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The map label for this gene is gltP [H]

Identifier: 54296906

GI number: 54296906

Start: 1050990

End: 1052270

Strand: Direct

Name: gltP [H]

Synonym: lpp0947

Alternate gene names: 54296906

Gene position: 1050990-1052270 (Clockwise)

Preceding gene: 54296905

Following gene: 54296911

Centisome position: 30.0

GC content: 37.47

Gene sequence:

>1281_bases
ATGTGTGCAGCACACCACCAAAAGAATAAATATATTTTTAGTACCCCACTAATTTATGCAGCGATGATTGGACTTGGGAT
AATAAGTGGATTATCCGATTTGCCTTTTTTAAAGGAAACAGGGCTTTTAATTTCTGATTTGTTTATTAAATTGTTCAAGT
GCATTAGTTTACCAATTATTTCCTTGTCGATTATTGTAACTCTGGCAAACTATCAAACGGATAGTTTGATGAAAAGTGTA
TGGCAAAGAACAATTAAATATACTTTTGCTACAACTTTAGTTGCAGCATTAATCAGCTGTTTTCTATATATTTTGATTCA
TCCAAGCACTGTTCAAGTCAACTTGGATGCGGCGAACCCAAAATCCACCAGCAGTTTGGGATATCTTGGCTATTTGAGTA
ACATGATACCGACTAATTTATTATCTCCATTCCTGGAGCAACAGGTTATGGGGGTATTGTTGCTTAGTATTGTTATCGGT
TTTGCTGTTCGTCAAATACCGGAGACAGAGCCACGTGAAACTATTATTCGATTTTTCCGCGGTGCTCATGGGATGTTTTT
AGTGATGACCAAATGGATAATTAAATTAATACCTTTGGGGTTATTCGGGTTCATTACTTCTACTGTAATTCAGTTGCGAT
CGGGTATGGATATTAAAGGGATAGGTCAATACTTGGTGATTATTGTTTTAGCTAATTTGATACAAGGATTAGTCATTCTG
CCTTTATGGCTGAAATCAAATGGTATTAAACCATTCTCTTCGATGCGCGCAATGTTACCTGCGTTATCTGTTGCTTTTTT
TTCCAAGTCATCTGTCGGTACTTTGCCTGTTACAATGAATACTGTAGAGGCTAATTTAAAGGTTAACCCTCAAGTCAGCC
GTTTTGTTTTACCATTATGCACAAGCATTAATATGAATGGATGTGCCGCATTTATTTTTGCCACAGTCATTTATCTTATG
CAAAGTCACGGCATCCAGGTTTCTTATGCTACTATGGGGATATGGGTTTTAGTATCAACTATAGCGGCAATAGGTAATGC
CGGCGTTCCTATGGGCTGCTTTTTCTTAAGCGTTAGTTTACTTTCCAGTATGAATGTGCCCATCACGCTTATGGGAGTTA
TTCTTCCCTTCTATGGTTTGATTGATATGTTGGAAACTGCCTTAAACGTATGGTCTGATGCTTGTGTTACCAAGGTTGTT
AATGATAAAGCAGAAGTTGGTGATGGAGTGGTGGGCATTAGACCAAAAGAGCGTTCATTATTAAATGCCGAGTTAGGTTA
A

Upstream 100 bases:

>100_bases
TTATAATTCCTCATTATTTCACTCCATATATCAAGCCATCTGTTGTTGCTGCTAATCATACTTTGCTTAAATAATTAATT
AAAGTTTTAAGGATTCAGCT

Downstream 100 bases:

>100_bases
AGCCAGCAAATCTTCAAGCGCAAATGAGTATAGCTTACATATAAGTCTCCAGAAAATTTTTTTGAGACTTATATCTATGA
AATCAGTTTGTAATTTATAA

Product: hypothetical protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MCAAHHQKNKYIFSTPLIYAAMIGLGIISGLSDLPFLKETGLLISDLFIKLFKCISLPIISLSIIVTLANYQTDSLMKSV
WQRTIKYTFATTLVAALISCFLYILIHPSTVQVNLDAANPKSTSSLGYLGYLSNMIPTNLLSPFLEQQVMGVLLLSIVIG
FAVRQIPETEPRETIIRFFRGAHGMFLVMTKWIIKLIPLGLFGFITSTVIQLRSGMDIKGIGQYLVIIVLANLIQGLVIL
PLWLKSNGIKPFSSMRAMLPALSVAFFSKSSVGTLPVTMNTVEANLKVNPQVSRFVLPLCTSINMNGCAAFIFATVIYLM
QSHGIQVSYATMGIWVLVSTIAAIGNAGVPMGCFFLSVSLLSSMNVPITLMGVILPFYGLIDMLETALNVWSDACVTKVV
NDKAEVGDGVVGIRPKERSLLNAELG

Sequences:

>Translated_426_residues
MCAAHHQKNKYIFSTPLIYAAMIGLGIISGLSDLPFLKETGLLISDLFIKLFKCISLPIISLSIIVTLANYQTDSLMKSV
WQRTIKYTFATTLVAALISCFLYILIHPSTVQVNLDAANPKSTSSLGYLGYLSNMIPTNLLSPFLEQQVMGVLLLSIVIG
FAVRQIPETEPRETIIRFFRGAHGMFLVMTKWIIKLIPLGLFGFITSTVIQLRSGMDIKGIGQYLVIIVLANLIQGLVIL
PLWLKSNGIKPFSSMRAMLPALSVAFFSKSSVGTLPVTMNTVEANLKVNPQVSRFVLPLCTSINMNGCAAFIFATVIYLM
QSHGIQVSYATMGIWVLVSTIAAIGNAGVPMGCFFLSVSLLSSMNVPITLMGVILPFYGLIDMLETALNVWSDACVTKVV
NDKAEVGDGVVGIRPKERSLLNAELG
>Mature_426_residues
MCAAHHQKNKYIFSTPLIYAAMIGLGIISGLSDLPFLKETGLLISDLFIKLFKCISLPIISLSIIVTLANYQTDSLMKSV
WQRTIKYTFATTLVAALISCFLYILIHPSTVQVNLDAANPKSTSSLGYLGYLSNMIPTNLLSPFLEQQVMGVLLLSIVIG
FAVRQIPETEPRETIIRFFRGAHGMFLVMTKWIIKLIPLGLFGFITSTVIQLRSGMDIKGIGQYLVIIVLANLIQGLVIL
PLWLKSNGIKPFSSMRAMLPALSVAFFSKSSVGTLPVTMNTVEANLKVNPQVSRFVLPLCTSINMNGCAAFIFATVIYLM
QSHGIQVSYATMGIWVLVSTIAAIGNAGVPMGCFFLSVSLLSSMNVPITLMGVILPFYGLIDMLETALNVWSDACVTKVV
NDKAEVGDGVVGIRPKERSLLNAELG

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI223468566, Length=250, Percent_Identity=28.8, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI223468564, Length=250, Percent_Identity=28.8, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI5032093, Length=253, Percent_Identity=28.8537549407115, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI21314632, Length=252, Percent_Identity=26.5873015873016, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI66773030, Length=376, Percent_Identity=23.936170212766, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI40254478, Length=408, Percent_Identity=23.0392156862745, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI194239697, Length=414, Percent_Identity=23.4299516908213, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI169790839, Length=432, Percent_Identity=21.9907407407407, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI4827012, Length=279, Percent_Identity=24.0143369175627, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI262359914, Length=342, Percent_Identity=21.0526315789474, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI301601644, Length=121, Percent_Identity=28.9256198347107, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1790514, Length=366, Percent_Identity=24.5901639344262, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1789473, Length=387, Percent_Identity=25.8397932816537, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1788024, Length=368, Percent_Identity=25.2717391304348, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1789947, Length=366, Percent_Identity=19.3989071038251, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71983099, Length=404, Percent_Identity=25.990099009901, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71983106, Length=404, Percent_Identity=25.990099009901, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71996953, Length=416, Percent_Identity=25, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI193206505, Length=431, Percent_Identity=24.5939675174014, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17541374, Length=391, Percent_Identity=26.0869565217391, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17537407, Length=409, Percent_Identity=22.4938875305623, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI193206654, Length=405, Percent_Identity=23.9506172839506, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24583025, Length=394, Percent_Identity=22.5888324873096, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI17137668, Length=394, Percent_Identity=22.5888324873096, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24583023, Length=394, Percent_Identity=22.5888324873096, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI281360481, Length=445, Percent_Identity=22.4719101123595, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI281360483, Length=445, Percent_Identity=22.4719101123595, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI17137666, Length=445, Percent_Identity=22.4719101123595, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 46386; Mature: 46386

Theoretical pI: Translated: 9.31; Mature: 9.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HCCCCC
>Mature Secondary Structure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HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]