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The map label for this gene is rmlD [C]

Identifier: 54296784

GI number: 54296784

Start: 920424

End: 921308

Strand: Direct

Name: rmlD [C]

Synonym: lpp0823

Alternate gene names: 54296784

Gene position: 920424-921308 (Clockwise)

Preceding gene: 54296783

Following gene: 54296785

Centisome position: 26.27

GC content: 38.08

Gene sequence:

>885_bases
ATGAAAATATTGGTTACAGGTGCTAATGGGCAAGTTGGTACCGAGATTATCAAGCGATTTTCTTCCTCTGAGCATGAAGT
ATATGCTTGTACCAGAGATATTCTAGATTGTTCCAAACTCGAACGGGTTCATGATGTGTTATCGGAAATCAAGCCGGATC
TTATCATTAATGCAGCAGCCTATACGGCTGTAGATAAGGCAGAGGATGAACCTGATTTGGCTCATATTGTGAACGCCGAA
TTTGTCTGTCGCCTGGTGAATTATTGTACCTTGAAAAACGTCCCCTTGATCCATCTTTCAACTGATTATGTATTTGATGG
AGAAAAGGAGGGAGCCTATCATGAAACCGATATTCCGCATCCAGTAAGTACCTATGGGCGCACGAAATGGGAAGGAGAAC
AGGCTATTTTATCCCAACTTAAAAAGTATATTATTTTGCGAGTTAGCTGGGTATTTGGTGAACAAGGGAAAAATTTTGTA
AAAACGATTTTAAATTTGGCTTCCAGCAGAAAAGAATTGAATATTGTTTCAGATCAATCGGGAAGGCCTACTTCAGCTCG
CGATATAGCAAGAGTACTATTTGAAATAGTACAGAAAATCAGACATTCTTCCTTTGACTATTGGGGGCTTTACCATTATG
CAGGGCAGGGTGTTACCAATTGGCATGAATTTGCAAACGTATTTCTTAATATGGCAAAAGAGAAACAGCTTCTCTTAACT
TTAACCGATTTAAATCCAATTAAGTCACAAGAATATCCTACTAGGGCAACAAGGCCTAAAAATTCGGTACTGGATACAAC
AAAGATAGAAACAATATTGGGTATAAAAAGCTGTAGTTGGAAAAATGATTTGCCAGATGTTATCGACCATTTTACAAAAA
AGTAA

Upstream 100 bases:

>100_bases
TTGGCCATTAGGAGAGCAGGTTCAATTGTCTCCAAAAGATGCTGCAGCCAAGCTTTTAAATTTAATAGATGCTGAACTTT
TACCGAGATATCAAGCCTAA

Downstream 100 bases:

>100_bases
GAATCTCACTATGAAAAATCAGATGAACAACCTTTTGGTAACTGGAGCTGCGGGCTTTATAGGAAGTAATTTTGTTAAAT
TTATGAACGATAAATACCCG

Product: dTDP-4-keto-L-rhamnose reductase

Products: NA

Alternate protein names: dTDP-4-keto-L-rhamnose reductase; dTDP-6-deoxy-L-lyxo-4-hexulose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MKILVTGANGQVGTEIIKRFSSSEHEVYACTRDILDCSKLERVHDVLSEIKPDLIINAAAYTAVDKAEDEPDLAHIVNAE
FVCRLVNYCTLKNVPLIHLSTDYVFDGEKEGAYHETDIPHPVSTYGRTKWEGEQAILSQLKKYIILRVSWVFGEQGKNFV
KTILNLASSRKELNIVSDQSGRPTSARDIARVLFEIVQKIRHSSFDYWGLYHYAGQGVTNWHEFANVFLNMAKEKQLLLT
LTDLNPIKSQEYPTRATRPKNSVLDTTKIETILGIKSCSWKNDLPDVIDHFTKK

Sequences:

>Translated_294_residues
MKILVTGANGQVGTEIIKRFSSSEHEVYACTRDILDCSKLERVHDVLSEIKPDLIINAAAYTAVDKAEDEPDLAHIVNAE
FVCRLVNYCTLKNVPLIHLSTDYVFDGEKEGAYHETDIPHPVSTYGRTKWEGEQAILSQLKKYIILRVSWVFGEQGKNFV
KTILNLASSRKELNIVSDQSGRPTSARDIARVLFEIVQKIRHSSFDYWGLYHYAGQGVTNWHEFANVFLNMAKEKQLLLT
LTDLNPIKSQEYPTRATRPKNSVLDTTKIETILGIKSCSWKNDLPDVIDHFTKK
>Mature_294_residues
MKILVTGANGQVGTEIIKRFSSSEHEVYACTRDILDCSKLERVHDVLSEIKPDLIINAAAYTAVDKAEDEPDLAHIVNAE
FVCRLVNYCTLKNVPLIHLSTDYVFDGEKEGAYHETDIPHPVSTYGRTKWEGEQAILSQLKKYIILRVSWVFGEQGKNFV
KTILNLASSRKELNIVSDQSGRPTSARDIARVLFEIVQKIRHSSFDYWGLYHYAGQGVTNWHEFANVFLNMAKEKQLLLT
LTDLNPIKSQEYPTRATRPKNSVLDTTKIETILGIKSCSWKNDLPDVIDHFTKK

Specific function: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. RmlD uses NADH and NADPH nearly equally well [H]

COG id: COG1091

COG function: function code M; dTDP-4-dehydrorhamnose reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family [H]

Homologues:

Organism=Homo sapiens, GI33519455, Length=311, Percent_Identity=29.2604501607717, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI11034825, Length=311, Percent_Identity=29.2604501607717, Blast_Score=113, Evalue=3e-25,
Organism=Escherichia coli, GI1788352, Length=288, Percent_Identity=36.8055555555556, Blast_Score=191, Evalue=4e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005913
- InterPro:   IPR016040 [H]

Pfam domain/function: PF04321 RmlD_sub_bind [H]

EC number: =1.1.1.133 [H]

Molecular weight: Translated: 33400; Mature: 33400

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILVTGANGQVGTEIIKRFSSSEHEVYACTRDILDCSKLERVHDVLSEIKPDLIINAAA
CEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHH
YTAVDKAEDEPDLAHIVNAEFVCRLVNYCTLKNVPLIHLSTDYVFDGEKEGAYHETDIPH
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCEEECCCCCCCCCCCCCCC
PVSTYGRTKWEGEQAILSQLKKYIILRVSWVFGEQGKNFVKTILNLASSRKELNIVSDQS
CHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEECCCC
GRPTSARDIARVLFEIVQKIRHSSFDYWGLYHYAGQGVTNWHEFANVFLNMAKEKQLLLT
CCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEE
LTDLNPIKSQEYPTRATRPKNSVLDTTKIETILGIKSCSWKNDLPDVIDHFTKK
EECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MKILVTGANGQVGTEIIKRFSSSEHEVYACTRDILDCSKLERVHDVLSEIKPDLIINAAA
CEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHH
YTAVDKAEDEPDLAHIVNAEFVCRLVNYCTLKNVPLIHLSTDYVFDGEKEGAYHETDIPH
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCEEECCCCCCCCCCCCCCC
PVSTYGRTKWEGEQAILSQLKKYIILRVSWVFGEQGKNFVKTILNLASSRKELNIVSDQS
CHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEECCCC
GRPTSARDIARVLFEIVQKIRHSSFDYWGLYHYAGQGVTNWHEFANVFLNMAKEKQLLLT
CCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEE
LTDLNPIKSQEYPTRATRPKNSVLDTTKIETILGIKSCSWKNDLPDVIDHFTKK
EECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]