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The map label for this gene is kdsA [H]

Identifier: 54294127

GI number: 54294127

Start: 1330212

End: 1331036

Strand: Direct

Name: kdsA [H]

Synonym: lpl1191

Alternate gene names: 54294127

Gene position: 1330212-1331036 (Clockwise)

Preceding gene: 54294126

Following gene: 54294128

Centisome position: 39.76

GC content: 41.33

Gene sequence:

>825_bases
ATGAGATTATGTGGTTTTGAAGCAGGCTTGGATAAGCCATTATTTTTGATTGCTGGCCCGTGTGTTATTGAAAGTGAAGA
ACTGGCATTAGAGACTGCAGGATATTTAAAGGAAATGTGCAGTCAATTGAATATCCCTTTCATCTATAAGTCTTCTTTTG
ATAAAGCAAACCGTTCATCCATTTCCAGTTACAGGGGGCCTGGCTTTGAAAAAGGGTTATCGATTCTGGAAAAGGTCAAA
TCACAAATAGGTGTTCCTGTTTTGACTGACGTTCATGAAGACACGCCCTTATTTGAAGTCTCCAGTGTGGTAGATGTATT
ACAAACGCCAGCCTTCCTATGCAGACAAACCAATTTTATTCAAAAAGTTGCTGCCATGAATAAGCCGGTTAATATTAAAA
AAGGACAGTTTCTTGCTCCCTGGGAAATGAAACATGTTATTGCGAAAGCAAAGGCGCAAGGTAATGAGCAAATTATGGCT
TGTGAGCGAGGAGTGAGCTTCGGCTACAATAATTTGGTTTCTGATATGCGTTCCCTCGTTATCATGCGTGAAACCGGCTG
TCCAGTGGTTTATGATGCAACACATTCGGTTCAATTGCCCGGTGGCAATAATGGTGTATCCGGGGGGCAGAGAGAATTTA
TTCCGGCTCTTGCAAGAGCAGCTGTAGCTGTTGGAATATCAGGGTTATTTATGGAAACTCACCCTGATCCGGATAATGCA
CTAAGTGATGGTCCCAATAGTTGGCCTCTAGATAAAATGAAACAACTTTTGGAGTCATTGAAAGCAGCGGATGAAGTGTA
TAAAAAGTACAGTACTGATTTCTAA

Upstream 100 bases:

>100_bases
AGTTTCATCCTGAATTCACATCGAATCCAAGAGATAGTCATCCCCTATTTAAGGAATTTGTATTTGCAGCTCGTATTCAC
CATCAAGAAAAGGACAAAAA

Downstream 100 bases:

>100_bases
ATTAAATGATATCCCGTGTAAAAAGAAGTATGGCACGGGAATATTTTTTATTTTGCTCCGCGCTGTTATCTGATTAACCA
TACCGTTTTTGATTTGATTC

Product: 2-dehydro-3-deoxyphosphooctonate aldolase

Products: NA

Alternate protein names: 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase; KDO-8-phosphate synthase; KDO 8-P synthase; KDOPS; Phospho-2-dehydro-3-deoxyoctonate aldolase [H]

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MRLCGFEAGLDKPLFLIAGPCVIESEELALETAGYLKEMCSQLNIPFIYKSSFDKANRSSISSYRGPGFEKGLSILEKVK
SQIGVPVLTDVHEDTPLFEVSSVVDVLQTPAFLCRQTNFIQKVAAMNKPVNIKKGQFLAPWEMKHVIAKAKAQGNEQIMA
CERGVSFGYNNLVSDMRSLVIMRETGCPVVYDATHSVQLPGGNNGVSGGQREFIPALARAAVAVGISGLFMETHPDPDNA
LSDGPNSWPLDKMKQLLESLKAADEVYKKYSTDF

Sequences:

>Translated_274_residues
MRLCGFEAGLDKPLFLIAGPCVIESEELALETAGYLKEMCSQLNIPFIYKSSFDKANRSSISSYRGPGFEKGLSILEKVK
SQIGVPVLTDVHEDTPLFEVSSVVDVLQTPAFLCRQTNFIQKVAAMNKPVNIKKGQFLAPWEMKHVIAKAKAQGNEQIMA
CERGVSFGYNNLVSDMRSLVIMRETGCPVVYDATHSVQLPGGNNGVSGGQREFIPALARAAVAVGISGLFMETHPDPDNA
LSDGPNSWPLDKMKQLLESLKAADEVYKKYSTDF
>Mature_274_residues
MRLCGFEAGLDKPLFLIAGPCVIESEELALETAGYLKEMCSQLNIPFIYKSSFDKANRSSISSYRGPGFEKGLSILEKVK
SQIGVPVLTDVHEDTPLFEVSSVVDVLQTPAFLCRQTNFIQKVAAMNKPVNIKKGQFLAPWEMKHVIAKAKAQGNEQIMA
CERGVSFGYNNLVSDMRSLVIMRETGCPVVYDATHSVQLPGGNNGVSGGQREFIPALARAAVAVGISGLFMETHPDPDNA
LSDGPNSWPLDKMKQLLESLKAADEVYKKYSTDF

Specific function: Synthesis Of Kdo 8-P Which Is Required For Lipid A Maturation And Cellular Growth. [C]

COG id: COG2877

COG function: function code M; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsA family [H]

Homologues:

Organism=Escherichia coli, GI1787466, Length=262, Percent_Identity=44.2748091603053, Blast_Score=249, Evalue=1e-67,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006218
- InterPro:   IPR006269 [H]

Pfam domain/function: PF00793 DAHP_synth_1 [H]

EC number: =2.5.1.55 [H]

Molecular weight: Translated: 29970; Mature: 29970

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLCGFEAGLDKPLFLIAGPCVIESEELALETAGYLKEMCSQLNIPFIYKSSFDKANRSS
CCCCCCCCCCCCCEEEEECCCEECCHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHH
ISSYRGPGFEKGLSILEKVKSQIGVPVLTDVHEDTPLFEVSSVVDVLQTPAFLCRQTNFI
HHHHCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHCHHHHHHHHHHH
QKVAAMNKPVNIKKGQFLAPWEMKHVIAKAKAQGNEQIMACERGVSFGYNNLVSDMRSLV
HHHHHCCCCCCCCCCCEECCHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHHHHH
IMRETGCPVVYDATHSVQLPGGNNGVSGGQREFIPALARAAVAVGISGLFMETHPDPDNA
HHHCCCCCEEEECCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCH
LSDGPNSWPLDKMKQLLESLKAADEVYKKYSTDF
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRLCGFEAGLDKPLFLIAGPCVIESEELALETAGYLKEMCSQLNIPFIYKSSFDKANRSS
CCCCCCCCCCCCCEEEEECCCEECCHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHH
ISSYRGPGFEKGLSILEKVKSQIGVPVLTDVHEDTPLFEVSSVVDVLQTPAFLCRQTNFI
HHHHCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHCHHHHHHHHHHH
QKVAAMNKPVNIKKGQFLAPWEMKHVIAKAKAQGNEQIMACERGVSFGYNNLVSDMRSLV
HHHHHCCCCCCCCCCCEECCHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHHHHH
IMRETGCPVVYDATHSVQLPGGNNGVSGGQREFIPALARAAVAVGISGLFMETHPDPDNA
HHHCCCCCEEEECCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCH
LSDGPNSWPLDKMKQLLESLKAADEVYKKYSTDF
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA