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The map label for this gene is proA [H]

Identifier: 54294347

GI number: 54294347

Start: 1579560

End: 1580813

Strand: Direct

Name: proA [H]

Synonym: lpl1415

Alternate gene names: 54294347

Gene position: 1579560-1580813 (Clockwise)

Preceding gene: 54294346

Following gene: 54294352

Centisome position: 47.21

GC content: 34.61

Gene sequence:

>1254_bases
ATGAATACTGATATTGCTAACCAATTAAGAGCCGCTAAAAAAGCAACTACTGATCTTAACTTAATACAAAGTGATACCCG
AACAATAATTTTGGAAACATTAGCGGCTAATTTAGAGAAGCACATTGAAAACATAATACAAGAAAATCAAAAAGATTTAA
GTTTAATGCTTGAGCAAGACCCCAGATATGATCGTTTATTGTTAAATAAAGAGAGAATTTTGTCATTGGCGAATGATGTG
AGAAAAGTAGCCAGTTTACCTAACCCATTAGGAGTTAGTCTCCTTGAAAAATCAATGCCAAATGGTTTGAGTATTAAGAA
AATCACAGTACCTTTAGGTGTCATCGCAGTCATTTATGAGTCAAGACCTAATGTAACTATTGATATATTCAGCCTATGCT
TTAAATCTGGAAACGTTTGTATTTTAAAAGGTGGAAAAGAAGCACATTTTACTAATAGTTATCTGCTTTTATTAATTAAA
AATACATTAAAGAATTTTAATATAAACACAGATATTGTTTGTTTATTACCACCCGAAAGAGCATTGATGACTCAATTATT
AAATGCCACAGGTCTTGTTGATTTATGCATTCCAAGAGGTAGCCAGAATTTAATTAATTTTGTCAGAGACAATGCCAAAA
TACCTGTCATTGAAACAGGGGCAGGTATCGTGCATACCTATTTTGATAAAAGTGGAGATTTGGGAAAAGGTAAAAAAATT
ATTAACAATGCTAAAACCAGAAGAGTAAGTGTTTGCAATGCGCTGGATACTTTGATTATTCATGCTGATCGTTTAAAAGA
TTTGCCAGAACTTGTGGAGACCTTGTCTCAAAAGCATGTGATTATCTATGCCGACCAGGACGCATATCATGTTTTAGATA
AGAATTATCCTGAACAACTTTTAATTAAGGCAAAACCACAAGACTTTGGCCATGAATTTCTGGACTATAAATTAGCAATA
AAAACAGTACCCAATATAAAAGCAGCTATTGGTCATATTCAACAATTCAGTTCCCATCATAGTGAGGCTATTATTGCAGA
AGATGAGTCTGCAATTGATCAATTTCTAATTGAAGTGGATGCTGCAGCTGTCTATGCCAATGCTTCTACTGCATTTACAG
ATGGTGGGGAGTTCGGATTAGGGGCTGAAATTGGAATTAGTACGCAAAAAGTTCATGCAAGAGGCCCCATGGGACTAGAG
GCTTTAACAAGCTACAAATGGGTGATAAGAGGGACGGGACAAATTAGAGATTGA

Upstream 100 bases:

>100_bases
TCGCCAGGTATGATTTCTTAAGATTAAAGGACTATCTTAGACTTCAAAATAAGCCTGCATTTATACATTACGATCAATTG
CATATTCTATAGGTATCAAA

Downstream 100 bases:

>100_bases
GCATAACCATATTTTCTCAGAACCCCACCCAACAATGACAACTCAATAATCACCACTTTTCTGATATTGGATTGTTATCA
AAATATTCACTGAGTCTGCG

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MNTDIANQLRAAKKATTDLNLIQSDTRTIILETLAANLEKHIENIIQENQKDLSLMLEQDPRYDRLLLNKERILSLANDV
RKVASLPNPLGVSLLEKSMPNGLSIKKITVPLGVIAVIYESRPNVTIDIFSLCFKSGNVCILKGGKEAHFTNSYLLLLIK
NTLKNFNINTDIVCLLPPERALMTQLLNATGLVDLCIPRGSQNLINFVRDNAKIPVIETGAGIVHTYFDKSGDLGKGKKI
INNAKTRRVSVCNALDTLIIHADRLKDLPELVETLSQKHVIIYADQDAYHVLDKNYPEQLLIKAKPQDFGHEFLDYKLAI
KTVPNIKAAIGHIQQFSSHHSEAIIAEDESAIDQFLIEVDAAAVYANASTAFTDGGEFGLGAEIGISTQKVHARGPMGLE
ALTSYKWVIRGTGQIRD

Sequences:

>Translated_417_residues
MNTDIANQLRAAKKATTDLNLIQSDTRTIILETLAANLEKHIENIIQENQKDLSLMLEQDPRYDRLLLNKERILSLANDV
RKVASLPNPLGVSLLEKSMPNGLSIKKITVPLGVIAVIYESRPNVTIDIFSLCFKSGNVCILKGGKEAHFTNSYLLLLIK
NTLKNFNINTDIVCLLPPERALMTQLLNATGLVDLCIPRGSQNLINFVRDNAKIPVIETGAGIVHTYFDKSGDLGKGKKI
INNAKTRRVSVCNALDTLIIHADRLKDLPELVETLSQKHVIIYADQDAYHVLDKNYPEQLLIKAKPQDFGHEFLDYKLAI
KTVPNIKAAIGHIQQFSSHHSEAIIAEDESAIDQFLIEVDAAAVYANASTAFTDGGEFGLGAEIGISTQKVHARGPMGLE
ALTSYKWVIRGTGQIRD
>Mature_417_residues
MNTDIANQLRAAKKATTDLNLIQSDTRTIILETLAANLEKHIENIIQENQKDLSLMLEQDPRYDRLLLNKERILSLANDV
RKVASLPNPLGVSLLEKSMPNGLSIKKITVPLGVIAVIYESRPNVTIDIFSLCFKSGNVCILKGGKEAHFTNSYLLLLIK
NTLKNFNINTDIVCLLPPERALMTQLLNATGLVDLCIPRGSQNLINFVRDNAKIPVIETGAGIVHTYFDKSGDLGKGKKI
INNAKTRRVSVCNALDTLIIHADRLKDLPELVETLSQKHVIIYADQDAYHVLDKNYPEQLLIKAKPQDFGHEFLDYKLAI
KTVPNIKAAIGHIQQFSSHHSEAIIAEDESAIDQFLIEVDAAAVYANASTAFTDGGEFGLGAEIGISTQKVHARGPMGLE
ALTSYKWVIRGTGQIRD

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI62912457, Length=417, Percent_Identity=34.7721822541966, Blast_Score=232, Evalue=6e-61,
Organism=Homo sapiens, GI21361368, Length=417, Percent_Identity=34.7721822541966, Blast_Score=231, Evalue=7e-61,
Organism=Escherichia coli, GI1786438, Length=413, Percent_Identity=40.9200968523002, Blast_Score=304, Evalue=8e-84,
Organism=Caenorhabditis elegans, GI17569967, Length=420, Percent_Identity=33.8095238095238, Blast_Score=222, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI17569969, Length=420, Percent_Identity=33.8095238095238, Blast_Score=221, Evalue=4e-58,
Organism=Saccharomyces cerevisiae, GI6324899, Length=426, Percent_Identity=36.6197183098592, Blast_Score=250, Evalue=3e-67,
Organism=Drosophila melanogaster, GI21357643, Length=407, Percent_Identity=33.6609336609337, Blast_Score=227, Evalue=1e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: NA

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 46051; Mature: 46051

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTDIANQLRAAKKATTDLNLIQSDTRTIILETLAANLEKHIENIIQENQKDLSLMLEQD
CCCCHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCC
PRYDRLLLNKERILSLANDVRKVASLPNPLGVSLLEKSMPNGLSIKKITVPLGVIAVIYE
CCHHHHHHCHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCEEEEEEECCEEEEEEEE
SRPNVTIDIFSLCFKSGNVCILKGGKEAHFTNSYLLLLIKNTLKNFNINTDIVCLLPPER
CCCCEEEEHHHHHHCCCCEEEEECCCCCCCCCCEEEEEEHHHHHCCCCCCCEEEEECCCH
ALMTQLLNATGLVDLCIPRGSQNLINFVRDNAKIPVIETGAGIVHTYFDKSGDLGKGKKI
HHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCCEEEECCCCEEEEEECCCCCCCCCHHH
INNAKTRRVSVCNALDTLIIHADRLKDLPELVETLSQKHVIIYADQDAYHVLDKNYPEQL
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHCCCCCCCE
LIKAKPQDFGHEFLDYKLAIKTVPNIKAAIGHIQQFSSHHSEAIIAEDESAIDQFLIEVD
EEEECCHHHCHHHHHEEEEEEECCCHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHH
AAAVYANASTAFTDGGEFGLGAEIGISTQKVHARGPMGLEALTSYKWVIRGTGQIRD
HHEEEECCCCEECCCCCCCCCCEECCCEEEEECCCCCCHHHHHCEEEEEECCCCCCC
>Mature Secondary Structure
MNTDIANQLRAAKKATTDLNLIQSDTRTIILETLAANLEKHIENIIQENQKDLSLMLEQD
CCCCHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCC
PRYDRLLLNKERILSLANDVRKVASLPNPLGVSLLEKSMPNGLSIKKITVPLGVIAVIYE
CCHHHHHHCHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCEEEEEEECCEEEEEEEE
SRPNVTIDIFSLCFKSGNVCILKGGKEAHFTNSYLLLLIKNTLKNFNINTDIVCLLPPER
CCCCEEEEHHHHHHCCCCEEEEECCCCCCCCCCEEEEEEHHHHHCCCCCCCEEEEECCCH
ALMTQLLNATGLVDLCIPRGSQNLINFVRDNAKIPVIETGAGIVHTYFDKSGDLGKGKKI
HHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCCEEEECCCCEEEEEECCCCCCCCCHHH
INNAKTRRVSVCNALDTLIIHADRLKDLPELVETLSQKHVIIYADQDAYHVLDKNYPEQL
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHCCCCCCCE
LIKAKPQDFGHEFLDYKLAIKTVPNIKAAIGHIQQFSSHHSEAIIAEDESAIDQFLIEVD
EEEECCHHHCHHHHHEEEEEEECCCHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHH
AAAVYANASTAFTDGGEFGLGAEIGISTQKVHARGPMGLEALTSYKWVIRGTGQIRD
HHEEEECCCCEECCCCCCCCCCEECCCEEEEECCCCCCHHHHHCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA