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The map label for this gene is cpxA [H]

Identifier: 54294528

GI number: 54294528

Start: 1778134

End: 1779501

Strand: Direct

Name: cpxA [H]

Synonym: lpl1604

Alternate gene names: 54294528

Gene position: 1778134-1779501 (Clockwise)

Preceding gene: 54294527

Following gene: 54294529

Centisome position: 53.15

GC content: 38.82

Gene sequence:

>1368_bases
ATGCGTAGTCTGTACTGGAAAATATTTGTTTCTTTTTGGCTGGCCACCATTTTAATTATTTTTACTACGGCATGGGTTAC
CAGCCAAATCGCACAAAAATCATCACAACCAGCTCGAGAAGAAATGTTCATGGACAGCTATGCCAATGCAGCTGTCGCAA
CCTATGAGTCAGGCCAACAATCAGCACTTTTGAAATGGCTTGATAAAATAGGCCTTTCTCGTCATATGACACTGTATTTA
CTAACCAGCACCGGCGAAATCATTGGTGCACAGAAACCACCTGACGCCGTAAAAAAAATTTCAGAAAATTTAATAAATGA
TGAACTCCCAAGTGATGGCATATTTAAAACAGGGAAATTAGCCGTTAGCCATGAGATCCTATCCACTTCTGGAAAATATT
ACCGGCTAGCAGCTGTCAGTGAAAAGCCAATCTCTTATTTTGTGCAAATTCCATGGGCTGGACTGACAATACGTTTAACT
CTGGCCATATTCATCAGTGGGCTTATCTGCTATTTACTCTCACGTTATTTAACTCAACCTTTACGCTCATTAGGCATGGC
AGCAAAATCTATCGCTAAAGGAAATTTAAATACCCGGGTTGGTCGCTTCAGAGGTCATAGTAAAGATGAGATTGCGGAGT
TAAGTAATGAATTTGATCGAATGGCCGAGCAATTAGAAACGCTTGTTCATTCCAAAGAGCGATTAATACAGGATATTTCC
CATGAATTACGCTCTCCATTGGCTCGACTTAAAATCGCCATAGAGTTAGGGAAAAAGAAAACCAAGCATTTGGCTGATAA
TGAATTTGCCCGCATGGAAATTGAAACATCCAGACTTAATGATTTGATAGGCGAAATCCTCGACTTTGCTCGTTTAGAAA
AATCGACAACAGAACTTCATTTATCCCAAACAAATATAGCAGATTTGCTTGCACAGGTTATAAGTGATGCCAATTATGAG
TTCAGTCACAATTCTATAAGAATACAAGCTGGAATAATTACACCTTGTGAATTAAATATTGACCAACGCCTAATACACAG
AGCTATAGAAAATATTGTTCGTAATGCATCACACTATTCTCCTCCAGATGAAAAGGTCCTGATTTCATCAAGCTATAATA
AAAACAAAGATCAAGTTTATATTGATATTAATGATAAAGGACCTGGGGTTCCCGAAGATCAACTGGAAAAAATATTTAAT
CCTTTCTACCGCGTGGATACCTCCAGAACAAAAAAAACTGGTGGCTATGGGCTTGGGCTCGCAATTGCAGCCAGGGCTGT
AGCATTACACCAAGGAGAAATTATTGCTAAAAATAGAGAGCAAGGTGGTTTGCTTGTTCGTATCATTTTACCTGCTGATG
TTAAATAG

Upstream 100 bases:

>100_bases
AGTATCGATGTTCACATCAGCAATTTGCGAAATAAATTAGGCGATAATCCTCAGGGAGAACCTTTAGTCAAAACAGTCCG
CGGGTTTGGGTACATGTTTA

Downstream 100 bases:

>100_bases
GATTTCTATATATCGAGTTCCTCCTTATTGGCTAAAATTGATCTTTGACTTGCATTTTTATTATCTAATTCCGCATACAC
ACAAATAATTATACATTTTG

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MRSLYWKIFVSFWLATILIIFTTAWVTSQIAQKSSQPAREEMFMDSYANAAVATYESGQQSALLKWLDKIGLSRHMTLYL
LTSTGEIIGAQKPPDAVKKISENLINDELPSDGIFKTGKLAVSHEILSTSGKYYRLAAVSEKPISYFVQIPWAGLTIRLT
LAIFISGLICYLLSRYLTQPLRSLGMAAKSIAKGNLNTRVGRFRGHSKDEIAELSNEFDRMAEQLETLVHSKERLIQDIS
HELRSPLARLKIAIELGKKKTKHLADNEFARMEIETSRLNDLIGEILDFARLEKSTTELHLSQTNIADLLAQVISDANYE
FSHNSIRIQAGIITPCELNIDQRLIHRAIENIVRNASHYSPPDEKVLISSSYNKNKDQVYIDINDKGPGVPEDQLEKIFN
PFYRVDTSRTKKTGGYGLGLAIAARAVALHQGEIIAKNREQGGLLVRIILPADVK

Sequences:

>Translated_455_residues
MRSLYWKIFVSFWLATILIIFTTAWVTSQIAQKSSQPAREEMFMDSYANAAVATYESGQQSALLKWLDKIGLSRHMTLYL
LTSTGEIIGAQKPPDAVKKISENLINDELPSDGIFKTGKLAVSHEILSTSGKYYRLAAVSEKPISYFVQIPWAGLTIRLT
LAIFISGLICYLLSRYLTQPLRSLGMAAKSIAKGNLNTRVGRFRGHSKDEIAELSNEFDRMAEQLETLVHSKERLIQDIS
HELRSPLARLKIAIELGKKKTKHLADNEFARMEIETSRLNDLIGEILDFARLEKSTTELHLSQTNIADLLAQVISDANYE
FSHNSIRIQAGIITPCELNIDQRLIHRAIENIVRNASHYSPPDEKVLISSSYNKNKDQVYIDINDKGPGVPEDQLEKIFN
PFYRVDTSRTKKTGGYGLGLAIAARAVALHQGEIIAKNREQGGLLVRIILPADVK
>Mature_455_residues
MRSLYWKIFVSFWLATILIIFTTAWVTSQIAQKSSQPAREEMFMDSYANAAVATYESGQQSALLKWLDKIGLSRHMTLYL
LTSTGEIIGAQKPPDAVKKISENLINDELPSDGIFKTGKLAVSHEILSTSGKYYRLAAVSEKPISYFVQIPWAGLTIRLT
LAIFISGLICYLLSRYLTQPLRSLGMAAKSIAKGNLNTRVGRFRGHSKDEIAELSNEFDRMAEQLETLVHSKERLIQDIS
HELRSPLARLKIAIELGKKKTKHLADNEFARMEIETSRLNDLIGEILDFARLEKSTTELHLSQTNIADLLAQVISDANYE
FSHNSIRIQAGIITPCELNIDQRLIHRAIENIVRNASHYSPPDEKVLISSSYNKNKDQVYIDINDKGPGVPEDQLEKIFN
PFYRVDTSRTKKTGGYGLGLAIAARAVALHQGEIIAKNREQGGLLVRIILPADVK

Specific function: This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synt

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=389, Percent_Identity=30.3341902313625, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1787894, Length=307, Percent_Identity=30.9446254071661, Blast_Score=132, Evalue=6e-32,
Organism=Escherichia coli, GI1788393, Length=277, Percent_Identity=27.4368231046931, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1789808, Length=300, Percent_Identity=28.6666666666667, Blast_Score=118, Evalue=6e-28,
Organism=Escherichia coli, GI1786783, Length=278, Percent_Identity=27.3381294964029, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1786600, Length=243, Percent_Identity=26.7489711934156, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1790551, Length=295, Percent_Identity=25.4237288135593, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790861, Length=245, Percent_Identity=27.3469387755102, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87082128, Length=309, Percent_Identity=25.5663430420712, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1786912, Length=244, Percent_Identity=27.8688524590164, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI145693157, Length=231, Percent_Identity=27.2727272727273, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI48994928, Length=236, Percent_Identity=25.4237288135593, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1787374, Length=312, Percent_Identity=24.6794871794872, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1789149, Length=408, Percent_Identity=24.5098039215686, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788549, Length=242, Percent_Identity=26.8595041322314, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87081816, Length=257, Percent_Identity=27.2373540856031, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1788279, Length=234, Percent_Identity=26.9230769230769, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1790436, Length=247, Percent_Identity=27.9352226720648, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789403, Length=250, Percent_Identity=24, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790300, Length=236, Percent_Identity=26.271186440678, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51026; Mature: 51026

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSLYWKIFVSFWLATILIIFTTAWVTSQIAQKSSQPAREEMFMDSYANAAVATYESGQQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEECCCCCH
SALLKWLDKIGLSRHMTLYLLTSTGEIIGAQKPPDAVKKISENLINDELPSDGIFKTGKL
HHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCH
AVSHEILSTSGKYYRLAAVSEKPISYFVQIPWAGLTIRLTLAIFISGLICYLLSRYLTQP
HHHHHHHHCCCCEEEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LRSLGMAAKSIAKGNLNTRVGRFRGHSKDEIAELSNEFDRMAEQLETLVHSKERLIQDIS
HHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HELRSPLARLKIAIELGKKKTKHLADNEFARMEIETSRLNDLIGEILDFARLEKSTTELH
HHHHHHHHHHHHHHHHCCHHHHHCCCCCHHEEEEHHHHHHHHHHHHHHHHHHHCCHHHEE
LSQTNIADLLAQVISDANYEFSHNSIRIQAGIITPCELNIDQRLIHRAIENIVRNASHYS
ECHHHHHHHHHHHHCCCCCEECCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCC
PPDEKVLISSSYNKNKDQVYIDINDKGPGVPEDQLEKIFNPFYRVDTSRTKKTGGYGLGL
CCCCEEEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
AIAARAVALHQGEIIAKNREQGGLLVRIILPADVK
HHHHHHHHHHCCCEEECCCCCCCEEEEEEECCCCC
>Mature Secondary Structure
MRSLYWKIFVSFWLATILIIFTTAWVTSQIAQKSSQPAREEMFMDSYANAAVATYESGQQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEECCCCCH
SALLKWLDKIGLSRHMTLYLLTSTGEIIGAQKPPDAVKKISENLINDELPSDGIFKTGKL
HHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCH
AVSHEILSTSGKYYRLAAVSEKPISYFVQIPWAGLTIRLTLAIFISGLICYLLSRYLTQP
HHHHHHHHCCCCEEEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LRSLGMAAKSIAKGNLNTRVGRFRGHSKDEIAELSNEFDRMAEQLETLVHSKERLIQDIS
HHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HELRSPLARLKIAIELGKKKTKHLADNEFARMEIETSRLNDLIGEILDFARLEKSTTELH
HHHHHHHHHHHHHHHHCCHHHHHCCCCCHHEEEEHHHHHHHHHHHHHHHHHHHCCHHHEE
LSQTNIADLLAQVISDANYEFSHNSIRIQAGIITPCELNIDQRLIHRAIENIVRNASHYS
ECHHHHHHHHHHHHCCCCCEECCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCC
PPDEKVLISSSYNKNKDQVYIDINDKGPGVPEDQLEKIFNPFYRVDTSRTKKTGGYGLGL
CCCCEEEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
AIAARAVALHQGEIIAKNREQGGLLVRIILPADVK
HHHHHHHHHHCCCEEECCCCCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]