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The map label for this gene is vanX [H]

Identifier: 54295422

GI number: 54295422

Start: 2860585

End: 2861316

Strand: Direct

Name: vanX [H]

Synonym: lpl2508

Alternate gene names: 54295422

Gene position: 2860585-2861316 (Clockwise)

Preceding gene: 54295421

Following gene: 54295423

Centisome position: 85.5

GC content: 37.98

Gene sequence:

>732_bases
ATGAAAAAAATCAGCGCTCTTATTTTTCTTTATCTCATAAGCACGGCCAGTTTTTCACTTCCCAAAGGCTTTGTTTATTT
ACACGATGTAGCGCCTGATATCATTGAAGACATAAGATATGCCACCCATAATAATTTCATAGGAAATCCTATCCCAGGTT
ACAAACGCGGAGTATGTATAGTCACCAGACAAACCGCACAACAATTAAAAAAAGCGGAAGAATACATCAAACCCAAAGGA
TATACGCTTAAAGTATATGATTGCTACAGGCCACAAAGAGCTGTGGATTATTTTTATAAGTGGAGCCGCAATGCCAAAGA
TAATCGAATGAAACCTGAATTTTATCCTCGTGAAATAAAACAGGATTTGTTTGACCGTGGTTATATTGCTCTAACCTCTG
GCCACACGCGAGGCAGTACCCTTGACTTAACTCTGGTGAAACTAACTGCCTCTCAAGAAAAAAAATCTAATCATCCTTTA
ACACGTTGCTACAATAAAAAGCCAGATTATCTTGATGACGATTCGATCGATACAGGAACTCGCTTTGATTGTCTGGATGT
GTCAGCCAACATTGATTATTCCAGGCTGAGTAAACAACAGAAAGCCAATCGCGAATTATTACAAAAACTCATGAAACGCT
TTGGTTTTAGACCTTATTACTATGAATGGTGGCATTTCACCCTGAAAAATGAACCTTATCCAGACACCTATTTCAATTTT
CCAGTCGAATAA

Upstream 100 bases:

>100_bases
TCGAAAGTTGACTTAACACCAGCGATGGAGGATGATAAGCGAAGCGAAAGCACCCCCACGCCAGTAAACTTCTAAGGATT
ATGAGTTTAACAATCTAACA

Downstream 100 bases:

>100_bases
ATAGTTAAGATCAGAACTCACTCTGACACACTTACTCATGTCCTGGATGAAACGACTCAACCCGAACCCGGAAGACAATT
AAAACCCAATGTGAATTTAT

Product: hypothetical protein

Products: NA

Alternate protein names: D-Ala-D-Ala dipeptidase [H]

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MKKISALIFLYLISTASFSLPKGFVYLHDVAPDIIEDIRYATHNNFIGNPIPGYKRGVCIVTRQTAQQLKKAEEYIKPKG
YTLKVYDCYRPQRAVDYFYKWSRNAKDNRMKPEFYPREIKQDLFDRGYIALTSGHTRGSTLDLTLVKLTASQEKKSNHPL
TRCYNKKPDYLDDDSIDTGTRFDCLDVSANIDYSRLSKQQKANRELLQKLMKRFGFRPYYYEWWHFTLKNEPYPDTYFNF
PVE

Sequences:

>Translated_243_residues
MKKISALIFLYLISTASFSLPKGFVYLHDVAPDIIEDIRYATHNNFIGNPIPGYKRGVCIVTRQTAQQLKKAEEYIKPKG
YTLKVYDCYRPQRAVDYFYKWSRNAKDNRMKPEFYPREIKQDLFDRGYIALTSGHTRGSTLDLTLVKLTASQEKKSNHPL
TRCYNKKPDYLDDDSIDTGTRFDCLDVSANIDYSRLSKQQKANRELLQKLMKRFGFRPYYYEWWHFTLKNEPYPDTYFNF
PVE
>Mature_243_residues
MKKISALIFLYLISTASFSLPKGFVYLHDVAPDIIEDIRYATHNNFIGNPIPGYKRGVCIVTRQTAQQLKKAEEYIKPKG
YTLKVYDCYRPQRAVDYFYKWSRNAKDNRMKPEFYPREIKQDLFDRGYIALTSGHTRGSTLDLTLVKLTASQEKKSNHPL
TRCYNKKPDYLDDDSIDTGTRFDCLDVSANIDYSRLSKQQKANRELLQKLMKRFGFRPYYYEWWHFTLKNEPYPDTYFNF
PVE

Specific function: Hydrolyzes the cellular pool of D-Ala-D-Ala dipeptides. May play a role in immunity or defense against glycopeptide antibiotics (perhaps at a moderate level) in the soil environment. Might confer vancomycin resistance to S.coelicolor [H]

COG id: COG2173

COG function: function code M; D-alanyl-D-alanine dipeptidase

Gene ontology:

Cell location: Secreted (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M15D family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009045
- InterPro:   IPR000755 [H]

Pfam domain/function: PF01427 Peptidase_M15 [H]

EC number: =3.4.13.22 [H]

Molecular weight: Translated: 28748; Mature: 28748

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKISALIFLYLISTASFSLPKGFVYLHDVAPDIIEDIRYATHNNFIGNPIPGYKRGVCI
CCHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEE
VTRQTAQQLKKAEEYIKPKGYTLKVYDCYRPQRAVDYFYKWSRNAKDNRMKPEFYPREIK
EEHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHH
QDLFDRGYIALTSGHTRGSTLDLTLVKLTASQEKKSNHPLTRCYNKKPDYLDDDSIDTGT
HHHHCCCEEEEECCCCCCCEEEEEEEEEECCHHHHCCCCHHHHCCCCCCCCCCCCCCCCC
RFDCLDVSANIDYSRLSKQQKANRELLQKLMKRFGFRPYYYEWWHFTLKNEPYPDTYFNF
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCC
PVE
CCC
>Mature Secondary Structure
MKKISALIFLYLISTASFSLPKGFVYLHDVAPDIIEDIRYATHNNFIGNPIPGYKRGVCI
CCHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEE
VTRQTAQQLKKAEEYIKPKGYTLKVYDCYRPQRAVDYFYKWSRNAKDNRMKPEFYPREIK
EEHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHH
QDLFDRGYIALTSGHTRGSTLDLTLVKLTASQEKKSNHPLTRCYNKKPDYLDDDSIDTGT
HHHHCCCEEEEECCCCCCCEEEEEEEEEECCHHHHCCCCHHHHCCCCCCCCCCCCCCCCC
RFDCLDVSANIDYSRLSKQQKANRELLQKLMKRFGFRPYYYEWWHFTLKNEPYPDTYFNF
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCC
PVE
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11881895; 12000953 [H]