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The map label for this gene is lly [H]

Identifier: 54295124

GI number: 54295124

Start: 2518550

End: 2519596

Strand: Direct

Name: lly [H]

Synonym: lpl2204

Alternate gene names: 54295124

Gene position: 2518550-2519596 (Clockwise)

Preceding gene: 54295123

Following gene: 54295125

Centisome position: 75.28

GC content: 41.36

Gene sequence:

>1047_bases
ATGCAAAATAATAACCCCTGCGGATTAGATGGCTTTGCCTTTTTAGAGTTTTCAGGCCCTGATAGGAATAAATTACATCA
GCAATTTTCTGAGATGGGGTTTCAGGCCGTTGCCCACCATAAAAATCAAGACATTACTCTTTTCAAACAAGGGGAAATAC
AATTTATAGTGAATGCGGCCTCCCATTGTCAGGCAGAAGCGCATGCTTCAACTCATGGTCCAGGCGCTTGTGCAATGGGC
TTTAAAGTAAAAGATGCCAAAGCCGCTTTTCAACACGCTATCGCGCATGGCGGTATAGCATTTCAGGATGCGCCTCATGC
CAATCACGGCTTGCCAGCCATCCAGGCTATTGGTGGTAGTGTTATTTATTTTGTCGATGAAGAACACCAACCCTTCTCTC
ATGAATGGAATATTACCTCGCCAGAACCCGTAGTTGGAAATGGTCTGACCGCAATCGACCATCTCACCCATAACGTTTAT
CGCGGTAATATGGATAAATGGGCCAGTTTCTATGCTTCCATTTTTAACTTCCAGGAAATTCGTTTTTTCAATATCAAAGG
AAAAATGACTGGTTTGGTCAGTCGAGCATTAGGTAGCCCTTGTGGCAAAATCAAAATTCCTTTAAACGAATCCAAAGATG
ATTTATCACAAATTGAAGAGTTTCTTCATGAATATCATGGCGAGGGCATTCAACACATCGCTCTCAATACCAATGATATT
TATAAAACAGTCAACGGCTTAAGAAAACAAGGGGTCAAATTCCTGGATGTGCCGGATACTTACTATGAGATGATTAATGA
CCGTCTCCCATGGCACAAGGAGCCACTGAATCAACTCCATGCTGAGAAAATTTTAATTGATGGAGAAGCAGATCCCAAAG
ACGGCTTGTTACTGCAAATATTTACTGAAAACATATTTGGACCAGTCTTTTTTGAAATTATTCAACGCAAAGGCAATCAG
GGGTTTGGTGAAGGGAATTTCCAGGCTCTATTCGAAGCTATTGAAAGAGATCAAGTTCGACGTGGTACTTTAAAAGAATT
AAGCTAG

Upstream 100 bases:

>100_bases
AGCTGATGGGATGTTTCTGGTGCAACCCATTTAATCTTTAAAATCCCCGGCAAGCAATACACTGCATTGCTATGTAAATA
AGTACAAGGAGAATCTGATA

Downstream 100 bases:

>100_bases
ACAAACAGTTGAAATGTAATGATGCTGTTTTTCAGGCATAAGCCAGGAGATCTATATGAAACTCGCCAGTTTGAAATCAA
CTCGTTCCCGGGATGGAGAG

Product: 4-hydroxyphenylpyruvate dioxygenase (legiolysin)

Products: NA

Alternate protein names: 4HPPD; HPD; HPPDase; Legiolysin [H]

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MQNNNPCGLDGFAFLEFSGPDRNKLHQQFSEMGFQAVAHHKNQDITLFKQGEIQFIVNAASHCQAEAHASTHGPGACAMG
FKVKDAKAAFQHAIAHGGIAFQDAPHANHGLPAIQAIGGSVIYFVDEEHQPFSHEWNITSPEPVVGNGLTAIDHLTHNVY
RGNMDKWASFYASIFNFQEIRFFNIKGKMTGLVSRALGSPCGKIKIPLNESKDDLSQIEEFLHEYHGEGIQHIALNTNDI
YKTVNGLRKQGVKFLDVPDTYYEMINDRLPWHKEPLNQLHAEKILIDGEADPKDGLLLQIFTENIFGPVFFEIIQRKGNQ
GFGEGNFQALFEAIERDQVRRGTLKELS

Sequences:

>Translated_348_residues
MQNNNPCGLDGFAFLEFSGPDRNKLHQQFSEMGFQAVAHHKNQDITLFKQGEIQFIVNAASHCQAEAHASTHGPGACAMG
FKVKDAKAAFQHAIAHGGIAFQDAPHANHGLPAIQAIGGSVIYFVDEEHQPFSHEWNITSPEPVVGNGLTAIDHLTHNVY
RGNMDKWASFYASIFNFQEIRFFNIKGKMTGLVSRALGSPCGKIKIPLNESKDDLSQIEEFLHEYHGEGIQHIALNTNDI
YKTVNGLRKQGVKFLDVPDTYYEMINDRLPWHKEPLNQLHAEKILIDGEADPKDGLLLQIFTENIFGPVFFEIIQRKGNQ
GFGEGNFQALFEAIERDQVRRGTLKELS
>Mature_348_residues
MQNNNPCGLDGFAFLEFSGPDRNKLHQQFSEMGFQAVAHHKNQDITLFKQGEIQFIVNAASHCQAEAHASTHGPGACAMG
FKVKDAKAAFQHAIAHGGIAFQDAPHANHGLPAIQAIGGSVIYFVDEEHQPFSHEWNITSPEPVVGNGLTAIDHLTHNVY
RGNMDKWASFYASIFNFQEIRFFNIKGKMTGLVSRALGSPCGKIKIPLNESKDDLSQIEEFLHEYHGEGIQHIALNTNDI
YKTVNGLRKQGVKFLDVPDTYYEMINDRLPWHKEPLNQLHAEKILIDGEADPKDGLLLQIFTENIFGPVFFEIIQRKGNQ
GFGEGNFQALFEAIERDQVRRGTLKELS

Specific function: Catalyzes the transformation of p-hydroxyphenylpyruvate into HGA. Has hemolytic and brown pigment production activity [H]

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI4504477, Length=352, Percent_Identity=29.2613636363636, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI285002264, Length=350, Percent_Identity=29.1428571428571, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI14249394, Length=346, Percent_Identity=26.3005780346821, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17555220, Length=346, Percent_Identity=30.635838150289, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17550752, Length=207, Percent_Identity=34.2995169082126, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24667510, Length=325, Percent_Identity=33.2307692307692, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI21356105, Length=299, Percent_Identity=34.1137123745819, Blast_Score=140, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =1.13.11.27 [H]

Molecular weight: Translated: 38923; Mature: 38923

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNNNPCGLDGFAFLEFSGPDRNKLHQQFSEMGFQAVAHHKNQDITLFKQGEIQFIVNAA
CCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEEECH
SHCQAEAHASTHGPGACAMGFKVKDAKAAFQHAIAHGGIAFQDAPHANHGLPAIQAIGGS
HHHHHHHCCCCCCCCEEEECEEECHHHHHHHHHHHHCCEEECCCCCCCCCCCHHHHCCCE
VIYFVDEEHQPFSHEWNITSPEPVVGNGLTAIDHLTHNVYRGNMDKWASFYASIFNFQEI
EEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEE
RFFNIKGKMTGLVSRALGSPCGKIKIPLNESKDDLSQIEEFLHEYHGEGIQHIALNTNDI
EEEEECCHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEECCHHH
YKTVNGLRKQGVKFLDVPDTYYEMINDRLPWHKEPLNQLHAEKILIDGEADPKDGLLLQI
HHHHHHHHHCCCEEEECCHHHHHHHHCCCCCCCCHHHHHHHHEEEECCCCCCCCCEEEEE
FTENIFGPVFFEIIQRKGNQGFGEGNFQALFEAIERDQVRRGTLKELS
EHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHCC
>Mature Secondary Structure
MQNNNPCGLDGFAFLEFSGPDRNKLHQQFSEMGFQAVAHHKNQDITLFKQGEIQFIVNAA
CCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEEECH
SHCQAEAHASTHGPGACAMGFKVKDAKAAFQHAIAHGGIAFQDAPHANHGLPAIQAIGGS
HHHHHHHCCCCCCCCEEEECEEECHHHHHHHHHHHHCCEEECCCCCCCCCCCHHHHCCCE
VIYFVDEEHQPFSHEWNITSPEPVVGNGLTAIDHLTHNVYRGNMDKWASFYASIFNFQEI
EEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEE
RFFNIKGKMTGLVSRALGSPCGKIKIPLNESKDDLSQIEEFLHEYHGEGIQHIALNTNDI
EEEEECCHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEECCHHH
YKTVNGLRKQGVKFLDVPDTYYEMINDRLPWHKEPLNQLHAEKILIDGEADPKDGLLLQI
HHHHHHHHHCCCEEEECCHHHHHHHHCCCCCCCCHHHHHHHHEEEECCCCCCCCCEEEEE
FTENIFGPVFFEIIQRKGNQGFGEGNFQALFEAIERDQVRRGTLKELS
EHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA