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The map label for this gene is pyrG [H]

Identifier: 54294126

GI number: 54294126

Start: 1328578

End: 1330215

Strand: Direct

Name: pyrG [H]

Synonym: lpl1190

Alternate gene names: 54294126

Gene position: 1328578-1330215 (Clockwise)

Preceding gene: 54294125

Following gene: 54294127

Centisome position: 39.71

GC content: 39.32

Gene sequence:

>1638_bases
ATGACAAAATATATTTTTATTACTGGCGGGGTTGTGTCTTCTTTAGGAAAAGGCATAGCAGCCGCATCTCTTGCAGCTAT
TCTTGAAGCTCGTGGTCTTCGCGTTACGTTGATAAAGCTTGATCCCTACATTAACGTTGATCCTGGTACTATGAGTCCCT
TTCAGCATGGTGAGGTTTTTGTAACGAATGACGGGGCGGAGACCGATTTGGATTTGGGACATTATGAGCGTTTTGTTAAA
ACAACAATGACCAAGCGCAATAATTTCACATCGGGAAAAATTTACGAAAATGTAATTAAGAAAGAAAGACGTGGTGATTA
TTTAGGAGGGACAGTTCAGGTTATTCCTCATATTACCAATGAAATCAAACGCTGTATCAAACTTGGTGCAGATGCATTCG
ATGTGGCTATGGTTGAAATAGGAGGAACTGTTGGTGATATTGAATCATTACCCTTTCTTGAAGCAATTAGGCAGATGCGT
ATTGAGTTAGGTTCACAACGAGCAATATTTATTCATCTTACTTTGGTTCCTTATATTGCTACTTCTGGGGAAACCAAAAC
CAAACCAACTCAACACTCGGTAAAGGAATTGCGTTCTATTGGTATCCAGCCAGATGTATTGATTTGCCGTTCAGAAAAAC
CATTATCCATGGCAGACAGGGCTAAAATCGCATTATTCACTAATGTTGAAAAAGAAGCTGTGATTTCTCTTGAGGATGCG
AATAGTATTTATCAAATACCTATGATTCTACATGCGCAGCATTTAGACGAAATTGTGGTTAAGAAACTAAGCCTGGAAGC
TAAGCAGGCTGATTTGAGCGAGTGGCAACGAGTAGTTGATATGCAAGCAGTTCAAACGATGACAGTGAAAATCGCTATGG
TAGGTAAATATACGGAGCTGAATGATGCCTACAAGTCGATTAATGAAGCTTTATTGCATGCTGGAATTCATACGGAAACA
AAAGTAGAAATTATCTATTTTGATGCTGAGATGATAGAAAAGCATGGCGCTTTATTACTTGAATCCATTGATGCTATTTT
GGTACCTGGTGGTTTTGGTGAGAGAGGAGTCGAAGGCAAAATTAAGGCTATCCAATATGCTCGGGAGCATAAAGTTCCTT
TTTTAGGGATATGTTTGGGTATGCAAACAGCTGTTATTGAGTTTGCGAGAAATGTAGTCGGTTTAACAGGAGCCAATTCG
ACTGAGTTTAATAAAGAAACATTGTATCCAGTGCTTGGTTTAATTAGTGAGTGGATGGATGCTGATGGTAGCAAACAGAC
CAGGGACGAAAGTACTGATTTGGGTGGAACTATGCGTTTGGGCGGGCAATACTGTCATCTTGCTGAAGGTACTCTGGCAA
GAAAAGTCTATGGCAAATCACAAATTATAGAGCGTCATCGACATCGATATGAAGTCAACAACAAATATGTGGATAGTTTG
GTAAAACATGGTTTAATTATTTCAGGACGATCAGCAGATAATTCACTGGTTGAGATGATAGAATTAGCAGACCACCCCTG
GTTTTTAGCTTGTCAGTTTCATCCTGAATTCACATCGAATCCAAGAGATAGTCATCCCCTATTTAAGGAATTTGTATTTG
CAGCTCGTATTCACCATCAAGAAAAGGACAAAAAATGA

Upstream 100 bases:

>100_bases
GTTATTTATATCTTCATTTTGATAGAATTGAATCCCGTTTACATGCAAATTAAATTGAACACCAAATTGGTGAATTCGGC
ATTTTGAGCGGGGTCAAAAA

Downstream 100 bases:

>100_bases
GATTATGTGGTTTTGAAGCAGGCTTGGATAAGCCATTATTTTTGATTGCTGGCCCGTGTGTTATTGAAAGTGAAGAACTG
GCATTAGAGACTGCAGGATA

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 545; Mature: 544

Protein sequence:

>545_residues
MTKYIFITGGVVSSLGKGIAAASLAAILEARGLRVTLIKLDPYINVDPGTMSPFQHGEVFVTNDGAETDLDLGHYERFVK
TTMTKRNNFTSGKIYENVIKKERRGDYLGGTVQVIPHITNEIKRCIKLGADAFDVAMVEIGGTVGDIESLPFLEAIRQMR
IELGSQRAIFIHLTLVPYIATSGETKTKPTQHSVKELRSIGIQPDVLICRSEKPLSMADRAKIALFTNVEKEAVISLEDA
NSIYQIPMILHAQHLDEIVVKKLSLEAKQADLSEWQRVVDMQAVQTMTVKIAMVGKYTELNDAYKSINEALLHAGIHTET
KVEIIYFDAEMIEKHGALLLESIDAILVPGGFGERGVEGKIKAIQYAREHKVPFLGICLGMQTAVIEFARNVVGLTGANS
TEFNKETLYPVLGLISEWMDADGSKQTRDESTDLGGTMRLGGQYCHLAEGTLARKVYGKSQIIERHRHRYEVNNKYVDSL
VKHGLIISGRSADNSLVEMIELADHPWFLACQFHPEFTSNPRDSHPLFKEFVFAARIHHQEKDKK

Sequences:

>Translated_545_residues
MTKYIFITGGVVSSLGKGIAAASLAAILEARGLRVTLIKLDPYINVDPGTMSPFQHGEVFVTNDGAETDLDLGHYERFVK
TTMTKRNNFTSGKIYENVIKKERRGDYLGGTVQVIPHITNEIKRCIKLGADAFDVAMVEIGGTVGDIESLPFLEAIRQMR
IELGSQRAIFIHLTLVPYIATSGETKTKPTQHSVKELRSIGIQPDVLICRSEKPLSMADRAKIALFTNVEKEAVISLEDA
NSIYQIPMILHAQHLDEIVVKKLSLEAKQADLSEWQRVVDMQAVQTMTVKIAMVGKYTELNDAYKSINEALLHAGIHTET
KVEIIYFDAEMIEKHGALLLESIDAILVPGGFGERGVEGKIKAIQYAREHKVPFLGICLGMQTAVIEFARNVVGLTGANS
TEFNKETLYPVLGLISEWMDADGSKQTRDESTDLGGTMRLGGQYCHLAEGTLARKVYGKSQIIERHRHRYEVNNKYVDSL
VKHGLIISGRSADNSLVEMIELADHPWFLACQFHPEFTSNPRDSHPLFKEFVFAARIHHQEKDKK
>Mature_544_residues
TKYIFITGGVVSSLGKGIAAASLAAILEARGLRVTLIKLDPYINVDPGTMSPFQHGEVFVTNDGAETDLDLGHYERFVKT
TMTKRNNFTSGKIYENVIKKERRGDYLGGTVQVIPHITNEIKRCIKLGADAFDVAMVEIGGTVGDIESLPFLEAIRQMRI
ELGSQRAIFIHLTLVPYIATSGETKTKPTQHSVKELRSIGIQPDVLICRSEKPLSMADRAKIALFTNVEKEAVISLEDAN
SIYQIPMILHAQHLDEIVVKKLSLEAKQADLSEWQRVVDMQAVQTMTVKIAMVGKYTELNDAYKSINEALLHAGIHTETK
VEIIYFDAEMIEKHGALLLESIDAILVPGGFGERGVEGKIKAIQYAREHKVPFLGICLGMQTAVIEFARNVVGLTGANST
EFNKETLYPVLGLISEWMDADGSKQTRDESTDLGGTMRLGGQYCHLAEGTLARKVYGKSQIIERHRHRYEVNNKYVDSLV
KHGLIISGRSADNSLVEMIELADHPWFLACQFHPEFTSNPRDSHPLFKEFVFAARIHHQEKDKK

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI148491070, Length=563, Percent_Identity=44.9378330373002, Blast_Score=488, Evalue=1e-138,
Organism=Homo sapiens, GI28559085, Length=557, Percent_Identity=44.7037701974865, Blast_Score=482, Evalue=1e-136,
Organism=Homo sapiens, GI28559083, Length=557, Percent_Identity=44.7037701974865, Blast_Score=482, Evalue=1e-136,
Organism=Homo sapiens, GI221316689, Length=557, Percent_Identity=44.7037701974865, Blast_Score=482, Evalue=1e-136,
Organism=Escherichia coli, GI1789142, Length=534, Percent_Identity=63.1086142322097, Blast_Score=697, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25148299, Length=610, Percent_Identity=38.3606557377049, Blast_Score=433, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6322563, Length=569, Percent_Identity=43.2337434094903, Blast_Score=462, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6319432, Length=572, Percent_Identity=43.006993006993, Blast_Score=447, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24664469, Length=558, Percent_Identity=43.5483870967742, Blast_Score=477, Evalue=1e-134,
Organism=Drosophila melanogaster, GI21357815, Length=503, Percent_Identity=41.948310139165, Blast_Score=404, Evalue=1e-113,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 60706; Mature: 60575

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKYIFITGGVVSSLGKGIAAASLAAILEARGLRVTLIKLDPYINVDPGTMSPFQHGEVF
CCEEEEEECHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCEEECCCCCCCCCCCCEEE
VTNDGAETDLDLGHYERFVKTTMTKRNNFTSGKIYENVIKKERRGDYLGGTVQVIPHITN
EECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHEEHHHHHH
EIKRCIKLGADAFDVAMVEIGGTVGDIESLPFLEAIRQMRIELGSQRAIFIHLTLVPYIA
HHHHHHHHCCCHHEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEEHHEE
TSGETKTKPTQHSVKELRSIGIQPDVLICRSEKPLSMADRAKIALFTNVEKEAVISLEDA
CCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCEEEEEECCCHHHEEEEECC
NSIYQIPMILHAQHLDEIVVKKLSLEAKQADLSEWQRVVDMQAVQTMTVKIAMVGKYTEL
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEEEEEEECCHHH
NDAYKSINEALLHAGIHTETKVEIIYFDAEMIEKHGALLLESIDAILVPGGFGERGVEGK
HHHHHHHHHHHHHCCCCCCCEEEEEEECHHHHHHCCHHHHHCCCEEEECCCCCCCCCCCH
IKAIQYAREHKVPFLGICLGMQTAVIEFARNVVGLTGANSTEFNKETLYPVLGLISEWMD
HHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHHHHC
ADGSKQTRDESTDLGGTMRLGGQYCHLAEGTLARKVYGKSQIIERHRHRYEVNNKYVDSL
CCCCCCCCCCCCCCCCEEEECCCEEEECCCHHHHHHHCHHHHHHHHHHHHHCCHHHHHHH
VKHGLIISGRSADNSLVEMIELADHPWFLACQFHPEFTSNPRDSHPLFKEFVFAARIHHQ
HHCCEEEECCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
EKDKK
HCCCC
>Mature Secondary Structure 
TKYIFITGGVVSSLGKGIAAASLAAILEARGLRVTLIKLDPYINVDPGTMSPFQHGEVF
CEEEEEECHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCEEECCCCCCCCCCCCEEE
VTNDGAETDLDLGHYERFVKTTMTKRNNFTSGKIYENVIKKERRGDYLGGTVQVIPHITN
EECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHEEHHHHHH
EIKRCIKLGADAFDVAMVEIGGTVGDIESLPFLEAIRQMRIELGSQRAIFIHLTLVPYIA
HHHHHHHHCCCHHEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEEHHEE
TSGETKTKPTQHSVKELRSIGIQPDVLICRSEKPLSMADRAKIALFTNVEKEAVISLEDA
CCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCEEEEEECCCHHHEEEEECC
NSIYQIPMILHAQHLDEIVVKKLSLEAKQADLSEWQRVVDMQAVQTMTVKIAMVGKYTEL
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEEEEEEECCHHH
NDAYKSINEALLHAGIHTETKVEIIYFDAEMIEKHGALLLESIDAILVPGGFGERGVEGK
HHHHHHHHHHHHHCCCCCCCEEEEEEECHHHHHHCCHHHHHCCCEEEECCCCCCCCCCCH
IKAIQYAREHKVPFLGICLGMQTAVIEFARNVVGLTGANSTEFNKETLYPVLGLISEWMD
HHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHHHHC
ADGSKQTRDESTDLGGTMRLGGQYCHLAEGTLARKVYGKSQIIERHRHRYEVNNKYVDSL
CCCCCCCCCCCCCCCCEEEECCCEEEECCCHHHHHHHCHHHHHHHHHHHHHCCHHHHHHH
VKHGLIISGRSADNSLVEMIELADHPWFLACQFHPEFTSNPRDSHPLFKEFVFAARIHHQ
HHCCEEEECCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
EKDKK
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA