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The map label for this gene is ispA [H]

Identifier: 54295170

GI number: 54295170

Start: 2569157

End: 2570053

Strand: Direct

Name: ispA [H]

Synonym: lpl2250

Alternate gene names: 54295170

Gene position: 2569157-2570053 (Clockwise)

Preceding gene: 54295169

Following gene: 54295172

Centisome position: 76.79

GC content: 40.69

Gene sequence:

>897_bases
ATGAACAAACAAGTGATTGATAAGTATACACAAAGACATGAGCTATATCTCGAGCAATTGCTCAATGAAATAGTAATACC
AGCTCCCCAAATTCGCTCCGCACTTCATTACGCTTTATTTTCAGGCGGCAAAAGAATAAGACCCATTTTGGTTTATTTAG
CTGGCGATTTAATTGATGTTGACCAGGAAGTTCTGGATATTATTGCGGCAGCGCTTGAGTTAACACATTGCTATTCCCTG
ATTCATGATGATCTTCCGGCGATGGACAATGACGATCTGCGCCGCGGTAAGCCGAGTTGTCATAAAGCATTTGATGAGGC
AACTGCTATTTTAGTCGGCGATGGCATGCAAGCTTTAGCGATTGAAGTCGTACTGATGAGATTATCGCCCCTTCTCCCCG
CAGCACAAGTCGTAGCCATTACTCAAGTATTGGTAAATGCCAGTGGAATAAGTGGAATGGTTAGTGGCCAAAGTCTTGAT
TTATCAGAACTGGCCAAATCATCGGTAACTGAGGAGCAATTACGAGAAATTCATCTTTTGAAAACTGGAAAACTGATCCT
GGCGTGTTTTGAAATGGTTTTAGCAGCACAACATGAGGTATCAGAGCAAATCAAATCCGCACTAAGAACTTATGGGAAAC
ATATAGGGCTTGTATTTCAAATGCAAGATGATTACCTGGATCTCTACGCTCCAACTCAAATATTGGGAAAAGGTCGCTCC
TCGGATCAGGCAAACCAAAAAACCACCTTTGCAACCTTATTTAACAAGCAACAATTGGAAGAAGAAATCGCTGTTCATTA
CCAAATTGCAATGGATTCTCTACGCTTATTTGGTATTAAAGCGGCTGCATTAATTGAATTAACCAAACAATTACAAAATC
GTAGCAATTTGTCTTGA

Upstream 100 bases:

>100_bases
GGAATTAGCCTTGCAAGACGTTGCCAAAATGCGTTGAATCAGGCAGAGCAAAAAATTGAAACGTTAACTGGTACTGATTC
CAACATTGAACTCGACTCAG

Downstream 100 bases:

>100_bases
CGCCATTGATGCACCGGACAATCCAATTGATATCCGTTTTAAATTAGGACTTTCTAACAACACGTGAAACAGGAATCCAG
GTTTCTATACCTTGCTCCAT

Product: hypothetical protein

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MNKQVIDKYTQRHELYLEQLLNEIVIPAPQIRSALHYALFSGGKRIRPILVYLAGDLIDVDQEVLDIIAAALELTHCYSL
IHDDLPAMDNDDLRRGKPSCHKAFDEATAILVGDGMQALAIEVVLMRLSPLLPAAQVVAITQVLVNASGISGMVSGQSLD
LSELAKSSVTEEQLREIHLLKTGKLILACFEMVLAAQHEVSEQIKSALRTYGKHIGLVFQMQDDYLDLYAPTQILGKGRS
SDQANQKTTFATLFNKQQLEEEIAVHYQIAMDSLRLFGIKAAALIELTKQLQNRSNLS

Sequences:

>Translated_298_residues
MNKQVIDKYTQRHELYLEQLLNEIVIPAPQIRSALHYALFSGGKRIRPILVYLAGDLIDVDQEVLDIIAAALELTHCYSL
IHDDLPAMDNDDLRRGKPSCHKAFDEATAILVGDGMQALAIEVVLMRLSPLLPAAQVVAITQVLVNASGISGMVSGQSLD
LSELAKSSVTEEQLREIHLLKTGKLILACFEMVLAAQHEVSEQIKSALRTYGKHIGLVFQMQDDYLDLYAPTQILGKGRS
SDQANQKTTFATLFNKQQLEEEIAVHYQIAMDSLRLFGIKAAALIELTKQLQNRSNLS
>Mature_298_residues
MNKQVIDKYTQRHELYLEQLLNEIVIPAPQIRSALHYALFSGGKRIRPILVYLAGDLIDVDQEVLDIIAAALELTHCYSL
IHDDLPAMDNDDLRRGKPSCHKAFDEATAILVGDGMQALAIEVVLMRLSPLLPAAQVVAITQVLVNASGISGMVSGQSLD
LSELAKSSVTEEQLREIHLLKTGKLILACFEMVLAAQHEVSEQIKSALRTYGKHIGLVFQMQDDYLDLYAPTQILGKGRS
SDQANQKTTFATLFNKQQLEEEIAVHYQIAMDSLRLFGIKAAALIELTKQLQNRSNLS

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=266, Percent_Identity=30.0751879699248, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1786623, Length=249, Percent_Identity=40.5622489959839, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1789578, Length=239, Percent_Identity=29.2887029288703, Blast_Score=96, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24651612, Length=244, Percent_Identity=25.8196721311475, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 33034; Mature: 33034

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKQVIDKYTQRHELYLEQLLNEIVIPAPQIRSALHYALFSGGKRIRPILVYLAGDLIDV
CCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHH
DQEVLDIIAAALELTHCYSLIHDDLPAMDNDDLRRGKPSCHKAFDEATAILVGDGMQALA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHEEEECCCHHHHH
IEVVLMRLSPLLPAAQVVAITQVLVNASGISGMVSGQSLDLSELAKSSVTEEQLREIHLL
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHH
KTGKLILACFEMVLAAQHEVSEQIKSALRTYGKHIGLVFQMQDDYLDLYAPTQILGKGRS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHCCHHHHCCCCC
SDQANQKTTFATLFNKQQLEEEIAVHYQIAMDSLRLFGIKAAALIELTKQLQNRSNLS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNKQVIDKYTQRHELYLEQLLNEIVIPAPQIRSALHYALFSGGKRIRPILVYLAGDLIDV
CCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHH
DQEVLDIIAAALELTHCYSLIHDDLPAMDNDDLRRGKPSCHKAFDEATAILVGDGMQALA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHEEEECCCHHHHH
IEVVLMRLSPLLPAAQVVAITQVLVNASGISGMVSGQSLDLSELAKSSVTEEQLREIHLL
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHH
KTGKLILACFEMVLAAQHEVSEQIKSALRTYGKHIGLVFQMQDDYLDLYAPTQILGKGRS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHCCHHHHCCCCC
SDQANQKTTFATLFNKQQLEEEIAVHYQIAMDSLRLFGIKAAALIELTKQLQNRSNLS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]