| Definition | Legionella pneumophila str. Paris, complete genome. |
|---|---|
| Accession | NC_006368 |
| Length | 3,503,610 |
Click here to switch to the map view.
The map label for this gene is gyrA [H]
Identifier: 54297327
GI number: 54297327
Start: 1527474
End: 1530065
Strand: Direct
Name: gyrA [H]
Synonym: lpp1372
Alternate gene names: 54297327
Gene position: 1527474-1530065 (Clockwise)
Preceding gene: 54297326
Following gene: 54297328
Centisome position: 43.6
GC content: 41.32
Gene sequence:
>2592_bases ATGGTATACCTAGCCAAAGAAGTCTTACCAGTCAACATAGAAGACGAATTGAAGCAATCCTATTTGGATTATGCGATGAG TGTCATTGTAGGCCGAGCGTTGCCTGATGTACGTGATGGTTTAAAACCGGTGCATAGGCGAGTTCTTTTTGCGATGAGCG AGTTGGGTAATGATTGGAATAAACCTTATAAAAAATCTGCTCGTGTAGTAGGGGATGTCATCGGTAAATACCATCCTCAC GGGGATACAGCTGTTTATGACACCATTGTTCGTATGGCCCAACCTTTTTCCATGCGCTACCTTTTAATCGATGGACAGGG GAATTTTGGCTCTGTAGATGGAGATGCTCCAGCTGCCATGCGTTACACTGAAGTAAGAATGTCCAAAGTGGCGCATGCTT TACTGGCTGATTTGGATAAGGAAACTGTTGATTTTAGCCCTAACTATGATGAAACAGAATTTGCTCCAGTGGTATTGCCA TCGAGAATTCCCAATTTACTAGTTAATGGCTCTTCCGGTATTGCGGTAGGGATGGCTACTAATATTCCACCACATAATCT TACCGAAGTAATCAATGCATGTATTGCCTTAGTGGATGAACCTGACACGAGTCTTGAAGATTTAATGGAAATTATTCCTG GCCCTGATTTTCCTACAGCAGCAATTATTAATGGTCGTGCTGGAATTATTGAAGGTTATCGTACTGGAAAAGGGCGGGTT GTTATCAGGGCACGAACAGAAATTGAAACGGATGAAAGTTCAGGCCGTCAGTCAATTATTATTCAGGAATTACCCTATCA GGTGAATAAAGCGCGTTTGATCGAGCGTATTGCTGAATTGGTAAGGGATAAGAAAGTCGAGGGAATTTCCGGCTTGAGGG ATGAGTCAGACAAGCAGGGAATGAGAGTAGTCATTGAATTAAAACGCAATGAAGTAGCAGATGTGGTATTGAATAACCTG TTCGCTCATACTCAAATGCAAAATGTATTCGGAATTAATATGGTTGCTTTGGTGGATGGCCAACCGCGTACTTTGAATTT GAAGCAAATACTGGAATATTTTATAAAACATCGAAGAGAGGTTGTTACCAGACGCACAATATTTGAATTGAAAAAAGCCA GAAGTCGAGCTCATTTATTGGAGGGCTTGGGAATCGCCTTAGCTAATATCGATGAAATGATCGCATTAATTAAGCAATCT CCTACTCCTCAAGACGCAAAAAGTGCTTTATTAAGCAAAATATGGCAACCTGGCTTAGTAAAGGCCATGTTGGAAAAGGC TGGCTCAAACGCGTCAAGGCCTGATGATTTAACTGAAGAGTATGGTTTGCATGAGAACGGATATAAATTATCTGAAGCGC AGGCACAAGCAATACTTGAATTAAGATTACATAGGCTAACAGCTCTTGAACAAGATAAAATAATTAATGAATTTGAAGAG CTATTGAATTTAATTAAAGAATTGCTTGACATATTGGCTTCACCTGAAAGACTTATGCAAGTTATTCGTGATGAATTGAT AGAGATTAAATCCCAATTTGGTGATGAGAGGCGAACGGAAATAACAGCCTCACAAGAAGATTTGACTATTGAAGATTTGA TTACCGAAGAAGACGTTGTGGTCACTTTATCTCATCAAGGTTATGTAAAATATCAGCCCATTACAGCCTATCAGGCTCAG CGCCGAGGTGGCAAAGGCAAATCGGCAACTCATGTCAAGGATGAGGATTTTGTTGAGCGTTTAGTGATTGCTAGTACTCA TGATACCTTATTGTGTTTCTCCAATCATGGCAAATTATATTGGCTAAAAGCATATCAATTGCCTCAAGCAAGCCGCGCTT CGAGAGGAAGGCCTATAATCAATATTCTTCCTTTGGCAGAAGGCGAAGAGATTAATGCTATGCTCCCTGTCCGTGAGTAT AAAGACGGCAGCTATGTGTTTATGGCAACCAAGAAGGGAACAGTTAAAAAAGTGCCTTTAAACGCATTTAGCAGGCCGCG TTCCAATGGTATTATTGCTGTGGACCTGGAAGAAGATGACAGCCTCGTCGGAGTCGATATTACTGATGGTACTCGCGATA TTATGTTGTTTACTGATGCAGGCAAAGTAATCCGTTTTGATGAAAATAAAGTGCGACCTATGGGGCGCACGGCTCGAGGG GTTCGCGGAATTCGAGTAGAAAAGGATCAAGCCGTTAAATCTCTTGTGGTAGTCGACCCAAATGGAGGCACCATTTTGAC TGCAACTGAAAACGGCTACGGTAAGAGAACCCATATCGATGAGTATCGAGTGTCAGGACGGGGAGGACAAGGTGTTATTT CCATTCAGGTTACTGAACGAAATGGTAAAGTGGTCCGTTCCTTGCAGGTTACCGATAATGACGAAGCCATGTTAATTACA GATAAAGGAACTTTGGTTCGTTTTAAAGTCAATGAATTATCTGTGATAGGCAGAAATACACAAGGGGTTCGCCTGATTAA TGTCAGTTCTGGTGAGACAGTTGTTGGAATGCAAAAAATTGTAGATCTTGGAGAAGAATTAGAAGAAGCAGAAGATTCAT CTCTTAATGCCGAAGACAACAGTGATGAATAG
Upstream 100 bases:
>100_bases AGCCATATGAAGCTTAAGGTCATTTAATTAAGACGCCCAGTGTGGTATCCTTTTGCATTAAATTAATCTTAATTTATTGT CTAAAGGATACATCCAAATC
Downstream 100 bases:
>100_bases CAGGGTTTTCAATTTTGGAGCTGGCCCTGCTATGCTGCCCGAGGAAATATTAAAAGAGGCTCAAGAGGAATTCCTTAATT GGCGTAATACTGGAATGTCC
Product: DNA gyrase, subunit A, type II topoisomerase
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 863; Mature: 863
Protein sequence:
>863_residues MVYLAKEVLPVNIEDELKQSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMSELGNDWNKPYKKSARVVGDVIGKYHPH GDTAVYDTIVRMAQPFSMRYLLIDGQGNFGSVDGDAPAAMRYTEVRMSKVAHALLADLDKETVDFSPNYDETEFAPVVLP SRIPNLLVNGSSGIAVGMATNIPPHNLTEVINACIALVDEPDTSLEDLMEIIPGPDFPTAAIINGRAGIIEGYRTGKGRV VIRARTEIETDESSGRQSIIIQELPYQVNKARLIERIAELVRDKKVEGISGLRDESDKQGMRVVIELKRNEVADVVLNNL FAHTQMQNVFGINMVALVDGQPRTLNLKQILEYFIKHRREVVTRRTIFELKKARSRAHLLEGLGIALANIDEMIALIKQS PTPQDAKSALLSKIWQPGLVKAMLEKAGSNASRPDDLTEEYGLHENGYKLSEAQAQAILELRLHRLTALEQDKIINEFEE LLNLIKELLDILASPERLMQVIRDELIEIKSQFGDERRTEITASQEDLTIEDLITEEDVVVTLSHQGYVKYQPITAYQAQ RRGGKGKSATHVKDEDFVERLVIASTHDTLLCFSNHGKLYWLKAYQLPQASRASRGRPIINILPLAEGEEINAMLPVREY KDGSYVFMATKKGTVKKVPLNAFSRPRSNGIIAVDLEEDDSLVGVDITDGTRDIMLFTDAGKVIRFDENKVRPMGRTARG VRGIRVEKDQAVKSLVVVDPNGGTILTATENGYGKRTHIDEYRVSGRGGQGVISIQVTERNGKVVRSLQVTDNDEAMLIT DKGTLVRFKVNELSVIGRNTQGVRLINVSSGETVVGMQKIVDLGEELEEAEDSSLNAEDNSDE
Sequences:
>Translated_863_residues MVYLAKEVLPVNIEDELKQSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMSELGNDWNKPYKKSARVVGDVIGKYHPH GDTAVYDTIVRMAQPFSMRYLLIDGQGNFGSVDGDAPAAMRYTEVRMSKVAHALLADLDKETVDFSPNYDETEFAPVVLP SRIPNLLVNGSSGIAVGMATNIPPHNLTEVINACIALVDEPDTSLEDLMEIIPGPDFPTAAIINGRAGIIEGYRTGKGRV VIRARTEIETDESSGRQSIIIQELPYQVNKARLIERIAELVRDKKVEGISGLRDESDKQGMRVVIELKRNEVADVVLNNL FAHTQMQNVFGINMVALVDGQPRTLNLKQILEYFIKHRREVVTRRTIFELKKARSRAHLLEGLGIALANIDEMIALIKQS PTPQDAKSALLSKIWQPGLVKAMLEKAGSNASRPDDLTEEYGLHENGYKLSEAQAQAILELRLHRLTALEQDKIINEFEE LLNLIKELLDILASPERLMQVIRDELIEIKSQFGDERRTEITASQEDLTIEDLITEEDVVVTLSHQGYVKYQPITAYQAQ RRGGKGKSATHVKDEDFVERLVIASTHDTLLCFSNHGKLYWLKAYQLPQASRASRGRPIINILPLAEGEEINAMLPVREY KDGSYVFMATKKGTVKKVPLNAFSRPRSNGIIAVDLEEDDSLVGVDITDGTRDIMLFTDAGKVIRFDENKVRPMGRTARG VRGIRVEKDQAVKSLVVVDPNGGTILTATENGYGKRTHIDEYRVSGRGGQGVISIQVTERNGKVVRSLQVTDNDEAMLIT DKGTLVRFKVNELSVIGRNTQGVRLINVSSGETVVGMQKIVDLGEELEEAEDSSLNAEDNSDE >Mature_863_residues MVYLAKEVLPVNIEDELKQSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMSELGNDWNKPYKKSARVVGDVIGKYHPH GDTAVYDTIVRMAQPFSMRYLLIDGQGNFGSVDGDAPAAMRYTEVRMSKVAHALLADLDKETVDFSPNYDETEFAPVVLP SRIPNLLVNGSSGIAVGMATNIPPHNLTEVINACIALVDEPDTSLEDLMEIIPGPDFPTAAIINGRAGIIEGYRTGKGRV VIRARTEIETDESSGRQSIIIQELPYQVNKARLIERIAELVRDKKVEGISGLRDESDKQGMRVVIELKRNEVADVVLNNL FAHTQMQNVFGINMVALVDGQPRTLNLKQILEYFIKHRREVVTRRTIFELKKARSRAHLLEGLGIALANIDEMIALIKQS PTPQDAKSALLSKIWQPGLVKAMLEKAGSNASRPDDLTEEYGLHENGYKLSEAQAQAILELRLHRLTALEQDKIINEFEE LLNLIKELLDILASPERLMQVIRDELIEIKSQFGDERRTEITASQEDLTIEDLITEEDVVVTLSHQGYVKYQPITAYQAQ RRGGKGKSATHVKDEDFVERLVIASTHDTLLCFSNHGKLYWLKAYQLPQASRASRGRPIINILPLAEGEEINAMLPVREY KDGSYVFMATKKGTVKKVPLNAFSRPRSNGIIAVDLEEDDSLVGVDITDGTRDIMLFTDAGKVIRFDENKVRPMGRTARG VRGIRVEKDQAVKSLVVVDPNGGTILTATENGYGKRTHIDEYRVSGRGGQGVISIQVTERNGKVVRSLQVTDNDEAMLIT DKGTLVRFKVNELSVIGRNTQGVRLINVSSGETVVGMQKIVDLGEELEEAEDSSLNAEDNSDE
Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]
COG id: COG0188
COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]
Homologues:
Organism=Homo sapiens, GI19913408, Length=319, Percent_Identity=26.9592476489028, Blast_Score=76, Evalue=2e-13, Organism=Homo sapiens, GI19913406, Length=322, Percent_Identity=26.3975155279503, Blast_Score=75, Evalue=2e-13, Organism=Escherichia coli, GI1788562, Length=843, Percent_Identity=65.361803084223, Blast_Score=1155, Evalue=0.0, Organism=Escherichia coli, GI1789396, Length=701, Percent_Identity=38.0884450784593, Blast_Score=425, Evalue=1e-120, Organism=Caenorhabditis elegans, GI17535065, Length=184, Percent_Identity=34.2391304347826, Blast_Score=75, Evalue=1e-13, Organism=Caenorhabditis elegans, GI212645657, Length=280, Percent_Identity=29.2857142857143, Blast_Score=75, Evalue=2e-13, Organism=Caenorhabditis elegans, GI212645845, Length=366, Percent_Identity=24.0437158469945, Blast_Score=69, Evalue=1e-11, Organism=Saccharomyces cerevisiae, GI6324241, Length=348, Percent_Identity=25.8620689655172, Blast_Score=74, Evalue=1e-13, Organism=Drosophila melanogaster, GI17136538, Length=352, Percent_Identity=26.1363636363636, Blast_Score=72, Evalue=2e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR020899 - InterPro: IPR005743 - InterPro: IPR006691 - InterPro: IPR002205 - InterPro: IPR013758 - InterPro: IPR013757 - InterPro: IPR013760 [H]
Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]
EC number: =5.99.1.3 [H]
Molecular weight: Translated: 95977; Mature: 95977
Theoretical pI: Translated: 5.27; Mature: 5.27
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.2 %Cys (Translated Protein) 2.4 %Met (Translated Protein) 2.7 %Cys+Met (Translated Protein) 0.2 %Cys (Mature Protein) 2.4 %Met (Mature Protein) 2.7 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MVYLAKEVLPVNIEDELKQSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMSELGNDWN CEEEECCEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCC KPYKKSARVVGDVIGKYHPHGDTAVYDTIVRMAQPFSMRYLLIDGQGNFGSVDGDAPAAM CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCHH RYTEVRMSKVAHALLADLDKETVDFSPNYDETEFAPVVLPSRIPNLLVNGSSGIAVGMAT HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCCEEEECCCCEEEEEEC NIPPHNLTEVINACIALVDEPDTSLEDLMEIIPGPDFPTAAIINGRAGIIEGYRTGKGRV CCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCEEEECCCCCEEECEECCCCEE VIRARTEIETDESSGRQSIIIQELPYQVNKARLIERIAELVRDKKVEGISGLRDESDKQG EEEEECCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC MRVVIELKRNEVADVVLNNLFAHTQMQNVFGINMVALVDGQPRTLNLKQILEYFIKHRRE CEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEECHHHHHHHHHHHHHH VVTRRTIFELKKARSRAHLLEGLGIALANIDEMIALIKQSPTPQDAKSALLSKIWQPGLV HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHH KAMLEKAGSNASRPDDLTEEYGLHENGYKLSEAQAQAILELRLHRLTALEQDKIINEFEE HHHHHHCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH LLNLIKELLDILASPERLMQVIRDELIEIKSQFGDERRTEITASQEDLTIEDLITEEDVV HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHEEECCCCCCCHHHHCCCCCEE VTLSHQGYVKYQPITAYQAQRRGGKGKSATHVKDEDFVERLVIASTHDTLLCFSNHGKLY EEEECCCEEEECCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCEE WLKAYQLPQASRASRGRPIINILPLAEGEEINAMLPVREYKDGSYVFMATKKGTVKKVPL EEEEECCCCCHHHCCCCCEEEEEECCCCCCCCEEECHHCCCCCCEEEEEECCCCEEECCC NAFSRPRSNGIIAVDLEEDDSLVGVDITDGTRDIMLFTDAGKVIRFDENKVRPMGRTARG CCCCCCCCCCEEEEEECCCCCEEEEEECCCCCEEEEEECCCCEEEECCCCCCCCCCHHCC VRGIRVEKDQAVKSLVVVDPNGGTILTATENGYGKRTHIDEYRVSGRGGQGVISIQVTER CCCEEECHHHCCEEEEEECCCCCEEEEECCCCCCCCCCCHHHEECCCCCCEEEEEEEECC NGKVVRSLQVTDNDEAMLITDKGTLVRFKVNELSVIGRNTQGVRLINVSSGETVVGMQKI CCCEEEEEEECCCCCEEEEECCCEEEEEEECEEEEEECCCCCEEEEEECCCCEEHHHHHH VDLGEELEEAEDSSLNAEDNSDE HHHHHHHHHHCCCCCCCCCCCCC >Mature Secondary Structure MVYLAKEVLPVNIEDELKQSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMSELGNDWN CEEEECCEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCC KPYKKSARVVGDVIGKYHPHGDTAVYDTIVRMAQPFSMRYLLIDGQGNFGSVDGDAPAAM CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCHH RYTEVRMSKVAHALLADLDKETVDFSPNYDETEFAPVVLPSRIPNLLVNGSSGIAVGMAT HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCCEEEECCCCEEEEEEC NIPPHNLTEVINACIALVDEPDTSLEDLMEIIPGPDFPTAAIINGRAGIIEGYRTGKGRV CCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCEEEECCCCCEEECEECCCCEE VIRARTEIETDESSGRQSIIIQELPYQVNKARLIERIAELVRDKKVEGISGLRDESDKQG EEEEECCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC MRVVIELKRNEVADVVLNNLFAHTQMQNVFGINMVALVDGQPRTLNLKQILEYFIKHRRE CEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEECHHHHHHHHHHHHHH VVTRRTIFELKKARSRAHLLEGLGIALANIDEMIALIKQSPTPQDAKSALLSKIWQPGLV HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHH KAMLEKAGSNASRPDDLTEEYGLHENGYKLSEAQAQAILELRLHRLTALEQDKIINEFEE HHHHHHCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH LLNLIKELLDILASPERLMQVIRDELIEIKSQFGDERRTEITASQEDLTIEDLITEEDVV HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHEEECCCCCCCHHHHCCCCCEE VTLSHQGYVKYQPITAYQAQRRGGKGKSATHVKDEDFVERLVIASTHDTLLCFSNHGKLY EEEECCCEEEECCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCEE WLKAYQLPQASRASRGRPIINILPLAEGEEINAMLPVREYKDGSYVFMATKKGTVKKVPL EEEEECCCCCHHHCCCCCEEEEEECCCCCCCCEEECHHCCCCCCEEEEEECCCCEEECCC NAFSRPRSNGIIAVDLEEDDSLVGVDITDGTRDIMLFTDAGKVIRFDENKVRPMGRTARG CCCCCCCCCCEEEEEECCCCCEEEEEECCCCCEEEEEECCCCEEEECCCCCCCCCCHHCC VRGIRVEKDQAVKSLVVVDPNGGTILTATENGYGKRTHIDEYRVSGRGGQGVISIQVTER CCCEEECHHHCCEEEEEECCCCCEEEEECCCCCCCCCCCHHHEECCCCCCEEEEEEEECC NGKVVRSLQVTDNDEAMLITDKGTLVRFKVNELSVIGRNTQGVRLINVSSGETVVGMQKI CCCEEEEEEECCCCCEEEEECCCEEEEEEECEEEEEECCCCCEEEEEECCCCEEHHHHHH VDLGEELEEAEDSSLNAEDNSDE HHHHHHHHHHCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11677609; 8849216 [H]