| Definition | Legionella pneumophila str. Lens, complete genome. |
|---|---|
| Accession | NC_006369 |
| Length | 3,345,687 |
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The map label for this gene is lvhB4 [H]
Identifier: 54293114
GI number: 54293114
Start: 183845
End: 186325
Strand: Direct
Name: lvhB4 [H]
Synonym: lpl0153
Alternate gene names: 54293114
Gene position: 183845-186325 (Clockwise)
Preceding gene: 54293113
Following gene: 54293115
Centisome position: 5.49
GC content: 43.21
Gene sequence:
>2481_bases ATGAACCTTTCTAAAACATTGAAGCACGTTTATCAGGAAGCAAAAGTATCTGATTTGTTTCCCATAACACATCTTAATAG CCCCTGCATTTTTGAATCGCAATCAGGCTTGGTTGGGTCGGTGATTAAGGTGAATGGTGCGGCTTTTGAAATCGAAGAAG CTGAGACTCTAAATCACCAACGCTTCTTGCTCCATCAGGCATTAGTGAGTTTGGATTCGCGTTTCATTATCTATGTGACC ACGCACCGACAAAAAATATCATGCCCTTTGATTGGGGAATTTAAGCCTGGCTTTGCCAAGGATCTGGATGAGCGTTATCA ACAACGCTTTAAAGATAAAAACCTGTATAAAAATACCCTGTACATCACCGTTGTGCTTAAAGGTGATGACACCAGTAAAA CTGGGTCATGGCTTAAGTGGGCAAAAAGTCTCTCGATTAAGGGGAATAGTGAGCTGTCCGAACACCATAGGGAACAAAGC ATCCAAACCTTAAATCGTGTTGTTGAGCAATTGCAAGCTAACCTCAATCCTTTCGAGGCAACGATACTTGGCAAACAGGA TGAGGTATTGGGTTTTAGCGAACTGCTTCAATTTCTTGGGTTGGTAGTGAATGCAGGCCAAACAACGTCATTCAAACATC CTGTGTGCAGTCCTCCAATAGCGAACTCTATTCCCCAGACCTTCAAACAAGAAGTCAAATACCCTGAAGGACATCTGGGC CAATATTTAAGTAGTTGTCAGCTTTTATTTGGGGAGTGCATCCAGTTTCAGGGCAATACTCAAAAGGATTGCGTGTTTGG TGCGATGCTGTCACTCAAAAAATACCCCACCAACACCGCCAGTATCCTCTTGGATTCCATGTTATCTCTGGATTGTGAAT TTATTGCCACCCACACTTTTGCCCCCATTGGCCGTGATAGTGCCCTGGATACGATTTCAAAAAAACGATCCAAGCTCTTA AGTGCCGAAGACAAGGCATTAAGCCAAACCACTGCATTAAGTGATTTGGAAGATGGCATTGCCAGTGAAACCCTGTTACT GGGTGCACATCATCATACAGTGATGTTATTGGCTCCGAACAAATCACTATTGGATGCAGCCATATTGGAAGCCACCAAAC GCTATGGCTCTGCTGGCATTGTTGTGGTGAAAGAAACGCTGGGACTTGAGCCTGCTTTCTGGAGCCAATTACCTTGCAAC CAGCATTTTATAACACGAGCTTCCCTGATTACCTCTCAAAATTTCGTGGACTTTTGCCCATTACATAACACCCAAACGGG CTTTTCCAATGAGAACTTTTTAGGTGGCGCGGTGACGCTTCTGGAAACTCCTTCGAAAACGCCAGTTTATTTTAACTACC ATGCACGAGGCTCTAAAACCAACCCCTCCAAAGGACATGCTGCCATTTTCGGAGGAAATAACGCAGGGAAAACCACACTG GTGAATTTCCTTGATGCGCAAATGGGGCGTTTTGGTGGACGAAGTTTTTTCATTGATAGGGATGAATCTTCCAAAATTTA CATTTTAGCTTCCGGTAACAGCTCATACCTCAAAATTGAGCCATCCAATCCAATAGCCATGAATCCTTTGCAACTCCCAG ATACCTCTGAAAACCGCTCCTTTCTGAAATCATGGTTTGCAACCTTGGTACAAGAAGAAAGCGAACGTGTTATCCCAAGT CCTATTGCAGAAATCATCAATGACTGTATTGATTACAGCTTTGAACAACTTGCACCAGAGTTCAGAACACTTAGTCACTT GAGCCAATTTCTACCTGTTGATTTTCCACGTTGGCCACATTTAAAAAGATGGTTAAAACGTAATGATTCCAGAATTGATG GCGAATTTCATTGGCTGTTTGACAACCAGCACGATGCCTTAAATCTTGATTTTGATAAGGTGGGCTTTGATGTGACCTAC CTGATGGACCAAGTACACAGCGTTATTGCAACGCCTGTCTATTTGTATTTGCTGCATCGTATGCGCCAATGCCTCGATGG TCGGTTAACTTCTTTTATTATCGCCGAAGCATGGCAGCTTTTTGCCTCACCTTTTTGGGAAAAAGCACTGCGGGAATGGC TGCCTACGATTCGAAAGAAAAACGGGCATTTTATTTTTGACACCCAATCCCCAAAAACGATTACGGATTCCCCCATTAAA CACATTGTTCTGGATAACCTGGCCACCTTGATTGCCTTTCCTAATCCGCTAGCAGATAAAGAAACCTACATGGAGCATTT AAAGCTGACTGAAGCTCAATTTGAAGCGATTAAAGAGAACACGCCTGAATCACGCATTTTTCTTTATAAACAAGACCACG AAGCCTTTTTATGCAAACTGGATTTAAGCGGTTTAAGCCAATACATCCGGGTACTTTCTGCCAATACCCAATCCGCTAAG TTGCTGGATGACATCATGCAAGAGGTCGGTCATGACCCAGAACTTTGGCTTCCTGTCTTTTATGAAAGGAGCAAAAAATG A
Upstream 100 bases:
>100_bases TGGCTGGTGTGTCGATACGACACCCATTTTTTTACCATCTGCGCAAAGCGTTTCTTATTGCCAGAAGCTCCCAATACATC ACTATGGAGGGTTCGCGCTT
Downstream 100 bases:
>100_bases AAAGAACCGCCTGTTTCTTAATTGCAGCGATGGGTATCAGCAGTGCCAGCCATGCGGATATTCTGGGTGTTGAGGACGCA CAGTTAATTTTATTGGCAAT
Product: hypothetical protein
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 826; Mature: 826
Protein sequence:
>826_residues MNLSKTLKHVYQEAKVSDLFPITHLNSPCIFESQSGLVGSVIKVNGAAFEIEEAETLNHQRFLLHQALVSLDSRFIIYVT THRQKISCPLIGEFKPGFAKDLDERYQQRFKDKNLYKNTLYITVVLKGDDTSKTGSWLKWAKSLSIKGNSELSEHHREQS IQTLNRVVEQLQANLNPFEATILGKQDEVLGFSELLQFLGLVVNAGQTTSFKHPVCSPPIANSIPQTFKQEVKYPEGHLG QYLSSCQLLFGECIQFQGNTQKDCVFGAMLSLKKYPTNTASILLDSMLSLDCEFIATHTFAPIGRDSALDTISKKRSKLL SAEDKALSQTTALSDLEDGIASETLLLGAHHHTVMLLAPNKSLLDAAILEATKRYGSAGIVVVKETLGLEPAFWSQLPCN QHFITRASLITSQNFVDFCPLHNTQTGFSNENFLGGAVTLLETPSKTPVYFNYHARGSKTNPSKGHAAIFGGNNAGKTTL VNFLDAQMGRFGGRSFFIDRDESSKIYILASGNSSYLKIEPSNPIAMNPLQLPDTSENRSFLKSWFATLVQEESERVIPS PIAEIINDCIDYSFEQLAPEFRTLSHLSQFLPVDFPRWPHLKRWLKRNDSRIDGEFHWLFDNQHDALNLDFDKVGFDVTY LMDQVHSVIATPVYLYLLHRMRQCLDGRLTSFIIAEAWQLFASPFWEKALREWLPTIRKKNGHFIFDTQSPKTITDSPIK HIVLDNLATLIAFPNPLADKETYMEHLKLTEAQFEAIKENTPESRIFLYKQDHEAFLCKLDLSGLSQYIRVLSANTQSAK LLDDIMQEVGHDPELWLPVFYERSKK
Sequences:
>Translated_826_residues MNLSKTLKHVYQEAKVSDLFPITHLNSPCIFESQSGLVGSVIKVNGAAFEIEEAETLNHQRFLLHQALVSLDSRFIIYVT THRQKISCPLIGEFKPGFAKDLDERYQQRFKDKNLYKNTLYITVVLKGDDTSKTGSWLKWAKSLSIKGNSELSEHHREQS IQTLNRVVEQLQANLNPFEATILGKQDEVLGFSELLQFLGLVVNAGQTTSFKHPVCSPPIANSIPQTFKQEVKYPEGHLG QYLSSCQLLFGECIQFQGNTQKDCVFGAMLSLKKYPTNTASILLDSMLSLDCEFIATHTFAPIGRDSALDTISKKRSKLL SAEDKALSQTTALSDLEDGIASETLLLGAHHHTVMLLAPNKSLLDAAILEATKRYGSAGIVVVKETLGLEPAFWSQLPCN QHFITRASLITSQNFVDFCPLHNTQTGFSNENFLGGAVTLLETPSKTPVYFNYHARGSKTNPSKGHAAIFGGNNAGKTTL VNFLDAQMGRFGGRSFFIDRDESSKIYILASGNSSYLKIEPSNPIAMNPLQLPDTSENRSFLKSWFATLVQEESERVIPS PIAEIINDCIDYSFEQLAPEFRTLSHLSQFLPVDFPRWPHLKRWLKRNDSRIDGEFHWLFDNQHDALNLDFDKVGFDVTY LMDQVHSVIATPVYLYLLHRMRQCLDGRLTSFIIAEAWQLFASPFWEKALREWLPTIRKKNGHFIFDTQSPKTITDSPIK HIVLDNLATLIAFPNPLADKETYMEHLKLTEAQFEAIKENTPESRIFLYKQDHEAFLCKLDLSGLSQYIRVLSANTQSAK LLDDIMQEVGHDPELWLPVFYERSKK >Mature_826_residues MNLSKTLKHVYQEAKVSDLFPITHLNSPCIFESQSGLVGSVIKVNGAAFEIEEAETLNHQRFLLHQALVSLDSRFIIYVT THRQKISCPLIGEFKPGFAKDLDERYQQRFKDKNLYKNTLYITVVLKGDDTSKTGSWLKWAKSLSIKGNSELSEHHREQS IQTLNRVVEQLQANLNPFEATILGKQDEVLGFSELLQFLGLVVNAGQTTSFKHPVCSPPIANSIPQTFKQEVKYPEGHLG QYLSSCQLLFGECIQFQGNTQKDCVFGAMLSLKKYPTNTASILLDSMLSLDCEFIATHTFAPIGRDSALDTISKKRSKLL SAEDKALSQTTALSDLEDGIASETLLLGAHHHTVMLLAPNKSLLDAAILEATKRYGSAGIVVVKETLGLEPAFWSQLPCN QHFITRASLITSQNFVDFCPLHNTQTGFSNENFLGGAVTLLETPSKTPVYFNYHARGSKTNPSKGHAAIFGGNNAGKTTL VNFLDAQMGRFGGRSFFIDRDESSKIYILASGNSSYLKIEPSNPIAMNPLQLPDTSENRSFLKSWFATLVQEESERVIPS PIAEIINDCIDYSFEQLAPEFRTLSHLSQFLPVDFPRWPHLKRWLKRNDSRIDGEFHWLFDNQHDALNLDFDKVGFDVTY LMDQVHSVIATPVYLYLLHRMRQCLDGRLTSFIIAEAWQLFASPFWEKALREWLPTIRKKNGHFIFDTQSPKTITDSPIK HIVLDNLATLIAFPNPLADKETYMEHLKLTEAQFEAIKENTPESRIFLYKQDHEAFLCKLDLSGLSQYIRVLSANTQSAK LLDDIMQEVGHDPELWLPVFYERSKK
Specific function: The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-
COG id: COG3451
COG function: function code U; Type IV secretory pathway, VirB4 components
Gene ontology:
Cell location: Cell inner membrane (Potential) [H]
Metaboloic importance: NA
Operon status: Not Known
Operon components: None
Similarity: Belongs to the trbE/virB4 family [H]
Homologues:
None
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003593 - InterPro: IPR004346 - InterPro: IPR018145 [H]
Pfam domain/function: PF03135 CagE_TrbE_VirB [H]
EC number: NA
Molecular weight: Translated: 93287; Mature: 93287
Theoretical pI: Translated: 6.69; Mature: 6.69
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.5 %Cys (Translated Protein) 1.2 %Met (Translated Protein) 2.7 %Cys+Met (Translated Protein) 1.5 %Cys (Mature Protein) 1.2 %Met (Mature Protein) 2.7 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNLSKTLKHVYQEAKVSDLFPITHLNSPCIFESQSGLVGSVIKVNGAAFEIEEAETLNHQ CCHHHHHHHHHHHHHHHHCCCHHCCCCCCEEECCCCCEEEEEEECCCEEEEHHHHHCCHH RFLLHQALVSLDSRFIIYVTTHRQKISCPLIGEFKPGFAKDLDERYQQRFKDKNLYKNTL HHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEE YITVVLKGDDTSKTGSWLKWAKSLSIKGNSELSEHHREQSIQTLNRVVEQLQANLNPFEA EEEEEEECCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE TILGKQDEVLGFSELLQFLGLVVNAGQTTSFKHPVCSPPIANSIPQTFKQEVKYPEGHLG EEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHH QYLSSCQLLFGECIQFQGNTQKDCVFGAMLSLKKYPTNTASILLDSMLSLDCEFIATHTF HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHCCC APIGRDSALDTISKKRSKLLSAEDKALSQTTALSDLEDGIASETLLLGAHHHTVMLLAPN CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEECCC KSLLDAAILEATKRYGSAGIVVVKETLGLEPAFWSQLPCNQHFITRASLITSQNFVDFCP HHHHHHHHHHHHHHCCCCCEEEEEHHCCCCCHHHCCCCCCCHHHHHHHHHHCCCCCEECC LHNTQTGFSNENFLGGAVTLLETPSKTPVYFNYHARGSKTNPSKGHAAIFGGNNAGKTTL CCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEECCCCCCCCCCCCEEEECCCCCCHHHH VNFLDAQMGRFGGRSFFIDRDESSKIYILASGNSSYLKIEPSNPIAMNPLQLPDTSENRS HHHHHHHHHHCCCCEEEEECCCCCEEEEEECCCCCEEEEECCCCEEECCCCCCCCCCHHH FLKSWFATLVQEESERVIPSPIAEIINDCIDYSFEQLAPEFRTLSHLSQFLPVDFPRWPH HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHCHHHHHHHHHHHHCCCCCCCCHH LKRWLKRNDSRIDGEFHWLFDNQHDALNLDFDKVGFDVTYLMDQVHSVIATPVYLYLLHR HHHHHHCCCCCCCCEEEEEECCCCCEEECCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH MRQCLDGRLTSFIIAEAWQLFASPFWEKALREWLPTIRKKNGHFIFDTQSPKTITDSPIK HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHH HIVLDNLATLIAFPNPLADKETYMEHLKLTEAQFEAIKENTPESRIFLYKQDHEAFLCKL HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEE DLSGLSQYIRVLSANTQSAKLLDDIMQEVGHDPELWLPVFYERSKK EHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEHHHCCCCC >Mature Secondary Structure MNLSKTLKHVYQEAKVSDLFPITHLNSPCIFESQSGLVGSVIKVNGAAFEIEEAETLNHQ CCHHHHHHHHHHHHHHHHCCCHHCCCCCCEEECCCCCEEEEEEECCCEEEEHHHHHCCHH RFLLHQALVSLDSRFIIYVTTHRQKISCPLIGEFKPGFAKDLDERYQQRFKDKNLYKNTL HHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEE YITVVLKGDDTSKTGSWLKWAKSLSIKGNSELSEHHREQSIQTLNRVVEQLQANLNPFEA EEEEEEECCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE TILGKQDEVLGFSELLQFLGLVVNAGQTTSFKHPVCSPPIANSIPQTFKQEVKYPEGHLG EEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHH QYLSSCQLLFGECIQFQGNTQKDCVFGAMLSLKKYPTNTASILLDSMLSLDCEFIATHTF HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHCCC APIGRDSALDTISKKRSKLLSAEDKALSQTTALSDLEDGIASETLLLGAHHHTVMLLAPN CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEECCC KSLLDAAILEATKRYGSAGIVVVKETLGLEPAFWSQLPCNQHFITRASLITSQNFVDFCP HHHHHHHHHHHHHHCCCCCEEEEEHHCCCCCHHHCCCCCCCHHHHHHHHHHCCCCCEECC LHNTQTGFSNENFLGGAVTLLETPSKTPVYFNYHARGSKTNPSKGHAAIFGGNNAGKTTL CCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEECCCCCCCCCCCCEEEECCCCCCHHHH VNFLDAQMGRFGGRSFFIDRDESSKIYILASGNSSYLKIEPSNPIAMNPLQLPDTSENRS HHHHHHHHHHCCCCEEEEECCCCCEEEEEECCCCCEEEEECCCCEEECCCCCCCCCCHHH FLKSWFATLVQEESERVIPSPIAEIINDCIDYSFEQLAPEFRTLSHLSQFLPVDFPRWPH HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHCHHHHHHHHHHHHCCCCCCCCHH LKRWLKRNDSRIDGEFHWLFDNQHDALNLDFDKVGFDVTYLMDQVHSVIATPVYLYLLHR HHHHHHCCCCCCCCEEEEEECCCCCEEECCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH MRQCLDGRLTSFIIAEAWQLFASPFWEKALREWLPTIRKKNGHFIFDTQSPKTITDSPIK HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHH HIVLDNLATLIAFPNPLADKETYMEHLKLTEAQFEAIKENTPESRIFLYKQDHEAFLCKL HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEE DLSGLSQYIRVLSANTQSAKLLDDIMQEVGHDPELWLPVFYERSKK EHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEHHHCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 10749166; 10882236; 7494028 [H]