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The map label for this gene is fadA11 [H]

Identifier: 54027434

GI number: 54027434

Start: 5778901

End: 5780223

Strand: Reverse

Name: fadA11 [H]

Synonym: nfa54600

Alternate gene names: 54027434

Gene position: 5780223-5778901 (Counterclockwise)

Preceding gene: 54027437

Following gene: 54027433

Centisome position: 96.0

GC content: 70.98

Gene sequence:

>1323_bases
GTGACCAGCAAAGCCCGTAGCGCCAAGAGCACGGCAAGCACTGCCAAGACCGCGCGCCCGGTCGCCATCGTTGGCGGCAA
CCGCATTCCGTTCGCTCGCTCCGATCGGGCGTACGCGAAGGCCAGCAACCAGGACATGTTCACCGCGGCGCTGGACGGCC
TGGTGAGCCGGTTCAACCTGCAGGGCGAGCGGCTGGGCATGGTCGTCGGCGGCGCCGTGCTCAAGCGCGTCGGCGAGCAC
GGCATGATCCGCGAGAGCGTGCTCGGCAGCAAGCTCTCGCCCTACACCCCGGCCCACGACCTGCAGCTGGCGTGTGGCAC
CGGCCTGCAGTCGATCGTCACCGTCGGCGACGCCATCGCGCTCGGCCGGATCGAGGCGGGCATCGGCGGCGGCACCGACA
CCACCTCGGACGCGCCGATCGGCGTCAGCGAGTCGATGCGCGAGTGGATGCTGCAGGCCAACCGCGCCAAGACCAACAAG
GACCGGCTCAAGCTGGTCGGTCAGCTGCGCCCGGGCATGCTCGGCATCGAGATCCCGCGCAACGCCGAACCGCGCACCGG
CCTGTCGATGGGCGAGCACGCCGCCATCACCGCCAAGGAGTTCGGCATCAGCCGCGAGGCGCAGGACGAGCTGGCCTACC
TCTCGCACAAGAACATGGCCGCCGCCTACGACCGGGGCTTCTTCGACGACCTGATCACCCCCTTCCTCGGTCTGACCCGC
GACGACAACCTGCGCCCCGACTCCTCGCTCGAGAAGCTGGCCAAGCTGAAGCCGGTCTTCGGCGTGCAGGCCGGTGACGC
GACCATGACCGCGGGCAACTCCACCCCGCTCACCGACGGCGCCTCCGCGGTGCTGCTCGCCAGCGAGGAGTGGGCCGCCG
AACGCAACCTGCCGGTGTTGGCCCGCCTGGTCGACAGCGAGGTCGCCGCGGTCGACTACGTGCACGGCCCGGACGGCCTG
CTGATGGCCCCCACCTACGCGGTGCCGCGCCTGCTCGCCCGCAACGGCCTGACCCTGCAGGACTTCGACTACTACGAGAT
CCACGAGGCGTTCGCCTCGGTCGTGCTCGCGACGCTGCAGGCCTGGGAGTCCGACCAGTACTGCAAGGAGCGGCTGGGCC
TGGACGGCGCGCTCGGCTCGATCGACCGCAGCAAGCTCAACGTCAACGGTTCCTCGCTGGCCGCGGGCCACCCGTTCGCG
GCCACCGGCGGCCGCATCGTCGCGGCCACCGCCAAGCAGCTCGCGGAGAACGGCGGCGGGCGCGCGCTGATCTCCATCTG
CGCGGCCGGCGGCCAGGGCGTGGTCGCGATCCTCGAGCGGTAA

Upstream 100 bases:

>100_bases
GTGCGTTCCGAACCACATTCGCGGGGTGCGGTGTCGACAACAAACTTACTCCAGAGTAAGTTTAATGTAAACCGCAGCGA
CGAGACCCTTGGAGACTCGA

Downstream 100 bases:

>100_bases
TCGCTCGGCGAATGCGCACAGGCGGCATCGGGAACCATCCTGGTGCCGCCTTTCTTTTCGTCGCGATGCAGCGCGATGCG
GCCTTGTGAGCTTTATCATC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: ACSs; Acetyl-CoA acyltransferase; Acyl-CoA ligase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 440; Mature: 439

Protein sequence:

>440_residues
MTSKARSAKSTASTAKTARPVAIVGGNRIPFARSDRAYAKASNQDMFTAALDGLVSRFNLQGERLGMVVGGAVLKRVGEH
GMIRESVLGSKLSPYTPAHDLQLACGTGLQSIVTVGDAIALGRIEAGIGGGTDTTSDAPIGVSESMREWMLQANRAKTNK
DRLKLVGQLRPGMLGIEIPRNAEPRTGLSMGEHAAITAKEFGISREAQDELAYLSHKNMAAAYDRGFFDDLITPFLGLTR
DDNLRPDSSLEKLAKLKPVFGVQAGDATMTAGNSTPLTDGASAVLLASEEWAAERNLPVLARLVDSEVAAVDYVHGPDGL
LMAPTYAVPRLLARNGLTLQDFDYYEIHEAFASVVLATLQAWESDQYCKERLGLDGALGSIDRSKLNVNGSSLAAGHPFA
ATGGRIVAATAKQLAENGGGRALISICAAGGQGVVAILER

Sequences:

>Translated_440_residues
MTSKARSAKSTASTAKTARPVAIVGGNRIPFARSDRAYAKASNQDMFTAALDGLVSRFNLQGERLGMVVGGAVLKRVGEH
GMIRESVLGSKLSPYTPAHDLQLACGTGLQSIVTVGDAIALGRIEAGIGGGTDTTSDAPIGVSESMREWMLQANRAKTNK
DRLKLVGQLRPGMLGIEIPRNAEPRTGLSMGEHAAITAKEFGISREAQDELAYLSHKNMAAAYDRGFFDDLITPFLGLTR
DDNLRPDSSLEKLAKLKPVFGVQAGDATMTAGNSTPLTDGASAVLLASEEWAAERNLPVLARLVDSEVAAVDYVHGPDGL
LMAPTYAVPRLLARNGLTLQDFDYYEIHEAFASVVLATLQAWESDQYCKERLGLDGALGSIDRSKLNVNGSSLAAGHPFA
ATGGRIVAATAKQLAENGGGRALISICAAGGQGVVAILER
>Mature_439_residues
TSKARSAKSTASTAKTARPVAIVGGNRIPFARSDRAYAKASNQDMFTAALDGLVSRFNLQGERLGMVVGGAVLKRVGEHG
MIRESVLGSKLSPYTPAHDLQLACGTGLQSIVTVGDAIALGRIEAGIGGGTDTTSDAPIGVSESMREWMLQANRAKTNKD
RLKLVGQLRPGMLGIEIPRNAEPRTGLSMGEHAAITAKEFGISREAQDELAYLSHKNMAAAYDRGFFDDLITPFLGLTRD
DNLRPDSSLEKLAKLKPVFGVQAGDATMTAGNSTPLTDGASAVLLASEEWAAERNLPVLARLVDSEVAAVDYVHGPDGLL
MAPTYAVPRLLARNGLTLQDFDYYEIHEAFASVVLATLQAWESDQYCKERLGLDGALGSIDRSKLNVNGSSLAAGHPFAA
TGGRIVAATAKQLAENGGGRALISICAAGGQGVVAILER

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4504327, Length=426, Percent_Identity=39.4366197183099, Blast_Score=271, Evalue=6e-73,
Organism=Homo sapiens, GI4501853, Length=434, Percent_Identity=30.4147465437788, Blast_Score=169, Evalue=6e-42,
Organism=Homo sapiens, GI167614485, Length=430, Percent_Identity=30.9302325581395, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI148539872, Length=429, Percent_Identity=28.2051282051282, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI4557237, Length=449, Percent_Identity=26.0579064587973, Blast_Score=139, Evalue=5e-33,
Organism=Escherichia coli, GI1788683, Length=425, Percent_Identity=39.7647058823529, Blast_Score=264, Evalue=1e-71,
Organism=Escherichia coli, GI87082165, Length=430, Percent_Identity=30.2325581395349, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1787663, Length=434, Percent_Identity=29.7235023041475, Blast_Score=141, Evalue=9e-35,
Organism=Escherichia coli, GI1788554, Length=436, Percent_Identity=30.045871559633, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI48994986, Length=434, Percent_Identity=27.8801843317972, Blast_Score=122, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17551802, Length=439, Percent_Identity=37.5854214123007, Blast_Score=266, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI133906874, Length=431, Percent_Identity=27.8422273781903, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI25147385, Length=429, Percent_Identity=25.6410256410256, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17535921, Length=430, Percent_Identity=27.2093023255814, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17535917, Length=435, Percent_Identity=21.6091954022989, Blast_Score=73, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6322031, Length=458, Percent_Identity=29.6943231441048, Blast_Score=157, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6325229, Length=369, Percent_Identity=29.2682926829268, Blast_Score=138, Evalue=2e-33,
Organism=Drosophila melanogaster, GI17137578, Length=431, Percent_Identity=39.4431554524362, Blast_Score=279, Evalue=3e-75,
Organism=Drosophila melanogaster, GI24655093, Length=430, Percent_Identity=27.2093023255814, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI17648125, Length=431, Percent_Identity=29.6983758700696, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24640423, Length=430, Percent_Identity=26.046511627907, Blast_Score=126, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012806
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 46333; Mature: 46202

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSKARSAKSTASTAKTARPVAIVGGNRIPFARSDRAYAKASNQDMFTAALDGLVSRFNL
CCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHCC
QGERLGMVVGGAVLKRVGEHGMIRESVLGSKLSPYTPAHDLQLACGTGLQSIVTVGDAIA
CCHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHE
LGRIEAGIGGGTDTTSDAPIGVSESMREWMLQANRAKTNKDRLKLVGQLRPGMLGIEIPR
ECCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEECCC
NAEPRTGLSMGEHAAITAKEFGISREAQDELAYLSHKNMAAAYDRGFFDDLITPFLGLTR
CCCCCCCCCCCCCCEEEHHHHCCCCHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHCCCC
DDNLRPDSSLEKLAKLKPVFGVQAGDATMTAGNSTPLTDGASAVLLASEEWAAERNLPVL
CCCCCCCHHHHHHHHHCHHHEECCCCCEEECCCCCCCCCCCCEEEEECHHHHHHCCCHHH
ARLVDSEVAAVDYVHGPDGLLMAPTYAVPRLLARNGLTLQDFDYYEIHEAFASVVLATLQ
HHHHHHHHHEEEEEECCCCEEECCHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHH
AWESDQYCKERLGLDGALGSIDRSKLNVNGSSLAAGHPFAATGGRIVAATAKQLAENGGG
HCCCHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCEEEHHHHHHHHHCCCC
RALISICAAGGQGVVAILER
EEEEEEECCCCCCEEEEECC
>Mature Secondary Structure 
TSKARSAKSTASTAKTARPVAIVGGNRIPFARSDRAYAKASNQDMFTAALDGLVSRFNL
CCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHCC
QGERLGMVVGGAVLKRVGEHGMIRESVLGSKLSPYTPAHDLQLACGTGLQSIVTVGDAIA
CCHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHE
LGRIEAGIGGGTDTTSDAPIGVSESMREWMLQANRAKTNKDRLKLVGQLRPGMLGIEIPR
ECCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEECCC
NAEPRTGLSMGEHAAITAKEFGISREAQDELAYLSHKNMAAAYDRGFFDDLITPFLGLTR
CCCCCCCCCCCCCCEEEHHHHCCCCHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHCCCC
DDNLRPDSSLEKLAKLKPVFGVQAGDATMTAGNSTPLTDGASAVLLASEEWAAERNLPVL
CCCCCCCHHHHHHHHHCHHHEECCCCCEEECCCCCCCCCCCCEEEEECHHHHHHCCCHHH
ARLVDSEVAAVDYVHGPDGLLMAPTYAVPRLLARNGLTLQDFDYYEIHEAFASVVLATLQ
HHHHHHHHHEEEEEECCCCEEECCHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHH
AWESDQYCKERLGLDGALGSIDRSKLNVNGSSLAAGHPFAATGGRIVAATAKQLAENGGG
HCCCHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCEEEHHHHHHHHHCCCC
RALISICAAGGQGVVAILER
EEEEEEECCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA