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The map label for this gene is lip2 [H]

Identifier: 54294774

GI number: 54294774

Start: 2071852

End: 2072817

Strand: Direct

Name: lip2 [H]

Synonym: lpl1851

Alternate gene names: 54294774

Gene position: 2071852-2072817 (Clockwise)

Preceding gene: 54294772

Following gene: 54294776

Centisome position: 61.93

GC content: 42.96

Gene sequence:

>966_bases
ATGGATTTAAGCAAAAGAATAGAACCCAAAACCTGGTCATTTGTTGAAAAAATACAAAATGCGGGTGGAAAACCGATTTA
TGACATACCGGTTGCAGAAGGCAGGGCAATATTTGATCAAATACAAGCTTTACCTAATGAGAAACCTGATGTCGATGTTG
AAGATAAAACTTTGCCAGTAGGGCCTGGCGGTAAGGTTGACATTCGCATTGTTCGCCCTAAAGGTGCAAAAGAAGCCTTA
CCTGTCATTATGTTTTTTCATGGTGCTGGCTGGGTTTTTGGCGACTATCAAACTCATGGTCGTCTCGTACGAGAAATAGC
AGTGGGTACTCATGCTGCAGTCGTGTTTGTTAAATACACTTTAGCTCCGGAAGCTCAGTACCCGACACAAATAGAAGAAT
CTTACGCTGCCATGAAATATATAGCAGAACATGGCAAGCAATTTAATCTTGATACTTCACGATTTGTCGCTGCAGGCGAC
AGTGTTGGTGGTAATATGACCAGCGTCATGACTCTTCTTGCTAAAGAACGTGGTGGCCCCCAAATTGATTATCAAGTACT
CATTTATCCTGTAACTGATGCCAATTTTGATAACGCTTCCTATAAAGAATTTGCTGAAGGTCCCTGGCTAACCAAAAAGG
CGATGGAGTGGTTTTGGGATAAGTATTTGCCCAATAAAGAAAAAAGAAAGGAAATTACAGCAAGTCCGCTGCAAGCCTCT
CTTGAACAACTTAAAGGCCTACCACCAGCACTGGTCATCACTGGTGAGTGTGATGTTTTGCGTGATGAGGGCGAAGCCTA
TGCCCATAAACTCAACGCAGCAGGTGTGACAGTGACTGCAGTTCGTCATCTGGGCACAATCCATGATTTCCTGATGCTCA
ATGATCTCTCTGAAACACCGGCATGCCGAAATGCCGTTGAAACCATTATTGGTCACTTAACTCAGATTTTTGGCAAGAAA
AAGTAA

Upstream 100 bases:

>100_bases
GTTATTATTATCCACAAACGAATTCAAATTTTCTTGATTTTTCAATTCAATATACTATACATAAGAAGTCATCCCTATTT
ATAAATTAAGGAAAATCAAA

Downstream 100 bases:

>100_bases
AACAATACATGACTAACATCCAAGTGGATGTTAGTCATGCTGAATGCATTTACAATAATTGTGCTATTTGGGGATTGCCG
TTCTTGAGTTGCTGATGTTG

Product: hypothetical protein

Products: NA

Alternate protein names: Triacylglycerol lipase [H]

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MDLSKRIEPKTWSFVEKIQNAGGKPIYDIPVAEGRAIFDQIQALPNEKPDVDVEDKTLPVGPGGKVDIRIVRPKGAKEAL
PVIMFFHGAGWVFGDYQTHGRLVREIAVGTHAAVVFVKYTLAPEAQYPTQIEESYAAMKYIAEHGKQFNLDTSRFVAAGD
SVGGNMTSVMTLLAKERGGPQIDYQVLIYPVTDANFDNASYKEFAEGPWLTKKAMEWFWDKYLPNKEKRKEITASPLQAS
LEQLKGLPPALVITGECDVLRDEGEAYAHKLNAAGVTVTAVRHLGTIHDFLMLNDLSETPACRNAVETIIGHLTQIFGKK
K

Sequences:

>Translated_321_residues
MDLSKRIEPKTWSFVEKIQNAGGKPIYDIPVAEGRAIFDQIQALPNEKPDVDVEDKTLPVGPGGKVDIRIVRPKGAKEAL
PVIMFFHGAGWVFGDYQTHGRLVREIAVGTHAAVVFVKYTLAPEAQYPTQIEESYAAMKYIAEHGKQFNLDTSRFVAAGD
SVGGNMTSVMTLLAKERGGPQIDYQVLIYPVTDANFDNASYKEFAEGPWLTKKAMEWFWDKYLPNKEKRKEITASPLQAS
LEQLKGLPPALVITGECDVLRDEGEAYAHKLNAAGVTVTAVRHLGTIHDFLMLNDLSETPACRNAVETIIGHLTQIFGKK
K
>Mature_321_residues
MDLSKRIEPKTWSFVEKIQNAGGKPIYDIPVAEGRAIFDQIQALPNEKPDVDVEDKTLPVGPGGKVDIRIVRPKGAKEAL
PVIMFFHGAGWVFGDYQTHGRLVREIAVGTHAAVVFVKYTLAPEAQYPTQIEESYAAMKYIAEHGKQFNLDTSRFVAAGD
SVGGNMTSVMTLLAKERGGPQIDYQVLIYPVTDANFDNASYKEFAEGPWLTKKAMEWFWDKYLPNKEKRKEITASPLQAS
LEQLKGLPPALVITGECDVLRDEGEAYAHKLNAAGVTVTAVRHLGTIHDFLMLNDLSETPACRNAVETIIGHLTQIFGKK
K

Specific function: Has An Esterase Activity. Triacetyl Glycerol (Triacetin) Is A Substrate Of The Enzyme. [C]

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Homo sapiens, GI68299767, Length=296, Percent_Identity=27.027027027027, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI206597554, Length=290, Percent_Identity=27.5862068965517, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI61966717, Length=291, Percent_Identity=25.4295532646048, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI157041239, Length=321, Percent_Identity=23.3644859813084, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI68051721, Length=280, Percent_Identity=24.6428571428571, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI1786682, Length=258, Percent_Identity=26.3565891472868, Blast_Score=93, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17567059, Length=256, Percent_Identity=26.953125, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71996133, Length=161, Percent_Identity=32.2981366459627, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17540028, Length=161, Percent_Identity=31.055900621118, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI72001146, Length=143, Percent_Identity=27.972027972028, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24656084, Length=162, Percent_Identity=27.7777777777778, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24656076, Length=162, Percent_Identity=27.7777777777778, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI20130169, Length=162, Percent_Identity=27.7777777777778, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094
- InterPro:   IPR002168 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: =3.1.1.3 [H]

Molecular weight: Translated: 35530; Mature: 35530

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLSKRIEPKTWSFVEKIQNAGGKPIYDIPVAEGRAIFDQIQALPNEKPDVDVEDKTLPV
CCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCEECC
GPGGKVDIRIVRPKGAKEALPVIMFFHGAGWVFGDYQTHGRLVREIAVGTHAAVVFVKYT
CCCCEEEEEEECCCCCCHHCCEEEEEECCCEEECCHHHHHHHHHHHHHCCCEEEEEEEEE
LAPEAQYPTQIEESYAAMKYIAEHGKQFNLDTSRFVAAGDSVGGNMTSVMTLLAKERGGP
ECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHEEEECCCCCCHHHHHHHHHHHHCCCC
QIDYQVLIYPVTDANFDNASYKEFAEGPWLTKKAMEWFWDKYLPNKEKRKEITASPLQAS
CEEEEEEEEEECCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHH
LEQLKGLPPALVITGECDVLRDEGEAYAHKLNAAGVTVTAVRHLGTIHDFLMLNDLSETP
HHHHHCCCCEEEEECCCCEECCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCH
ACRNAVETIIGHLTQIFGKKK
HHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDLSKRIEPKTWSFVEKIQNAGGKPIYDIPVAEGRAIFDQIQALPNEKPDVDVEDKTLPV
CCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCEECC
GPGGKVDIRIVRPKGAKEALPVIMFFHGAGWVFGDYQTHGRLVREIAVGTHAAVVFVKYT
CCCCEEEEEEECCCCCCHHCCEEEEEECCCEEECCHHHHHHHHHHHHHCCCEEEEEEEEE
LAPEAQYPTQIEESYAAMKYIAEHGKQFNLDTSRFVAAGDSVGGNMTSVMTLLAKERGGP
ECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHEEEECCCCCCHHHHHHHHHHHHCCCC
QIDYQVLIYPVTDANFDNASYKEFAEGPWLTKKAMEWFWDKYLPNKEKRKEITASPLQAS
CEEEEEEEEEECCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHH
LEQLKGLPPALVITGECDVLRDEGEAYAHKLNAAGVTVTAVRHLGTIHDFLMLNDLSETP
HHHHHCCCCEEEEECCCCEECCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCH
ACRNAVETIIGHLTQIFGKKK
HHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1907455 [H]