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The map label for this gene is upp

Identifier: 54295088

GI number: 54295088

Start: 2479376

End: 2480020

Strand: Direct

Name: upp

Synonym: lpl2168

Alternate gene names: 54295088

Gene position: 2479376-2480020 (Clockwise)

Preceding gene: 54295087

Following gene: 54295089

Centisome position: 74.11

GC content: 41.4

Gene sequence:

>645_bases
ATGGACTTCAATCAAGTTAAGGTTATAAATCATCCCCTCATTCAGCACAAACTCACCATAATGAGGAAAAAAGAAACCAG
CACAGTAAAATTTCGGACACTCATGCACGAAGTCAGCATGCTATTAGCTTATGAAGTTACTCGGGATTTGGAAATAGAAT
ATGAAGAAATAGAAACTCCTTTGGCTACCATGCAATCACCCGTTTTGAAAGGAAAAAAACTTGTTTTTGTCTCGATATTA
CGCGCGGGTAATGGTCTACTGGACGGCATGTTACAACTAGTTCCTACTGCCAGAATTGGTCATATAGGTCTCTATCGGGA
TCCCAAAACACTGGAAGCAGTCGAATACTACTTCAAGCTACCTGAACACACACAAGACAGAGACGTTATTGTTGTTGACC
CCATGCTGGCGACAGGAAATTCAGCCATTGCTGCGGTTAAAGAAGTCAAAGCCTTACATCCCAAATCAATTAAATTTCTT
TGTCTACTGGCCGCTCCTGAAGGAATTTCCAATTTTCATGGAGAACATCCTGATGTTCCAATATTTACCGCAGCCATAGA
TGAGCAACTGAATGATCATGGATACATTGTCCCTGGTTTAGGCGATGCAGGAGACAGACTATATGGCACAAAACTGGCTC
ATTAA

Upstream 100 bases:

>100_bases
TTGGGAGGCAGGACGACAGATTGCACAAAAGAAACGAATTAATGGAACACCCCCAATAGAAATTATCAGTGATGGCACGA
TATTTTAATAAGGAATCATA

Downstream 100 bases:

>100_bases
TGCTGAATTATCTTTATTTCAGGGATACCCAATCAGCCAATAGTACGTTTAAATAATAATTAAGATTGTCTTGCCATTTC
AGTAATGACTGCTTTCACTT

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MDFNQVKVINHPLIQHKLTIMRKKETSTVKFRTLMHEVSMLLAYEVTRDLEIEYEEIETPLATMQSPVLKGKKLVFVSIL
RAGNGLLDGMLQLVPTARIGHIGLYRDPKTLEAVEYYFKLPEHTQDRDVIVVDPMLATGNSAIAAVKEVKALHPKSIKFL
CLLAAPEGISNFHGEHPDVPIFTAAIDEQLNDHGYIVPGLGDAGDRLYGTKLAH

Sequences:

>Translated_214_residues
MDFNQVKVINHPLIQHKLTIMRKKETSTVKFRTLMHEVSMLLAYEVTRDLEIEYEEIETPLATMQSPVLKGKKLVFVSIL
RAGNGLLDGMLQLVPTARIGHIGLYRDPKTLEAVEYYFKLPEHTQDRDVIVVDPMLATGNSAIAAVKEVKALHPKSIKFL
CLLAAPEGISNFHGEHPDVPIFTAAIDEQLNDHGYIVPGLGDAGDRLYGTKLAH
>Mature_214_residues
MDFNQVKVINHPLIQHKLTIMRKKETSTVKFRTLMHEVSMLLAYEVTRDLEIEYEEIETPLATMQSPVLKGKKLVFVSIL
RAGNGLLDGMLQLVPTARIGHIGLYRDPKTLEAVEYYFKLPEHTQDRDVIVVDPMLATGNSAIAAVKEVKALHPKSIKFL
CLLAAPEGISNFHGEHPDVPIFTAAIDEQLNDHGYIVPGLGDAGDRLYGTKLAH

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=31.6831683168317, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=31.6831683168317, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI21450816, Length=175, Percent_Identity=29.7142857142857, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI87082118, Length=203, Percent_Identity=51.2315270935961, Blast_Score=212, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17539892, Length=205, Percent_Identity=26.3414634146341, Blast_Score=80, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17539894, Length=205, Percent_Identity=26.3414634146341, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321920, Length=192, Percent_Identity=38.0208333333333, Blast_Score=121, Evalue=9e-29,
Organism=Drosophila melanogaster, GI28573516, Length=203, Percent_Identity=29.5566502463054, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28573514, Length=203, Percent_Identity=29.5566502463054, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28573512, Length=203, Percent_Identity=29.5566502463054, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI45550449, Length=203, Percent_Identity=29.5566502463054, Blast_Score=90, Evalue=1e-18,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_LEGPA (Q5X340)

Other databases:

- EMBL:   CR628336
- RefSeq:   YP_124508.1
- ProteinModelPortal:   Q5X340
- SMR:   Q5X340
- STRING:   Q5X340
- GeneID:   3117618
- GenomeReviews:   CR628336_GR
- KEGG:   lpp:lpp2196
- LegioList:   lpp2196
- eggNOG:   COG0035
- HOGENOM:   HBG326432
- OMA:   LRAGNGF
- ProtClustDB:   PRK00129
- BioCyc:   LPNE297246:LPP2196-MONOMER
- HAMAP:   MF_01218_B
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 23877; Mature: 23877

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: BINDING 81-81 BINDING 106-106 BINDING 196-196 BINDING 202-202

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFNQVKVINHPLIQHKLTIMRKKETSTVKFRTLMHEVSMLLAYEVTRDLEIEYEEIETP
CCCCCEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHCCC
LATMQSPVLKGKKLVFVSILRAGNGLLDGMLQLVPTARIGHIGLYRDPKTLEAVEYYFKL
HHHHHHHHHCCCCEEEEEHHHHCCHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHCC
PEHTQDRDVIVVDPMLATGNSAIAAVKEVKALHPKSIKFLCLLAAPEGISNFHGEHPDVP
CCCCCCCCEEEECCEEECCCHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHCCCCCCCCC
IFTAAIDEQLNDHGYIVPGLGDAGDRLYGTKLAH
EEHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDFNQVKVINHPLIQHKLTIMRKKETSTVKFRTLMHEVSMLLAYEVTRDLEIEYEEIETP
CCCCCEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHCCC
LATMQSPVLKGKKLVFVSILRAGNGLLDGMLQLVPTARIGHIGLYRDPKTLEAVEYYFKL
HHHHHHHHHCCCCEEEEEHHHHCCHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHCC
PEHTQDRDVIVVDPMLATGNSAIAAVKEVKALHPKSIKFLCLLAAPEGISNFHGEHPDVP
CCCCCCCCEEEECCEEECCCHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHCCCCCCCCC
IFTAAIDEQLNDHGYIVPGLGDAGDRLYGTKLAH
EEHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA