Click here to switch to the map view.

The map label for this gene is clpA [H]

Identifier: 54296839

GI number: 54296839

Start: 988579

End: 990846

Strand: Direct

Name: clpA [H]

Synonym: lpp0880

Alternate gene names: 54296839

Gene position: 988579-990846 (Clockwise)

Preceding gene: 54296838

Following gene: 54296840

Centisome position: 28.22

GC content: 39.73

Gene sequence:

>2268_bases
ATGTTAAATAAAGAACTAGAATTCACCTTGAATCTAGCTTTCAAGGAAGCAAAAGAAAAGCGTCATGAGTTCATGACTGT
TGAACATTTGCTGTTGTCTTTGCTTGATAATCCAGCAGCAGGAAATGTATTACAAGCTTGTGATGCTAACATCGAGGCAT
TACGTCGTGATTTGATCGAATTTATTGATGAAACAACCCCAAGAATTCCTGAGGATGAATTGGACAGGGAAACTCAACCA
ACATTAGGTTTTCAAAGGGTTTTACAGCGTGCAGTATTTCATGTGCAATCAGCAGGCAAAACGGAAGTCACTGGAGCTAA
TGTATTAGCCGCAATTTTTAGTGAGCAAGAAAGTCAGGCTGTATATTTTTTGCGACGTGAAAATATTACTCGCCTTGATG
TCATTAATTATATTTCTCATGGAGTGTCAAAATATCAAAACAATGATATGCATGAAAACATGAATTCATCTATGGAAGAA
GACATGATGACCCCTGAGGGTAATGAGTCTCCACTTGATAGTTATTGCACCAATCTCAACAGACGTGCAAAACAGGGCAA
GATAGATCCATTGATAGGGCGGCATGAAGAGATACAAAGAACTATACAAGTGCTTTGCAGACGCCGTAAAAATAATCCTT
TATTAGTTGGCGAGGCAGGTGTAGGTAAAACTGCTATCGCAGAAGGTTTGGCCAGACGTATAGTGGATGGTGAAATCCCA
GATTCCATAAGAGGCTGCGTAGTCTACTCTCTTGATTTGGGCGCGTTATTGGCAGGAACGAAATACAGAGGGGATTTTGA
AAAACGATTGAAAGCTGTGCTGAAACAGTTGGGTCAGCAAGAAGGAGCCATTTTATTCATAGATGAAATTCACACCATTA
TTGGAGCAGGTGCTGCATCTGGAGGAGTCATGGATGCTTCCAACCTGATTAAGCCATTATTGGCAAATGGTGAATTGAAA
TGTATTGGCTCAACTACTTATCAGGAATATCGTGGAATATTTGAAAAAGACAGGGCCTTGGCAAGACGATTCCAAAAAAT
TGATATTTCAGAACCAACAATCGATGAAACTTTTGAAATATTAAAAGGATTAAAAGGCAAATTGGAAGCTCACCATGGAG
TAAAATTTTCAATTCCTTCATTAAAAGCGGCAGCAGAATTATCTGCAAAATACATCAATGATCGATTTTTGCCTGACAAA
GCGATTGATGTGGTGGATGAAGCGGGCGCTTATCAGAATTTATTGACGGCAAATAAACGTAAAAAAATTATAAGCGTGAC
TGAAATCGAGAGTGTTGTCGCAAAAATTGCTCGTATCCCAATTAAAAAGGTATCTGCGCGCGACAAAGATACTCTGCGTA
ACCTGGAACGTGATTTAAAATTATTGGTCTATGGTCAAGACCAGGCAATTACTGCCTTGGCTTCAGCAATCAAATTGGGT
AGATCCGGACTTAGAGAACCTCAGAAGCCAGTAGGTTGTTTCTTGTTTGCCGGACCAACTGGTGTAGGAAAGACAGAGGT
AACAAGGCAACTGGCTAATGTGTTAGGCATAGAGTTGCTGCGTTTTGATATGTCTGAGTACATGGAAAAACACACTGTTT
CACGTTTGATAGGAGCACCTCCTGGCTATGTAGGATACGATCAAGGTGGTTTATTGACTGAAGCCGTGACTAAGAATCCA
CATGCTGTTCTGCTACTTGATGAAATAGAAAAAGCACATCCTGATGTCTTTAATTTATTGTTGCAGATAATGGATCATGG
CACTTTAACTGATACCAACGGTCGTCAAGCTGATTTCAGACATATCATACTTGTAATGACCAGTAACGCAGGGGCCAGTG
AAATTGTTCGTAACTCCATAGGTTTTTCAACGCAAGACAATACCAATGATGGGTTGGAAGTAATTAAAAAGCAATTCAGT
CCTGAGTTTAGGAACCGTTTGGATGCTATTATCAATTTTGCACCGTTAGATACTCAGACTATAGGACTAGTTGTTGATAA
ATTCATTATGGAGTTGGATGAACAATTAAGTCATAAAGGCGTTACTTTTACAGTTGATAAGTCAGCCAGGGAATGGCTGA
TGGAGCATGGTTATGATAAAGCCATGGGAGCACGACCTATGGCCAGATTGATTCAGGAAAATATCAAAAAGCCTCTTGCT
GATGAACTGTTGTTTGGTAAATTAATGCATGGTGGTCATGTCACTTTGCGAGTGAAAGACGGTAAACTGCATTTTGACAG
TCATGATCATAGAGAAGGTGTTTGTTAA

Upstream 100 bases:

>100_bases
GTCGCCCTGGTAAATGAATACGCCAGAATGAATCAACATCCATTATTATCTAGTATGGAACCGGAGTAAACTGGTGGTGG
GTTGGTAAGGAGCAATGACA

Downstream 100 bases:

>100_bases
ACGGAAACCCTCTTCAGTTCTGTGCATGACAAATTTTTTGTTATGCACAGACAAAATCACAATAATTATGAGATAGTAAT
TGTCATTAACCTGTTAGTTG

Product: ATP-dependent Clp protease ATP-binding subunit ClpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 755; Mature: 755

Protein sequence:

>755_residues
MLNKELEFTLNLAFKEAKEKRHEFMTVEHLLLSLLDNPAAGNVLQACDANIEALRRDLIEFIDETTPRIPEDELDRETQP
TLGFQRVLQRAVFHVQSAGKTEVTGANVLAAIFSEQESQAVYFLRRENITRLDVINYISHGVSKYQNNDMHENMNSSMEE
DMMTPEGNESPLDSYCTNLNRRAKQGKIDPLIGRHEEIQRTIQVLCRRRKNNPLLVGEAGVGKTAIAEGLARRIVDGEIP
DSIRGCVVYSLDLGALLAGTKYRGDFEKRLKAVLKQLGQQEGAILFIDEIHTIIGAGAASGGVMDASNLIKPLLANGELK
CIGSTTYQEYRGIFEKDRALARRFQKIDISEPTIDETFEILKGLKGKLEAHHGVKFSIPSLKAAAELSAKYINDRFLPDK
AIDVVDEAGAYQNLLTANKRKKIISVTEIESVVAKIARIPIKKVSARDKDTLRNLERDLKLLVYGQDQAITALASAIKLG
RSGLREPQKPVGCFLFAGPTGVGKTEVTRQLANVLGIELLRFDMSEYMEKHTVSRLIGAPPGYVGYDQGGLLTEAVTKNP
HAVLLLDEIEKAHPDVFNLLLQIMDHGTLTDTNGRQADFRHIILVMTSNAGASEIVRNSIGFSTQDNTNDGLEVIKKQFS
PEFRNRLDAIINFAPLDTQTIGLVVDKFIMELDEQLSHKGVTFTVDKSAREWLMEHGYDKAMGARPMARLIQENIKKPLA
DELLFGKLMHGGHVTLRVKDGKLHFDSHDHREGVC

Sequences:

>Translated_755_residues
MLNKELEFTLNLAFKEAKEKRHEFMTVEHLLLSLLDNPAAGNVLQACDANIEALRRDLIEFIDETTPRIPEDELDRETQP
TLGFQRVLQRAVFHVQSAGKTEVTGANVLAAIFSEQESQAVYFLRRENITRLDVINYISHGVSKYQNNDMHENMNSSMEE
DMMTPEGNESPLDSYCTNLNRRAKQGKIDPLIGRHEEIQRTIQVLCRRRKNNPLLVGEAGVGKTAIAEGLARRIVDGEIP
DSIRGCVVYSLDLGALLAGTKYRGDFEKRLKAVLKQLGQQEGAILFIDEIHTIIGAGAASGGVMDASNLIKPLLANGELK
CIGSTTYQEYRGIFEKDRALARRFQKIDISEPTIDETFEILKGLKGKLEAHHGVKFSIPSLKAAAELSAKYINDRFLPDK
AIDVVDEAGAYQNLLTANKRKKIISVTEIESVVAKIARIPIKKVSARDKDTLRNLERDLKLLVYGQDQAITALASAIKLG
RSGLREPQKPVGCFLFAGPTGVGKTEVTRQLANVLGIELLRFDMSEYMEKHTVSRLIGAPPGYVGYDQGGLLTEAVTKNP
HAVLLLDEIEKAHPDVFNLLLQIMDHGTLTDTNGRQADFRHIILVMTSNAGASEIVRNSIGFSTQDNTNDGLEVIKKQFS
PEFRNRLDAIINFAPLDTQTIGLVVDKFIMELDEQLSHKGVTFTVDKSAREWLMEHGYDKAMGARPMARLIQENIKKPLA
DELLFGKLMHGGHVTLRVKDGKLHFDSHDHREGVC
>Mature_755_residues
MLNKELEFTLNLAFKEAKEKRHEFMTVEHLLLSLLDNPAAGNVLQACDANIEALRRDLIEFIDETTPRIPEDELDRETQP
TLGFQRVLQRAVFHVQSAGKTEVTGANVLAAIFSEQESQAVYFLRRENITRLDVINYISHGVSKYQNNDMHENMNSSMEE
DMMTPEGNESPLDSYCTNLNRRAKQGKIDPLIGRHEEIQRTIQVLCRRRKNNPLLVGEAGVGKTAIAEGLARRIVDGEIP
DSIRGCVVYSLDLGALLAGTKYRGDFEKRLKAVLKQLGQQEGAILFIDEIHTIIGAGAASGGVMDASNLIKPLLANGELK
CIGSTTYQEYRGIFEKDRALARRFQKIDISEPTIDETFEILKGLKGKLEAHHGVKFSIPSLKAAAELSAKYINDRFLPDK
AIDVVDEAGAYQNLLTANKRKKIISVTEIESVVAKIARIPIKKVSARDKDTLRNLERDLKLLVYGQDQAITALASAIKLG
RSGLREPQKPVGCFLFAGPTGVGKTEVTRQLANVLGIELLRFDMSEYMEKHTVSRLIGAPPGYVGYDQGGLLTEAVTKNP
HAVLLLDEIEKAHPDVFNLLLQIMDHGTLTDTNGRQADFRHIILVMTSNAGASEIVRNSIGFSTQDNTNDGLEVIKKQFS
PEFRNRLDAIINFAPLDTQTIGLVVDKFIMELDEQLSHKGVTFTVDKSAREWLMEHGYDKAMGARPMARLIQENIKKPLA
DELLFGKLMHGGHVTLRVKDGKLHFDSHDHREGVC

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=317, Percent_Identity=31.8611987381703, Blast_Score=157, Evalue=5e-38,
Organism=Escherichia coli, GI1787109, Length=739, Percent_Identity=66.7117726657645, Blast_Score=1016, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=411, Percent_Identity=44.7688564476886, Blast_Score=305, Evalue=6e-84,
Organism=Saccharomyces cerevisiae, GI6320464, Length=327, Percent_Identity=45.565749235474, Blast_Score=280, Evalue=6e-76,
Organism=Saccharomyces cerevisiae, GI6323002, Length=419, Percent_Identity=39.3794749403341, Blast_Score=265, Evalue=2e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 84076; Mature: 84076

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNKELEFTLNLAFKEAKEKRHEFMTVEHLLLSLLDNPAAGNVLQACDANIEALRRDLIE
CCCCCEEHEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHHH
FIDETTPRIPEDELDRETQPTLGFQRVLQRAVFHVQSAGKTEVTGANVLAAIFSEQESQA
HHHHCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCE
VYFLRRENITRLDVINYISHGVSKYQNNDMHENMNSSMEEDMMTPEGNESPLDSYCTNLN
EEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHCCCCCCCCCCHHHHHHHHH
RRAKQGKIDPLIGRHEEIQRTIQVLCRRRKNNPLLVGEAGVGKTAIAEGLARRIVDGEIP
HHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCC
DSIRGCVVYSLDLGALLAGTKYRGDFEKRLKAVLKQLGQQEGAILFIDEIHTIIGAGAAS
CCCCCEEEEEECHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHCCCCC
GGVMDASNLIKPLLANGELKCIGSTTYQEYRGIFEKDRALARRFQKIDISEPTIDETFEI
CCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LKGLKGKLEAHHGVKFSIPSLKAAAELSAKYINDRFLPDKAIDVVDEAGAYQNLLTANKR
HHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHH
KKIISVTEIESVVAKIARIPIKKVSARDKDTLRNLERDLKLLVYGQDQAITALASAIKLG
HHHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHH
RSGLREPQKPVGCFLFAGPTGVGKTEVTRQLANVLGIELLRFDMSEYMEKHTVSRLIGAP
HHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PGYVGYDQGGLLTEAVTKNPHAVLLLDEIEKAHPDVFNLLLQIMDHGTLTDTNGRQADFR
CCCCCCCCCCCCHHHHCCCCCEEEEEHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCE
HIILVMTSNAGASEIVRNSIGFSTQDNTNDGLEVIKKQFSPEFRNRLDAIINFAPLDTQT
EEEEEEECCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHH
IGLVVDKFIMELDEQLSHKGVTFTVDKSAREWLMEHGYDKAMGARPMARLIQENIKKPLA
HHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHCHHH
DELLFGKLMHGGHVTLRVKDGKLHFDSHDHREGVC
HHHHHHHHHCCCEEEEEEECCEEECCCCCCCCCCC
>Mature Secondary Structure
MLNKELEFTLNLAFKEAKEKRHEFMTVEHLLLSLLDNPAAGNVLQACDANIEALRRDLIE
CCCCCEEHEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHHH
FIDETTPRIPEDELDRETQPTLGFQRVLQRAVFHVQSAGKTEVTGANVLAAIFSEQESQA
HHHHCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCE
VYFLRRENITRLDVINYISHGVSKYQNNDMHENMNSSMEEDMMTPEGNESPLDSYCTNLN
EEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHCCCCCCCCCCHHHHHHHHH
RRAKQGKIDPLIGRHEEIQRTIQVLCRRRKNNPLLVGEAGVGKTAIAEGLARRIVDGEIP
HHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCC
DSIRGCVVYSLDLGALLAGTKYRGDFEKRLKAVLKQLGQQEGAILFIDEIHTIIGAGAAS
CCCCCEEEEEECHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHCCCCC
GGVMDASNLIKPLLANGELKCIGSTTYQEYRGIFEKDRALARRFQKIDISEPTIDETFEI
CCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LKGLKGKLEAHHGVKFSIPSLKAAAELSAKYINDRFLPDKAIDVVDEAGAYQNLLTANKR
HHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHH
KKIISVTEIESVVAKIARIPIKKVSARDKDTLRNLERDLKLLVYGQDQAITALASAIKLG
HHHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHH
RSGLREPQKPVGCFLFAGPTGVGKTEVTRQLANVLGIELLRFDMSEYMEKHTVSRLIGAP
HHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PGYVGYDQGGLLTEAVTKNPHAVLLLDEIEKAHPDVFNLLLQIMDHGTLTDTNGRQADFR
CCCCCCCCCCCCHHHHCCCCCEEEEEHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCE
HIILVMTSNAGASEIVRNSIGFSTQDNTNDGLEVIKKQFSPEFRNRLDAIINFAPLDTQT
EEEEEEECCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHH
IGLVVDKFIMELDEQLSHKGVTFTVDKSAREWLMEHGYDKAMGARPMARLIQENIKKPLA
HHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHCHHH
DELLFGKLMHGGHVTLRVKDGKLHFDSHDHREGVC
HHHHHHHHHCCCEEEEEEECCEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]