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The map label for this gene is htrA [H]

Identifier: 54296924

GI number: 54296924

Start: 1071687

End: 1072778

Strand: Direct

Name: htrA [H]

Synonym: lpp0965

Alternate gene names: 54296924

Gene position: 1071687-1072778 (Clockwise)

Preceding gene: 54296923

Following gene: 54296925

Centisome position: 30.59

GC content: 39.93

Gene sequence:

>1092_bases
ATGGAGATGATGAGACAACAACGTAACTTATTACTTATCCCTTTTATTTTATGTTTTATTCTGGCAAGACCTGTTTTTAG
TTTAAACCTGGATGCTCTCCTTCCAGATGAACGGAATACAGTTGAAGTATTTCAAAAAGCCTCATCCAAAGTTGTTTATG
TTCATCGATTGGCAAATGCTACTGTTCAGCGTCGTTACTCATTACAAAAAACACATATTCCTGATGGGGCAGGCTCCGGT
ATTATTTGGGATAACAAAGGCCATGTTGTAACCAATTTTCATGTCATTAACGGTGCTGATGACATAGCAATCACTTTGGG
AAATATGACTGTTCCTGCCAAAGTGATTGGTTCAGAGCCTCGCAAGGACATTGCAGTCCTGGAAATTAAATCACCCAAGG
CTCTGAATTATTTAAAATCATTTCAGCCCTTTGAAATAGTCTCTCTTAATGATTTGATCGTTGGGCAAAAAGCGATTGCG
ATTGGGAATCCTTTTGGGTTAGATCATAGTCTATCAAAAGGGGTGATCTCCGCTTTAGGGAGAAAAGTCCCTGGTATAGG
CGGGGTAACAATTTATGATATGATCCAGACGGATACCCCTATCAATCCGGGTAATTCAGGGGGGCCTCTATTAAATAGCG
CAGGCCAATTAATTGGTATGAACACCATGATTTATTCACGATCGGGTTCTTCTGCAGGTATTGGTTTCGCAGTTCCCGCG
GAAGATATTCAGAAAATTGCATCTCAAATTATTAATCATGGTCGAGTGGTATTGTCTGGTATCGGTATTCAACGAGTTGA
GCCACATCTTGCTGAAAGGTTGGGAGTTAAAAAGGGTATTTTGATTGCTGATGTGGTGCCTGGAACTCCTGCAGACAAAT
TGAAGTTACGAGGTACTCACAGAAATCAATGGGGGCGTATTGTTTTAGGGGATGTTATTGTAGGTGTGAATGCACATCCT
GTCCCAAATTATGATGCTCTGTATAATTTGCTCACGGAAATTAAGGTGGGAGAGCAAATTACTGTTTCAATAATAAGGAA
TGGTAAGAAAATGGATGTCAAAATGAAAACAATTGATATTGCAGCGCTTTAA

Upstream 100 bases:

>100_bases
ATCATTACTATTACAGATTTTCCACAATCAGTAATTGATAAATTATTAGCGCGACAGGCATTTCGCAAGAGATTTGCCAG
CCGTGCAGGTATGGAGTTAA

Downstream 100 bases:

>100_bases
CTCTCTTCATTTTTTCTAACTATTATTTCCCCGGAAAAGAATAATACGTCAATCCGGGGTTCACTCACTTTTCTTAATGC
TATATGATATAGTTCAATAA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MEMMRQQRNLLLIPFILCFILARPVFSLNLDALLPDERNTVEVFQKASSKVVYVHRLANATVQRRYSLQKTHIPDGAGSG
IIWDNKGHVVTNFHVINGADDIAITLGNMTVPAKVIGSEPRKDIAVLEIKSPKALNYLKSFQPFEIVSLNDLIVGQKAIA
IGNPFGLDHSLSKGVISALGRKVPGIGGVTIYDMIQTDTPINPGNSGGPLLNSAGQLIGMNTMIYSRSGSSAGIGFAVPA
EDIQKIASQIINHGRVVLSGIGIQRVEPHLAERLGVKKGILIADVVPGTPADKLKLRGTHRNQWGRIVLGDVIVGVNAHP
VPNYDALYNLLTEIKVGEQITVSIIRNGKKMDVKMKTIDIAAL

Sequences:

>Translated_363_residues
MEMMRQQRNLLLIPFILCFILARPVFSLNLDALLPDERNTVEVFQKASSKVVYVHRLANATVQRRYSLQKTHIPDGAGSG
IIWDNKGHVVTNFHVINGADDIAITLGNMTVPAKVIGSEPRKDIAVLEIKSPKALNYLKSFQPFEIVSLNDLIVGQKAIA
IGNPFGLDHSLSKGVISALGRKVPGIGGVTIYDMIQTDTPINPGNSGGPLLNSAGQLIGMNTMIYSRSGSSAGIGFAVPA
EDIQKIASQIINHGRVVLSGIGIQRVEPHLAERLGVKKGILIADVVPGTPADKLKLRGTHRNQWGRIVLGDVIVGVNAHP
VPNYDALYNLLTEIKVGEQITVSIIRNGKKMDVKMKTIDIAAL
>Mature_363_residues
MEMMRQQRNLLLIPFILCFILARPVFSLNLDALLPDERNTVEVFQKASSKVVYVHRLANATVQRRYSLQKTHIPDGAGSG
IIWDNKGHVVTNFHVINGADDIAITLGNMTVPAKVIGSEPRKDIAVLEIKSPKALNYLKSFQPFEIVSLNDLIVGQKAIA
IGNPFGLDHSLSKGVISALGRKVPGIGGVTIYDMIQTDTPINPGNSGGPLLNSAGQLIGMNTMIYSRSGSSAGIGFAVPA
EDIQKIASQIINHGRVVLSGIGIQRVEPHLAERLGVKKGILIADVVPGTPADKLKLRGTHRNQWGRIVLGDVIVGVNAHP
VPNYDALYNLLTEIKVGEQITVSIIRNGKKMDVKMKTIDIAAL

Specific function: A putative protease, its function overlaps that of the related putative proteases HhoA and HhoB [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential). Cell outer membrane (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=334, Percent_Identity=29.0419161676647, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI4506141, Length=297, Percent_Identity=29.2929292929293, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI7019477, Length=327, Percent_Identity=28.4403669724771, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI24308541, Length=266, Percent_Identity=28.1954887218045, Blast_Score=86, Evalue=4e-17,
Organism=Escherichia coli, GI1786356, Length=285, Percent_Identity=36.4912280701754, Blast_Score=174, Evalue=9e-45,
Organism=Escherichia coli, GI1789629, Length=291, Percent_Identity=36.7697594501718, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1789630, Length=286, Percent_Identity=32.8671328671329, Blast_Score=134, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24646839, Length=306, Percent_Identity=24.8366013071895, Blast_Score=79, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 39213; Mature: 39213

Theoretical pI: Translated: 10.17; Mature: 10.17

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEMMRQQRNLLLIPFILCFILARPVFSLNLDALLPDERNTVEVFQKASSKVVYVHRLANA
CCCHHHHCCEEEHHHHHHHHHHCCHHEECCCEECCCCCCHHHHHHHCCCCEEEEEEHHHH
TVQRRYSLQKTHIPDGAGSGIIWDNKGHVVTNFHVINGADDIAITLGNMTVPAKVIGSEP
HHHHHHHHHHCCCCCCCCCCEEECCCCCEEEEEEEECCCCCEEEEECCEECCHHHCCCCC
RKDIAVLEIKSPKALNYLKSFQPFEIVSLNDLIVGQKAIAIGNPFGLDHSLSKGVISALG
CCCEEEEEECCCHHHHHHHCCCCEEEEEECCEEECCEEEEECCCCCCCCHHHHHHHHHHH
RKVPGIGGVTIYDMIQTDTPINPGNSGGPLLNSAGQLIGMNTMIYSRSGSSAGIGFAVPA
HCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHCCCCEEEEEEEEEECCCCCCCCEEECCH
EDIQKIASQIINHGRVVLSGIGIQRVEPHLAERLGVKKGILIADVVPGTPADKLKLRGTH
HHHHHHHHHHHHCCEEEEEECCCHHCCHHHHHHCCCCCCEEEEEECCCCCCCCEEEECCC
RNQWGRIVLGDVIVGVNAHPVPNYDALYNLLTEIKVGEQITVSIIRNGKKMDVKMKTIDI
CCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEECCCEEEEEEEEEEE
AAL
EEC
>Mature Secondary Structure
MEMMRQQRNLLLIPFILCFILARPVFSLNLDALLPDERNTVEVFQKASSKVVYVHRLANA
CCCHHHHCCEEEHHHHHHHHHHCCHHEECCCEECCCCCCHHHHHHHCCCCEEEEEEHHHH
TVQRRYSLQKTHIPDGAGSGIIWDNKGHVVTNFHVINGADDIAITLGNMTVPAKVIGSEP
HHHHHHHHHHCCCCCCCCCCEEECCCCCEEEEEEEECCCCCEEEEECCEECCHHHCCCCC
RKDIAVLEIKSPKALNYLKSFQPFEIVSLNDLIVGQKAIAIGNPFGLDHSLSKGVISALG
CCCEEEEEECCCHHHHHHHCCCCEEEEEECCEEECCEEEEECCCCCCCCHHHHHHHHHHH
RKVPGIGGVTIYDMIQTDTPINPGNSGGPLLNSAGQLIGMNTMIYSRSGSSAGIGFAVPA
HCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHCCCCEEEEEEEEEECCCCCCCCEEECCH
EDIQKIASQIINHGRVVLSGIGIQRVEPHLAERLGVKKGILIADVVPGTPADKLKLRGTH
HHHHHHHHHHHHCCEEEEEECCCHHCCHHHHHHCCCCCCEEEEEECCCCCCCCEEEECCC
RNQWGRIVLGDVIVGVNAHPVPNYDALYNLLTEIKVGEQITVSIIRNGKKMDVKMKTIDI
CCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEECCCEEEEEEEEEEE
AAL
EEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]