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The map label for this gene is dapE [H]

Identifier: 54293862

GI number: 54293862

Start: 1029978

End: 1031111

Strand: Reverse

Name: dapE [H]

Synonym: lpl0918

Alternate gene names: 54293862

Gene position: 1031111-1029978 (Counterclockwise)

Preceding gene: 54293863

Following gene: 54293857

Centisome position: 30.82

GC content: 40.65

Gene sequence:

>1134_bases
ATGACTGATATTACGCAAATTCTGACTGACCTCATTGGCTTTCCTTCTATTACACCAGAAGATGCTGGCTGCCAAAAATA
CATGATTCAATTTCTGGAGCAATTGGGATTTACTTGTCAACAACTGAATAATGGGCCCGTATCCAATTTTTTTGCCTGCT
ATGGCAAAATTGGGCCTTTATTGGTGTTCGCAGGCCATACCGATGTAGTTCCTGTTGGTGAAGTATCAAAATGGGATACA
GACCCTTTCTCTCTCGAAGAAAAAAATGGCATGCTCTATGGTCGTGGGGTTGCTGATATGAAAGGCAGCCTGGCCTGTAT
GTTACATATGGCCAGAAGATTTATTAAAACTTATCCTTCCTTTCCAGGCAGACTAGGATTTCTGATCACCAGCGGCGAAG
AAGGCGATGAATTTAATTTGGGCACCCCTTATGCGATGCAAAAACTGGAGCAACAAGGGATTGTTATTGATTATTGCATA
GTAGGTGAACCTTCAAGCAGCTTGAAAACTGGTGATGTCATCAAAATTGGAAGACGTGGATCATTAAGTGCCAAAATACA
TCTGAGTGGAAAGCAAGGTCATGTTGCCTATCCGCATTTGGCTGACAATCCAATTCATAGAATTAGCCCAGTATTAGCCG
AGCTCACTTCAATGCAATGGGATAATGGCAATGCTTATTTTCCTCCTACCTCCATGCAAATAACTTATATCCATTGTGGA
GGGCATGCGGGTAATATTATCCCAGGCGAATTAAATCTGCATTTGAACTTTAGATATTCGACAGAGCAAACAGACGAGTC
ATTAAAAACGAGAGTAATTAATGCCTTTACACACCATAAACTTAACCCCACTATAGAATGGCGATTAAATGGCGAACCAT
TCTTAACGAATAAAGGCATATTGCTAGAAAGCTGCAAACAAACAGTGCTTGAACATATTGGGACTCTCCCCGAACTTTCA
ACAAGTGGTGGAACTTCAGATGGGCGTTTTATAGCACCTTATGGGGTTGAGGTCATAGAGCTGGGACTGGTAAATGCAAC
CATTCATCAGGTTAATGAATGCACTTCTCTACAGGATTTGAATACACTTGAAACCATGTATTTCTCAATCTGTGAGAAAT
TATTAATTGATTAA

Upstream 100 bases:

>100_bases
GATGGAAGCCACAGTTTATATTGTGCTGTCATTGTTAAACAAGTGGATGAAAAAACTCGCGCGAAGGTAAGCATTAATGA
TTTACTAAGAGCCAATCAAG

Downstream 100 bases:

>100_bases
TCAAACCAATTCTGTAATGAGGGTTCGCACCAACAGTCCAAATTACAGTAATAGGTTAGTAACCTCATCTTTAAATATCC
TCTGGCGGTCGGATTTGCAT

Product: succinyl-diaminopimelate desuccinylase

Products: NA

Alternate protein names: SDAP desuccinylase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase [H]

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MTDITQILTDLIGFPSITPEDAGCQKYMIQFLEQLGFTCQQLNNGPVSNFFACYGKIGPLLVFAGHTDVVPVGEVSKWDT
DPFSLEEKNGMLYGRGVADMKGSLACMLHMARRFIKTYPSFPGRLGFLITSGEEGDEFNLGTPYAMQKLEQQGIVIDYCI
VGEPSSSLKTGDVIKIGRRGSLSAKIHLSGKQGHVAYPHLADNPIHRISPVLAELTSMQWDNGNAYFPPTSMQITYIHCG
GHAGNIIPGELNLHLNFRYSTEQTDESLKTRVINAFTHHKLNPTIEWRLNGEPFLTNKGILLESCKQTVLEHIGTLPELS
TSGGTSDGRFIAPYGVEVIELGLVNATIHQVNECTSLQDLNTLETMYFSICEKLLID

Sequences:

>Translated_377_residues
MTDITQILTDLIGFPSITPEDAGCQKYMIQFLEQLGFTCQQLNNGPVSNFFACYGKIGPLLVFAGHTDVVPVGEVSKWDT
DPFSLEEKNGMLYGRGVADMKGSLACMLHMARRFIKTYPSFPGRLGFLITSGEEGDEFNLGTPYAMQKLEQQGIVIDYCI
VGEPSSSLKTGDVIKIGRRGSLSAKIHLSGKQGHVAYPHLADNPIHRISPVLAELTSMQWDNGNAYFPPTSMQITYIHCG
GHAGNIIPGELNLHLNFRYSTEQTDESLKTRVINAFTHHKLNPTIEWRLNGEPFLTNKGILLESCKQTVLEHIGTLPELS
TSGGTSDGRFIAPYGVEVIELGLVNATIHQVNECTSLQDLNTLETMYFSICEKLLID
>Mature_376_residues
TDITQILTDLIGFPSITPEDAGCQKYMIQFLEQLGFTCQQLNNGPVSNFFACYGKIGPLLVFAGHTDVVPVGEVSKWDTD
PFSLEEKNGMLYGRGVADMKGSLACMLHMARRFIKTYPSFPGRLGFLITSGEEGDEFNLGTPYAMQKLEQQGIVIDYCIV
GEPSSSLKTGDVIKIGRRGSLSAKIHLSGKQGHVAYPHLADNPIHRISPVLAELTSMQWDNGNAYFPPTSMQITYIHCGG
HAGNIIPGELNLHLNFRYSTEQTDESLKTRVINAFTHHKLNPTIEWRLNGEPFLTNKGILLESCKQTVLEHIGTLPELST
SGGTSDGRFIAPYGVEVIELGLVNATIHQVNECTSLQDLNTLETMYFSICEKLLID

Specific function: Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bact

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family. DapE subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788816, Length=372, Percent_Identity=49.4623655913978, Blast_Score=382, Evalue=1e-107,
Organism=Escherichia coli, GI1789236, Length=218, Percent_Identity=26.605504587156, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1790395, Length=269, Percent_Identity=28.2527881040892, Blast_Score=81, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17551016, Length=270, Percent_Identity=28.5185185185185, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17563146, Length=223, Percent_Identity=26.0089686098655, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005941
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.5.1.18 [H]

Molecular weight: Translated: 41577; Mature: 41446

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDITQILTDLIGFPSITPEDAGCQKYMIQFLEQLGFTCQQLNNGPVSNFFACYGKIGPL
CCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHCCCEE
LVFAGHTDVVPVGEVSKWDTDPFSLEEKNGMLYGRGVADMKGSLACMLHMARRFIKTYPS
EEECCCCCCEECCCCCCCCCCCCCEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCC
FPGRLGFLITSGEEGDEFNLGTPYAMQKLEQQGIVIDYCIVGEPSSSLKTGDVIKIGRRG
CCCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCCCCEEEECCCC
SLSAKIHLSGKQGHVAYPHLADNPIHRISPVLAELTSMQWDNGNAYFPPTSMQITYIHCG
CCEEEEEECCCCCCEECCCCCCCCHHHHHHHHHHHHHCEECCCCEECCCCCEEEEEEEEC
GHAGNIIPGELNLHLNFRYSTEQTDESLKTRVINAFTHHKLNPTIEWRLNGEPFLTNKGI
CCCCCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEECCCH
LLESCKQTVLEHIGTLPELSTSGGTSDGRFIAPYGVEVIELGLVNATIHQVNECTSLQDL
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCCCEEEEEEHHHHHHHHHHHHCCHHHH
NTLETMYFSICEKLLID
HHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TDITQILTDLIGFPSITPEDAGCQKYMIQFLEQLGFTCQQLNNGPVSNFFACYGKIGPL
CCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHCCCEE
LVFAGHTDVVPVGEVSKWDTDPFSLEEKNGMLYGRGVADMKGSLACMLHMARRFIKTYPS
EEECCCCCCEECCCCCCCCCCCCCEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCC
FPGRLGFLITSGEEGDEFNLGTPYAMQKLEQQGIVIDYCIVGEPSSSLKTGDVIKIGRRG
CCCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCCCCEEEECCCC
SLSAKIHLSGKQGHVAYPHLADNPIHRISPVLAELTSMQWDNGNAYFPPTSMQITYIHCG
CCEEEEEECCCCCCEECCCCCCCCHHHHHHHHHHHHHCEECCCCEECCCCCEEEEEEEEC
GHAGNIIPGELNLHLNFRYSTEQTDESLKTRVINAFTHHKLNPTIEWRLNGEPFLTNKGI
CCCCCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEECCCH
LLESCKQTVLEHIGTLPELSTSGGTSDGRFIAPYGVEVIELGLVNATIHQVNECTSLQDL
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCCCEEEEEEHHHHHHHHHHHHCCHHHH
NTLETMYFSICEKLLID
HHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA