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The map label for this gene is mdmC [H]

Identifier: 54295123

GI number: 54295123

Start: 2517827

End: 2518483

Strand: Direct

Name: mdmC [H]

Synonym: lpl2203

Alternate gene names: 54295123

Gene position: 2517827-2518483 (Clockwise)

Preceding gene: 54295122

Following gene: 54295124

Centisome position: 75.26

GC content: 38.81

Gene sequence:

>657_bases
ATGAAACATTTATCCCTTACTCCAGAGTTGTATGAATACCTGATTGATGTTTCCTTGCGTGAACATCCTGCTCTTACGGC
ATTACGCAAAGAAACATCCTCTATGGAGCTCGCCAATATGCAGGTAGCTCCTGAGCAAGCTCAATTTATGCAGATGCTGA
TACGTTTAATTGGTGCAAAGAAGGTATTGGAACTTGGGACATTCACAGGTTATAGTGCCTTGGCCATGTCCCTTGCTTTG
CCTGATGATGGGCAAGTTATCACCTGTGATATTAATGAGGGATGGACAAAGCATGCCCATCCTTATTGGCGTGAAGCCAA
ACAGGAACATAAAATTAAATTACGCCTTGGACCTGCTCTTGACACTTTGCACTCATTACTTGATGAAGGTGGAGAGCATC
AATTTGATTTCATTTTTATTGATGCTGACAAAACCAATTATCTGAATTACTATGAACTGGCTTTAAAATTGGTTACACCT
AAAGGATTAATTGCCATAGATAATATTTTTTGGGATGGAAAAGTAATTGATCCGAGTGATACGACTGGACAAACCAGAGA
AATTAAAAAATTAAATCAATTGATTAAAAACGACTCAAGGGTCTTTGTCAGTTTGTTAGCTATAGCTGATGGGATGTTTC
TGGTGCAACCCATTTAA

Upstream 100 bases:

>100_bases
TGACTGAAATTTTTACTCGCTCAGCTAAAGATAATTTACCTACCAGCGAGATTGCTGATACTTTGGCTAAGGAAAAATTG
GCTTAATTTGGATACCGTTT

Downstream 100 bases:

>100_bases
TCTTTAAAATCCCCGGCAAGCAATACACTGCATTGCTATGTAAATAAGTACAAGGAGAATCTGATAATGCAAAATAATAA
CCCCTGCGGATTAGATGGCT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MKHLSLTPELYEYLIDVSLREHPALTALRKETSSMELANMQVAPEQAQFMQMLIRLIGAKKVLELGTFTGYSALAMSLAL
PDDGQVITCDINEGWTKHAHPYWREAKQEHKIKLRLGPALDTLHSLLDEGGEHQFDFIFIDADKTNYLNYYELALKLVTP
KGLIAIDNIFWDGKVIDPSDTTGQTREIKKLNQLIKNDSRVFVSLLAIADGMFLVQPI

Sequences:

>Translated_218_residues
MKHLSLTPELYEYLIDVSLREHPALTALRKETSSMELANMQVAPEQAQFMQMLIRLIGAKKVLELGTFTGYSALAMSLAL
PDDGQVITCDINEGWTKHAHPYWREAKQEHKIKLRLGPALDTLHSLLDEGGEHQFDFIFIDADKTNYLNYYELALKLVTP
KGLIAIDNIFWDGKVIDPSDTTGQTREIKKLNQLIKNDSRVFVSLLAIADGMFLVQPI
>Mature_218_residues
MKHLSLTPELYEYLIDVSLREHPALTALRKETSSMELANMQVAPEQAQFMQMLIRLIGAKKVLELGTFTGYSALAMSLAL
PDDGQVITCDINEGWTKHAHPYWREAKQEHKIKLRLGPALDTLHSLLDEGGEHQFDFIFIDADKTNYLNYYELALKLVTP
KGLIAIDNIFWDGKVIDPSDTTGQTREIKKLNQLIKNDSRVFVSLLAIADGMFLVQPI

Specific function: 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics [H]

COG id: COG4122

COG function: function code R; Predicted O-methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Type 3 family [H]

Homologues:

Organism=Homo sapiens, GI31542747, Length=213, Percent_Identity=46.4788732394366, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17565612, Length=207, Percent_Identity=40.0966183574879, Blast_Score=147, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI72001028, Length=208, Percent_Identity=39.4230769230769, Blast_Score=137, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI72001127, Length=195, Percent_Identity=40.5128205128205, Blast_Score=135, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI25148771, Length=203, Percent_Identity=37.9310344827586, Blast_Score=128, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI71991493, Length=181, Percent_Identity=30.3867403314917, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002935 [H]

Pfam domain/function: PF01596 Methyltransf_3 [H]

EC number: NA

Molecular weight: Translated: 24671; Mature: 24671

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS00018 EF_HAND_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHLSLTPELYEYLIDVSLREHPALTALRKETSSMELANMQVAPEQAQFMQMLIRLIGAK
CCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHEEECCHHHHHHHHHHHHHCHH
KVLELGTFTGYSALAMSLALPDDGQVITCDINEGWTKHAHPYWREAKQEHKIKLRLGPAL
HHHHHHCCCCHHHHHEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHHCCEEEEEECHHH
DTLHSLLDEGGEHQFDFIFIDADKTNYLNYYELALKLVTPKGLIAIDNIFWDGKVIDPSD
HHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHEEEEEECCCCEEEEEEEEECCEEECCCC
TTGQTREIKKLNQLIKNDSRVFVSLLAIADGMFLVQPI
CCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEECC
>Mature Secondary Structure
MKHLSLTPELYEYLIDVSLREHPALTALRKETSSMELANMQVAPEQAQFMQMLIRLIGAK
CCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHEEECCHHHHHHHHHHHHHCHH
KVLELGTFTGYSALAMSLALPDDGQVITCDINEGWTKHAHPYWREAKQEHKIKLRLGPAL
HHHHHHCCCCHHHHHEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHHCCEEEEEECHHH
DTLHSLLDEGGEHQFDFIFIDADKTNYLNYYELALKLVTPKGLIAIDNIFWDGKVIDPSD
HHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHEEEEEECCCCEEEEEEEEECCEEECCCC
TTGQTREIKKLNQLIKNDSRVFVSLLAIADGMFLVQPI
CCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629172 [H]