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The map label for this gene is csrD [H]

Identifier: 54296850

GI number: 54296850

Start: 1000658

End: 1002577

Strand: Direct

Name: csrD [H]

Synonym: lpp0891

Alternate gene names: 54296850

Gene position: 1000658-1002577 (Clockwise)

Preceding gene: 54296849

Following gene: 54296851

Centisome position: 28.56

GC content: 37.14

Gene sequence:

>1920_bases
ATGACATTAACTAAGAAAATGGCTGTAGGCGTGTTGATTATGTTGTTATTCGTTTTTATCGGAACTTATTTCATCACTAT
GAATAATGCGCGTAATTTTTTTATCCAACAACTTGAAAGTAATGCTCAAGATACTGCGACATCATTAGGTTTGTCTTTAT
CTCAGTCTTTAATCAATCATGATGTACCTACCATGGATTCTATGGTTAAAGCTGTTTTTGACAGAGGATATTTTTCATCA
ATTAAAGTACAAGACATAAAAGGGAAAGTGATCATTTTAAAGAAACAATTGCCACAAGAAAGCGATATACCACAATGGTT
TGTGAACTTGATAAAATGGCCCTCGACTGAGAAGTCATCCTTAATTATGGATGGGTGGATGCAAGCAGGAGTTGTTTTAG
TCGCTAGTGATCCGAGCTATGTTTACGCCTCTTTGTGGCGTAATGCTGTAGAAATGGTAAACGCTTATCTGATTTTTGCG
TTAGTTGCTTTGGTTCTAAGCTATGGCTTTCTAAAATATTTATTGCAACCTTTAAAACGAGTCACAGCACAGGCTTTGGC
AATTTCAGAACATGAGTTTCCTGTAGAAACGAAGATTCCTAAAACTCCTGAATTGAGGCAAGTTACCTTGGCTATGAATC
AAATGGTTACTAAAGTCAAATCCTTATTTCAAGACCAATTAAAACAAACAGAATCACTTAGAACACAGGTTTACCAAGAT
TCATTAACAGGGATGAGTAATCGTCGTTATTTTTTACAGCATTTGGCTTTGATTCTGGATAATGAAGATGAATTTATACC
TGGTTATGTCATGATGCTGGTCATAGACGGTCTGGATGAGTTAAATCAGAAGCAAGGGTATCAGCAAGGGGATCAATTGG
TATTAACTGTAGCCAAAATATGTAAAAGCTATTGGAAGCAATCGTCTGTTAGTACATTGGCAAGAATTAACGGGACGACC
TTTGCCTTAATTAGTCATGAAAGGGATCCTTTGGTGTTTGAAAAGGAATGTCAGGAGTTTGAACAAATTTTGAGCCAAGG
TATCAATGATATTAAAATTTGCAAAATACACATGGGGGCTGCGAGTTATTTTCTCCACCAACCTGTCTCCAATCTGTTGT
CTACGGTAGATCAAGCGGTTAAAAAGGCTCGTGAAACCGGCGTATTTTATTGCCAGAAAGAGCATGATACTTATAAATAT
CCTCAGTTAATCAGCGGCGATGAAATTAGAAACTCATTGCAACAGAAAAAAATAAGCTTGTATGCGCAGGCAGTTACAGA
CGGTAAGAATTGTTTTCATAAAGAGGTCTTCGTTCGAATTCGCAACCAGGAAGGGGAGGAGTTAGGCGCTGGTTATTTTA
TACCAGTTGCTGAGAAATTAGGATTGGCCTATCCTATTGATCAGTATGTGCTCAATGAATTAACCGTCATGGACATTGCA
ACACATACCCATTTTGCTCTTAATATTTCAGAAGATACTTTAGCAAATAAAGTCAATAGCACTGGTTATTTGCGTCAATT
GGAAGACACTCCTGCAGCTGTCTTGAGAAATCTTTCACTGGAAATTAATGAGGCTCACGTTTTGTCACATTTTTCAAACT
CCAAGTTCTTTATCAAGCAAGCCAAAAAATTGGGGGTGACAGTTGGAATAGATCGTGTGGGTATTAAATTTTCTCCGTTG
CATTATTTGAGTGATTTAAACATAGATTATTTAAAGCTGCATGGGAGTCTGGTGACAGATATTGATGAAAATGAAAGCAA
GCAGTTTTTCATACATTATTTTAATGAAATGGCTAAAACGATGGATATTGCGGTGGTAGCAACTCAAGTGGAAAGCGAGG
CTCAATGGCAAGCATTACAAATAGTCCACATACCTTGGGGGCAGGGACGCTTTTTATCTTCTGTAGAATTAATAAAATAA

Upstream 100 bases:

>100_bases
TGCGAAAACAAGGGGAGAGAGTTCATTGATGGGGGATTCAAAAAGTTTGGGCAAGTGGGATGCTCTAATGAAACGTATGG
AATAAAAAAGGTGATAGACC

Downstream 100 bases:

>100_bases
CGAGATGAAAAACAGATTATTCTCAAGGCATTAAAATGAATTCGCGAATAGCCTTAAACCCGCCAGGTGCCTCTGTAAAA
TGGTACAAGAATAAGGTATG

Product: hypothetical protein

Products: NA

Alternate protein names: Regulator of CsrB and CsrC decay CsrD [H]

Number of amino acids: Translated: 639; Mature: 638

Protein sequence:

>639_residues
MTLTKKMAVGVLIMLLFVFIGTYFITMNNARNFFIQQLESNAQDTATSLGLSLSQSLINHDVPTMDSMVKAVFDRGYFSS
IKVQDIKGKVIILKKQLPQESDIPQWFVNLIKWPSTEKSSLIMDGWMQAGVVLVASDPSYVYASLWRNAVEMVNAYLIFA
LVALVLSYGFLKYLLQPLKRVTAQALAISEHEFPVETKIPKTPELRQVTLAMNQMVTKVKSLFQDQLKQTESLRTQVYQD
SLTGMSNRRYFLQHLALILDNEDEFIPGYVMMLVIDGLDELNQKQGYQQGDQLVLTVAKICKSYWKQSSVSTLARINGTT
FALISHERDPLVFEKECQEFEQILSQGINDIKICKIHMGAASYFLHQPVSNLLSTVDQAVKKARETGVFYCQKEHDTYKY
PQLISGDEIRNSLQQKKISLYAQAVTDGKNCFHKEVFVRIRNQEGEELGAGYFIPVAEKLGLAYPIDQYVLNELTVMDIA
THTHFALNISEDTLANKVNSTGYLRQLEDTPAAVLRNLSLEINEAHVLSHFSNSKFFIKQAKKLGVTVGIDRVGIKFSPL
HYLSDLNIDYLKLHGSLVTDIDENESKQFFIHYFNEMAKTMDIAVVATQVESEAQWQALQIVHIPWGQGRFLSSVELIK

Sequences:

>Translated_639_residues
MTLTKKMAVGVLIMLLFVFIGTYFITMNNARNFFIQQLESNAQDTATSLGLSLSQSLINHDVPTMDSMVKAVFDRGYFSS
IKVQDIKGKVIILKKQLPQESDIPQWFVNLIKWPSTEKSSLIMDGWMQAGVVLVASDPSYVYASLWRNAVEMVNAYLIFA
LVALVLSYGFLKYLLQPLKRVTAQALAISEHEFPVETKIPKTPELRQVTLAMNQMVTKVKSLFQDQLKQTESLRTQVYQD
SLTGMSNRRYFLQHLALILDNEDEFIPGYVMMLVIDGLDELNQKQGYQQGDQLVLTVAKICKSYWKQSSVSTLARINGTT
FALISHERDPLVFEKECQEFEQILSQGINDIKICKIHMGAASYFLHQPVSNLLSTVDQAVKKARETGVFYCQKEHDTYKY
PQLISGDEIRNSLQQKKISLYAQAVTDGKNCFHKEVFVRIRNQEGEELGAGYFIPVAEKLGLAYPIDQYVLNELTVMDIA
THTHFALNISEDTLANKVNSTGYLRQLEDTPAAVLRNLSLEINEAHVLSHFSNSKFFIKQAKKLGVTVGIDRVGIKFSPL
HYLSDLNIDYLKLHGSLVTDIDENESKQFFIHYFNEMAKTMDIAVVATQVESEAQWQALQIVHIPWGQGRFLSSVELIK
>Mature_638_residues
TLTKKMAVGVLIMLLFVFIGTYFITMNNARNFFIQQLESNAQDTATSLGLSLSQSLINHDVPTMDSMVKAVFDRGYFSSI
KVQDIKGKVIILKKQLPQESDIPQWFVNLIKWPSTEKSSLIMDGWMQAGVVLVASDPSYVYASLWRNAVEMVNAYLIFAL
VALVLSYGFLKYLLQPLKRVTAQALAISEHEFPVETKIPKTPELRQVTLAMNQMVTKVKSLFQDQLKQTESLRTQVYQDS
LTGMSNRRYFLQHLALILDNEDEFIPGYVMMLVIDGLDELNQKQGYQQGDQLVLTVAKICKSYWKQSSVSTLARINGTTF
ALISHERDPLVFEKECQEFEQILSQGINDIKICKIHMGAASYFLHQPVSNLLSTVDQAVKKARETGVFYCQKEHDTYKYP
QLISGDEIRNSLQQKKISLYAQAVTDGKNCFHKEVFVRIRNQEGEELGAGYFIPVAEKLGLAYPIDQYVLNELTVMDIAT
HTHFALNISEDTLANKVNSTGYLRQLEDTPAAVLRNLSLEINEAHVLSHFSNSKFFIKQAKKLGVTVGIDRVGIKFSPLH
YLSDLNIDYLKLHGSLVTDIDENESKQFFIHYFNEMAKTMDIAVVATQVESEAQWQALQIVHIPWGQGRFLSSVELIK

Specific function: Serves as a specificity factor required for RNase E- mediated decay of the small global regulatory RNAs CsrB and CsrC, it is probably not a nuclease. Nor does its activity involve c-di- GMP, despite its domain composition. Positively modulates motility ge

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GGDEF domain [H]

Homologues:

Organism=Escherichia coli, GI1789650, Length=526, Percent_Identity=22.8136882129278, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI87081921, Length=435, Percent_Identity=22.7586206896552, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1788849, Length=263, Percent_Identity=23.9543726235741, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1790496, Length=233, Percent_Identity=25.7510729613734, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI87082096, Length=238, Percent_Identity=27.7310924369748, Blast_Score=77, Evalue=5e-15,
Organism=Escherichia coli, GI87081845, Length=242, Percent_Identity=24.7933884297521, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI1787541, Length=404, Percent_Identity=23.2673267326733, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788956, Length=319, Percent_Identity=22.884012539185, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87081743, Length=232, Percent_Identity=24.5689655172414, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF [H]

EC number: NA

Molecular weight: Translated: 72485; Mature: 72353

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS50885 HAMP ; PS50883 EAL ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLTKKMAVGVLIMLLFVFIGTYFITMNNARNFFIQQLESNAQDTATSLGLSLSQSLINH
CCCHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
DVPTMDSMVKAVFDRGYFSSIKVQDIKGKVIILKKQLPQESDIPQWFVNLIKWPSTEKSS
CCCCHHHHHHHHHCCCCCCCEEEEECCCCEEEEECCCCCCCCCHHHHHHHHCCCCCCCCH
LIMDGWMQAGVVLVASDPSYVYASLWRNAVEMVNAYLIFALVALVLSYGFLKYLLQPLKR
HHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTAQALAISEHEFPVETKIPKTPELRQVTLAMNQMVTKVKSLFQDQLKQTESLRTQVYQD
HHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLTGMSNRRYFLQHLALILDNEDEFIPGYVMMLVIDGLDELNQKQGYQQGDQLVLTVAKI
HHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCHHHHHHHCCCCCCHHHHHHHHHH
CKSYWKQSSVSTLARINGTTFALISHERDPLVFEKECQEFEQILSQGINDIKICKIHMGA
HHHHHCCHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCH
ASYFLHQPVSNLLSTVDQAVKKARETGVFYCQKEHDTYKYPQLISGDEIRNSLQQKKISL
HHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
YAQAVTDGKNCFHKEVFVRIRNQEGEELGAGYFIPVAEKLGLAYPIDQYVLNELTVMDIA
HHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCEEEECHHHCCCCCCHHHHHHHHHHHEEEE
THTHFALNISEDTLANKVNSTGYLRQLEDTPAAVLRNLSLEINEAHVLSHFSNSKFFIKQ
ECCEEEEECCHHHHHHHCCCCHHHHHHCCCHHHHHHHCCCEECHHHHHHHCCCCHHHHHH
AKKLGVTVGIDRVGIKFSPLHYLSDLNIDYLKLHGSLVTDIDENESKQFFIHYFNEMAKT
HHHCCEEEEEECCCCEECCHHHHHCCCEEEEEECCCEEECCCCCCCHHHHHHHHHHHHHH
MDIAVVATQVESEAQWQALQIVHIPWGQGRFLSSVELIK
HHHHHEEHHHHCCCCEEEEEEEECCCCCCCHHCCHHHCC
>Mature Secondary Structure 
TLTKKMAVGVLIMLLFVFIGTYFITMNNARNFFIQQLESNAQDTATSLGLSLSQSLINH
CCHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
DVPTMDSMVKAVFDRGYFSSIKVQDIKGKVIILKKQLPQESDIPQWFVNLIKWPSTEKSS
CCCCHHHHHHHHHCCCCCCCEEEEECCCCEEEEECCCCCCCCCHHHHHHHHCCCCCCCCH
LIMDGWMQAGVVLVASDPSYVYASLWRNAVEMVNAYLIFALVALVLSYGFLKYLLQPLKR
HHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTAQALAISEHEFPVETKIPKTPELRQVTLAMNQMVTKVKSLFQDQLKQTESLRTQVYQD
HHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLTGMSNRRYFLQHLALILDNEDEFIPGYVMMLVIDGLDELNQKQGYQQGDQLVLTVAKI
HHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCHHHHHHHCCCCCCHHHHHHHHHH
CKSYWKQSSVSTLARINGTTFALISHERDPLVFEKECQEFEQILSQGINDIKICKIHMGA
HHHHHCCHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCH
ASYFLHQPVSNLLSTVDQAVKKARETGVFYCQKEHDTYKYPQLISGDEIRNSLQQKKISL
HHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
YAQAVTDGKNCFHKEVFVRIRNQEGEELGAGYFIPVAEKLGLAYPIDQYVLNELTVMDIA
HHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCEEEECHHHCCCCCCHHHHHHHHHHHEEEE
THTHFALNISEDTLANKVNSTGYLRQLEDTPAAVLRNLSLEINEAHVLSHFSNSKFFIKQ
ECCEEEEECCHHHHHHHCCCCHHHHHHCCCHHHHHHHCCCEECHHHHHHHCCCCHHHHHH
AKKLGVTVGIDRVGIKFSPLHYLSDLNIDYLKLHGSLVTDIDENESKQFFIHYFNEMAKT
HHHCCEEEEEECCCCEECCHHHHHCCCEEEEEECCCEEECCCCCCCHHHHHHHHHHHHHH
MDIAVVATQVESEAQWQALQIVHIPWGQGRFLSSVELIK
HHHHHEEHHHHCCCCEEEEEEEECCCCCCCHHCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 3049542 [H]