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The map label for this gene is srrA [H]

Identifier: 55979989

GI number: 55979989

Start: 20401

End: 21072

Strand: Reverse

Name: srrA [H]

Synonym: TTHA0020

Alternate gene names: 55979989

Gene position: 21072-20401 (Counterclockwise)

Preceding gene: 55979990

Following gene: 55979988

Centisome position: 1.14

GC content: 70.39

Gene sequence:

>672_bases
ATGGCCCGCGTGTTGCTCGTGGAGGACGACTCCCAGGTGGGGGAGCTGGTGCGCCGCTTCCTGGAACGGGAGGGGTTCGC
CGTGGCCTGGGTCCGCTTCGGAAGGGAGGCTCTAGAGCGGGTAGGGGAGGAGGGGGCGGACGTGGTGGTCCTGGACCGGG
GCCTGCCGGATATGGAGGGGTTGGAGGTCTTGAAGGGGCTCCGCTCCTTGGACCCCCTCCTTCCCGTCCTCCTCCTCACG
GGGCGCGCCGACGAGGAGAGCCGGGTGGAGGGGCTTCTGGAGGGGGCGGACGACTACCTGGGGAAGCCCTTTTCCCTGAG
GGAGCTCCTCGCCCGCATCAAGGCCCTCCTGCGCCGGGCGGGGAAGGAGGGGAGGAGGCGCTTCGGGCCCTTGGAGGTGG
ACCTGGGGGGGCGGCGGGCCTACCTGGAAGGGGAGCCCCTCCGGCTTTCCCCCACGGAGATGAACCTCCTTTTGGTCTTC
GCCCAGGCCCCGGGCCGGGTCTTCACCCGGGGAGAGCTCCTGGAGCGGGTCTGGGGCCCGGAGTTTGAGGGCTCGGAGCG
GGTGGTGGACGCCTACGTGCGCCTCCTCCGCAAGAAGCTCAGGGACGACCCCGAGGCTCCCCGCTTCATTGAGACGGTGG
TGGGGTTGGGGTACCGCTTCCTCGGGGATTGA

Upstream 100 bases:

>100_bases
CGGCGGAGACCTTCCACGACGAGGGGGTGGCCCGGCTTCTGGGCCTTCCCGAGGGGGAGTATCCTGGGGTCGTGGTGGTC
CTGGGGCGGTAGGAGGTGGT

Downstream 100 bases:

>100_bases
GAACCCCGCCTTGGCAGGGCGCTTGGATGGAGGCCGTCTTCGTCTACGGGACCCTGAAGCGGGGGGAGAGGAACCACGGC
CTCGTGGCTCCCTACCTCCA

Product: response regulator

Products: NA

Alternate protein names: Staphylococcal respiratory response protein A [H]

Number of amino acids: Translated: 223; Mature: 222

Protein sequence:

>223_residues
MARVLLVEDDSQVGELVRRFLEREGFAVAWVRFGREALERVGEEGADVVVLDRGLPDMEGLEVLKGLRSLDPLLPVLLLT
GRADEESRVEGLLEGADDYLGKPFSLRELLARIKALLRRAGKEGRRRFGPLEVDLGGRRAYLEGEPLRLSPTEMNLLLVF
AQAPGRVFTRGELLERVWGPEFEGSERVVDAYVRLLRKKLRDDPEAPRFIETVVGLGYRFLGD

Sequences:

>Translated_223_residues
MARVLLVEDDSQVGELVRRFLEREGFAVAWVRFGREALERVGEEGADVVVLDRGLPDMEGLEVLKGLRSLDPLLPVLLLT
GRADEESRVEGLLEGADDYLGKPFSLRELLARIKALLRRAGKEGRRRFGPLEVDLGGRRAYLEGEPLRLSPTEMNLLLVF
AQAPGRVFTRGELLERVWGPEFEGSERVVDAYVRLLRKKLRDDPEAPRFIETVVGLGYRFLGD
>Mature_222_residues
ARVLLVEDDSQVGELVRRFLEREGFAVAWVRFGREALERVGEEGADVVVLDRGLPDMEGLEVLKGLRSLDPLLPVLLLTG
RADEESRVEGLLEGADDYLGKPFSLRELLARIKALLRRAGKEGRRRFGPLEVDLGGRRAYLEGEPLRLSPTEMNLLLVFA
QAPGRVFTRGELLERVWGPEFEGSERVVDAYVRLLRKKLRDDPEAPRFIETVVGLGYRFLGD

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. SrrA binds to the agr, spa and tst promoters and represses their transcript

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=39.9103139013453, Blast_Score=144, Evalue=4e-36,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=38.5650224215247, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1789809, Length=230, Percent_Identity=35.6521739130435, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1789402, Length=218, Percent_Identity=40.8256880733945, Blast_Score=141, Evalue=3e-35,
Organism=Escherichia coli, GI1786911, Length=229, Percent_Identity=37.5545851528384, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI1786784, Length=219, Percent_Identity=36.986301369863, Blast_Score=134, Evalue=4e-33,
Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=33.3333333333333, Blast_Score=132, Evalue=1e-32,
Organism=Escherichia coli, GI1790863, Length=232, Percent_Identity=34.051724137931, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=33.4841628959276, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=36.4035087719298, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI1790552, Length=223, Percent_Identity=35.4260089686099, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=32.8828828828829, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1787229, Length=231, Percent_Identity=30.7359307359307, Blast_Score=103, Evalue=8e-24,
Organism=Escherichia coli, GI145693140, Length=234, Percent_Identity=30.3418803418803, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1790437, Length=114, Percent_Identity=36.8421052631579, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1790299, Length=142, Percent_Identity=33.0985915492958, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788550, Length=159, Percent_Identity=33.9622641509434, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI1788191, Length=122, Percent_Identity=31.9672131147541, Blast_Score=61, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25139; Mature: 25008

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARVLLVEDDSQVGELVRRFLEREGFAVAWVRFGREALERVGEEGADVVVLDRGLPDMEG
CCEEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHH
LEVLKGLRSLDPLLPVLLLTGRADEESRVEGLLEGADDYLGKPFSLRELLARIKALLRRA
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCHHHHCCCCHHHHHHHHHHHHHHHHH
GKEGRRRFGPLEVDLGGRRAYLEGEPLRLSPTEMNLLLVFAQAPGRVFTRGELLERVWGP
CHHHHHHCCCEEEECCCCEEEECCCCCEECCCCEEEEEEEECCCCCCHHHHHHHHHHCCC
EFEGSERVVDAYVRLLRKKLRDDPEAPRFIETVVGLGYRFLGD
CCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHCCC
>Mature Secondary Structure 
ARVLLVEDDSQVGELVRRFLEREGFAVAWVRFGREALERVGEEGADVVVLDRGLPDMEG
CEEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHH
LEVLKGLRSLDPLLPVLLLTGRADEESRVEGLLEGADDYLGKPFSLRELLARIKALLRRA
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCHHHHCCCCHHHHHHHHHHHHHHHHH
GKEGRRRFGPLEVDLGGRRAYLEGEPLRLSPTEMNLLLVFAQAPGRVFTRGELLERVWGP
CHHHHHHCCCEEEECCCCEEEECCCCCEECCCCEEEEEEEECCCCCCHHHHHHHHHHCCC
EFEGSERVVDAYVRLLRKKLRDDPEAPRFIETVVGLGYRFLGD
CCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA