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The map label for this gene is fadA [H]

Identifier: 54297262

GI number: 54297262

Start: 1457030

End: 1458214

Strand: Direct

Name: fadA [H]

Synonym: lpp1307

Alternate gene names: 54297262

Gene position: 1457030-1458214 (Clockwise)

Preceding gene: 54297261

Following gene: 54297265

Centisome position: 41.59

GC content: 41.01

Gene sequence:

>1185_bases
ATGACTGACGTATATGTAGTTGACGTATTACGTACACCAGTAGGTAAAGCACCAAGAGGTGTTTTTAAAAACACATTACC
CGATGATTTATTGGCTCATACTATTAAATGTTTAATACATAGACATCAAAACATTGATTGGCAAGAGATAGCTGACGTAG
TAATAGGTTGTGCAATGCCAGAAGCGGAACAAGGTATGAATGTAGCAAGAATCGCTTCTTTATTGGCTGATCTTCCACAA
TCTGTTCCAGCAATGACTATTAATCGTTTTTGCTCATCTGGCATACAAAGTATAGTTACTGCAGCAGATACAATCCGTAA
TCAGGAGGCTCATTTAGCACTAGGTGGCGGTGTCGAAAGCATGTCCATGGTACCTATGGGTGGAAATAAATACACGGCGA
ATCCATCTATTTTTAATGATGAGCACGTTGCTATAGCTTATGGCATGGGGATTACAGCAGAAAACGTTGCCAAGCGCTGG
GAAATTACTCGAGAACAACAGGATGAATTCGCCATAGAAAGCCATAAAAAAGCAATTGCTGCGCAGGAAAGACTCGATTT
CAACGCTGAAATAAGTCCAATCGAAATATCTATAAGATACCCTGATCTGAAAACTTCAAAGGTTGAAATAAAGAAAAAAT
TGATAAATAAGGACGAAGGCCCAAGAGCAGACACATCTTACGAAGCGATTTCTAAATTAAAACCAGTATTTGCTTTAAAC
GGGACAGTGACTGCAGGAAATAGTTCTCAGACGAGTGACGGAGCTGGAGTGGCATTACTAGCTAGTGAGAAGGCTTTAAA
ACAGTATGATTTAAAACCTTTAGGCCGTTTAATGAGCTATGCCGTTGCGGGAGTACCGCCTGAAATCATGGGAATCGGAC
CAGTAAAGGCAATTCCTATGGCGCTAAAGCGTGCTGGAATTACTTTAGATCAATTGGATTGGATTGAATTGAATGAAGCT
TTTGCTGCCCAAGCTTTGGCAGTTATTAAAGACCTTGACTTACCTAGAGAGAAAGTTAACCCTTTAGGAGGGGCTATTGC
TTTGGGACATCCTTTAGGAGCAACGGGCACCATAAGAACAGCTACATTACTACATGGATTGAGAAGAATAAAAGGGCGCT
ACGGTATGGTAACCATGTGTATTGGAACCGGAATGGGAGCTGCTGCGATATTTGAAGCGCTATAA

Upstream 100 bases:

>100_bases
AGCATTCATAAAATTAGCCAATACATCATTAACCCAAGCCAGAATCAGTCATCTGCTAGAGACTGGTAAACCACTGCGCA
ACTAAGCAAGGAGAATTAGG

Downstream 100 bases:

>100_bases
ATATATCATTTTAATCCAATCTATAATGCTAGTATAAGACGTTCTTGGCACCAAGCAAAGCTTGGTGCCAAGAACTGATT
AGTATCAGCAGATTTGAACT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MTDVYVVDVLRTPVGKAPRGVFKNTLPDDLLAHTIKCLIHRHQNIDWQEIADVVIGCAMPEAEQGMNVARIASLLADLPQ
SVPAMTINRFCSSGIQSIVTAADTIRNQEAHLALGGGVESMSMVPMGGNKYTANPSIFNDEHVAIAYGMGITAENVAKRW
EITREQQDEFAIESHKKAIAAQERLDFNAEISPIEISIRYPDLKTSKVEIKKKLINKDEGPRADTSYEAISKLKPVFALN
GTVTAGNSSQTSDGAGVALLASEKALKQYDLKPLGRLMSYAVAGVPPEIMGIGPVKAIPMALKRAGITLDQLDWIELNEA
FAAQALAVIKDLDLPREKVNPLGGAIALGHPLGATGTIRTATLLHGLRRIKGRYGMVTMCIGTGMGAAAIFEAL

Sequences:

>Translated_394_residues
MTDVYVVDVLRTPVGKAPRGVFKNTLPDDLLAHTIKCLIHRHQNIDWQEIADVVIGCAMPEAEQGMNVARIASLLADLPQ
SVPAMTINRFCSSGIQSIVTAADTIRNQEAHLALGGGVESMSMVPMGGNKYTANPSIFNDEHVAIAYGMGITAENVAKRW
EITREQQDEFAIESHKKAIAAQERLDFNAEISPIEISIRYPDLKTSKVEIKKKLINKDEGPRADTSYEAISKLKPVFALN
GTVTAGNSSQTSDGAGVALLASEKALKQYDLKPLGRLMSYAVAGVPPEIMGIGPVKAIPMALKRAGITLDQLDWIELNEA
FAAQALAVIKDLDLPREKVNPLGGAIALGHPLGATGTIRTATLLHGLRRIKGRYGMVTMCIGTGMGAAAIFEAL
>Mature_393_residues
TDVYVVDVLRTPVGKAPRGVFKNTLPDDLLAHTIKCLIHRHQNIDWQEIADVVIGCAMPEAEQGMNVARIASLLADLPQS
VPAMTINRFCSSGIQSIVTAADTIRNQEAHLALGGGVESMSMVPMGGNKYTANPSIFNDEHVAIAYGMGITAENVAKRWE
ITREQQDEFAIESHKKAIAAQERLDFNAEISPIEISIRYPDLKTSKVEIKKKLINKDEGPRADTSYEAISKLKPVFALNG
TVTAGNSSQTSDGAGVALLASEKALKQYDLKPLGRLMSYAVAGVPPEIMGIGPVKAIPMALKRAGITLDQLDWIELNEAF
AAQALAVIKDLDLPREKVNPLGGAIALGHPLGATGTIRTATLLHGLRRIKGRYGMVTMCIGTGMGAAAIFEAL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=391, Percent_Identity=46.8030690537084, Blast_Score=332, Evalue=5e-91,
Organism=Homo sapiens, GI167614485, Length=403, Percent_Identity=40.9429280397022, Blast_Score=277, Evalue=1e-74,
Organism=Homo sapiens, GI148539872, Length=397, Percent_Identity=38.7909319899244, Blast_Score=235, Evalue=5e-62,
Organism=Homo sapiens, GI4557237, Length=406, Percent_Identity=32.7586206896552, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI4504327, Length=437, Percent_Identity=30.8924485125858, Blast_Score=169, Evalue=6e-42,
Organism=Homo sapiens, GI194353979, Length=244, Percent_Identity=35.655737704918, Blast_Score=140, Evalue=2e-33,
Organism=Escherichia coli, GI48994986, Length=397, Percent_Identity=43.3249370277078, Blast_Score=288, Evalue=3e-79,
Organism=Escherichia coli, GI1787663, Length=409, Percent_Identity=41.320293398533, Blast_Score=277, Evalue=1e-75,
Organism=Escherichia coli, GI1788554, Length=406, Percent_Identity=41.1330049261084, Blast_Score=260, Evalue=1e-70,
Organism=Escherichia coli, GI87082165, Length=409, Percent_Identity=36.6748166259169, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1788683, Length=438, Percent_Identity=31.5068493150685, Blast_Score=158, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI133906874, Length=402, Percent_Identity=38.5572139303483, Blast_Score=253, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI17535921, Length=407, Percent_Identity=35.6265356265356, Blast_Score=201, Evalue=8e-52,
Organism=Caenorhabditis elegans, GI25147385, Length=402, Percent_Identity=32.8358208955224, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17551802, Length=440, Percent_Identity=31.3636363636364, Blast_Score=177, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI17535917, Length=395, Percent_Identity=29.3670886075949, Blast_Score=140, Evalue=9e-34,
Organism=Saccharomyces cerevisiae, GI6322031, Length=401, Percent_Identity=40.6483790523691, Blast_Score=258, Evalue=1e-69,
Organism=Saccharomyces cerevisiae, GI6325229, Length=409, Percent_Identity=34.9633251833741, Blast_Score=206, Evalue=4e-54,
Organism=Drosophila melanogaster, GI24655093, Length=410, Percent_Identity=39.7560975609756, Blast_Score=268, Evalue=4e-72,
Organism=Drosophila melanogaster, GI17648125, Length=408, Percent_Identity=39.7058823529412, Blast_Score=254, Evalue=8e-68,
Organism=Drosophila melanogaster, GI24640423, Length=409, Percent_Identity=35.2078239608802, Blast_Score=203, Evalue=1e-52,
Organism=Drosophila melanogaster, GI17137578, Length=436, Percent_Identity=30.9633027522936, Blast_Score=164, Evalue=8e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 42287; Mature: 42156

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDVYVVDVLRTPVGKAPRGVFKNTLPDDLLAHTIKCLIHRHQNIDWQEIADVVIGCAMP
CCCEEEEEEHHCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
EAEQGMNVARIASLLADLPQSVPAMTINRFCSSGIQSIVTAADTIRNQEAHLALGGGVES
CHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCC
MSMVPMGGNKYTANPSIFNDEHVAIAYGMGITAENVAKRWEITREQQDEFAIESHKKAIA
CEEEECCCCEEECCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQERLDFNAEISPIEISIRYPDLKTSKVEIKKKLINKDEGPRADTSYEAISKLKPVFALN
HHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCEEEEC
GTVTAGNSSQTSDGAGVALLASEKALKQYDLKPLGRLMSYAVAGVPPEIMGIGPVKAIPM
CEEECCCCCCCCCCCCEEEEECHHHHHHCCCHHHHHHHHHHHHCCCHHHCCCCCHHHHHH
ALKRAGITLDQLDWIELNEAFAAQALAVIKDLDLPREKVNPLGGAIALGHPLGATGTIRT
HHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEEECCCCCCCCCHHH
ATLLHGLRRIKGRYGMVTMCIGTGMGAAAIFEAL
HHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHCC
>Mature Secondary Structure 
TDVYVVDVLRTPVGKAPRGVFKNTLPDDLLAHTIKCLIHRHQNIDWQEIADVVIGCAMP
CCEEEEEEHHCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
EAEQGMNVARIASLLADLPQSVPAMTINRFCSSGIQSIVTAADTIRNQEAHLALGGGVES
CHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCC
MSMVPMGGNKYTANPSIFNDEHVAIAYGMGITAENVAKRWEITREQQDEFAIESHKKAIA
CEEEECCCCEEECCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQERLDFNAEISPIEISIRYPDLKTSKVEIKKKLINKDEGPRADTSYEAISKLKPVFALN
HHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCEEEEC
GTVTAGNSSQTSDGAGVALLASEKALKQYDLKPLGRLMSYAVAGVPPEIMGIGPVKAIPM
CEEECCCCCCCCCCCCEEEEECHHHHHHCCCHHHHHHHHHHHHCCCHHHCCCCCHHHHHH
ALKRAGITLDQLDWIELNEAFAAQALAVIKDLDLPREKVNPLGGAIALGHPLGATGTIRT
HHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEEECCCCCCCCCHHH
ATLLHGLRRIKGRYGMVTMCIGTGMGAAAIFEAL
HHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]