Click here to switch to the map view.

The map label for this gene is clpA [H]

Identifier: 54293795

GI number: 54293795

Start: 966133

End: 968400

Strand: Direct

Name: clpA [H]

Synonym: lpl0851

Alternate gene names: 54293795

Gene position: 966133-968400 (Clockwise)

Preceding gene: 54293794

Following gene: 54293796

Centisome position: 28.88

GC content: 40.26

Gene sequence:

>2268_bases
ATGTTAAATAAAGAACTAGAATTCACCTTGAATCTAGCTTTCAAGGAAGCAAAAGAAAAGCGTCATGAGTTCATGACTGT
TGAACATTTGCTGTTGTCTTTGCTTGATAATCCAGCAGCAGGAAATGTATTACAGGCTTGTGATGCTAACATCGAGGCAT
TACGTCGTGATTTAATCGAATTTATTGATGAAACAACCCCAAGAATTCCTGAGGATGAACTGGACAGGGAAACTCAACCA
ACATTAGGTTTTCAAAGGGTTTTACAGCGTGCAGTATTTCATGTGCAGTCAGCAGGCAAAACGGAAGTCACTGGAGCTAA
TGTATTAGCCGCAATTTTTAGTGAGCAAGAAAGTCAGGCTGTATATTTTTTGCGACGTGAAAATATTACTCGCCTTGATG
TGATTAATTATATTTCTCATGGAGTGTCAAAATATCAAAACAATGATATGCATGAAAACATGAATTCATCTATGGACGAA
GACATGATGACACCTGAGGGTAATGAATCTCCGCTCGATAGTTATTGCACCAATCTCAACAGACGCGCAAAACAGGGCAA
GATAGATCCGTTGATAGGGCGGCATGAAGAGATACAAAGAACTATACAAGTACTTTGCAGACGCCGTAAAAATAATCCTT
TATTAGTTGGCGAGGCAGGTGTAGGTAAAACTGCTATCGCGGAAGGTTTGGCCAGACGCATAGTGGATGGTGAAATCCCA
GATTCCATAAGAGGCTGCGTAGTCTACTCTCTTGATTTGGGCGCGTTATTGGCAGGAACGAAATACAGAGGGGATTTTGA
AAAACGATTGAAAGCTGTGCTGAAACAGTTGGGTCAGCAAGAAGGAGCCATTTTATTCATAGATGAAATTCACACCATTA
TTGGCGCAGGCGCTGCATCTGGAGGGGTCATGGATGCTTCCAACCTGGTTAAGCCATTATTGGCAAATGGTGAATTGAAA
TGCATCGGCTCAACCACTTATCAGGAATATCGTGGAATATTTGAAAAAGACAGGGCCTTGGCAAGACGATTCCAAAAAAT
TGATATTTCAGAACCAACAATCGATGAAACTTTTGAAATATTAAAAGGATTAAAAGGCAAATTGGAAGCTCACCATGGAG
TAAAATTTTCAATTGCTTCATTAAAAGCAGCGGCAGAATTATCTGCAAAATACATCAATGATCGGTTTTTGCCTGACAAA
GCGATTGATGTGGTGGATGAAGCAGGTGCTTATCAGAATTTACTGACAGCAAATAAACGTAAAAAAATTATTAGCGTGAC
TGAAATAGAGAGTGTTGTCGCAAAAATTGCTCGTATCCCAATTAAAAAGGTATCTGCGCGCGATAAAGATACTCTGCGTA
ACCTGGAGCGTGATTTAAAATTATTAGTCTATGGGCAAGACCAGGCAATTACTGCCTTGGCTTCAGCAATCAAACTGGGT
AGATCCGGACTTAGAGAACCTCAGAAGCCAGTAGGTTGTTTCTTGTTTGCCGGGCCAACTGGTGTAGGAAAGACAGAGGT
AACAAGGCAACTGGCTAATGTTTTAGGCATAGAGTTGCTGCGTTTTGATATGTCAGAGTACATGGAAAAACACACTGTTT
CACGTTTGATTGGAGCACCTCCTGGCTATGTAGGATACGATCAAGGTGGTTTATTGACTGAAGCCGTGACTAAGAATCCA
CATGCTGTTCTGCTACTTGATGAAATAGAAAAAGCACATCCTGATGTTTTTAATTTATTGTTGCAGATAATGGATCATGG
CACTTTAACTGATACTAACGGTCGTCAAGCTGATTTCAGACATATCATACTTGTAATGACCAGTAACGCAGGAGCCAGTG
AACTTGTTCGTAACTCCATAGGTTTTTCAACGCAAGACAATACCAATGATGGGTTGGAAGTAATTAAAAAGCAATTCAGT
CCTGAGTTTAGGAACCGTTTGGATGCTATTATCAATTTTGCTCCGTTAGATACACAGACTATAGGACTAGTCGTTGATAA
ATTCATTATGGAGTTGGATGAACAATTAAGTCATAAAGGCGTTACTTTTACAGTTGATAAGTCAGCCAGGGAATGGCTGA
TGGAGCATGGTTATGATAAAGCCATGGGAGCAAGACCTATGGCCAGATTGATTCAGGAAAACATCAAAAAGCCTCTTGCT
GATGAACTGTTGTTTGGTAAATTAATGCATGGCGGTCATGTCACTTTGCGAGTGAAAGACGGTAAACTGCATTTTGACAG
TCATGATCATAGAGAAGGTGTTTGTTAA

Upstream 100 bases:

>100_bases
GTCGCCCTGGTAAATGAATACGCCAGAATGAATCAACATCCATTATTATCTAGTATGGAACCGGAGTAAACTGGTGGTTG
GTTGGTAAGGAGCAATGACA

Downstream 100 bases:

>100_bases
ACGGGAACCCTCTTCAGTTCTGTGCATGACAAATTTTTTGTTATGCACAGACAAAATCACAAGAATCCTGAGATAGTAAT
TGTCGTTAACCTGTTAGTCG

Product: ATP-dependent Clp protease ATP-binding subunit ClpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 755; Mature: 755

Protein sequence:

>755_residues
MLNKELEFTLNLAFKEAKEKRHEFMTVEHLLLSLLDNPAAGNVLQACDANIEALRRDLIEFIDETTPRIPEDELDRETQP
TLGFQRVLQRAVFHVQSAGKTEVTGANVLAAIFSEQESQAVYFLRRENITRLDVINYISHGVSKYQNNDMHENMNSSMDE
DMMTPEGNESPLDSYCTNLNRRAKQGKIDPLIGRHEEIQRTIQVLCRRRKNNPLLVGEAGVGKTAIAEGLARRIVDGEIP
DSIRGCVVYSLDLGALLAGTKYRGDFEKRLKAVLKQLGQQEGAILFIDEIHTIIGAGAASGGVMDASNLVKPLLANGELK
CIGSTTYQEYRGIFEKDRALARRFQKIDISEPTIDETFEILKGLKGKLEAHHGVKFSIASLKAAAELSAKYINDRFLPDK
AIDVVDEAGAYQNLLTANKRKKIISVTEIESVVAKIARIPIKKVSARDKDTLRNLERDLKLLVYGQDQAITALASAIKLG
RSGLREPQKPVGCFLFAGPTGVGKTEVTRQLANVLGIELLRFDMSEYMEKHTVSRLIGAPPGYVGYDQGGLLTEAVTKNP
HAVLLLDEIEKAHPDVFNLLLQIMDHGTLTDTNGRQADFRHIILVMTSNAGASELVRNSIGFSTQDNTNDGLEVIKKQFS
PEFRNRLDAIINFAPLDTQTIGLVVDKFIMELDEQLSHKGVTFTVDKSAREWLMEHGYDKAMGARPMARLIQENIKKPLA
DELLFGKLMHGGHVTLRVKDGKLHFDSHDHREGVC

Sequences:

>Translated_755_residues
MLNKELEFTLNLAFKEAKEKRHEFMTVEHLLLSLLDNPAAGNVLQACDANIEALRRDLIEFIDETTPRIPEDELDRETQP
TLGFQRVLQRAVFHVQSAGKTEVTGANVLAAIFSEQESQAVYFLRRENITRLDVINYISHGVSKYQNNDMHENMNSSMDE
DMMTPEGNESPLDSYCTNLNRRAKQGKIDPLIGRHEEIQRTIQVLCRRRKNNPLLVGEAGVGKTAIAEGLARRIVDGEIP
DSIRGCVVYSLDLGALLAGTKYRGDFEKRLKAVLKQLGQQEGAILFIDEIHTIIGAGAASGGVMDASNLVKPLLANGELK
CIGSTTYQEYRGIFEKDRALARRFQKIDISEPTIDETFEILKGLKGKLEAHHGVKFSIASLKAAAELSAKYINDRFLPDK
AIDVVDEAGAYQNLLTANKRKKIISVTEIESVVAKIARIPIKKVSARDKDTLRNLERDLKLLVYGQDQAITALASAIKLG
RSGLREPQKPVGCFLFAGPTGVGKTEVTRQLANVLGIELLRFDMSEYMEKHTVSRLIGAPPGYVGYDQGGLLTEAVTKNP
HAVLLLDEIEKAHPDVFNLLLQIMDHGTLTDTNGRQADFRHIILVMTSNAGASELVRNSIGFSTQDNTNDGLEVIKKQFS
PEFRNRLDAIINFAPLDTQTIGLVVDKFIMELDEQLSHKGVTFTVDKSAREWLMEHGYDKAMGARPMARLIQENIKKPLA
DELLFGKLMHGGHVTLRVKDGKLHFDSHDHREGVC
>Mature_755_residues
MLNKELEFTLNLAFKEAKEKRHEFMTVEHLLLSLLDNPAAGNVLQACDANIEALRRDLIEFIDETTPRIPEDELDRETQP
TLGFQRVLQRAVFHVQSAGKTEVTGANVLAAIFSEQESQAVYFLRRENITRLDVINYISHGVSKYQNNDMHENMNSSMDE
DMMTPEGNESPLDSYCTNLNRRAKQGKIDPLIGRHEEIQRTIQVLCRRRKNNPLLVGEAGVGKTAIAEGLARRIVDGEIP
DSIRGCVVYSLDLGALLAGTKYRGDFEKRLKAVLKQLGQQEGAILFIDEIHTIIGAGAASGGVMDASNLVKPLLANGELK
CIGSTTYQEYRGIFEKDRALARRFQKIDISEPTIDETFEILKGLKGKLEAHHGVKFSIASLKAAAELSAKYINDRFLPDK
AIDVVDEAGAYQNLLTANKRKKIISVTEIESVVAKIARIPIKKVSARDKDTLRNLERDLKLLVYGQDQAITALASAIKLG
RSGLREPQKPVGCFLFAGPTGVGKTEVTRQLANVLGIELLRFDMSEYMEKHTVSRLIGAPPGYVGYDQGGLLTEAVTKNP
HAVLLLDEIEKAHPDVFNLLLQIMDHGTLTDTNGRQADFRHIILVMTSNAGASELVRNSIGFSTQDNTNDGLEVIKKQFS
PEFRNRLDAIINFAPLDTQTIGLVVDKFIMELDEQLSHKGVTFTVDKSAREWLMEHGYDKAMGARPMARLIQENIKKPLA
DELLFGKLMHGGHVTLRVKDGKLHFDSHDHREGVC

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=317, Percent_Identity=31.5457413249211, Blast_Score=155, Evalue=1e-37,
Organism=Escherichia coli, GI1787109, Length=739, Percent_Identity=66.5764546684709, Blast_Score=1015, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=411, Percent_Identity=44.5255474452555, Blast_Score=301, Evalue=1e-82,
Organism=Saccharomyces cerevisiae, GI6320464, Length=327, Percent_Identity=45.8715596330275, Blast_Score=281, Evalue=3e-76,
Organism=Saccharomyces cerevisiae, GI6323002, Length=419, Percent_Identity=39.3794749403341, Blast_Score=266, Evalue=8e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 84021; Mature: 84021

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNKELEFTLNLAFKEAKEKRHEFMTVEHLLLSLLDNPAAGNVLQACDANIEALRRDLIE
CCCCCEEHEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHHH
FIDETTPRIPEDELDRETQPTLGFQRVLQRAVFHVQSAGKTEVTGANVLAAIFSEQESQA
HHHHCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCE
VYFLRRENITRLDVINYISHGVSKYQNNDMHENMNSSMDEDMMTPEGNESPLDSYCTNLN
EEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHCCCCCCCCCCHHHHHHHHH
RRAKQGKIDPLIGRHEEIQRTIQVLCRRRKNNPLLVGEAGVGKTAIAEGLARRIVDGEIP
HHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCC
DSIRGCVVYSLDLGALLAGTKYRGDFEKRLKAVLKQLGQQEGAILFIDEIHTIIGAGAAS
CCCCCEEEEEECHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHCCCCC
GGVMDASNLVKPLLANGELKCIGSTTYQEYRGIFEKDRALARRFQKIDISEPTIDETFEI
CCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LKGLKGKLEAHHGVKFSIASLKAAAELSAKYINDRFLPDKAIDVVDEAGAYQNLLTANKR
HHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHH
KKIISVTEIESVVAKIARIPIKKVSARDKDTLRNLERDLKLLVYGQDQAITALASAIKLG
HHHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHH
RSGLREPQKPVGCFLFAGPTGVGKTEVTRQLANVLGIELLRFDMSEYMEKHTVSRLIGAP
HHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PGYVGYDQGGLLTEAVTKNPHAVLLLDEIEKAHPDVFNLLLQIMDHGTLTDTNGRQADFR
CCCCCCCCCCCCHHHHCCCCCEEEEEHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCE
HIILVMTSNAGASELVRNSIGFSTQDNTNDGLEVIKKQFSPEFRNRLDAIINFAPLDTQT
EEEEEEECCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHH
IGLVVDKFIMELDEQLSHKGVTFTVDKSAREWLMEHGYDKAMGARPMARLIQENIKKPLA
HHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHCHHH
DELLFGKLMHGGHVTLRVKDGKLHFDSHDHREGVC
HHHHHHHHHCCCEEEEEEECCEEECCCCCCCCCCC
>Mature Secondary Structure
MLNKELEFTLNLAFKEAKEKRHEFMTVEHLLLSLLDNPAAGNVLQACDANIEALRRDLIE
CCCCCEEHEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHHH
FIDETTPRIPEDELDRETQPTLGFQRVLQRAVFHVQSAGKTEVTGANVLAAIFSEQESQA
HHHHCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCE
VYFLRRENITRLDVINYISHGVSKYQNNDMHENMNSSMDEDMMTPEGNESPLDSYCTNLN
EEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHCCCCCCCCCCHHHHHHHHH
RRAKQGKIDPLIGRHEEIQRTIQVLCRRRKNNPLLVGEAGVGKTAIAEGLARRIVDGEIP
HHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCC
DSIRGCVVYSLDLGALLAGTKYRGDFEKRLKAVLKQLGQQEGAILFIDEIHTIIGAGAAS
CCCCCEEEEEECHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHCCCCC
GGVMDASNLVKPLLANGELKCIGSTTYQEYRGIFEKDRALARRFQKIDISEPTIDETFEI
CCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LKGLKGKLEAHHGVKFSIASLKAAAELSAKYINDRFLPDKAIDVVDEAGAYQNLLTANKR
HHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHH
KKIISVTEIESVVAKIARIPIKKVSARDKDTLRNLERDLKLLVYGQDQAITALASAIKLG
HHHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHH
RSGLREPQKPVGCFLFAGPTGVGKTEVTRQLANVLGIELLRFDMSEYMEKHTVSRLIGAP
HHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PGYVGYDQGGLLTEAVTKNPHAVLLLDEIEKAHPDVFNLLLQIMDHGTLTDTNGRQADFR
CCCCCCCCCCCCHHHHCCCCCEEEEEHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCE
HIILVMTSNAGASELVRNSIGFSTQDNTNDGLEVIKKQFSPEFRNRLDAIINFAPLDTQT
EEEEEEECCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHH
IGLVVDKFIMELDEQLSHKGVTFTVDKSAREWLMEHGYDKAMGARPMARLIQENIKKPLA
HHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHCHHH
DELLFGKLMHGGHVTLRVKDGKLHFDSHDHREGVC
HHHHHHHHHCCCEEEEEEECCEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]