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The map label for this gene is fabF [H]

Identifier: 54294283

GI number: 54294283

Start: 1503668

End: 1504906

Strand: Direct

Name: fabF [H]

Synonym: lpl1348

Alternate gene names: 54294283

Gene position: 1503668-1504906 (Clockwise)

Preceding gene: 54294282

Following gene: 54294284

Centisome position: 44.94

GC content: 42.78

Gene sequence:

>1239_bases
TTGAATAGTCGGCGTGTGGTTATTACCGGCATGGGTATGCTTACTCCTGTCGGACTTAATGTAGAAGAAACTTGGCGAAG
TATTTTAGCTGGAGTTAGTGGGGTAGGTTTGGTGGAAGATTTTGACACTACTGAATACCCAACTAAGATTTGGGCTAAGG
TCAAGAATTTTAATGTTGAGAATCACATGCCAATTAAAGACGCCCGCAAAATGGACGTCTTTACACAATACGGTATGGCT
GCTGCTGATGAAGCGATGCTTGACTCGGGTTTAAAAATTGATGAAGCCTTATCTCGTCGAATCGGTGTCGCAGTGGGGGC
AGGTATTGGTGGTATTCAAACAATCACAAATAACCAGGATAAACTGGTTGCCGGTGGACCACGTAAGGTTTCGCCATTTT
TTATTCCGGCAGGTATTATCAATATGGTTGCTGGACAGATTTCTATTAAACATAATTTAAAAGGACCTAATATTTCGGTT
GTGACTGCATGTACTACCGGAACACATAATATCGGGCTAGCCGGGCGTATAATTGCTTATGGCGATGCCGATGTCATGAT
TTGTGGTGGGGCGGAAATGACCACAACGCCACTTTGTCTTGCTGGGTTTTCAGCAGTAAGATCTTTATCCAAACGGAATG
ATGAGCCTGAGAAAGCCTCAAGGCCTTGGGATAAAGACAGAGACGGTTTTGTTATGGGTGAGGGTGCTGGTATTTTGGTT
TTAGAAGAATATGAACACGCTAAAGCTCGTGGAGCCAAAATTTATGCTGAATTGGTTGGTTTTGGTATGTCAGGAGATGC
TTATCATATTACTGCACCCGATGAAGATGCCGATGGAGCTTCACGAGCTATGGAGGCAGCCATCCAGGATGCTGGTATCG
ATCCCAGACAAGTTGATTATATTAATGCTCACGGTACGTCGACTTATTTAAACGATTTAAATGAAACAAAAGCCATTAAG
CGTGTTTTCGAGAACCATGCTTATGATCTGGCGGTTAGCTCAACCAAATCCATGACAGGCCATTTGCTCGGAGCTGCAGG
TGCAGTAGAGGCAATTATAAGTATTTTAGCCATCAGAGATCAGGTGGCTCCACCTACAATAAATTTGGATAATCCTGATG
AAGGTTGTGACTTGAATTATGTAGCACATGTACCACAAAGCAGAACAATTAATTATGTTCTAAGTAATTCACTTGGTTTT
GGTGGGACAAACGGTAGCTTACTGTTCAAGCGAATCTAA

Upstream 100 bases:

>100_bases
TGATGAAAAAGCTGAGAAAATTACTACAATTCAAGAAGCAATTGATTATATTGAATCTAACTTAAATAAAGAAGAAGCTT
AATTTTTTAAGGAGCTCTCA

Downstream 100 bases:

>100_bases
ATGCAATTCTCTAGACATAAAAAACTGGTTATTCTTGTTTTATCCTTGTTTTTTATGTCTTTCTTGTTTTTATTTTGGAA
TATATATCGCTTATTGTATA

Product: 3-oxoacyl-[acyl-carrier-protein] synthase II (Beta-ketoacyl-ACP synthase II)

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MNSRRVVITGMGMLTPVGLNVEETWRSILAGVSGVGLVEDFDTTEYPTKIWAKVKNFNVENHMPIKDARKMDVFTQYGMA
AADEAMLDSGLKIDEALSRRIGVAVGAGIGGIQTITNNQDKLVAGGPRKVSPFFIPAGIINMVAGQISIKHNLKGPNISV
VTACTTGTHNIGLAGRIIAYGDADVMICGGAEMTTTPLCLAGFSAVRSLSKRNDEPEKASRPWDKDRDGFVMGEGAGILV
LEEYEHAKARGAKIYAELVGFGMSGDAYHITAPDEDADGASRAMEAAIQDAGIDPRQVDYINAHGTSTYLNDLNETKAIK
RVFENHAYDLAVSSTKSMTGHLLGAAGAVEAIISILAIRDQVAPPTINLDNPDEGCDLNYVAHVPQSRTINYVLSNSLGF
GGTNGSLLFKRI

Sequences:

>Translated_412_residues
MNSRRVVITGMGMLTPVGLNVEETWRSILAGVSGVGLVEDFDTTEYPTKIWAKVKNFNVENHMPIKDARKMDVFTQYGMA
AADEAMLDSGLKIDEALSRRIGVAVGAGIGGIQTITNNQDKLVAGGPRKVSPFFIPAGIINMVAGQISIKHNLKGPNISV
VTACTTGTHNIGLAGRIIAYGDADVMICGGAEMTTTPLCLAGFSAVRSLSKRNDEPEKASRPWDKDRDGFVMGEGAGILV
LEEYEHAKARGAKIYAELVGFGMSGDAYHITAPDEDADGASRAMEAAIQDAGIDPRQVDYINAHGTSTYLNDLNETKAIK
RVFENHAYDLAVSSTKSMTGHLLGAAGAVEAIISILAIRDQVAPPTINLDNPDEGCDLNYVAHVPQSRTINYVLSNSLGF
GGTNGSLLFKRI
>Mature_412_residues
MNSRRVVITGMGMLTPVGLNVEETWRSILAGVSGVGLVEDFDTTEYPTKIWAKVKNFNVENHMPIKDARKMDVFTQYGMA
AADEAMLDSGLKIDEALSRRIGVAVGAGIGGIQTITNNQDKLVAGGPRKVSPFFIPAGIINMVAGQISIKHNLKGPNISV
VTACTTGTHNIGLAGRIIAYGDADVMICGGAEMTTTPLCLAGFSAVRSLSKRNDEPEKASRPWDKDRDGFVMGEGAGILV
LEEYEHAKARGAKIYAELVGFGMSGDAYHITAPDEDADGASRAMEAAIQDAGIDPRQVDYINAHGTSTYLNDLNETKAIK
RVFENHAYDLAVSSTKSMTGHLLGAAGAVEAIISILAIRDQVAPPTINLDNPDEGCDLNYVAHVPQSRTINYVLSNSLGF
GGTNGSLLFKRI

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=416, Percent_Identity=49.5192307692308, Blast_Score=378, Evalue=1e-105,
Organism=Homo sapiens, GI223972627, Length=166, Percent_Identity=53.6144578313253, Blast_Score=158, Evalue=7e-39,
Organism=Homo sapiens, GI41872631, Length=425, Percent_Identity=24.7058823529412, Blast_Score=96, Evalue=7e-20,
Organism=Escherichia coli, GI1787337, Length=413, Percent_Identity=62.227602905569, Blast_Score=504, Evalue=1e-144,
Organism=Escherichia coli, GI1788663, Length=415, Percent_Identity=36.6265060240964, Blast_Score=237, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI71983541, Length=413, Percent_Identity=38.7409200968523, Blast_Score=269, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI71983535, Length=265, Percent_Identity=44.9056603773585, Blast_Score=214, Evalue=7e-56,
Organism=Caenorhabditis elegans, GI212642053, Length=355, Percent_Identity=27.6056338028169, Blast_Score=124, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI17550940, Length=278, Percent_Identity=28.0575539568345, Blast_Score=86, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6320904, Length=443, Percent_Identity=38.8261851015801, Blast_Score=284, Evalue=2e-77,
Organism=Drosophila melanogaster, GI24644341, Length=416, Percent_Identity=46.6346153846154, Blast_Score=342, Evalue=3e-94,
Organism=Drosophila melanogaster, GI221330659, Length=426, Percent_Identity=24.1784037558685, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI19920632, Length=426, Percent_Identity=24.1784037558685, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24581345, Length=430, Percent_Identity=22.7906976744186, Blast_Score=89, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43901; Mature: 43901

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSRRVVITGMGMLTPVGLNVEETWRSILAGVSGVGLVEDFDTTEYPTKIWAKVKNFNVE
CCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHCCCCC
NHMPIKDARKMDVFTQYGMAAADEAMLDSGLKIDEALSRRIGVAVGAGIGGIQTITNNQD
CCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHCEEEECCCCCEEEECCCCC
KLVAGGPRKVSPFFIPAGIINMVAGQISIKHNLKGPNISVVTACTTGTHNIGLAGRIIAY
EEEECCCCCCCCEEECHHHHHHHHCEEEEEECCCCCCEEEEEEEECCCCCCCCCEEEEEE
GDADVMICGGAEMTTTPLCLAGFSAVRSLSKRNDEPEKASRPWDKDRDGFVMGEGAGILV
CCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCEEEECCCCEEE
LEEYEHAKARGAKIYAELVGFGMSGDAYHITAPDEDADGASRAMEAAIQDAGIDPRQVDY
EECCCHHHHCCHHEEEHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCEEE
INAHGTSTYLNDLNETKAIKRVFENHAYDLAVSSTKSMTGHLLGAAGAVEAIISILAIRD
EECCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
QVAPPTINLDNPDEGCDLNYVAHVPQSRTINYVLSNSLGFGGTNGSLLFKRI
CCCCCEECCCCCCCCCCCCEEEECCCCCEEEEEEECCCCCCCCCCCEEEEEC
>Mature Secondary Structure
MNSRRVVITGMGMLTPVGLNVEETWRSILAGVSGVGLVEDFDTTEYPTKIWAKVKNFNVE
CCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHCCCCC
NHMPIKDARKMDVFTQYGMAAADEAMLDSGLKIDEALSRRIGVAVGAGIGGIQTITNNQD
CCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHCEEEECCCCCEEEECCCCC
KLVAGGPRKVSPFFIPAGIINMVAGQISIKHNLKGPNISVVTACTTGTHNIGLAGRIIAY
EEEECCCCCCCCEEECHHHHHHHHCEEEEEECCCCCCEEEEEEEECCCCCCCCCEEEEEE
GDADVMICGGAEMTTTPLCLAGFSAVRSLSKRNDEPEKASRPWDKDRDGFVMGEGAGILV
CCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCEEEECCCCEEE
LEEYEHAKARGAKIYAELVGFGMSGDAYHITAPDEDADGASRAMEAAIQDAGIDPRQVDY
EECCCHHHHCCHHEEEHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCEEE
INAHGTSTYLNDLNETKAIKRVFENHAYDLAVSSTKSMTGHLLGAAGAVEAIISILAIRD
EECCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
QVAPPTINLDNPDEGCDLNYVAHVPQSRTINYVLSNSLGFGGTNGSLLFKRI
CCCCCEECCCCCCCCCCCCEEEECCCCCEEEEEEECCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]