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The map label for this gene is ada [H]

Identifier: 54294092

GI number: 54294092

Start: 1288301

End: 1289371

Strand: Direct

Name: ada [H]

Synonym: lpl1156

Alternate gene names: 54294092

Gene position: 1288301-1289371 (Clockwise)

Preceding gene: 54294091

Following gene: 54294097

Centisome position: 38.51

GC content: 39.87

Gene sequence:

>1071_bases
ATGGTGATGTTTGAAATTAACGATCAAAGAAAAAAGGAATATTATACTGCTCTGCTGAGTAAAAATACCTGCTATGAAGG
GATTTTTTATGTTGGAGTGAAAACAACAGGTGTTTTTTGCCGACCAACTTGCCCTGCAAGAAAACCAAAATTGGAAAATT
GTGAATTTTTTCATACCGCGCAAGAGGCTCTATTAGCCTCTTACAGACCCTGTAGACGTTGTCAACCTCTGTCACATCCA
AATCAAGTCTCTGATTTGGTCAAACATTTGGTTGATGCAGTTGAGGCTAATCCTGAAAAAAGATGGAAAGACAGTGATTT
TGCAGCCTTATCAGTTGATGTTGCAACAGCGAGGCGCCAATTTAAGAAAAGATTTGGAATGACATTTGTAGCATACGCTC
GTGCCAGAAGAATGGGTATGGCAATGAAACAAATCAGAGAAGGTGATTTAGTGATTAATGCGCAAATTGATGCTGGATAT
CATTCAGGCAGCGGGTTTAGAGATGCTTTTGCGAAGATTATGGGAGCCGCTCCATCTCATTTTAATGAACAGCACAAAGT
TATTAAGGCTTCCTGGTTAGATACACCTTTAGGTCCTATGCTTGCTGTTGCAGATGAAAGCGCTTTATATTTACTTGAAT
TCGTCGATAGAAGAGGATTGGAAAGAGAAGTTGAAAGGCTGAGAAATAAAACCAAAGCAGTCATTATCCCGGGAGATTCT
CCAGTGTTAAAGGCTATACAAAAAGAGTTGGAGCTTTATTTTTCAGGAAAACTAAGACAGTTTAATACACCTATCCATTT
AATTGGCAGCCCTTTTCAAAAAAAGGCATGGCTGGCGTTAATCGATATTCCCTATGGTGAAACAAGAAGTTATCTGCAAC
AGGCTAAAGTAATAGGTAATCCGTCGGCTTACAGGGCGGTGGCTAATGCTAATGGTGCTAATCAATTAGCTATAGTGGTT
CCTTGTCATCGGATTATCAACGCTAATGGCGAATTGGGGGGATATGGGGGTGGTGTAAATCGTAAACATTGGTTACTTGA
ACATGAAAGAAGACATGATCGAGGTTGCTAA

Upstream 100 bases:

>100_bases
ATAACTGGCGCCTTTTCTAATTTTAAAAATTCACTGTCTGATTTTCGGCTTCACCATTTTAAAGAAGATTTATAATAATT
AGTAAGAAAGCTTGTCAGGA

Downstream 100 bases:

>100_bases
ACTAATTTTGCTACGCTCAAAAAGGAGTATAGAATAAACATGTTAACCTTCCAGAAGCTGTAGTGATTGATACAATTTAT
TGTTTCATTCCTGGTTTGCT

Product: hypothetical protein

Products: NA

Alternate protein names: Regulatory protein of adaptative response; O-6-methylguanine-DNA alkyltransferase [H]

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MVMFEINDQRKKEYYTALLSKNTCYEGIFYVGVKTTGVFCRPTCPARKPKLENCEFFHTAQEALLASYRPCRRCQPLSHP
NQVSDLVKHLVDAVEANPEKRWKDSDFAALSVDVATARRQFKKRFGMTFVAYARARRMGMAMKQIREGDLVINAQIDAGY
HSGSGFRDAFAKIMGAAPSHFNEQHKVIKASWLDTPLGPMLAVADESALYLLEFVDRRGLEREVERLRNKTKAVIIPGDS
PVLKAIQKELELYFSGKLRQFNTPIHLIGSPFQKKAWLALIDIPYGETRSYLQQAKVIGNPSAYRAVANANGANQLAIVV
PCHRIINANGELGGYGGGVNRKHWLLEHERRHDRGC

Sequences:

>Translated_356_residues
MVMFEINDQRKKEYYTALLSKNTCYEGIFYVGVKTTGVFCRPTCPARKPKLENCEFFHTAQEALLASYRPCRRCQPLSHP
NQVSDLVKHLVDAVEANPEKRWKDSDFAALSVDVATARRQFKKRFGMTFVAYARARRMGMAMKQIREGDLVINAQIDAGY
HSGSGFRDAFAKIMGAAPSHFNEQHKVIKASWLDTPLGPMLAVADESALYLLEFVDRRGLEREVERLRNKTKAVIIPGDS
PVLKAIQKELELYFSGKLRQFNTPIHLIGSPFQKKAWLALIDIPYGETRSYLQQAKVIGNPSAYRAVANANGANQLAIVV
PCHRIINANGELGGYGGGVNRKHWLLEHERRHDRGC
>Mature_356_residues
MVMFEINDQRKKEYYTALLSKNTCYEGIFYVGVKTTGVFCRPTCPARKPKLENCEFFHTAQEALLASYRPCRRCQPLSHP
NQVSDLVKHLVDAVEANPEKRWKDSDFAALSVDVATARRQFKKRFGMTFVAYARARRMGMAMKQIREGDLVINAQIDAGY
HSGSGFRDAFAKIMGAAPSHFNEQHKVIKASWLDTPLGPMLAVADESALYLLEFVDRRGLEREVERLRNKTKAVIIPGDS
PVLKAIQKELELYFSGKLRQFNTPIHLIGSPFQKKAWLALIDIPYGETRSYLQQAKVIGNPSAYRAVANANGANQLAIVV
PCHRIINANGELGGYGGGVNRKHWLLEHERRHDRGC

Specific function: The methylated ADA protein acts as a positive regulator of its own synthesis, as well as that of other proteins. The transcription-activating function of the ADA protein resides in its N-terminus. It activates the transcription of alkA, alkB and aidB [H]

COG id: COG2169

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI197304670, Length=169, Percent_Identity=30.1775147928994, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1788542, Length=356, Percent_Identity=32.5842696629214, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1787596, Length=162, Percent_Identity=41.358024691358, Blast_Score=110, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI115533068, Length=103, Percent_Identity=43.6893203883495, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI115533070, Length=103, Percent_Identity=43.6893203883495, Blast_Score=81, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6320001, Length=87, Percent_Identity=41.3793103448276, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17137554, Length=174, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004026
- InterPro:   IPR016221
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR018062
- InterPro:   IPR018060
- InterPro:   IPR001497
- InterPro:   IPR014048
- InterPro:   IPR008332
- InterPro:   IPR011991 [H]

Pfam domain/function: PF02805 Ada_Zn_binding; PF01035 DNA_binding_1; PF00165 HTH_AraC; PF02870 Methyltransf_1N [H]

EC number: =2.1.1.63 [H]

Molecular weight: Translated: 40155; Mature: 40155

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: PS01124 HTH_ARAC_FAMILY_2 ; PS00374 MGMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVMFEINDQRKKEYYTALLSKNTCYEGIFYVGVKTTGVFCRPTCPARKPKLENCEFFHTA
CEEEEECCHHHHHHHHHHHCCCCCCCCEEEEEEEECCEEECCCCCCCCCCCCCCHHHHHH
QEALLASYRPCRRCQPLSHPNQVSDLVKHLVDAVEANPEKRWKDSDFAALSVDVATARRQ
HHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHCCCCCCCEEEEEHHHHHHHH
FKKRFGMTFVAYARARRMGMAMKQIREGDLVINAQIDAGYHSGSGFRDAFAKIMGAAPSH
HHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHCCCCCC
FNEQHKVIKASWLDTPLGPMLAVADESALYLLEFVDRRGLEREVERLRNKTKAVIIPGDS
CCCHHHEEEECCCCCCCCCEEEECCCCHHHHHHHHHHCCHHHHHHHHHCCCCEEEECCCC
PVLKAIQKELELYFSGKLRQFNTPIHLIGSPFQKKAWLALIDIPYGETRSYLQQAKVIGN
HHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCC
PSAYRAVANANGANQLAIVVPCHRIINANGELGGYGGGVNRKHWLLEHERRHDRGC
CHHHHHHHCCCCCCEEEEEECCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MVMFEINDQRKKEYYTALLSKNTCYEGIFYVGVKTTGVFCRPTCPARKPKLENCEFFHTA
CEEEEECCHHHHHHHHHHHCCCCCCCCEEEEEEEECCEEECCCCCCCCCCCCCCHHHHHH
QEALLASYRPCRRCQPLSHPNQVSDLVKHLVDAVEANPEKRWKDSDFAALSVDVATARRQ
HHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHCCCCCCCEEEEEHHHHHHHH
FKKRFGMTFVAYARARRMGMAMKQIREGDLVINAQIDAGYHSGSGFRDAFAKIMGAAPSH
HHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHCCCCCC
FNEQHKVIKASWLDTPLGPMLAVADESALYLLEFVDRRGLEREVERLRNKTKAVIIPGDS
CCCHHHEEEECCCCCCCCCEEEECCCCHHHHHHHHHHCCHHHHHHHHHCCCCEEEECCCC
PVLKAIQKELELYFSGKLRQFNTPIHLIGSPFQKKAWLALIDIPYGETRSYLQQAKVIGN
HHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCC
PSAYRAVANANGANQLAIVVPCHRIINANGELGGYGGGVNRKHWLLEHERRHDRGC
CHHHHHHHCCCCCCEEEEEECCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2987251; 3887409; 9097040; 9278503; 2982792; 3536913; 3009022; 3529081; 1581309; 8202360; 8500619; 8156986 [H]