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The map label for this gene is adk [H]

Identifier: 54294297

GI number: 54294297

Start: 1518732

End: 1519388

Strand: Direct

Name: adk [H]

Synonym: lpl1362

Alternate gene names: 54294297

Gene position: 1518732-1519388 (Clockwise)

Preceding gene: 54294296

Following gene: 54294298

Centisome position: 45.39

GC content: 41.86

Gene sequence:

>657_bases
ATGCGATTAATGCTTTTAGGTGGACCGGGAGCCGGCAAAGGAACCCAAGCTTCACTTTTAATTAACCGTTATAAAATTCC
TCAAATTTCTACCGGTGACATGCTGCGTGCTGCCATAGCAAAAGGTACGCCCTTAGGATTAAGTGCCCAAAAAATCATGG
AATCAGGTGGCTTGGTGTCTGATGATATTATTATCGGGTTAGTGAAGGAAAGACTAAAAAACCCTGATTGTGATCGAGGA
TTCCTATTTGATGGTTTTCCAAGAACATTGGTTCAGGCCGAAGCTTTAAAAGATGCAGAAATCCATTTGGATCATGTGAT
AGAAATAGCCGTCGATGACGAAGAAATAATTGAACGCATCAGCGGGCGACGCATTCACCAGCCTTCTGGTAGGGTTTATC
ACGTTGTGAATCAACCGCCGAAAAATCCGGGTGTAGATGACATCACAGGTGAGCCTCTGATTCAACGTGATGATGATAAA
GAAGAAACCATACGTAAGCGCTTACAGGTTTACCATAGTCAAACAGCGCCATTGGTGCAATATTATAAGGAATGGGCTGA
ATCTGGTTCTAAAGAAGCTCCAAAATTTCACACTATTAGTGGTACAGGTACAGTAGATCAAATATTTGATAACATCGTAA
CGATACTCGAAACTTAG

Upstream 100 bases:

>100_bases
ATTTGTCAATGTGCACTAAATAATTATAAAATTTTATAGTGCTACTATGTTACTATATTTGAAAGTATATAATGATTACG
AATTATTTAAGGAGTTTTGG

Downstream 100 bases:

>100_bases
GAGTTAACATGCCGACCCAGACTATTAAAAGCGCTGAATTTGAATCATTAATTAATGACAATGAGATAGTTTTCATTGAT
TTCTGGGCTGGGTGGTGTGC

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MRLMLLGGPGAGKGTQASLLINRYKIPQISTGDMLRAAIAKGTPLGLSAQKIMESGGLVSDDIIIGLVKERLKNPDCDRG
FLFDGFPRTLVQAEALKDAEIHLDHVIEIAVDDEEIIERISGRRIHQPSGRVYHVVNQPPKNPGVDDITGEPLIQRDDDK
EETIRKRLQVYHSQTAPLVQYYKEWAESGSKEAPKFHTISGTGTVDQIFDNIVTILET

Sequences:

>Translated_218_residues
MRLMLLGGPGAGKGTQASLLINRYKIPQISTGDMLRAAIAKGTPLGLSAQKIMESGGLVSDDIIIGLVKERLKNPDCDRG
FLFDGFPRTLVQAEALKDAEIHLDHVIEIAVDDEEIIERISGRRIHQPSGRVYHVVNQPPKNPGVDDITGEPLIQRDDDK
EETIRKRLQVYHSQTAPLVQYYKEWAESGSKEAPKFHTISGTGTVDQIFDNIVTILET
>Mature_218_residues
MRLMLLGGPGAGKGTQASLLINRYKIPQISTGDMLRAAIAKGTPLGLSAQKIMESGGLVSDDIIIGLVKERLKNPDCDRG
FLFDGFPRTLVQAEALKDAEIHLDHVIEIAVDDEEIIERISGRRIHQPSGRVYHVVNQPPKNPGVDDITGEPLIQRDDDK
EETIRKRLQVYHSQTAPLVQYYKEWAESGSKEAPKFHTISGTGTVDQIFDNIVTILET

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=219, Percent_Identity=46.1187214611872, Blast_Score=196, Evalue=1e-50,
Organism=Homo sapiens, GI4502013, Length=219, Percent_Identity=46.1187214611872, Blast_Score=196, Evalue=1e-50,
Organism=Homo sapiens, GI19923437, Length=218, Percent_Identity=42.6605504587156, Blast_Score=171, Evalue=6e-43,
Organism=Homo sapiens, GI310110345, Length=226, Percent_Identity=38.0530973451327, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI53832003, Length=226, Percent_Identity=38.0530973451327, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI8051579, Length=226, Percent_Identity=38.0530973451327, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI53832001, Length=226, Percent_Identity=38.0530973451327, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI4502011, Length=216, Percent_Identity=28.2407407407407, Blast_Score=101, Evalue=4e-22,
Organism=Homo sapiens, GI22749187, Length=182, Percent_Identity=30.7692307692308, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI28144899, Length=223, Percent_Identity=29.1479820627803, Blast_Score=91, Evalue=7e-19,
Organism=Homo sapiens, GI28144897, Length=223, Percent_Identity=29.1479820627803, Blast_Score=91, Evalue=7e-19,
Organism=Homo sapiens, GI7706497, Length=223, Percent_Identity=27.3542600896861, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI21450759, Length=139, Percent_Identity=30.2158273381295, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI237858799, Length=139, Percent_Identity=30.2158273381295, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1786680, Length=216, Percent_Identity=55.0925925925926, Blast_Score=246, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI17552384, Length=213, Percent_Identity=44.131455399061, Blast_Score=187, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI17537943, Length=219, Percent_Identity=32.8767123287671, Blast_Score=119, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI17567503, Length=217, Percent_Identity=31.3364055299539, Blast_Score=108, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6320432, Length=202, Percent_Identity=50.990099009901, Blast_Score=206, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6321018, Length=217, Percent_Identity=44.7004608294931, Blast_Score=150, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6322828, Length=184, Percent_Identity=26.6304347826087, Blast_Score=73, Evalue=3e-14,
Organism=Drosophila melanogaster, GI22026816, Length=183, Percent_Identity=53.551912568306, Blast_Score=207, Evalue=3e-54,
Organism=Drosophila melanogaster, GI17737899, Length=184, Percent_Identity=42.3913043478261, Blast_Score=152, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24645822, Length=184, Percent_Identity=42.3913043478261, Blast_Score=152, Evalue=2e-37,
Organism=Drosophila melanogaster, GI17647141, Length=217, Percent_Identity=28.5714285714286, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24663208, Length=217, Percent_Identity=28.5714285714286, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI221459597, Length=185, Percent_Identity=23.7837837837838, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21356893, Length=185, Percent_Identity=23.7837837837838, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 24107; Mature: 24107

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLMLLGGPGAGKGTQASLLINRYKIPQISTGDMLRAAIAKGTPLGLSAQKIMESGGLVS
CEEEEEECCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHCCCCCCCCHHHHHHCCCCCC
DDIIIGLVKERLKNPDCDRGFLFDGFPRTLVQAEALKDAEIHLDHVIEIAVDDEEIIERI
HHHHHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHHCCCCEEEEEEEEEEECHHHHHHHH
SGRRIHQPSGRVYHVVNQPPKNPGVDDITGEPLIQRDDDKEETIRKRLQVYHSQTAPLVQ
CCCEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHH
YYKEWAESGSKEAPKFHTISGTGTVDQIFDNIVTILET
HHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MRLMLLGGPGAGKGTQASLLINRYKIPQISTGDMLRAAIAKGTPLGLSAQKIMESGGLVS
CEEEEEECCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHCCCCCCCCHHHHHHCCCCCC
DDIIIGLVKERLKNPDCDRGFLFDGFPRTLVQAEALKDAEIHLDHVIEIAVDDEEIIERI
HHHHHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHHCCCCEEEEEEEEEEECHHHHHHHH
SGRRIHQPSGRVYHVVNQPPKNPGVDDITGEPLIQRDDDKEETIRKRLQVYHSQTAPLVQ
CCCEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHH
YYKEWAESGSKEAPKFHTISGTGTVDQIFDNIVTILET
HHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA