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The map label for this gene is ksgA [H]

Identifier: 55980052

GI number: 55980052

Start: 82794

End: 83609

Strand: Direct

Name: ksgA [H]

Synonym: TTHA0083

Alternate gene names: 55980052

Gene position: 82794-83609 (Clockwise)

Preceding gene: 55980051

Following gene: 55980053

Centisome position: 4.48

GC content: 71.57

Gene sequence:

>816_bases
ATGAGTAAGCTCGCCTCGCCCCAAAGCGTCCGCGCCCTCCTTGAGCGGCACGGGCTCTTCGCCGACAAGCGCTTCGGCCA
GAACTTCCTGGTCTCGGAGGCCCACCTGCGCCGCATCGTGGAGGCGGCCCGGCCCTTCACCGGGCCCGTCTTTGAGGTGG
GGCCTGGGCTTGGGGCCCTCACCCGGGCCCTCCTCGAGGCCGGGGCCGAGGTGACGGCCATAGAGAAGGACCTGCGCCTG
AGGCCTGTCCTGGAGGAGACCCTTTCCGGCCTCCCGGTGCGCCTCGTCTTCCAGGACGCCCTCCTCTACCCCTGGGAGGA
GGTGCCCCAGGGAAGCCTCCTCGTGGCCAACCTCCCCTACCACATCGCCACCCCCCTGGTCACCCGCCTCCTCAAGACCG
GGCGCTTCGCCCGCCTCGTCTTCCTGGTGCAGAAGGAAGTGGCCGAGCGCATGACCGCAAGGCCCAAGACCCCGGCCTAC
GGGGTCCTCACCCTCCGGGTGGCCCACCACGCCGTGGCGGAGAGGCTCTTTGACCTCCCTCCGGGGGCCTTCTTTCCCCC
GCCCAAGGTGTGGAGCAGCCTGGTGCGCCTCACCCCCACGGGCGCCCTGGACGACCCCGGCCTCTTCCGCCTCGTTGAGG
CCGCCTTCGGAAAGCGGCGGAAGACGCTTTTAAACGCCCTGGCCGCGGCCGGCTACCCCAAGGCGCGGGTGGAGGAGGCC
CTGAGGGCCCTGGGCCTCCCCCCTAGGGTGCGGGCCGAGGAGCTGGACCTCGAGGCCTTCCGCCGGCTGAGGGAGGGCCT
CGAGGGGGCGGTGTAG

Upstream 100 bases:

>100_bases
CTCAAGGACCGCTTCGCCCTCATTGACGCCCTGGACCTGGGGGAGTACCTGGTCCTGGACCCCGAGGCCGACCCCCCGAG
GCCCGAGGTGCGGCGCCTCC

Downstream 100 bases:

>100_bases
GCCCGCCTCCCTTCCCTACACCGTCCCTTCTCCTTCTGTGTAGCCCACCCCCCTTGCGCCCCACCCCGGGGTGATAAGAT
GGGCGGGAAATGAGGCCGGC

Product: dimethyladenosine transferase

Products: NA

Alternate protein names: 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase; 16S rRNA dimethyladenosine transferase; 16S rRNA dimethylase; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase [H]

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MSKLASPQSVRALLERHGLFADKRFGQNFLVSEAHLRRIVEAARPFTGPVFEVGPGLGALTRALLEAGAEVTAIEKDLRL
RPVLEETLSGLPVRLVFQDALLYPWEEVPQGSLLVANLPYHIATPLVTRLLKTGRFARLVFLVQKEVAERMTARPKTPAY
GVLTLRVAHHAVAERLFDLPPGAFFPPPKVWSSLVRLTPTGALDDPGLFRLVEAAFGKRRKTLLNALAAAGYPKARVEEA
LRALGLPPRVRAEELDLEAFRRLREGLEGAV

Sequences:

>Translated_271_residues
MSKLASPQSVRALLERHGLFADKRFGQNFLVSEAHLRRIVEAARPFTGPVFEVGPGLGALTRALLEAGAEVTAIEKDLRL
RPVLEETLSGLPVRLVFQDALLYPWEEVPQGSLLVANLPYHIATPLVTRLLKTGRFARLVFLVQKEVAERMTARPKTPAY
GVLTLRVAHHAVAERLFDLPPGAFFPPPKVWSSLVRLTPTGALDDPGLFRLVEAAFGKRRKTLLNALAAAGYPKARVEEA
LRALGLPPRVRAEELDLEAFRRLREGLEGAV
>Mature_270_residues
SKLASPQSVRALLERHGLFADKRFGQNFLVSEAHLRRIVEAARPFTGPVFEVGPGLGALTRALLEAGAEVTAIEKDLRLR
PVLEETLSGLPVRLVFQDALLYPWEEVPQGSLLVANLPYHIATPLVTRLLKTGRFARLVFLVQKEVAERMTARPKTPAYG
VLTLRVAHHAVAERLFDLPPGAFFPPPKVWSSLVRLTPTGALDDPGLFRLVEAAFGKRRKTLLNALAAAGYPKARVEEAL
RALGLPPRVRAEELDLEAFRRLREGLEGAV

Specific function: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits [H]

COG id: COG0030

COG function: function code J; Dimethyladenosine transferase (rRNA methylation)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily [H]

Homologues:

Organism=Homo sapiens, GI156415992, Length=291, Percent_Identity=30.5841924398625, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI7657198, Length=287, Percent_Identity=29.9651567944251, Blast_Score=98, Evalue=7e-21,
Organism=Escherichia coli, GI1786236, Length=264, Percent_Identity=34.8484848484849, Blast_Score=134, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI25146882, Length=213, Percent_Identity=36.150234741784, Blast_Score=99, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6324989, Length=227, Percent_Identity=32.5991189427313, Blast_Score=88, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21358017, Length=219, Percent_Identity=33.3333333333333, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI21357273, Length=279, Percent_Identity=30.4659498207885, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023165
- InterPro:   IPR020596
- InterPro:   IPR001737
- InterPro:   IPR020598
- InterPro:   IPR011530 [H]

Pfam domain/function: PF00398 RrnaAD [H]

EC number: =2.1.1.182 [H]

Molecular weight: Translated: 29866; Mature: 29735

Theoretical pI: Translated: 10.69; Mature: 10.69

Prosite motif: PS01131 RRNA_A_DIMETH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKLASPQSVRALLERHGLFADKRFGQNFLVSEAHLRRIVEAARPFTGPVFEVGPGLGAL
CCCCCCHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHCCCCHHHH
TRALLEAGAEVTAIEKDLRLRPVLEETLSGLPVRLVFQDALLYPWEEVPQGSLLVANLPY
HHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHCCHHHCCCCCEEEECCCH
HIATPLVTRLLKTGRFARLVFLVQKEVAERMTARPKTPAYGVLTLRVAHHAVAERLFDLP
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCC
PGAFFPPPKVWSSLVRLTPTGALDDPGLFRLVEAAFGKRRKTLLNALAAAGYPKARVEEA
CCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
LRALGLPPRVRAEELDLEAFRRLREGLEGAV
HHHCCCCCCCCHHHCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SKLASPQSVRALLERHGLFADKRFGQNFLVSEAHLRRIVEAARPFTGPVFEVGPGLGAL
CCCCCHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHCCCCHHHH
TRALLEAGAEVTAIEKDLRLRPVLEETLSGLPVRLVFQDALLYPWEEVPQGSLLVANLPY
HHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHCCHHHCCCCCEEEECCCH
HIATPLVTRLLKTGRFARLVFLVQKEVAERMTARPKTPAYGVLTLRVAHHAVAERLFDLP
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCC
PGAFFPPPKVWSSLVRLTPTGALDDPGLFRLVEAAFGKRRKTLLNALAAAGYPKARVEEA
CCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
LRALGLPPRVRAEELDLEAFRRLREGLEGAV
HHHCCCCCCCCHHHCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA