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The map label for this gene is tyrP [H]

Identifier: 54293638

GI number: 54293638

Start: 771195

End: 772391

Strand: Reverse

Name: tyrP [H]

Synonym: lpl0691

Alternate gene names: 54293638

Gene position: 772391-771195 (Counterclockwise)

Preceding gene: 54293639

Following gene: 54293637

Centisome position: 23.09

GC content: 41.6

Gene sequence:

>1197_bases
GTGATCAATTCAAAATTAATTGGTGGTATATTACTCATAGTAGGCACTTCGATTGGTGGTGGGATGCTAGCGCTACCTGT
TTCTACAGCCGAGGTGGGATTTGCTAACTCATTATTTTTCCTGTTTTTTTGCTGGTTGGTGATGACCGCTGGAGCTTTAT
TAATTCTTGAGGTAAATCTACGACTCCCTGCAGGAAGCAATATGATTTCAATGGCGAAATCAACCTTGGGTCTGCCAGGT
CAGGTAATTGCCTGGATAACCTACCTTCTTCTTCTTTATACCCTCCTGGCAGCTTATATTTCAGGTGGAAGTGATGTATT
TAGCAGTCTGCTGCATAAGGCCCACATTGATTTACCGAATTGGATAACGTCTGTAATATTTACTGCCATGTTCAGCCTTA
TTGTATATAGTGGTATACGCTCTGTAGACTACGTTAATCGTGGACTTATGTTTGGCAAACTGGGCGTCTATATTTTATTG
GTTATTATTATCAGTCCCCATATATCCACAGCAGGATTAACAGGCGGCTCAGCGAAAGCCTTTACTGGCACTCTCATGAT
CTTGGTCACCTCTTTTGGATTTGCATCCATCGTGCCCAGCTTACGTGATTATTTTAACGATGATATACGTAGCTTACGTC
GAGTTATTTTGTTTGGTTCTCTTATCCCATTATTCTGCTACATAGTCTGGGATGCAGTAATTATGGGCGTTATCTCACGC
GAGGGAGAAAATGGTTTGTTGTCCCTAATGAACTCGGATCATGCAACCAGCGGCCTCACTGAGGCACTTAGTCAATCGGT
AAGCAGCCAGTGGATCAGTGGATTTTTTGGTTTTTTCACTTCTATCTGTATGGTTACTGCATTTCTGGGGGTTTCATTAG
GATTATTTGATTTTCTTGCTGATGGGTTAAAGCTTAAAAAATCTGGTAATCAAGGCAAATATACGCTGGCTCTCACTTTT
ATCCCTCCATTGGCAGTGGTGTTGTTTAACCCGGGTATCTACCTGCATGCATTAAGTTATGCCGGGGTTTGTTGTGTCAT
TTTACTGCTGTTATTGCCTGCTATCATGGCATGGAAAGGAAGACAAACCTGTAGCCAATCTCCATCAGAAACTCATTTGA
TTCCTGGAGGAAATCCAGCTTTAAGCCTTATAGGATTTATCGCTATTGGTTTGCTTATCATTGCGATCATGTATTAA

Upstream 100 bases:

>100_bases
GAAAAGAAAATGATTGAGGTCTACAATAAGGAAGTTGACTTTTTTTGAGGAACAAAGTATCATTTTGTTCTATATTTGTA
CTGTTTTTGGGTTATACTTC

Downstream 100 bases:

>100_bases
TTAAAGCCTGAATATCAGCGTGAAAAAGTACAAATTTGATATATTTTAAAGTAAAGCAAAACCACTATAAGGGCTATTTT
GTAAATCAGATAAGGAACCT

Product: hypothetical protein

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MINSKLIGGILLIVGTSIGGGMLALPVSTAEVGFANSLFFLFFCWLVMTAGALLILEVNLRLPAGSNMISMAKSTLGLPG
QVIAWITYLLLLYTLLAAYISGGSDVFSSLLHKAHIDLPNWITSVIFTAMFSLIVYSGIRSVDYVNRGLMFGKLGVYILL
VIIISPHISTAGLTGGSAKAFTGTLMILVTSFGFASIVPSLRDYFNDDIRSLRRVILFGSLIPLFCYIVWDAVIMGVISR
EGENGLLSLMNSDHATSGLTEALSQSVSSQWISGFFGFFTSICMVTAFLGVSLGLFDFLADGLKLKKSGNQGKYTLALTF
IPPLAVVLFNPGIYLHALSYAGVCCVILLLLLPAIMAWKGRQTCSQSPSETHLIPGGNPALSLIGFIAIGLLIIAIMY

Sequences:

>Translated_398_residues
MINSKLIGGILLIVGTSIGGGMLALPVSTAEVGFANSLFFLFFCWLVMTAGALLILEVNLRLPAGSNMISMAKSTLGLPG
QVIAWITYLLLLYTLLAAYISGGSDVFSSLLHKAHIDLPNWITSVIFTAMFSLIVYSGIRSVDYVNRGLMFGKLGVYILL
VIIISPHISTAGLTGGSAKAFTGTLMILVTSFGFASIVPSLRDYFNDDIRSLRRVILFGSLIPLFCYIVWDAVIMGVISR
EGENGLLSLMNSDHATSGLTEALSQSVSSQWISGFFGFFTSICMVTAFLGVSLGLFDFLADGLKLKKSGNQGKYTLALTF
IPPLAVVLFNPGIYLHALSYAGVCCVILLLLLPAIMAWKGRQTCSQSPSETHLIPGGNPALSLIGFIAIGLLIIAIMY
>Mature_398_residues
MINSKLIGGILLIVGTSIGGGMLALPVSTAEVGFANSLFFLFFCWLVMTAGALLILEVNLRLPAGSNMISMAKSTLGLPG
QVIAWITYLLLLYTLLAAYISGGSDVFSSLLHKAHIDLPNWITSVIFTAMFSLIVYSGIRSVDYVNRGLMFGKLGVYILL
VIIISPHISTAGLTGGSAKAFTGTLMILVTSFGFASIVPSLRDYFNDDIRSLRRVILFGSLIPLFCYIVWDAVIMGVISR
EGENGLLSLMNSDHATSGLTEALSQSVSSQWISGFFGFFTSICMVTAFLGVSLGLFDFLADGLKLKKSGNQGKYTLALTF
IPPLAVVLFNPGIYLHALSYAGVCCVILLLLLPAIMAWKGRQTCSQSPSETHLIPGGNPALSLIGFIAIGLLIIAIMY

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=390, Percent_Identity=35.3846153846154, Blast_Score=205, Evalue=4e-54,
Organism=Escherichia coli, GI1790145, Length=395, Percent_Identity=30.6329113924051, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1789552, Length=382, Percent_Identity=27.4869109947644, Blast_Score=131, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 42568; Mature: 42568

Theoretical pI: Translated: 8.35; Mature: 8.35

Prosite motif: PS00867 CPSASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINSKLIGGILLIVGTSIGGGMLALPVSTAEVGFANSLFFLFFCWLVMTAGALLILEVNL
CCCCHHHHHHHHHEECCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEE
RLPAGSNMISMAKSTLGLPGQVIAWITYLLLLYTLLAAYISGGSDVFSSLLHKAHIDLPN
ECCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHH
WITSVIFTAMFSLIVYSGIRSVDYVNRGLMFGKLGVYILLVIIISPHISTAGLTGGSAKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH
FTGTLMILVTSFGFASIVPSLRDYFNDDIRSLRRVILFGSLIPLFCYIVWDAVIMGVISR
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
EGENGLLSLMNSDHATSGLTEALSQSVSSQWISGFFGFFTSICMVTAFLGVSLGLFDFLA
CCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DGLKLKKSGNQGKYTLALTFIPPLAVVLFNPGIYLHALSYAGVCCVILLLLLPAIMAWKG
CCCEEECCCCCCCEEEEEEEHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RQTCSQSPSETHLIPGGNPALSLIGFIAIGLLIIAIMY
CHHHCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MINSKLIGGILLIVGTSIGGGMLALPVSTAEVGFANSLFFLFFCWLVMTAGALLILEVNL
CCCCHHHHHHHHHEECCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEE
RLPAGSNMISMAKSTLGLPGQVIAWITYLLLLYTLLAAYISGGSDVFSSLLHKAHIDLPN
ECCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHH
WITSVIFTAMFSLIVYSGIRSVDYVNRGLMFGKLGVYILLVIIISPHISTAGLTGGSAKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH
FTGTLMILVTSFGFASIVPSLRDYFNDDIRSLRRVILFGSLIPLFCYIVWDAVIMGVISR
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
EGENGLLSLMNSDHATSGLTEALSQSVSSQWISGFFGFFTSICMVTAFLGVSLGLFDFLA
CCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DGLKLKKSGNQGKYTLALTFIPPLAVVLFNPGIYLHALSYAGVCCVILLLLLPAIMAWKG
CCCEEECCCCCCCEEEEEEEHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RQTCSQSPSETHLIPGGNPALSLIGFIAIGLLIIAIMY
CHHHCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3049553; 9097040; 9278503 [H]