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The map label for this gene is capD [H]

Identifier: 54293939

GI number: 54293939

Start: 1125610

End: 1127475

Strand: Direct

Name: capD [H]

Synonym: lpl0995

Alternate gene names: 54293939

Gene position: 1125610-1127475 (Clockwise)

Preceding gene: 54293938

Following gene: 54293941

Centisome position: 33.64

GC content: 41.64

Gene sequence:

>1866_bases
ATGCAAAAAATAATCATATTGACAAAAAAAATCATTGCAAAACTCCCGGTAATTTTGTTTGATGTGGCTGCAATACCAGT
TGCCTGGTATGCCGCTTACTGGTTGCGCTATAACATGCAGCCATATCCCGGCAGCCTGACATCCACCCATTCTTTTATTG
CTTTAGCTTTATTATCAATTGTTCAGATTAGTTGTTACTATTATTTTAAAATTTACAGAGGATTATGGCGTTTCTCTTCT
CTGAATGATGTTATCAGGATACTGAAGGCTACTATCACAGCAATGGTTTTAGTAATCCCTGTTTTTTACTTGACTTCAAT
TCTTCAGCACCTGCCCAGATCAGTTTTTCCTTTGTATTGCATTATCCTGGCCACCATCCTTTGCGGGGGTAGGTTGGTGA
TCCGTCTGCATTGGGATAAGCCTGACAGAGGAAATAGGGAATTGGAAACGAAAAGAGTTTTGGTGGTTGGTGCCGGGCAG
GCTGGTGAAGGCTTGGTGCGTGATTTGAAAAGAAGCAGTTATTATCGGCCAATAGGCTTTGTAGATGACAATAAAAGCAA
GAGAGGATTAGAAGTTCATGGAGTGCGGGTTCTGGGAACGACCAACCAAATTACCGAATTAGTCAATCAATACGACGTGG
ATTTGATTTTCATTGCCATACCTTCTGCCAAATCGGCAACCATGCGAAGAATTGTAACGCTTTGTGAACAAAGCCATGTG
CCTTTTAGTACTTTACCCAGTATTTCAGCTCTGGCTGCGGGTCGAGTTGAAGTGAATGCGCTGAGGCCTGTGAATATTGA
GGATTTATTGGGTCGGGATCAAGTGACGCTCGAATGGGAAAAAATTGCTCGTTCAATCGCAGGAAGACGTATATTGATTA
CAGGCGGTGGTGGCTCAATCGGCTCAGAATTGTGCCGTCAGGTTATGGCCTTAGAGCCTGCGAGCATAGCCATTGTTGAG
AATAGTGAGTTTAACCTGTATCGCATTGAACAGGAGTTGTTAAAGAGTTTTCCAGGTATCCCCGTTGAATTGAGTTTAAT
CAGTGTGACAGACGAAATTGCGATTAATCATTTATTTCGTCGGTTTCAGCCTGAAATTGTATTTCATGCGGCTGCATACA
AACATGTTCCCATGCTTCAGCATCAAGTACGGGTTGCTGTGTTTAATAATGTCATAGGTACTCAAGTTGTTGCCAAAGCC
AGTGTGACATTTGGCGCTGAGAAATTTATTTTAATTTCCACTGATAAAGCAGTGAATCCAACGAATATAATGGGAACTAC
CAAGAGAGTCGCTGAAATTTATTGTCAGAATTTAAATGCACGAGTTAAAACCCAGTTTATTACGGTTCGTTTTGGAAATG
TCTTGGGTTCAGCTGGTAGTGTGGTGCCTTTGTTCCAAAAACAGTTGCAGGAAGGTGGTCCACTGACTGTGACCCATCCC
GATATGCAAAGATATTTTATGACTATACCGGAAGCATGCCAGTTGATTTTGCAAGCGATGGTGAATGGGGAGGGCGGTGA
AATTTTTGTTCTGGATATGGGAGAGCCGGTTAAAATCAGTTATCTTGCAGAACAAATGATTCGCTTGGCAGGCAAAGAAC
CAGGAAGAGACATCATGATTGAATATACAGGGTTGCGTCCTGGTGAAAAAATGTATGAAGAGTTGTTTCATGAGACAGAA
CAGTTAACTTCAACAAAACATGAAAAATTATTCAAAGCAAGGTTTCGTGAACTGGATTGGAATGATTTGACACAAACCAT
GCGAATGTTGCAGGCAGCTTGTATTGAGCATCAGGATGAAGAATTACTCGTTCTGTTAAAAAGTCTGGTGCCTGAGTTTC
AATTGGAACCTATGGTTGAAGCTTAA

Upstream 100 bases:

>100_bases
ACAATATAGGTATGAATTGTTTGCTAATTTTTGATGCGGGAAACTGTAACATAGTGTACCATCTTTCCTTTATAAAGGAT
TACAGACTGTGGTTTTTATA

Downstream 100 bases:

>100_bases
GCAATAGACCTAATCTGGTAAATCAAGATGCTGTTATATCAATTACTTATGTTGATTTTGAAACACAATTTTCTCATAAT
TTGATGGTAAAATGAAAAAC

Product: hypothetical protein

Products: dTDP-4-dehydro-6-deoxy-D-glucose; H2O [C]

Alternate protein names: NA

Number of amino acids: Translated: 621; Mature: 621

Protein sequence:

>621_residues
MQKIIILTKKIIAKLPVILFDVAAIPVAWYAAYWLRYNMQPYPGSLTSTHSFIALALLSIVQISCYYYFKIYRGLWRFSS
LNDVIRILKATITAMVLVIPVFYLTSILQHLPRSVFPLYCIILATILCGGRLVIRLHWDKPDRGNRELETKRVLVVGAGQ
AGEGLVRDLKRSSYYRPIGFVDDNKSKRGLEVHGVRVLGTTNQITELVNQYDVDLIFIAIPSAKSATMRRIVTLCEQSHV
PFSTLPSISALAAGRVEVNALRPVNIEDLLGRDQVTLEWEKIARSIAGRRILITGGGGSIGSELCRQVMALEPASIAIVE
NSEFNLYRIEQELLKSFPGIPVELSLISVTDEIAINHLFRRFQPEIVFHAAAYKHVPMLQHQVRVAVFNNVIGTQVVAKA
SVTFGAEKFILISTDKAVNPTNIMGTTKRVAEIYCQNLNARVKTQFITVRFGNVLGSAGSVVPLFQKQLQEGGPLTVTHP
DMQRYFMTIPEACQLILQAMVNGEGGEIFVLDMGEPVKISYLAEQMIRLAGKEPGRDIMIEYTGLRPGEKMYEELFHETE
QLTSTKHEKLFKARFRELDWNDLTQTMRMLQAACIEHQDEELLVLLKSLVPEFQLEPMVEA

Sequences:

>Translated_621_residues
MQKIIILTKKIIAKLPVILFDVAAIPVAWYAAYWLRYNMQPYPGSLTSTHSFIALALLSIVQISCYYYFKIYRGLWRFSS
LNDVIRILKATITAMVLVIPVFYLTSILQHLPRSVFPLYCIILATILCGGRLVIRLHWDKPDRGNRELETKRVLVVGAGQ
AGEGLVRDLKRSSYYRPIGFVDDNKSKRGLEVHGVRVLGTTNQITELVNQYDVDLIFIAIPSAKSATMRRIVTLCEQSHV
PFSTLPSISALAAGRVEVNALRPVNIEDLLGRDQVTLEWEKIARSIAGRRILITGGGGSIGSELCRQVMALEPASIAIVE
NSEFNLYRIEQELLKSFPGIPVELSLISVTDEIAINHLFRRFQPEIVFHAAAYKHVPMLQHQVRVAVFNNVIGTQVVAKA
SVTFGAEKFILISTDKAVNPTNIMGTTKRVAEIYCQNLNARVKTQFITVRFGNVLGSAGSVVPLFQKQLQEGGPLTVTHP
DMQRYFMTIPEACQLILQAMVNGEGGEIFVLDMGEPVKISYLAEQMIRLAGKEPGRDIMIEYTGLRPGEKMYEELFHETE
QLTSTKHEKLFKARFRELDWNDLTQTMRMLQAACIEHQDEELLVLLKSLVPEFQLEPMVEA
>Mature_621_residues
MQKIIILTKKIIAKLPVILFDVAAIPVAWYAAYWLRYNMQPYPGSLTSTHSFIALALLSIVQISCYYYFKIYRGLWRFSS
LNDVIRILKATITAMVLVIPVFYLTSILQHLPRSVFPLYCIILATILCGGRLVIRLHWDKPDRGNRELETKRVLVVGAGQ
AGEGLVRDLKRSSYYRPIGFVDDNKSKRGLEVHGVRVLGTTNQITELVNQYDVDLIFIAIPSAKSATMRRIVTLCEQSHV
PFSTLPSISALAAGRVEVNALRPVNIEDLLGRDQVTLEWEKIARSIAGRRILITGGGGSIGSELCRQVMALEPASIAIVE
NSEFNLYRIEQELLKSFPGIPVELSLISVTDEIAINHLFRRFQPEIVFHAAAYKHVPMLQHQVRVAVFNNVIGTQVVAKA
SVTFGAEKFILISTDKAVNPTNIMGTTKRVAEIYCQNLNARVKTQFITVRFGNVLGSAGSVVPLFQKQLQEGGPLTVTHP
DMQRYFMTIPEACQLILQAMVNGEGGEIFVLDMGEPVKISYLAEQMIRLAGKEPGRDIMIEYTGLRPGEKMYEELFHETE
QLTSTKHEKLFKARFRELDWNDLTQTMRMLQAACIEHQDEELLVLLKSLVPEFQLEPMVEA

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG1086

COG function: function code MG; Predicted nucleoside-diphosphate sugar epimerases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the polysaccharide synthase family [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=290, Percent_Identity=25.1724137931034, Blast_Score=77, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR003869 [H]

Pfam domain/function: PF02719 Polysacc_synt_2 [H]

EC number: 4.2.1.46 [C]

Molecular weight: Translated: 69879; Mature: 69879

Theoretical pI: Translated: 8.51; Mature: 8.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKIIILTKKIIAKLPVILFDVAAIPVAWYAAYWLRYNMQPYPGSLTSTHSFIALALLSI
CCEEEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
VQISCYYYFKIYRGLWRFSSLNDVIRILKATITAMVLVIPVFYLTSILQHLPRSVFPLYC
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
IILATILCGGRLVIRLHWDKPDRGNRELETKRVLVVGAGQAGEGLVRDLKRSSYYRPIGF
HHHHHHHCCCEEEEEEECCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCCCCC
VDDNKSKRGLEVHGVRVLGTTNQITELVNQYDVDLIFIAIPSAKSATMRRIVTLCEQSHV
CCCCCCCCCCEEEEEEEEECCHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHCCCC
PFSTLPSISALAAGRVEVNALRPVNIEDLLGRDQVTLEWEKIARSIAGRRILITGGGGSI
CHHHCCCHHHHHCCCEEEEEECCCCHHHHCCCCCEEEEHHHHHHHHCCCEEEEECCCCCH
GSELCRQVMALEPASIAIVENSEFNLYRIEQELLKSFPGIPVELSLISVTDEIAINHLFR
HHHHHHHHHHCCCCEEEEEECCCCCEEHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHH
RFQPEIVFHAAAYKHVPMLQHQVRVAVFNNVIGTQVVAKASVTFGAEKFILISTDKAVNP
HCCCHHEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCEEEEEECCCCCCC
TNIMGTTKRVAEIYCQNLNARVKTQFITVRFGNVLGSAGSVVPLFQKQLQEGGPLTVTHP
CCCCCHHHHHHHHHHHCCCCEEEEEEEEEEECHHHCCCCCCHHHHHHHHHCCCCEEEECH
DMQRYFMTIPEACQLILQAMVNGEGGEIFVLDMGEPVKISYLAEQMIRLAGKEPGRDIMI
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEE
EYTGLRPGEKMYEELFHETEQLTSTKHEKLFKARFRELDWNDLTQTMRMLQAACIEHQDE
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCH
ELLVLLKSLVPEFQLEPMVEA
HHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MQKIIILTKKIIAKLPVILFDVAAIPVAWYAAYWLRYNMQPYPGSLTSTHSFIALALLSI
CCEEEEHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
VQISCYYYFKIYRGLWRFSSLNDVIRILKATITAMVLVIPVFYLTSILQHLPRSVFPLYC
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
IILATILCGGRLVIRLHWDKPDRGNRELETKRVLVVGAGQAGEGLVRDLKRSSYYRPIGF
HHHHHHHCCCEEEEEEECCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCCCCC
VDDNKSKRGLEVHGVRVLGTTNQITELVNQYDVDLIFIAIPSAKSATMRRIVTLCEQSHV
CCCCCCCCCCEEEEEEEEECCHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHCCCC
PFSTLPSISALAAGRVEVNALRPVNIEDLLGRDQVTLEWEKIARSIAGRRILITGGGGSI
CHHHCCCHHHHHCCCEEEEEECCCCHHHHCCCCCEEEEHHHHHHHHCCCEEEEECCCCCH
GSELCRQVMALEPASIAIVENSEFNLYRIEQELLKSFPGIPVELSLISVTDEIAINHLFR
HHHHHHHHHHCCCCEEEEEECCCCCEEHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHH
RFQPEIVFHAAAYKHVPMLQHQVRVAVFNNVIGTQVVAKASVTFGAEKFILISTDKAVNP
HCCCHHEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCEEEEEECCCCCCC
TNIMGTTKRVAEIYCQNLNARVKTQFITVRFGNVLGSAGSVVPLFQKQLQEGGPLTVTHP
CCCCCHHHHHHHHHHHCCCCEEEEEEEEEEECHHHCCCCCCHHHHHHHHHCCCCEEEECH
DMQRYFMTIPEACQLILQAMVNGEGGEIFVLDMGEPVKISYLAEQMIRLAGKEPGRDIMI
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEE
EYTGLRPGEKMYEELFHETEQLTSTKHEKLFKARFRELDWNDLTQTMRMLQAACIEHQDE
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCH
ELLVLLKSLVPEFQLEPMVEA
HHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.093 {dTDPglucose}} [C]

Substrates: dTDPglucose [C]

Specific reaction: dTDPglucose --> dTDP-4-dehydro-6-deoxy-D-glucose + H2O [C]

General reaction: Elimination (of H2O C-O bond cleavage [C]

Inhibitor: p-Chloromercuribenzoate; TMP [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]