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The map label for this gene is thrC [H]

Identifier: 161936272

GI number: 161936272

Start: 1543426

End: 1544694

Strand: Direct

Name: thrC [H]

Synonym: lpl1383

Alternate gene names: 161936272

Gene position: 1543426-1544694 (Clockwise)

Preceding gene: 54294317

Following gene: 54294319

Centisome position: 46.13

GC content: 36.64

Gene sequence:

>1269_bases
ATGAAAATTAGAATAAAGAGTACGAGAGGACAATGTATCTCCACAATAGACGAAGCAATACTGTCAGGCTTGGCAGGGGA
TGGCGGGTTATTTGTACCGGACAGGTTCCCCGATTTAACAATAAAAAAATTTTATGAATACGGTAATTTAATCGACTTTT
CTGCTCATTTACTCTCGCCATTTTTTTCAGATAGTAAAATTGATGTAAATAATGCTTTTTTTCAAAAATTCCTCACCTTC
TCCTTTCCGCTGCATTATCTTTTTAAGAAAAGTTATGTACTCGAGTTGTTTCATGGGCCAACCCTGTCTTTCAAAGATTT
AGGAACTCAATTTTTCAGTGAATGTTTATTGCATCTGATAGAAAACAAGAGCGCCAAAGTCCTGGTCGCAACATCTGGTG
ATACTGGCGCTGCGATTGCTCATGCTTTGCATGGGAAAAGAGATCTGGAAGGAATCATTTTATTTCCCAAAGATAAACTT
ACTTTCAGACAACAATCTCAAATTACTTGTTGGGGGGAGAATATTCGTGCATTGGCTGTTAATGGCAGTTTTGATCAATG
TCAACAGCTGGTGAAGCTGGTATTTGCCAAAAGAGAACATAAAGGAATATTGACTACAGCCAATAGCATGAATATTGTCA
GATTATTACCACAGATTATTTTTTATGCTTTTACCAGCATTCAACTGGCATTAAGACATAATCATTCTGTTAATTTTATA
GTTCCAGGCGGAAACCTGGGTAATGTTACGGCTTGTTATTGGGCAAAAATGCTGGGTTTTCCGGTTGAACAAATTTTAAT
AGCTAATAATACTAATAGTGCACTGGGCGAATTTTTATTAACGGGAGCTTATCAAGCCAAATCGGTTACTAAAACATTGG
CAACAGCGATGGATGTAGGTGAGCCAAGCAATTTGGAGCGCTTATTCGTTTTATTTAATAATTATTCTGAATGTAAAAAA
CAGATGAATGCAGAATCTGTTAGTGATGAACAAATTAAGCAAGCTATCCTACATTGTTACAATAAATATCATTATATAAT
TTGCCCTCATACCGCTACAGCTTATCATCGTCTAAGTACAATCAATCAGGATAAACCCTGGGTTATTGTGGCACCAGGGC
ACCCGGCGAAATTTGAAGAGGTATTAGAACCACTATTGAAAAAAGAAATCCCTGTCCCGGAACAGCTGAAGATCCTTTTA
GGCAGAAAACAACATTATTCAATCATAGAGCCAAACTATCATTCTTTGTATCATTTCTTAGTTGAATGA

Upstream 100 bases:

>100_bases
ACTAAAATATAGCTGTTAGCAATATACCGCGAAGCAAAAGTTGTCTTTGAAAGTGATTTATTGGTTACCAATATTTCATC
AGAAGGTGCAAAGGCTGCAG

Downstream 100 bases:

>100_bases
AGGCCATTACAGAAGCAAATTGTTGTGATGGCATATAATAGCACTGGTTAATTATCACCAGCGTCTTTGATTGGCTCAAA
CTCATAAGCTAAGTCAGCAT

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MKIRIKSTRGQCISTIDEAILSGLAGDGGLFVPDRFPDLTIKKFYEYGNLIDFSAHLLSPFFSDSKIDVNNAFFQKFLTF
SFPLHYLFKKSYVLELFHGPTLSFKDLGTQFFSECLLHLIENKSAKVLVATSGDTGAAIAHALHGKRDLEGIILFPKDKL
TFRQQSQITCWGENIRALAVNGSFDQCQQLVKLVFAKREHKGILTTANSMNIVRLLPQIIFYAFTSIQLALRHNHSVNFI
VPGGNLGNVTACYWAKMLGFPVEQILIANNTNSALGEFLLTGAYQAKSVTKTLATAMDVGEPSNLERLFVLFNNYSECKK
QMNAESVSDEQIKQAILHCYNKYHYIICPHTATAYHRLSTINQDKPWVIVAPGHPAKFEEVLEPLLKKEIPVPEQLKILL
GRKQHYSIIEPNYHSLYHFLVE

Sequences:

>Translated_422_residues
MKIRIKSTRGQCISTIDEAILSGLAGDGGLFVPDRFPDLTIKKFYEYGNLIDFSAHLLSPFFSDSKIDVNNAFFQKFLTF
SFPLHYLFKKSYVLELFHGPTLSFKDLGTQFFSECLLHLIENKSAKVLVATSGDTGAAIAHALHGKRDLEGIILFPKDKL
TFRQQSQITCWGENIRALAVNGSFDQCQQLVKLVFAKREHKGILTTANSMNIVRLLPQIIFYAFTSIQLALRHNHSVNFI
VPGGNLGNVTACYWAKMLGFPVEQILIANNTNSALGEFLLTGAYQAKSVTKTLATAMDVGEPSNLERLFVLFNNYSECKK
QMNAESVSDEQIKQAILHCYNKYHYIICPHTATAYHRLSTINQDKPWVIVAPGHPAKFEEVLEPLLKKEIPVPEQLKILL
GRKQHYSIIEPNYHSLYHFLVE
>Mature_422_residues
MKIRIKSTRGQCISTIDEAILSGLAGDGGLFVPDRFPDLTIKKFYEYGNLIDFSAHLLSPFFSDSKIDVNNAFFQKFLTF
SFPLHYLFKKSYVLELFHGPTLSFKDLGTQFFSECLLHLIENKSAKVLVATSGDTGAAIAHALHGKRDLEGIILFPKDKL
TFRQQSQITCWGENIRALAVNGSFDQCQQLVKLVFAKREHKGILTTANSMNIVRLLPQIIFYAFTSIQLALRHNHSVNFI
VPGGNLGNVTACYWAKMLGFPVEQILIANNTNSALGEFLLTGAYQAKSVTKTLATAMDVGEPSNLERLFVLFNNYSECKK
QMNAESVSDEQIKQAILHCYNKYHYIICPHTATAYHRLSTINQDKPWVIVAPGHPAKFEEVLEPLLKKEIPVPEQLKILL
GRKQHYSIIEPNYHSLYHFLVE

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=433, Percent_Identity=31.1778290993072, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI149193323, Length=437, Percent_Identity=29.9771167048055, Blast_Score=166, Evalue=4e-41,
Organism=Escherichia coli, GI1786185, Length=386, Percent_Identity=36.0103626943005, Blast_Score=224, Evalue=9e-60,
Organism=Saccharomyces cerevisiae, GI6319901, Length=455, Percent_Identity=32.0879120879121, Blast_Score=204, Evalue=2e-53,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 47622; Mature: 47622

Theoretical pI: Translated: 8.53; Mature: 8.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIRIKSTRGQCISTIDEAILSGLAGDGGLFVPDRFPDLTIKKFYEYGNLIDFSAHLLSP
CEEEEECCCCHHHHHHHHHHHHCCCCCCCEECCCCCCCHHHHHHHHHCCEEEHHHHHHHH
FFSDSKIDVNNAFFQKFLTFSFPLHYLFKKSYVLELFHGPTLSFKDLGTQFFSECLLHLI
HCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHH
ENKSAKVLVATSGDTGAAIAHALHGKRDLEGIILFPKDKLTFRQQSQITCWGENIRALAV
CCCCCEEEEEECCCCHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCEEEECCCEEEEEE
NGSFDQCQQLVKLVFAKREHKGILTTANSMNIVRLLPQIIFYAFTSIQLALRHNHSVNFI
CCCHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHEEEECCCCEEEE
VPGGNLGNVTACYWAKMLGFPVEQILIANNTNSALGEFLLTGAYQAKSVTKTLATAMDVG
ECCCCCCCHHHHHHHHHHCCCHHHEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCC
EPSNLERLFVLFNNYSECKKQMNAESVSDEQIKQAILHCYNKYHYIICPHTATAYHRLST
CCCCCEEEEEEECCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHH
INQDKPWVIVAPGHPAKFEEVLEPLLKKEIPVPEQLKILLGRKQHYSIIEPNYHSLYHFL
CCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCEEECCCHHHHHHHH
VE
CC
>Mature Secondary Structure
MKIRIKSTRGQCISTIDEAILSGLAGDGGLFVPDRFPDLTIKKFYEYGNLIDFSAHLLSP
CEEEEECCCCHHHHHHHHHHHHCCCCCCCEECCCCCCCHHHHHHHHHCCEEEHHHHHHHH
FFSDSKIDVNNAFFQKFLTFSFPLHYLFKKSYVLELFHGPTLSFKDLGTQFFSECLLHLI
HCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHH
ENKSAKVLVATSGDTGAAIAHALHGKRDLEGIILFPKDKLTFRQQSQITCWGENIRALAV
CCCCCEEEEEECCCCHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCEEEECCCEEEEEE
NGSFDQCQQLVKLVFAKREHKGILTTANSMNIVRLLPQIIFYAFTSIQLALRHNHSVNFI
CCCHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHEEEECCCCEEEE
VPGGNLGNVTACYWAKMLGFPVEQILIANNTNSALGEFLLTGAYQAKSVTKTLATAMDVG
ECCCCCCCHHHHHHHHHHCCCHHHEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCC
EPSNLERLFVLFNNYSECKKQMNAESVSDEQIKQAILHCYNKYHYIICPHTATAYHRLST
CCCCCEEEEEEECCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHH
INQDKPWVIVAPGHPAKFEEVLEPLLKKEIPVPEQLKILLGRKQHYSIIEPNYHSLYHFL
CCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCEEECCCHHHHHHHH
VE
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12089438 [H]