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The map label for this gene is pdxB [H]

Identifier: 54293893

GI number: 54293893

Start: 1061307

End: 1062359

Strand: Reverse

Name: pdxB [H]

Synonym: lpl0949

Alternate gene names: 54293893

Gene position: 1062359-1061307 (Counterclockwise)

Preceding gene: 54293894

Following gene: 54293884

Centisome position: 31.75

GC content: 39.41

Gene sequence:

>1053_bases
ATGAACATTTTAGCAGATGCTTTATTGCCAGGATTAGATAGTGCTTTTCCACCACCATTTACCGTAACCTTGTATCATAA
GGCCGATGAAATTCCAGAATTGCTTCACCATAAGGACGTTCTTCTTTGCCGTTCAACCCTAAAAATCAATGGCGATTTAC
TCAAACACCATCAAATCAAGGTTGTTGCGACAGCAACCAGTGGAACTGATCATATTGATTTTCCTTTTTTAGAATCACAA
AACATATCTATTATTGATGCCAAAGGATGCAATGCTACATCTGTTGCTGACTATGTTGTTGCTTGCCTTGCCTATTTAGA
TAAACAGCAACTTATTCAAGGTAAAACAGCAGGAATTATTGGTTTAGGGCAAGTAGGTACTAAAGTTTATGAACGACTAA
ATGCTGCCGAATTTCAGTTATGCCTTTATGACCCACCCAAAGCAACCAGAGATACTTCTTTTCAAAGCTGCTCTCTTGAA
GATCTTTTGGAATGTGACTTCCTATGTGTCCATGCTGAATTACATAGCAATGCGCCCTACCCAAGCCTTAATTTAATTAA
TCGGGATTTCCTCAAGGAATTAAAGCCTGGCTGCATTATCATCAATGCTTCTCGAGGAGGGATCATTAATGAAGAAGCCC
TTTTGCATCTTGGCTCTGCCATACTTTATTGCACCGATGTCTACAATAACGAACCTCATATAGACAACCGGATTGTCTCC
AGGGCAACTCTTTGCACACCACATATTGCAGGACACAGCCTCGAAGCCAAATTTGCTGCAGTCGCAATCGTGAGTCGTAA
ATTACATCAAATGCTTGGTCTTCCATACCCACAATTTGCAACCCCTGAAAAACCCTATAGATTAAATGACGACAGCAACT
GGAGAGAGTTGGCTTTATCAATATATAACCCGATTCATGAAACACTAGAGTTAAAACACGCTGGAAATCTATCCTCAGCA
TTCTTGACTCTTCGCAAGAATCATCATCACCGCCATGATTTCACAACTTATTTTGATTCTGATTCAATAAAAAAGTATCC
ATTATTAGGTTAA

Upstream 100 bases:

>100_bases
TTTTAATATTGATTGTACTAATTTTTACTAATGTATTGGGATATATTCTTACTCCCCTTATCTATGGTTCATTATATATT
TTAAGCGCGATTTTTAATTT

Downstream 100 bases:

>100_bases
TGGTGTTGATGTCTGTTTCTAATAATTAATCCTTGCCCCGAAATTTTAATTATTCATCAAACGTCTTACAACTTCCTGAT
CAGAAAAAACATGTTTTGTA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MNILADALLPGLDSAFPPPFTVTLYHKADEIPELLHHKDVLLCRSTLKINGDLLKHHQIKVVATATSGTDHIDFPFLESQ
NISIIDAKGCNATSVADYVVACLAYLDKQQLIQGKTAGIIGLGQVGTKVYERLNAAEFQLCLYDPPKATRDTSFQSCSLE
DLLECDFLCVHAELHSNAPYPSLNLINRDFLKELKPGCIIINASRGGIINEEALLHLGSAILYCTDVYNNEPHIDNRIVS
RATLCTPHIAGHSLEAKFAAVAIVSRKLHQMLGLPYPQFATPEKPYRLNDDSNWRELALSIYNPIHETLELKHAGNLSSA
FLTLRKNHHHRHDFTTYFDSDSIKKYPLLG

Sequences:

>Translated_350_residues
MNILADALLPGLDSAFPPPFTVTLYHKADEIPELLHHKDVLLCRSTLKINGDLLKHHQIKVVATATSGTDHIDFPFLESQ
NISIIDAKGCNATSVADYVVACLAYLDKQQLIQGKTAGIIGLGQVGTKVYERLNAAEFQLCLYDPPKATRDTSFQSCSLE
DLLECDFLCVHAELHSNAPYPSLNLINRDFLKELKPGCIIINASRGGIINEEALLHLGSAILYCTDVYNNEPHIDNRIVS
RATLCTPHIAGHSLEAKFAAVAIVSRKLHQMLGLPYPQFATPEKPYRLNDDSNWRELALSIYNPIHETLELKHAGNLSSA
FLTLRKNHHHRHDFTTYFDSDSIKKYPLLG
>Mature_350_residues
MNILADALLPGLDSAFPPPFTVTLYHKADEIPELLHHKDVLLCRSTLKINGDLLKHHQIKVVATATSGTDHIDFPFLESQ
NISIIDAKGCNATSVADYVVACLAYLDKQQLIQGKTAGIIGLGQVGTKVYERLNAAEFQLCLYDPPKATRDTSFQSCSLE
DLLECDFLCVHAELHSNAPYPSLNLINRDFLKELKPGCIIINASRGGIINEEALLHLGSAILYCTDVYNNEPHIDNRIVS
RATLCTPHIAGHSLEAKFAAVAIVSRKLHQMLGLPYPQFATPEKPYRLNDDSNWRELALSIYNPIHETLELKHAGNLSSA
FLTLRKNHHHRHDFTTYFDSDSIKKYPLLG

Specific function: Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=259, Percent_Identity=27.4131274131274, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI4557497, Length=259, Percent_Identity=25.4826254826255, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI61743967, Length=259, Percent_Identity=25.4826254826255, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI145580575, Length=259, Percent_Identity=25.8687258687259, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI145580578, Length=259, Percent_Identity=25.4826254826255, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI4557499, Length=259, Percent_Identity=25.4826254826255, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1788660, Length=356, Percent_Identity=31.1797752808989, Blast_Score=151, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI17532191, Length=290, Percent_Identity=26.2068965517241, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324055, Length=153, Percent_Identity=30.718954248366, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322116, Length=281, Percent_Identity=24.1992882562278, Blast_Score=66, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6320925, Length=285, Percent_Identity=24.9122807017544, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19921140, Length=287, Percent_Identity=24.7386759581882, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI62472511, Length=249, Percent_Identity=27.3092369477912, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24646446, Length=292, Percent_Identity=26.7123287671233, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24646448, Length=292, Percent_Identity=26.7123287671233, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24646452, Length=292, Percent_Identity=26.7123287671233, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24646450, Length=292, Percent_Identity=26.7123287671233, Blast_Score=78, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR020921
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.290 [H]

Molecular weight: Translated: 38943; Mature: 38943

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILADALLPGLDSAFPPPFTVTLYHKADEIPELLHHKDVLLCRSTLKINGDLLKHHQIK
CCCCHHHHHCCCCCCCCCCEEEEEEECHHHHHHHHHCCHHEEEHHHHEECCCEEECEEEE
VVATATSGTDHIDFPFLESQNISIIDAKGCNATSVADYVVACLAYLDKQQLIQGKTAGII
EEEEECCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCHHHHHCCCCCCEE
GLGQVGTKVYERLNAAEFQLCLYDPPKATRDTSFQSCSLEDLLECDFLCVHAELHSNAPY
EEHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHCCCEEEEEEEHHCCCCC
PSLNLINRDFLKELKPGCIIINASRGGIINEEALLHLGSAILYCTDVYNNEPHIDNRIVS
CCHHHHCHHHHHHCCCCEEEEECCCCCCCCHHHHHHHCCEEEEEEECCCCCCCCHHHHHH
RATLCTPHIAGHSLEAKFAAVAIVSRKLHQMLGLPYPQFATPEKPYRLNDDSNWRELALS
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCHHHHHHH
IYNPIHETLELKHAGNLSSAFLTLRKNHHHRHDFTTYFDSDSIKKYPLLG
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCC
>Mature Secondary Structure
MNILADALLPGLDSAFPPPFTVTLYHKADEIPELLHHKDVLLCRSTLKINGDLLKHHQIK
CCCCHHHHHCCCCCCCCCCEEEEEEECHHHHHHHHHCCHHEEEHHHHEECCCEEECEEEE
VVATATSGTDHIDFPFLESQNISIIDAKGCNATSVADYVVACLAYLDKQQLIQGKTAGII
EEEEECCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCHHHHHCCCCCCEE
GLGQVGTKVYERLNAAEFQLCLYDPPKATRDTSFQSCSLEDLLECDFLCVHAELHSNAPY
EEHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHCCCEEEEEEEHHCCCCC
PSLNLINRDFLKELKPGCIIINASRGGIINEEALLHLGSAILYCTDVYNNEPHIDNRIVS
CCHHHHCHHHHHHCCCCEEEEECCCCCCCCHHHHHHHCCEEEEEEECCCCCCCCHHHHHH
RATLCTPHIAGHSLEAKFAAVAIVSRKLHQMLGLPYPQFATPEKPYRLNDDSNWRELALS
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCHHHHHHH
IYNPIHETLELKHAGNLSSAFLTLRKNHHHRHDFTTYFDSDSIKKYPLLG
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA