Click here to switch to the map view.

The map label for this gene is dxs [H]

Identifier: 55979975

GI number: 55979975

Start: 5493

End: 7340

Strand: Reverse

Name: dxs [H]

Synonym: TTHA0006

Alternate gene names: 55979975

Gene position: 7340-5493 (Counterclockwise)

Preceding gene: 55979976

Following gene: 55979974

Centisome position: 0.4

GC content: 67.05

Gene sequence:

>1848_bases
ATGATCTTGGACAAGGTGAACAGCCCCGAGGACCTGAAGCGCCTGAGCCTGGAGGAACTTCTCCTCCTGGCCGAGGAGAT
CCGGAGCGAGATCATCCGGGTCACGGCGCAAAACGGCGGGCACTTGGCGAGCTCCCTGGGGGCGGTGGAACTCGTCCTCG
CCCTGCACCGGGTCTTTGACTCCCCCAGGGACCGGATCCTCTTTGACGTGGGGCACCAGGCCTACGCCCACAAGCTCGTC
ACGGGGCGCAAGGACCGGTTCCACACCCTGCGGAAGGAAGGGGGGATCTCCGGGTTCACCAAGGTCTCCGAGTCCCCCCA
CGACGCCATCACCGCGGGCCACGCCTCCACCTCCCTCGCCAACGCCTTGGGGATGGTCCTCGCCCGGGACCTCATGGGGG
AGGACTACCACGTGGTGGCGGTGATCGGGGACGGGGCCTTGACGGGGGGGATGGCCCTCGCCGCCCTCAACAAGATCGGG
GAGCTCCAGAAGAGGATGCTCATCGTCCTCAACGACAACGAGATGAGCATCTCCGAGAACGTGGGGGCCCTCAACAAGTA
CTTCAAGGAGCTTCAGATCAGGAAGTGGGTCCAGGACGCGGAGAAGCTGGGGAAGAACATCCTGGAACGCATCTCCCCCC
AGCTTTTCGGCCTCGTGGACCGGGCCAAGGAGGCGGCGAAGTTCCTTTTGCACCAGGAAAACCCCTTCTACGCCTGGGGG
ATCCGCTACGTGGGCCCGGTGGACGGCCACGACCTCAAGGGGCTCGTCCACATCCTGGAGCACCTCAAGGCCCTGGACGG
CCCCACCCTCCTCCACGTGGTCACGAAGAAGGGCAAGGGGTACAAGGTGGCCGAGGCCGACCCCATCTACTGGCACGGCC
CCCCAGGCTTTGACCCCAAGAAGCCGGAGAAGGTGTCCAAGGGGTACACCTGGAGCCAGGCCTTTGGGGACGCCGTCACC
GAGCTCGCCCACATGGAGCCCAGGCTCTTCGTCCTCACCCCGGCCATGCGGGAAGGCTCGGGGCTCGTGCGCTACTCCTT
GGAGCACCCGGAGCGCTACCTGGACGTGGGGATCTGCGAGGACGTGGCGGTGACCACGGCGGCGGGGCTTGCGCTACGGG
GGATGAAGCCCATCGTGGCCATCTACTCCACCTTCCTCCAGAGGGCCTACGACCAGGTGATCCACGACGTGGCCATTGAG
AACCTCCCCGTGGTCTTCGCCATTGACCGGGCGGGGATCGTGGGGGCCGACGGGGCCACCCACCACGGGGTCTTTGACAT
CGCCTATCTCCGCACCGTCCCCAACCTCCAGATCGCCGCCCCCAAGGACGCCCTGGAGCTTCGGGCCATGCTGAAAAAGG
CCCTGGAGGTGGGGGGCCCCGTGGCCATCCGCTACCCCCGGGACAACGTGGAGCGGGCCCCCGAGGGCGTCTGGCCGGAG
ATCGCCTGGGGCAAGTGGGAGGTGCTGAAGGAGGGCACGGAGGCCTACATCCTGGCCTTCGGCAAGACCCTGAGGTACGC
CCTCGAGGCCGCCGGGGACGACCCCAGGGTGGGGGTGGTGAACGCCCGCTTCCTCAAGCCCCTGGACCGGGAGATGCTGA
GGGAGCTCTCCCGCTACAAGCTCCTCACCGTGGAGGACCACCAGAAGATGGGCGGGTTTGGGAGCGCGGTCCTCGAGGCC
CTGAACGAGATGGGCCTGAAGCCCGAGGTCCAGATCCTCGGCCTTCCCGACCGCTTCTTTGAGCACGGGGCGATCCCGAG
CCTCCACCGCCAGGCGGGCATTGACGCCGAGGGGATCCGGAAGGCCCTGGCGGCGATGGGGGTGGCCTTGGTGCATGAAC
GGGCCTGA

Upstream 100 bases:

>100_bases
GCGAGGCCCTCTACGAGGTCTGGTTCGCCCCCAAGGTGGGGGAGGTCCGGACCCGAGAGGGGAGGCTTCTTACGGACCGC
AACTTCCGGTGAGGTGCGCC

Downstream 100 bases:

>100_bases
GGTCCTGCGCTTCGCCGCCAACCTCTACCGCGTCCCCGTGGAAGGGGGGTACTTCCTGGTGGACGCCGGGCTTCCCTGGG
AGGCACGAAGGCTCCTCTCC

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 615; Mature: 615

Protein sequence:

>615_residues
MILDKVNSPEDLKRLSLEELLLLAEEIRSEIIRVTAQNGGHLASSLGAVELVLALHRVFDSPRDRILFDVGHQAYAHKLV
TGRKDRFHTLRKEGGISGFTKVSESPHDAITAGHASTSLANALGMVLARDLMGEDYHVVAVIGDGALTGGMALAALNKIG
ELQKRMLIVLNDNEMSISENVGALNKYFKELQIRKWVQDAEKLGKNILERISPQLFGLVDRAKEAAKFLLHQENPFYAWG
IRYVGPVDGHDLKGLVHILEHLKALDGPTLLHVVTKKGKGYKVAEADPIYWHGPPGFDPKKPEKVSKGYTWSQAFGDAVT
ELAHMEPRLFVLTPAMREGSGLVRYSLEHPERYLDVGICEDVAVTTAAGLALRGMKPIVAIYSTFLQRAYDQVIHDVAIE
NLPVVFAIDRAGIVGADGATHHGVFDIAYLRTVPNLQIAAPKDALELRAMLKKALEVGGPVAIRYPRDNVERAPEGVWPE
IAWGKWEVLKEGTEAYILAFGKTLRYALEAAGDDPRVGVVNARFLKPLDREMLRELSRYKLLTVEDHQKMGGFGSAVLEA
LNEMGLKPEVQILGLPDRFFEHGAIPSLHRQAGIDAEGIRKALAAMGVALVHERA

Sequences:

>Translated_615_residues
MILDKVNSPEDLKRLSLEELLLLAEEIRSEIIRVTAQNGGHLASSLGAVELVLALHRVFDSPRDRILFDVGHQAYAHKLV
TGRKDRFHTLRKEGGISGFTKVSESPHDAITAGHASTSLANALGMVLARDLMGEDYHVVAVIGDGALTGGMALAALNKIG
ELQKRMLIVLNDNEMSISENVGALNKYFKELQIRKWVQDAEKLGKNILERISPQLFGLVDRAKEAAKFLLHQENPFYAWG
IRYVGPVDGHDLKGLVHILEHLKALDGPTLLHVVTKKGKGYKVAEADPIYWHGPPGFDPKKPEKVSKGYTWSQAFGDAVT
ELAHMEPRLFVLTPAMREGSGLVRYSLEHPERYLDVGICEDVAVTTAAGLALRGMKPIVAIYSTFLQRAYDQVIHDVAIE
NLPVVFAIDRAGIVGADGATHHGVFDIAYLRTVPNLQIAAPKDALELRAMLKKALEVGGPVAIRYPRDNVERAPEGVWPE
IAWGKWEVLKEGTEAYILAFGKTLRYALEAAGDDPRVGVVNARFLKPLDREMLRELSRYKLLTVEDHQKMGGFGSAVLEA
LNEMGLKPEVQILGLPDRFFEHGAIPSLHRQAGIDAEGIRKALAAMGVALVHERA
>Mature_615_residues
MILDKVNSPEDLKRLSLEELLLLAEEIRSEIIRVTAQNGGHLASSLGAVELVLALHRVFDSPRDRILFDVGHQAYAHKLV
TGRKDRFHTLRKEGGISGFTKVSESPHDAITAGHASTSLANALGMVLARDLMGEDYHVVAVIGDGALTGGMALAALNKIG
ELQKRMLIVLNDNEMSISENVGALNKYFKELQIRKWVQDAEKLGKNILERISPQLFGLVDRAKEAAKFLLHQENPFYAWG
IRYVGPVDGHDLKGLVHILEHLKALDGPTLLHVVTKKGKGYKVAEADPIYWHGPPGFDPKKPEKVSKGYTWSQAFGDAVT
ELAHMEPRLFVLTPAMREGSGLVRYSLEHPERYLDVGICEDVAVTTAAGLALRGMKPIVAIYSTFLQRAYDQVIHDVAIE
NLPVVFAIDRAGIVGADGATHHGVFDIAYLRTVPNLQIAAPKDALELRAMLKKALEVGGPVAIRYPRDNVERAPEGVWPE
IAWGKWEVLKEGTEAYILAFGKTLRYALEAAGDDPRVGVVNARFLKPLDREMLRELSRYKLLTVEDHQKMGGFGSAVLEA
LNEMGLKPEVQILGLPDRFFEHGAIPSLHRQAGIDAEGIRKALAAMGVALVHERA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=677, Percent_Identity=24.9630723781388, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI4507521, Length=677, Percent_Identity=24.9630723781388, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI225637459, Length=394, Percent_Identity=26.3959390862944, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI225637461, Length=394, Percent_Identity=26.3959390862944, Blast_Score=97, Evalue=6e-20,
Organism=Homo sapiens, GI225637463, Length=430, Percent_Identity=26.2790697674419, Blast_Score=97, Evalue=7e-20,
Organism=Homo sapiens, GI133778974, Length=387, Percent_Identity=25.3229974160207, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI1786622, Length=611, Percent_Identity=44.8445171849427, Blast_Score=500, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI17539652, Length=423, Percent_Identity=25.0591016548463, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319698, Length=284, Percent_Identity=26.056338028169, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24666278, Length=586, Percent_Identity=24.9146757679181, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI45551847, Length=620, Percent_Identity=25.3225806451613, Blast_Score=99, Evalue=1e-20,
Organism=Drosophila melanogaster, GI45550715, Length=620, Percent_Identity=25.3225806451613, Blast_Score=99, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24645119, Length=369, Percent_Identity=28.1842818428184, Blast_Score=97, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 67658; Mature: 67658

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILDKVNSPEDLKRLSLEELLLLAEEIRSEIIRVTAQNGGHLASSLGAVELVLALHRVFD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHC
SPRDRILFDVGHQAYAHKLVTGRKDRFHTLRKEGGISGFTKVSESPHDAITAGHASTSLA
CCCCCEEEECCCHHHHHHHHCCCHHHHHHHHHHCCCCCHHHCCCCCCHHHCCCCHHHHHH
NALGMVLARDLMGEDYHVVAVIGDGALTGGMALAALNKIGELQKRMLIVLNDNEMSISEN
HHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHCEEEEECCCCCCHHHH
VGALNKYFKELQIRKWVQDAEKLGKNILERISPQLFGLVDRAKEAAKFLLHQENPFYAWG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCEEEEE
IRYVGPVDGHDLKGLVHILEHLKALDGPTLLHVVTKKGKGYKVAEADPIYWHGPPGFDPK
EEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEECCCCEEECCCCCCCCC
KPEKVSKGYTWSQAFGDAVTELAHMEPRLFVLTPAMREGSGLVRYSLEHPERYLDVGICE
CCHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEECCCCHHHHCCCCCC
DVAVTTAAGLALRGMKPIVAIYSTFLQRAYDQVIHDVAIENLPVVFAIDRAGIVGADGAT
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEECCCCCC
HHGVFDIAYLRTVPNLQIAAPKDALELRAMLKKALEVGGPVAIRYPRDNVERAPEGVWPE
CCCHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHCCCCCCCC
IAWGKWEVLKEGTEAYILAFGKTLRYALEAAGDDPRVGVVNARFLKPLDREMLRELSRYK
CCCCHHHHHHCCCCEEEEHHHHHHHHHHHHCCCCCCEEEECHHHHCHHHHHHHHHHHHCE
LLTVEDHQKMGGFGSAVLEALNEMGLKPEVQILGLPDRFFEHGAIPSLHRQAGIDAEGIR
EEEEECHHHHCCHHHHHHHHHHHCCCCCCEEEEECCHHHHHCCCCCHHHHHCCCCHHHHH
KALAAMGVALVHERA
HHHHHHHHHHHHCCC
>Mature Secondary Structure
MILDKVNSPEDLKRLSLEELLLLAEEIRSEIIRVTAQNGGHLASSLGAVELVLALHRVFD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHC
SPRDRILFDVGHQAYAHKLVTGRKDRFHTLRKEGGISGFTKVSESPHDAITAGHASTSLA
CCCCCEEEECCCHHHHHHHHCCCHHHHHHHHHHCCCCCHHHCCCCCCHHHCCCCHHHHHH
NALGMVLARDLMGEDYHVVAVIGDGALTGGMALAALNKIGELQKRMLIVLNDNEMSISEN
HHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHCEEEEECCCCCCHHHH
VGALNKYFKELQIRKWVQDAEKLGKNILERISPQLFGLVDRAKEAAKFLLHQENPFYAWG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCEEEEE
IRYVGPVDGHDLKGLVHILEHLKALDGPTLLHVVTKKGKGYKVAEADPIYWHGPPGFDPK
EEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEECCCCEEECCCCCCCCC
KPEKVSKGYTWSQAFGDAVTELAHMEPRLFVLTPAMREGSGLVRYSLEHPERYLDVGICE
CCHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEECCCCHHHHCCCCCC
DVAVTTAAGLALRGMKPIVAIYSTFLQRAYDQVIHDVAIENLPVVFAIDRAGIVGADGAT
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEECCCCCC
HHGVFDIAYLRTVPNLQIAAPKDALELRAMLKKALEVGGPVAIRYPRDNVERAPEGVWPE
CCCHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHCCCCCCCC
IAWGKWEVLKEGTEAYILAFGKTLRYALEAAGDDPRVGVVNARFLKPLDREMLRELSRYK
CCCCHHHHHHCCCCEEEEHHHHHHHHHHHHCCCCCCEEEECHHHHCHHHHHHHHHHHHCE
LLTVEDHQKMGGFGSAVLEALNEMGLKPEVQILGLPDRFFEHGAIPSLHRQAGIDAEGIR
EEEEECHHHHCCHHHHHHHHHHHCCCCCCEEEEECCHHHHHCCCCCHHHHHCCCCHHHHH
KALAAMGVALVHERA
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA