Click here to switch to the map view.

The map label for this gene is xasA [C]

Identifier: 54294578

GI number: 54294578

Start: 1843782

End: 1845176

Strand: Direct

Name: xasA [C]

Synonym: lpl1654

Alternate gene names: 54294578

Gene position: 1843782-1845176 (Clockwise)

Preceding gene: 54294577

Following gene: 54294580

Centisome position: 55.11

GC content: 39.5

Gene sequence:

>1395_bases
ATGAATCATTCAAAAAAGGTTCTGAACGTTTTTTCTTTAGTTATGATCAACGTCATTGCTGTAGATAGTTTGAGGACCTT
GCCTATCAGCGCAAAACTTGGATTTTCTCTGGTCTTTTATTATATTTTTGCAGCCCTTACCTTTTTTATTCCAGTAGCAT
TGGTTGCTGCAGAGCTCGCTACCGCCTATCCTAATACCGGCGGAATTTATGTCTGGGTCAGGGAAGCATTCGGGAGACGG
GCAGGATTTATAACTATTTGGCTGCAATGGATCTATAACGTGGTTTGGTATCCAACTATGTTAGCTTTTATCGCCGCCAC
GTTATCCTATTTAATCGCTCCTCATTTGGGGAATAACAAATTTTATTTATTAGGCACAGCACTTAGCTTGTTTTGGGTGT
TTACTTTTTTGAATTGCTTTGGCATGAAACTATCCAGCATTGTAAGTATTATCGGCGCCTCCATAGGCACACTACTTCCT
ATGATAGTGATTATTGTCCTGGGCGCAGTTTGGATATTTCAAGATAGACCTGTAGCAGTCAATTACCCCACAACATGGTT
ACCTGATTTTAGTTCTTTAGGAAATCTGTCTTTATTTTCAGCGGTTTTATTTGGCCTTATAGGAATGGAAATGTCTGCTG
TTCATGCTGAAGAAGTAAAAAACCCGCAAAGAGATTATCCAAAAGCGCTTTTTTATTCGGCTCTTTTAATTATATCCACC
TTATCATTAGGTTCTTTGGCAATTGTTATTGTAGTACCAAACGATAGTTTGAGCGTTGTTTCAGGCCTTGTTGATGCCTA
CGCCATATTTTTTAATTCCTATAATATGCCGTGGATGACATCAGTGATTGCCGTGTTAATTATTTTAGGAGGTCTCAGTG
GCGTTTCAGCCTGGATAATAGGTCCAACCAAAGGATTACTAGTGTCTGCACGCGATGGTTCCTTACCTGCATTGTTTTCC
CGTGTCAATAAATACGGCTCGCCGGTAGCCATACTGCTCACTCAAGGCATTATATTTACTGTATTAAGTACAGTCTTCAT
TTTACTCGATTCAATTAATGCTGCGTACTGGGTATTAAGCGATTTAAGTGCTCAAATGGCATTGTTGGTATATATCATGA
TGTTCGCTGCAGCAATTAAATTGCGATACAGCAAGCCCGAACAGCCGCGTGGCTATACTATTCCTGGTGGAAATCTGGTA
ATGTCTCTTATCTCTGGAATTGGGATCATCTGCTGCATAGCTGCTATGATTGTCGGATTTATCCCTCCTTCACAAATCCC
TATAAAGAATGTTTTTCTCTTTGAATGTTTTCTGATCGGCGGCCTTATTCTATTTGTTTTCATTCCTTGGTTATTTGCTA
AAAAACACGACGAGCAATTATGTAGTGAAGAATAA

Upstream 100 bases:

>100_bases
AAACTGTACAGACAAACTTTTCTTTACTCTGTTAACTTATCATAATACCATTTATACCCCATTCAATACCCGGGTTTATT
GCACTCATAAAGGATAAATA

Downstream 100 bases:

>100_bases
TTGAGCAAGAAATATAAGCCCACAAAAAATTTTGTTGGGCTTTTCAAGATGATTCTTAAAAGTTATTAATCAATTGTAAT
AGATCAGCCCTCATACAAGA

Product: hypothetical protein

Products: L-glutamate [Cytoplasm]; 4-aminobutyrate [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MNHSKKVLNVFSLVMINVIAVDSLRTLPISAKLGFSLVFYYIFAALTFFIPVALVAAELATAYPNTGGIYVWVREAFGRR
AGFITIWLQWIYNVVWYPTMLAFIAATLSYLIAPHLGNNKFYLLGTALSLFWVFTFLNCFGMKLSSIVSIIGASIGTLLP
MIVIIVLGAVWIFQDRPVAVNYPTTWLPDFSSLGNLSLFSAVLFGLIGMEMSAVHAEEVKNPQRDYPKALFYSALLIIST
LSLGSLAIVIVVPNDSLSVVSGLVDAYAIFFNSYNMPWMTSVIAVLIILGGLSGVSAWIIGPTKGLLVSARDGSLPALFS
RVNKYGSPVAILLTQGIIFTVLSTVFILLDSINAAYWVLSDLSAQMALLVYIMMFAAAIKLRYSKPEQPRGYTIPGGNLV
MSLISGIGIICCIAAMIVGFIPPSQIPIKNVFLFECFLIGGLILFVFIPWLFAKKHDEQLCSEE

Sequences:

>Translated_464_residues
MNHSKKVLNVFSLVMINVIAVDSLRTLPISAKLGFSLVFYYIFAALTFFIPVALVAAELATAYPNTGGIYVWVREAFGRR
AGFITIWLQWIYNVVWYPTMLAFIAATLSYLIAPHLGNNKFYLLGTALSLFWVFTFLNCFGMKLSSIVSIIGASIGTLLP
MIVIIVLGAVWIFQDRPVAVNYPTTWLPDFSSLGNLSLFSAVLFGLIGMEMSAVHAEEVKNPQRDYPKALFYSALLIIST
LSLGSLAIVIVVPNDSLSVVSGLVDAYAIFFNSYNMPWMTSVIAVLIILGGLSGVSAWIIGPTKGLLVSARDGSLPALFS
RVNKYGSPVAILLTQGIIFTVLSTVFILLDSINAAYWVLSDLSAQMALLVYIMMFAAAIKLRYSKPEQPRGYTIPGGNLV
MSLISGIGIICCIAAMIVGFIPPSQIPIKNVFLFECFLIGGLILFVFIPWLFAKKHDEQLCSEE
>Mature_464_residues
MNHSKKVLNVFSLVMINVIAVDSLRTLPISAKLGFSLVFYYIFAALTFFIPVALVAAELATAYPNTGGIYVWVREAFGRR
AGFITIWLQWIYNVVWYPTMLAFIAATLSYLIAPHLGNNKFYLLGTALSLFWVFTFLNCFGMKLSSIVSIIGASIGTLLP
MIVIIVLGAVWIFQDRPVAVNYPTTWLPDFSSLGNLSLFSAVLFGLIGMEMSAVHAEEVKNPQRDYPKALFYSALLIIST
LSLGSLAIVIVVPNDSLSVVSGLVDAYAIFFNSYNMPWMTSVIAVLIILGGLSGVSAWIIGPTKGLLVSARDGSLPALFS
RVNKYGSPVAILLTQGIIFTVLSTVFILLDSINAAYWVLSDLSAQMALLVYIMMFAAAIKLRYSKPEQPRGYTIPGGNLV
MSLISGIGIICCIAAMIVGFIPPSQIPIKNVFLFECFLIGGLILFVFIPWLFAKKHDEQLCSEE

Specific function: Probable Amino Acid Transporter. Involved In Extreme Acid Resistance. [C]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI115648063, Length=406, Percent_Identity=28.0788177339901, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI115648022, Length=406, Percent_Identity=28.0788177339901, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI186910308, Length=404, Percent_Identity=25.7425742574257, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI186910306, Length=404, Percent_Identity=25.7425742574257, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI186910304, Length=404, Percent_Identity=25.7425742574257, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI33286428, Length=362, Percent_Identity=27.0718232044199, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI9790235, Length=293, Percent_Identity=26.6211604095563, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1787768, Length=463, Percent_Identity=30.2375809935205, Blast_Score=222, Evalue=3e-59,
Organism=Escherichia coli, GI2367353, Length=344, Percent_Identity=27.3255813953488, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI87081798, Length=433, Percent_Identity=24.9422632794457, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1786602, Length=278, Percent_Identity=23.021582733813, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1790575, Length=326, Percent_Identity=25.1533742331288, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789017, Length=369, Percent_Identity=25.4742547425474, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI48994921, Length=475, Percent_Identity=20.6315789473684, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1787890, Length=329, Percent_Identity=24.3161094224924, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1786908, Length=325, Percent_Identity=23.0769230769231, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87082380, Length=257, Percent_Identity=28.0155642023346, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI32566699, Length=355, Percent_Identity=25.0704225352113, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21357367, Length=353, Percent_Identity=24.6458923512748, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI221331183, Length=303, Percent_Identity=25.7425742574257, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI17647653, Length=303, Percent_Identity=25.7425742574257, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24664379, Length=303, Percent_Identity=25.7425742574257, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI45550968, Length=345, Percent_Identity=24.9275362318841, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19921172, Length=345, Percent_Identity=24.9275362318841, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50778; Mature: 50778

Theoretical pI: Translated: 8.62; Mature: 8.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCC
>Mature Secondary Structure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CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-aminobutyrate [Cytoplasm]; L-glutamate [Periplasm] [C]

Specific reaction: 4-aminobutyrate [Cytoplasm] + L-glutamate [Periplasm] = L-glutamate [Cytoplasm] + 4-aminobutyrate [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8366052 [H]