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The map label for this gene is hemB [H]

Identifier: 54294695

GI number: 54294695

Start: 1979173

End: 1980168

Strand: Direct

Name: hemB [H]

Synonym: lpl1772

Alternate gene names: 54294695

Gene position: 1979173-1980168 (Clockwise)

Preceding gene: 54294694

Following gene: 54294696

Centisome position: 59.16

GC content: 38.96

Gene sequence:

>996_bases
ATGATTAAATATAATTTGCCTTTAAGATTATCTCGTTTAAGAAAAAATGCCATGTCAAGAGCATTAGTAAGAGAGACGAG
GCTGCATACACAACAACTGATTGCTCCATTGTTTATTAGCGAATATTTAACTGAAGCAAAAGAAATCAGCGCTATGCCAG
GCCAATTTCAACTAGGCCTCAATTGTATACCTGAGGAAATTGAATCTTTATCAAAACTAAGTATCCCTGCAGTCCTCTTA
TTCGGTATCCCTAAGCAAAAAGACGCTTGCGGCAGTGAATCAATGAATAATAATGGAATCATCCAACAAGCGATCAAAAA
AATTAAATCCGTTAATAGTGACATGTTAGTGATCACTGATCTTTGCTTTTGCGAATACACCGATCATGGTCATTGCGGGG
TTCTGGATGGTAGTCAAATTAATATCGCTTCTACCTTAGAGTTATTAGGAAAACAAGCAGTAAGTCACGCTGAAGCAGGT
GCTGATTGGGTTGCCCCCAGTGGTATGACAGACGGAATGGTTTTAGCTATACGCCAAGCACTGGATACTGCCTCATTTCA
TGAAATTCCTATTTTAAGTTACAGTGCCAAATATTGCTCGTGCCTTTATGGGCCTTTTAGAGAGGCCGCGCAAGGTGCAC
CTCAGTTTGGCGATAGGAAAGCGTATCAAATGGATCCGGCAAACAGTGAAGAAGCTGTAAGAGAAACCCGGTTAGACCTG
GAAGAAGGCGCTGACATGATTATGGTTAAACCGGCCGGTTTTTATCTTGATATTATTTATAAACTTAAACAACATTTTGC
CGATGTACCGCTTTGTGCCTATCAGGTCAGCGGTGAATATTCGATGATAAAAAATGCAGCAAAAAATAATCTAATCCATG
AAGAACAAGCAATGACTGAAAGTCTCATTGCGATTAAACGTGCTGGCGCTGATTTTATTATTTCTTATTTTGCTAAAGGC
ATGGCTGAGTTATTAAACTCTCAAAATTTTATTTAA

Upstream 100 bases:

>100_bases
TAATGGCGTCGATATTCTATATACTAAAAGCACATCATCACCAGAAAAAGCAAAACCTGACCAATAAAACCTTAATCCAC
ATTGTCTAAGGATGTAATAA

Downstream 100 bases:

>100_bases
TTATGAGTCAAATAAATCAAATCAAGAACTATAAAACGACTATATAAAGAGAAAGACTTGCCTCATCTATAACAAATCCC
ATATAGTAAATGGGATTGGC

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MIKYNLPLRLSRLRKNAMSRALVRETRLHTQQLIAPLFISEYLTEAKEISAMPGQFQLGLNCIPEEIESLSKLSIPAVLL
FGIPKQKDACGSESMNNNGIIQQAIKKIKSVNSDMLVITDLCFCEYTDHGHCGVLDGSQINIASTLELLGKQAVSHAEAG
ADWVAPSGMTDGMVLAIRQALDTASFHEIPILSYSAKYCSCLYGPFREAAQGAPQFGDRKAYQMDPANSEEAVRETRLDL
EEGADMIMVKPAGFYLDIIYKLKQHFADVPLCAYQVSGEYSMIKNAAKNNLIHEEQAMTESLIAIKRAGADFIISYFAKG
MAELLNSQNFI

Sequences:

>Translated_331_residues
MIKYNLPLRLSRLRKNAMSRALVRETRLHTQQLIAPLFISEYLTEAKEISAMPGQFQLGLNCIPEEIESLSKLSIPAVLL
FGIPKQKDACGSESMNNNGIIQQAIKKIKSVNSDMLVITDLCFCEYTDHGHCGVLDGSQINIASTLELLGKQAVSHAEAG
ADWVAPSGMTDGMVLAIRQALDTASFHEIPILSYSAKYCSCLYGPFREAAQGAPQFGDRKAYQMDPANSEEAVRETRLDL
EEGADMIMVKPAGFYLDIIYKLKQHFADVPLCAYQVSGEYSMIKNAAKNNLIHEEQAMTESLIAIKRAGADFIISYFAKG
MAELLNSQNFI
>Mature_331_residues
MIKYNLPLRLSRLRKNAMSRALVRETRLHTQQLIAPLFISEYLTEAKEISAMPGQFQLGLNCIPEEIESLSKLSIPAVLL
FGIPKQKDACGSESMNNNGIIQQAIKKIKSVNSDMLVITDLCFCEYTDHGHCGVLDGSQINIASTLELLGKQAVSHAEAG
ADWVAPSGMTDGMVLAIRQALDTASFHEIPILSYSAKYCSCLYGPFREAAQGAPQFGDRKAYQMDPANSEEAVRETRLDL
EEGADMIMVKPAGFYLDIIYKLKQHFADVPLCAYQVSGEYSMIKNAAKNNLIHEEQAMTESLIAIKRAGADFIISYFAKG
MAELLNSQNFI

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=307, Percent_Identity=37.1335504885993, Blast_Score=224, Evalue=6e-59,
Organism=Escherichia coli, GI87081728, Length=319, Percent_Identity=48.9028213166144, Blast_Score=291, Evalue=5e-80,
Organism=Saccharomyces cerevisiae, GI6321398, Length=332, Percent_Identity=39.7590361445783, Blast_Score=233, Evalue=5e-62,
Organism=Drosophila melanogaster, GI21358291, Length=324, Percent_Identity=37.3456790123457, Blast_Score=226, Evalue=2e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 36557; Mature: 36557

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKYNLPLRLSRLRKNAMSRALVRETRLHTQQLIAPLFISEYLTEAKEISAMPGQFQLGL
CEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECC
NCIPEEIESLSKLSIPAVLLFGIPKQKDACGSESMNNNGIIQQAIKKIKSVNSDMLVITD
CCCHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEH
LCFCEYTDHGHCGVLDGSQINIASTLELLGKQAVSHAEAGADWVAPSGMTDGMVLAIRQA
HHHHCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
LDTASFHEIPILSYSAKYCSCLYGPFREAAQGAPQFGDRKAYQMDPANSEEAVRETRLDL
HHCCCCCCCCEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCHHHHHHHHHCCH
EEGADMIMVKPAGFYLDIIYKLKQHFADVPLCAYQVSGEYSMIKNAAKNNLIHEEQAMTE
HHCCCEEEECCCCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCHHHHHHHHH
SLIAIKRAGADFIISYFAKGMAELLNSQNFI
HHHHHHHCCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIKYNLPLRLSRLRKNAMSRALVRETRLHTQQLIAPLFISEYLTEAKEISAMPGQFQLGL
CEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECC
NCIPEEIESLSKLSIPAVLLFGIPKQKDACGSESMNNNGIIQQAIKKIKSVNSDMLVITD
CCCHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEH
LCFCEYTDHGHCGVLDGSQINIASTLELLGKQAVSHAEAGADWVAPSGMTDGMVLAIRQA
HHHHCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
LDTASFHEIPILSYSAKYCSCLYGPFREAAQGAPQFGDRKAYQMDPANSEEAVRETRLDL
HHCCCCCCCCEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCHHHHHHHHHCCH
EEGADMIMVKPAGFYLDIIYKLKQHFADVPLCAYQVSGEYSMIKNAAKNNLIHEEQAMTE
HHCCCEEEECCCCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCHHHHHHHHH
SLIAIKRAGADFIISYFAKGMAELLNSQNFI
HHHHHHHCCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]