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The map label for this gene is thlA [H]

Identifier: 54294712

GI number: 54294712

Start: 2002000

End: 2003184

Strand: Direct

Name: thlA [H]

Synonym: lpl1789

Alternate gene names: 54294712

Gene position: 2002000-2003184 (Clockwise)

Preceding gene: 54294711

Following gene: 54294713

Centisome position: 59.84

GC content: 44.47

Gene sequence:

>1185_bases
ATGGAACATAATGATGTCGTGATAGTCGCAGCAAAAAGAACACCAATGGGAGCTATGCTAGGCAATTTATCTGCACTTTC
CTCCCCAGAGTTAGGGGCAGTAGCGCATATGGCGGTGTTGTCTCAATCAGGTATTGCTCCGGCAGAAATCGATGAAGTGA
TCAGTGGTTGTGTATTACAAGCTGGTATTGGTCAAGCGCCTGCCAGACAGGCAGCAATAAAAGCAGGCATTCCTAATTCG
GCAGGAGCCACGACCATTAATAAAATGTGTGGTTCGGGCATGAAAGCTGTGATGTTTGCACATGATTTAATCAAGGCAGG
TACAGCTAATGTAGTTTTGGCTAGCGGTATGGAAAGTATGAGTAATGCCCCGTATTTATTATCCAAAGCAAGAGCAGGAT
ATCGACTGGGTCATGGTGAACTGAAAGACCATATGTTCCTTGATGGATTAGAAGATGCTTATGATAAAGGACAATTAATG
GGGTGTTTCGCTGAAACAACTGCAAAACACTTTAATTTCAGCAGAGAACAACAAGACGAATATGCCTTACGCTCAATGAA
CAGAGCGCTAAAAGCAATAGAGAATGGTGCCTTTCGAGAAGAAATAGCTCCCGTCACCTTAACTACCCGCAAAGGAGATG
TCACAATTGATGTCGATGAGGGACCTGATGCAGCCAAACTTGCCAAAATACCTCAGTTAAAACCAGCCTTTCAAGCAGAT
GGTACAGTCACAGCAGCCAATTCAAGTTCTATTTCAGATGGTGCGGCCAGCTTGATTTTAATGAGTGCCTCGAACGCAGA
AAAACGTGGCATTAAACCCTTGGCAAAAATTATAGCACATGCCAGCCATTCCCAAGCTCCACAATGGTTCACAACCGCTC
CTGTTGATGCAATCCGTAAGGTAATGAACAAGGCGTCATGGAAACAAGATGATGTGGATCTTTTTGAGATTAATGAAGCG
TTTGCAGTGGTAGCGATGGCAGCAATTACTCAGCTTGAATTGAACCCGGAACAAGTCAATATACATGGCGGGGCATGCGC
TTTAGGGCATCCCATTGGTGCTTCGGGAGCTCGCATTCTGGTTACTTTAATGCATGCGCTAAAACACCAGGGTAAAAAAC
GCGGAATAGCTTCTTTATGTATAGGCGGTGGTGAAGCTACAGCTATGGCAATTGAGCTAATTTAA

Upstream 100 bases:

>100_bases
GGGATGCGAAGTTGTATGAAATTGGGGCAGGCACTTCTGAAATAAGAAGAATGCTAATTGGTCGTGAACTTTTTAAAGAA
ACAGCATAAGGAATGAGACA

Downstream 100 bases:

>100_bases
CGGTTAAAGATGACCTGGGTAAAAATTTTATTTTTACCCAGTTTTTTATATTCAAACTGGTTGCTATTTTTATTTGTGAC
CAGATAATGTTTTACCTATC

Product: hypothetical protein

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MEHNDVVIVAAKRTPMGAMLGNLSALSSPELGAVAHMAVLSQSGIAPAEIDEVISGCVLQAGIGQAPARQAAIKAGIPNS
AGATTINKMCGSGMKAVMFAHDLIKAGTANVVLASGMESMSNAPYLLSKARAGYRLGHGELKDHMFLDGLEDAYDKGQLM
GCFAETTAKHFNFSREQQDEYALRSMNRALKAIENGAFREEIAPVTLTTRKGDVTIDVDEGPDAAKLAKIPQLKPAFQAD
GTVTAANSSSISDGAASLILMSASNAEKRGIKPLAKIIAHASHSQAPQWFTTAPVDAIRKVMNKASWKQDDVDLFEINEA
FAVVAMAAITQLELNPEQVNIHGGACALGHPIGASGARILVTLMHALKHQGKKRGIASLCIGGGEATAMAIELI

Sequences:

>Translated_394_residues
MEHNDVVIVAAKRTPMGAMLGNLSALSSPELGAVAHMAVLSQSGIAPAEIDEVISGCVLQAGIGQAPARQAAIKAGIPNS
AGATTINKMCGSGMKAVMFAHDLIKAGTANVVLASGMESMSNAPYLLSKARAGYRLGHGELKDHMFLDGLEDAYDKGQLM
GCFAETTAKHFNFSREQQDEYALRSMNRALKAIENGAFREEIAPVTLTTRKGDVTIDVDEGPDAAKLAKIPQLKPAFQAD
GTVTAANSSSISDGAASLILMSASNAEKRGIKPLAKIIAHASHSQAPQWFTTAPVDAIRKVMNKASWKQDDVDLFEINEA
FAVVAMAAITQLELNPEQVNIHGGACALGHPIGASGARILVTLMHALKHQGKKRGIASLCIGGGEATAMAIELI
>Mature_394_residues
MEHNDVVIVAAKRTPMGAMLGNLSALSSPELGAVAHMAVLSQSGIAPAEIDEVISGCVLQAGIGQAPARQAAIKAGIPNS
AGATTINKMCGSGMKAVMFAHDLIKAGTANVVLASGMESMSNAPYLLSKARAGYRLGHGELKDHMFLDGLEDAYDKGQLM
GCFAETTAKHFNFSREQQDEYALRSMNRALKAIENGAFREEIAPVTLTTRKGDVTIDVDEGPDAAKLAKIPQLKPAFQAD
GTVTAANSSSISDGAASLILMSASNAEKRGIKPLAKIIAHASHSQAPQWFTTAPVDAIRKVMNKASWKQDDVDLFEINEA
FAVVAMAAITQLELNPEQVNIHGGACALGHPIGASGARILVTLMHALKHQGKKRGIASLCIGGGEATAMAIELI

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=392, Percent_Identity=46.9387755102041, Blast_Score=344, Evalue=8e-95,
Organism=Homo sapiens, GI4557237, Length=390, Percent_Identity=47.1794871794872, Blast_Score=338, Evalue=6e-93,
Organism=Homo sapiens, GI167614485, Length=391, Percent_Identity=39.6419437340153, Blast_Score=259, Evalue=2e-69,
Organism=Homo sapiens, GI4501853, Length=396, Percent_Identity=37.3737373737374, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI4504327, Length=423, Percent_Identity=31.9148936170213, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI194353979, Length=390, Percent_Identity=27.9487179487179, Blast_Score=122, Evalue=4e-28,
Organism=Escherichia coli, GI87082165, Length=389, Percent_Identity=44.987146529563, Blast_Score=332, Evalue=4e-92,
Organism=Escherichia coli, GI1788554, Length=390, Percent_Identity=48.4615384615385, Blast_Score=327, Evalue=8e-91,
Organism=Escherichia coli, GI1787663, Length=393, Percent_Identity=39.1857506361323, Blast_Score=242, Evalue=4e-65,
Organism=Escherichia coli, GI48994986, Length=400, Percent_Identity=35.75, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI1788683, Length=425, Percent_Identity=29.1764705882353, Blast_Score=144, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI25147385, Length=392, Percent_Identity=41.0714285714286, Blast_Score=307, Evalue=5e-84,
Organism=Caenorhabditis elegans, GI17535921, Length=394, Percent_Identity=41.8781725888325, Blast_Score=303, Evalue=9e-83,
Organism=Caenorhabditis elegans, GI133906874, Length=390, Percent_Identity=40.5128205128205, Blast_Score=291, Evalue=4e-79,
Organism=Caenorhabditis elegans, GI17535917, Length=402, Percent_Identity=33.5820895522388, Blast_Score=201, Evalue=8e-52,
Organism=Caenorhabditis elegans, GI17551802, Length=425, Percent_Identity=30.5882352941176, Blast_Score=178, Evalue=6e-45,
Organism=Saccharomyces cerevisiae, GI6325229, Length=396, Percent_Identity=44.4444444444444, Blast_Score=315, Evalue=1e-86,
Organism=Saccharomyces cerevisiae, GI6322031, Length=389, Percent_Identity=34.4473007712082, Blast_Score=180, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24655093, Length=390, Percent_Identity=45.3846153846154, Blast_Score=342, Evalue=2e-94,
Organism=Drosophila melanogaster, GI24640423, Length=390, Percent_Identity=45.8974358974359, Blast_Score=332, Evalue=4e-91,
Organism=Drosophila melanogaster, GI17648125, Length=395, Percent_Identity=36.2025316455696, Blast_Score=233, Evalue=1e-61,
Organism=Drosophila melanogaster, GI17137578, Length=422, Percent_Identity=31.7535545023697, Blast_Score=167, Evalue=9e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 41230; Mature: 41230

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00098 THIOLASE_1 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHNDVVIVAAKRTPMGAMLGNLSALSSPELGAVAHMAVLSQSGIAPAEIDEVISGCVLQ
CCCCCEEEEEECCCCHHHHHHCHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
AGIGQAPARQAAIKAGIPNSAGATTINKMCGSGMKAVMFAHDLIKAGTANVVLASGMESM
CCCCCCCHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCHHHH
SNAPYLLSKARAGYRLGHGELKDHMFLDGLEDAYDKGQLMGCFAETTAKHFNFSREQQDE
CCCCHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHCCCCEEHHHHHHHHHHCCCCHHHHHH
YALRSMNRALKAIENGAFREEIAPVTLTTRKGDVTIDVDEGPDAAKLAKIPQLKPAFQAD
HHHHHHHHHHHHHHCCCHHHHCCCEEEEECCCCEEEEECCCCCHHHHHCCCCCCCCCCCC
GTVTAANSSSISDGAASLILMSASNAEKRGIKPLAKIIAHASHSQAPQWFTTAPVDAIRK
CEEEECCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
VMNKASWKQDDVDLFEINEAFAVVAMAAITQLELNPEQVNIHGGACALGHPIGASGARIL
HHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHEECCCCEEEECCCEEECCCCCCCCHHHHH
VTLMHALKHQGKKRGIASLCIGGGEATAMAIELI
HHHHHHHHHCHHHCCCHHEEECCCCEEEEEEEEC
>Mature Secondary Structure
MEHNDVVIVAAKRTPMGAMLGNLSALSSPELGAVAHMAVLSQSGIAPAEIDEVISGCVLQ
CCCCCEEEEEECCCCHHHHHHCHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
AGIGQAPARQAAIKAGIPNSAGATTINKMCGSGMKAVMFAHDLIKAGTANVVLASGMESM
CCCCCCCHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCHHHH
SNAPYLLSKARAGYRLGHGELKDHMFLDGLEDAYDKGQLMGCFAETTAKHFNFSREQQDE
CCCCHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHCCCCEEHHHHHHHHHHCCCCHHHHHH
YALRSMNRALKAIENGAFREEIAPVTLTTRKGDVTIDVDEGPDAAKLAKIPQLKPAFQAD
HHHHHHHHHHHHHHCCCHHHHCCCEEEEECCCCEEEEECCCCCHHHHHCCCCCCCCCCCC
GTVTAANSSSISDGAASLILMSASNAEKRGIKPLAKIIAHASHSQAPQWFTTAPVDAIRK
CEEEECCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
VMNKASWKQDDVDLFEINEAFAVVAMAAITQLELNPEQVNIHGGACALGHPIGASGARIL
HHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHEECCCCEEEECCCEEECCCCCCCCHHHHH
VTLMHALKHQGKKRGIASLCIGGGEATAMAIELI
HHHHHHHHHCHHHCCCHHEEECCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]