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The map label for this gene is purM [H]

Identifier: 54294566

GI number: 54294566

Start: 1829340

End: 1830383

Strand: Reverse

Name: purM [H]

Synonym: lpl1642

Alternate gene names: 54294566

Gene position: 1830383-1829340 (Counterclockwise)

Preceding gene: 54294567

Following gene: 54294565

Centisome position: 54.71

GC content: 40.13

Gene sequence:

>1044_bases
ATGTCTACTATCAATTACAAATCAGCGGGTGTCGATATCGAGGCAGGAAATGAAGCTGTCGCACGCATTAAACGTAATGT
TGAAAAAACATTTTCGCCTCAAGTCCTGACAGGAATCGGTAGTTTTGGTGCAATGTATGATTTGAAGCCTTTTATGGAAA
AATTCAAACACCCCGTCATGGTTCAAAGCATTGATGGCGTAGGCACTAAGACAATAGTTGCTCGGATGATGCAAAAATTT
GATACAATCGGAATTGATTTGGTCAGTGCGACCACCAACGATATTATTGTGTTGGGTGCAAGGCCATTAACACTTTTGGA
TTATATTGCAACTGATCGCTTGAAGCCTGAATATATTGAAGAAATTATTATTGGCATGACGCAAGCTTGCCTCGAAAATA
ATATTTCCCTGGTCGGTGGTGAGACAGCTGAAATGCCTGATACCTATCTGAAGGGAGAGCATGATTTGGTAGGTATTATC
ACTGGTGTAGTGGAAAAGGATGAAGCCATACTAGGAAAAGATATAACTCCAGGCGATTCGGTCTTGGCATTTCCTTCCAG
TGGCTTACATACCAATGGATACTCACTCGCCAGAAAACTTTTGTTTGAACTAGGTGGATATACTGTAGAATCCCAGCTTG
ACGAGTTGGATGCTGCAGTTGGTGAGGCTTTACTGGAACCTCATATCAATTATACAAATCCTGTTCTACACCTGTTGAAT
AATAAAATCCCTATCAAGGGAATGGCTCATATTACTGGCGGAGGTGTACTGGAAAACATTCCACGAGTATTACCTAATCA
TTGTTCCGTTGAAATCAATAAGAATTCATGTCCGGTGTTGCCGATCTTTAATGTGTTAAAAGCATTGGGGAAACTGGATG
ATCAGGAAATGTATCGTACTTTTAATATGGGAATAGGATTGGTAATGATAGCTTCACCTGGTGTTGTTTCTGAAATTCAT
ACAGCGCTAAAAGAATTCCCTAATTTCCCTGTTTATGAAGTAGGACAAGTCGTATCAGGAAAACCAGAAGTGAGATTATT
GTGA

Upstream 100 bases:

>100_bases
CTACAGAGCAGCCAGTTTTACAGATGAATTCGGTTATCAACTTGCCTGTCGAAGAAGCGAGACAGGCTTGGGGAGATGGC
TTAAGAGAGAGGCTATTATA

Downstream 100 bases:

>100_bases
TGAAGATTGCAGTTGTTCAGTTTCCAGGCTCCAATTGCGAACGTGAGACAATGCTTGCGGTGCAACGAGCAGGTATGACT
CCAGTTGAGTTTCTGTGGAA

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MSTINYKSAGVDIEAGNEAVARIKRNVEKTFSPQVLTGIGSFGAMYDLKPFMEKFKHPVMVQSIDGVGTKTIVARMMQKF
DTIGIDLVSATTNDIIVLGARPLTLLDYIATDRLKPEYIEEIIIGMTQACLENNISLVGGETAEMPDTYLKGEHDLVGII
TGVVEKDEAILGKDITPGDSVLAFPSSGLHTNGYSLARKLLFELGGYTVESQLDELDAAVGEALLEPHINYTNPVLHLLN
NKIPIKGMAHITGGGVLENIPRVLPNHCSVEINKNSCPVLPIFNVLKALGKLDDQEMYRTFNMGIGLVMIASPGVVSEIH
TALKEFPNFPVYEVGQVVSGKPEVRLL

Sequences:

>Translated_347_residues
MSTINYKSAGVDIEAGNEAVARIKRNVEKTFSPQVLTGIGSFGAMYDLKPFMEKFKHPVMVQSIDGVGTKTIVARMMQKF
DTIGIDLVSATTNDIIVLGARPLTLLDYIATDRLKPEYIEEIIIGMTQACLENNISLVGGETAEMPDTYLKGEHDLVGII
TGVVEKDEAILGKDITPGDSVLAFPSSGLHTNGYSLARKLLFELGGYTVESQLDELDAAVGEALLEPHINYTNPVLHLLN
NKIPIKGMAHITGGGVLENIPRVLPNHCSVEINKNSCPVLPIFNVLKALGKLDDQEMYRTFNMGIGLVMIASPGVVSEIH
TALKEFPNFPVYEVGQVVSGKPEVRLL
>Mature_346_residues
STINYKSAGVDIEAGNEAVARIKRNVEKTFSPQVLTGIGSFGAMYDLKPFMEKFKHPVMVQSIDGVGTKTIVARMMQKFD
TIGIDLVSATTNDIIVLGARPLTLLDYIATDRLKPEYIEEIIIGMTQACLENNISLVGGETAEMPDTYLKGEHDLVGIIT
GVVEKDEAILGKDITPGDSVLAFPSSGLHTNGYSLARKLLFELGGYTVESQLDELDAAVGEALLEPHINYTNPVLHLLNN
KIPIKGMAHITGGGVLENIPRVLPNHCSVEINKNSCPVLPIFNVLKALGKLDDQEMYRTFNMGIGLVMIASPGVVSEIHT
ALKEFPNFPVYEVGQVVSGKPEVRLL

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=349, Percent_Identity=38.10888252149, Blast_Score=234, Evalue=9e-62,
Organism=Homo sapiens, GI209869995, Length=349, Percent_Identity=38.10888252149, Blast_Score=234, Evalue=9e-62,
Organism=Homo sapiens, GI209869993, Length=349, Percent_Identity=38.10888252149, Blast_Score=234, Evalue=9e-62,
Organism=Escherichia coli, GI1788845, Length=347, Percent_Identity=42.9394812680115, Blast_Score=265, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI17567511, Length=345, Percent_Identity=39.1304347826087, Blast_Score=209, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6321203, Length=338, Percent_Identity=35.5029585798817, Blast_Score=207, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24582400, Length=291, Percent_Identity=34.7079037800687, Blast_Score=169, Evalue=2e-42,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 37663; Mature: 37532

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTINYKSAGVDIEAGNEAVARIKRNVEKTFSPQVLTGIGSFGAMYDLKPFMEKFKHPVM
CCCCCCCCCCCEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEE
VQSIDGVGTKTIVARMMQKFDTIGIDLVSATTNDIIVLGARPLTLLDYIATDRLKPEYIE
EEECCCCCHHHHHHHHHHHHHHCCEEEEECCCCCEEEECCCHHHHHHHHHHCCCCHHHHH
EIIIGMTQACLENNISLVGGETAEMPDTYLKGEHDLVGIITGVVEKDEAILGKDITPGDS
HHHHHHHHHHHHCCCEEECCCCCCCCHHHHCCCCCHHHHHHHHHHCCCHHHCCCCCCCCC
VLAFPSSGLHTNGYSLARKLLFELGGYTVESQLDELDAAVGEALLEPHINYTNPVLHLLN
EEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHC
NKIPIKGMAHITGGGVLENIPRVLPNHCSVEINKNSCPVLPIFNVLKALGKLDDQEMYRT
CCCCCCEEEEECCCHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHH
FNMGIGLVMIASPGVVSEIHTALKEFPNFPVYEVGQVVSGKPEVRLL
HHCCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEC
>Mature Secondary Structure 
STINYKSAGVDIEAGNEAVARIKRNVEKTFSPQVLTGIGSFGAMYDLKPFMEKFKHPVM
CCCCCCCCCCEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEE
VQSIDGVGTKTIVARMMQKFDTIGIDLVSATTNDIIVLGARPLTLLDYIATDRLKPEYIE
EEECCCCCHHHHHHHHHHHHHHCCEEEEECCCCCEEEECCCHHHHHHHHHHCCCCHHHHH
EIIIGMTQACLENNISLVGGETAEMPDTYLKGEHDLVGIITGVVEKDEAILGKDITPGDS
HHHHHHHHHHHHCCCEEECCCCCCCCHHHHCCCCCHHHHHHHHHHCCCHHHCCCCCCCCC
VLAFPSSGLHTNGYSLARKLLFELGGYTVESQLDELDAAVGEALLEPHINYTNPVLHLLN
EEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHC
NKIPIKGMAHITGGGVLENIPRVLPNHCSVEINKNSCPVLPIFNVLKALGKLDDQEMYRT
CCCCCCEEEEECCCHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHH
FNMGIGLVMIASPGVVSEIHTALKEFPNFPVYEVGQVVSGKPEVRLL
HHCCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA