP008226_GR
- KEGG:   ttj:TTHA0085
- eggNOG:   COG0377
- HOGENOM:   HBG553221
- OMA:   GKPIGSN
- ProtClustDB:   PRK06411
- BioCyc:   TTHE300852:TTHA0085-MONOMER
- HAMAP:   MF_01356
- InterPro:   IPR006137
- InterPro:   IPR006138
- InterPro:   IPR014406
- PANTHER:   PTHR11995:SF2
- PANTHER:   PTHR11995
- TIGRFAMs:   TIGR01957

Pfam domain/function: PF01058 Oxidored_q6

EC number: =1.6.99.5

Molecular weight: Translated: 20239; Mature: 20108

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: PS01150 COMPLEX1_20K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
7.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALKDLFERDVQELEREGILFTTLEKLVAWGRSNSLWPATFGLACCAIEMMASTDARNDL
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHH
ARFGSEVFRASPRQADVMIVAGRLSKKMAPVMRRVWEQMPDPKWVISMGACASSGGMFNN
HHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCC
YAIVQNVDSVVPVDVYVPGCPPRPEALIYAVMQLQKKVRGQAYNERGERLPPVAAWKRTR
HHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCHHHHHCCCCCCCHHHHHCCC
G
C
>Mature Secondary Structure 
ALKDLFERDVQELEREGILFTTLEKLVAWGRSNSLWPATFGLACCAIEMMASTDARNDL
CHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHH
ARFGSEVFRASPRQADVMIVAGRLSKKMAPVMRRVWEQMPDPKWVISMGACASSGGMFNN
HHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCC
YAIVQNVDSVVPVDVYVPGCPPRPEALIYAVMQLQKKVRGQAYNERGERLPPVAAWKRTR
HHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCHHHHHCCCCCCCHHHHHCCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9020134