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The map label for this gene is glpK [H]

Identifier: 54297324

GI number: 54297324

Start: 1523443

End: 1524918

Strand: Direct

Name: glpK [H]

Synonym: lpp1369

Alternate gene names: 54297324

Gene position: 1523443-1524918 (Clockwise)

Preceding gene: 54297322

Following gene: 54297326

Centisome position: 43.48

GC content: 40.38

Gene sequence:

>1476_bases
ATGAACTATATACTAGCTATTGACCAGGGAACAAGTAGCACTCGCGCTATGATCTACACCCTTCAAGGTGATTTAATCGC
AAATAGTCAGTATCCTCTTACTCAATATTACCCCAATTTGGGTTGGGTAGAACACGATCCTGAGGAAATATGGCAAAAAA
CTCTGAATGCGATGAGGGATGTCGTATCTCAAGTTCAAGGAAAAGCAATTTTATGCTGTGGCCTTACCAACCAACGGGAA
ACCACTCTGATTTGGAACAAAAAAACAGGGGAATGCCTCGCGCCAGCTATTGTGTGGCAAGATAGACGTACGGAAGAGTT
TTGTTATTCCTTGTCTGAATACTCATCAATGATACAAGAGAAAACCGGATTACTTCCTGATCCCTATTTTTCAGCGAGCA
AATTAAACTGGTTACTAAAGAATAATGCTCAAGCTCAATCACTAATTAACCAGGGGGATTTGGCATTTGGGACAATAGAC
AGTTTTTTAATATGGCGCATGACTAAAGGTGCCAGTCATGCTACCGATATCACCAACGCATCCAGAACTATGCTGTTTAA
TATTCATGATGAAAAATGGGATAAGCAGTTACTCGAGCTTTTTTCTATTTCAGAATCGATATTACCAGAGGTTTACTCCA
GTGATAATCATTTTGGGGTGATAGATAAAGAATGGCTGGGAGTAGAAATACCAATTACCGGGGTTGCAGGCGATCAACAA
GCCGCTTTAATTGGGCAAGGTTGTTTTAATGGCGGAATGGTTAAAGCTACTTTTGGTACGGGGGGATTTTTATTGCTCAA
TACAGGTGATAAACCGGTTTTCTCAAAGCATAAATTGTTGACTACTATTGCCTATAAAATTAAAGAAAAAACAGCTTATG
GTTTGGAGGGTAGTATTTATCATGCCGGAACAACTGTTAAATGGTTACGCGATGAAATGAAGTTGATATCTCATTCTGCT
GAAACTGAAGTATTGGCACAAAGTCTTGATAGCAATAACGGTGTATATCTTGTTTCATCTTTTACTGGTCTTGGAGCACC
TCATTGGTTATCAATAACAGGAACGGCTATTATTGGTGTATCCCGTTCAACGAATAGAGCGCATTTTGCCAGAGCCGCCC
TGGAAGGAGTTTGTTATCAAACACGTGATGTATTAACCTGTATGAGAGATGATAGTCAATTGGATTTGACTTTATTAAGA
GCGGATGGAGGGATGGCAGTAAACCAATGGTTTCTACAATTTATGGCTGATCAGTGTCAGTTGACAATTCAAAAACCCAA
GGACATTGAAACGACTGCCAAAGGGGCAGCAGTATTAGCCGCAATAGGTTCTGGTCTATTTGATTCAGTTTCTTCAGTAA
ATAAGGTATGGGACGTTGAGAACGAGTTTCAGCCATCCAGGGAAAGAGAGGTAGTTGAAAAAGATTTTCGTGGCTGGTTA
GAGGCGTTGGCAATGGTTAAAGCAAGGCATGCATAG

Upstream 100 bases:

>100_bases
GCCTCCACCAATAATTGCAACATCAAAAACCTGATCCATGTTTTTATCTCCGAAAAAAGATTACACTCAATATATATAAA
TATAGAGGGATTTTATAATA

Downstream 100 bases:

>100_bases
ACTAGTCTTATATTTAAATTGGTGCGATTAAATTAGATCGCAGTAGCTCGTATTATAGTTTAATACAAGCTACTGATTAA
CACATTGGATTTTTTATTTT

Product: glycerol kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK [H]

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MNYILAIDQGTSSTRAMIYTLQGDLIANSQYPLTQYYPNLGWVEHDPEEIWQKTLNAMRDVVSQVQGKAILCCGLTNQRE
TTLIWNKKTGECLAPAIVWQDRRTEEFCYSLSEYSSMIQEKTGLLPDPYFSASKLNWLLKNNAQAQSLINQGDLAFGTID
SFLIWRMTKGASHATDITNASRTMLFNIHDEKWDKQLLELFSISESILPEVYSSDNHFGVIDKEWLGVEIPITGVAGDQQ
AALIGQGCFNGGMVKATFGTGGFLLLNTGDKPVFSKHKLLTTIAYKIKEKTAYGLEGSIYHAGTTVKWLRDEMKLISHSA
ETEVLAQSLDSNNGVYLVSSFTGLGAPHWLSITGTAIIGVSRSTNRAHFARAALEGVCYQTRDVLTCMRDDSQLDLTLLR
ADGGMAVNQWFLQFMADQCQLTIQKPKDIETTAKGAAVLAAIGSGLFDSVSSVNKVWDVENEFQPSREREVVEKDFRGWL
EALAMVKARHA

Sequences:

>Translated_491_residues
MNYILAIDQGTSSTRAMIYTLQGDLIANSQYPLTQYYPNLGWVEHDPEEIWQKTLNAMRDVVSQVQGKAILCCGLTNQRE
TTLIWNKKTGECLAPAIVWQDRRTEEFCYSLSEYSSMIQEKTGLLPDPYFSASKLNWLLKNNAQAQSLINQGDLAFGTID
SFLIWRMTKGASHATDITNASRTMLFNIHDEKWDKQLLELFSISESILPEVYSSDNHFGVIDKEWLGVEIPITGVAGDQQ
AALIGQGCFNGGMVKATFGTGGFLLLNTGDKPVFSKHKLLTTIAYKIKEKTAYGLEGSIYHAGTTVKWLRDEMKLISHSA
ETEVLAQSLDSNNGVYLVSSFTGLGAPHWLSITGTAIIGVSRSTNRAHFARAALEGVCYQTRDVLTCMRDDSQLDLTLLR
ADGGMAVNQWFLQFMADQCQLTIQKPKDIETTAKGAAVLAAIGSGLFDSVSSVNKVWDVENEFQPSREREVVEKDFRGWL
EALAMVKARHA
>Mature_491_residues
MNYILAIDQGTSSTRAMIYTLQGDLIANSQYPLTQYYPNLGWVEHDPEEIWQKTLNAMRDVVSQVQGKAILCCGLTNQRE
TTLIWNKKTGECLAPAIVWQDRRTEEFCYSLSEYSSMIQEKTGLLPDPYFSASKLNWLLKNNAQAQSLINQGDLAFGTID
SFLIWRMTKGASHATDITNASRTMLFNIHDEKWDKQLLELFSISESILPEVYSSDNHFGVIDKEWLGVEIPITGVAGDQQ
AALIGQGCFNGGMVKATFGTGGFLLLNTGDKPVFSKHKLLTTIAYKIKEKTAYGLEGSIYHAGTTVKWLRDEMKLISHSA
ETEVLAQSLDSNNGVYLVSSFTGLGAPHWLSITGTAIIGVSRSTNRAHFARAALEGVCYQTRDVLTCMRDDSQLDLTLLR
ADGGMAVNQWFLQFMADQCQLTIQKPKDIETTAKGAAVLAAIGSGLFDSVSSVNKVWDVENEFQPSREREVVEKDFRGWL
EALAMVKARHA

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI4504007, Length=502, Percent_Identity=42.2310756972112, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI189409120, Length=502, Percent_Identity=42.2310756972112, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI42794763, Length=507, Percent_Identity=41.8145956607495, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI41393575, Length=442, Percent_Identity=44.5701357466063, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI88196792, Length=501, Percent_Identity=31.5369261477046, Blast_Score=278, Evalue=7e-75,
Organism=Escherichia coli, GI1790361, Length=493, Percent_Identity=44.421906693712, Blast_Score=431, Evalue=1e-122,
Organism=Escherichia coli, GI1789987, Length=486, Percent_Identity=24.6913580246914, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1789168, Length=493, Percent_Identity=24.1379310344828, Blast_Score=92, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17535599, Length=447, Percent_Identity=38.7024608501119, Blast_Score=323, Evalue=9e-89,
Organism=Caenorhabditis elegans, GI71986140, Length=511, Percent_Identity=23.091976516634, Blast_Score=165, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI71986147, Length=287, Percent_Identity=26.8292682926829, Blast_Score=112, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6321755, Length=484, Percent_Identity=33.4710743801653, Blast_Score=259, Evalue=9e-70,
Organism=Drosophila melanogaster, GI17864214, Length=491, Percent_Identity=39.918533604888, Blast_Score=327, Evalue=1e-89,
Organism=Drosophila melanogaster, GI24655555, Length=452, Percent_Identity=37.6106194690265, Blast_Score=318, Evalue=8e-87,
Organism=Drosophila melanogaster, GI24655560, Length=452, Percent_Identity=37.6106194690265, Blast_Score=318, Evalue=8e-87,
Organism=Drosophila melanogaster, GI24655570, Length=452, Percent_Identity=37.6106194690265, Blast_Score=318, Evalue=8e-87,
Organism=Drosophila melanogaster, GI24655574, Length=452, Percent_Identity=37.6106194690265, Blast_Score=318, Evalue=8e-87,
Organism=Drosophila melanogaster, GI24655565, Length=452, Percent_Identity=37.6106194690265, Blast_Score=318, Evalue=8e-87,
Organism=Drosophila melanogaster, GI24654573, Length=419, Percent_Identity=41.2887828162291, Blast_Score=307, Evalue=9e-84,
Organism=Drosophila melanogaster, GI19922058, Length=527, Percent_Identity=29.2220113851992, Blast_Score=228, Evalue=9e-60,
Organism=Drosophila melanogaster, GI24652871, Length=494, Percent_Identity=29.3522267206478, Blast_Score=216, Evalue=3e-56,
Organism=Drosophila melanogaster, GI21357867, Length=528, Percent_Identity=27.4621212121212, Blast_Score=211, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24656367, Length=508, Percent_Identity=27.5590551181102, Blast_Score=207, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24656372, Length=371, Percent_Identity=28.8409703504043, Blast_Score=169, Evalue=5e-42,
Organism=Drosophila melanogaster, GI45552909, Length=286, Percent_Identity=29.3706293706294, Blast_Score=126, Evalue=3e-29,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 54546; Mature: 54546

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS00933 FGGY_KINASES_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYILAIDQGTSSTRAMIYTLQGDLIANSQYPLTQYYPNLGWVEHDPEEIWQKTLNAMRD
CCEEEEEECCCCCCEEEEEEEECCEEECCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHH
VVSQVQGKAILCCGLTNQRETTLIWNKKTGECLAPAIVWQDRRTEEFCYSLSEYSSMIQE
HHHHHCCCEEEEEECCCCCCEEEEEECCCCCHHCHHHEECCCCHHHHHHHHHHHHHHHHH
KTGLLPDPYFSASKLNWLLKNNAQAQSLINQGDLAFGTIDSFLIWRMTKGASHATDITNA
HHCCCCCCCCCHHHHHHHHCCCCHHHHHHCCCCEEEHHHHHHHHHHCCCCCCCCCCCCCC
SRTMLFNIHDEKWDKQLLELFSISESILPEVYSSDNHFGVIDKEWLGVEIPITGVAGDQQ
CEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEECCCCCCC
AALIGQGCFNGGMVKATFGTGGFLLLNTGDKPVFSKHKLLTTIAYKIKEKTAYGLEGSIY
CEEEECCCCCCCEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEE
HAGTTVKWLRDEMKLISHSAETEVLAQSLDSNNGVYLVSSFTGLGAPHWLSITGTAIIGV
ECCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEEECEEEEEE
SRSTNRAHFARAALEGVCYQTRDVLTCMRDDSQLDLTLLRADGGMAVNQWFLQFMADQCQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHE
LTIQKPKDIETTAKGAAVLAAIGSGLFDSVSSVNKVWDVENEFQPSREREVVEKDFRGWL
EEECCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
EALAMVKARHA
HHHHHHHHCCC
>Mature Secondary Structure
MNYILAIDQGTSSTRAMIYTLQGDLIANSQYPLTQYYPNLGWVEHDPEEIWQKTLNAMRD
CCEEEEEECCCCCCEEEEEEEECCEEECCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHH
VVSQVQGKAILCCGLTNQRETTLIWNKKTGECLAPAIVWQDRRTEEFCYSLSEYSSMIQE
HHHHHCCCEEEEEECCCCCCEEEEEECCCCCHHCHHHEECCCCHHHHHHHHHHHHHHHHH
KTGLLPDPYFSASKLNWLLKNNAQAQSLINQGDLAFGTIDSFLIWRMTKGASHATDITNA
HHCCCCCCCCCHHHHHHHHCCCCHHHHHHCCCCEEEHHHHHHHHHHCCCCCCCCCCCCCC
SRTMLFNIHDEKWDKQLLELFSISESILPEVYSSDNHFGVIDKEWLGVEIPITGVAGDQQ
CEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEECCCCCCC
AALIGQGCFNGGMVKATFGTGGFLLLNTGDKPVFSKHKLLTTIAYKIKEKTAYGLEGSIY
CEEEECCCCCCCEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEE
HAGTTVKWLRDEMKLISHSAETEVLAQSLDSNNGVYLVSSFTGLGAPHWLSITGTAIIGV
ECCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEEECEEEEEE
SRSTNRAHFARAALEGVCYQTRDVLTCMRDDSQLDLTLLRADGGMAVNQWFLQFMADQCQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHE
LTIQKPKDIETTAKGAAVLAAIGSGLFDSVSSVNKVWDVENEFQPSREREVVEKDFRGWL
EEECCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
EALAMVKARHA
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA