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The map label for this gene is groEL [H]

Identifier: 54027249

GI number: 54027249

Start: 5576327

End: 5577952

Strand: Reverse

Name: groEL [H]

Synonym: nfa52750

Alternate gene names: 54027249

Gene position: 5577952-5576327 (Counterclockwise)

Preceding gene: 54027250

Following gene: 54027248

Centisome position: 92.64

GC content: 68.88

Gene sequence:

>1626_bases
ATGGCCAAGACAATTGCGTATGACGAAGAGGCCCGCCGCGGCCTCGAGCGCGGTCTGAACAGCCTCGCCGACGCGGTCAA
GGTGACGCTGGGCCCCAAGGGTCGCAACGTTGTCCTGGAGAAGAAGTGGGGCGCCCCCACGATCACCAACGATGGTGTGT
CCATCGCCAAGGAGATCGAGCTGGAGGATCCCTACGAGAAGATCGGCGCCGAGCTGGTCAAGGAAGTCGCCAAGAAGACC
GACGACGTCGCGGGCGACGGCACCACCACCGCCACCGTGCTCGCCCAGGCGCTGGTGCGCGAGGGTCTGCGCAACGTGGC
CGCGGGCGCGAACCCGCTGGGCCTCAAGCGCGGCATCGAGAAGGCCGTCGAGGCCGTGACCGCCAAGCTGCTCGACACCG
CCAAGGAGGTCGAGACCAAGGAGCAGATCGCCGCCACCGCGGGCATCTCCGCGGGCGACGCGTCCATCGGTGAGCTGATC
GCCGAGGCCATGGACAAGGTCGGCAAGGAAGGCGTCATCACCGTCGAGGAGAGCAACACCTTCGGCCTCCAGCTGGAGCT
GACCGAGGGCATGCGCTTCGACAAGGGCTACATCTCCGGCTACTTCGTGACCGATCCCGAGCGTCAGGAAGCGGTCCTCG
AGGATCCCTACATCCTGCTCGTCGGCTCGAAGGTCTCCACCGTCAAGGACCTGCTGCCGCTGCTGGAGAAGGTCATCCAG
GCCGGCAAGCCGCTGCTGATCATCGCCGAGGACGTCGAGGGCGAGGCCCTGTCGACCCTGGTCGTGAACAAGATCCGTGG
CACCTTCAAGTCCGTCGCCGTCAAGGCCCCGGGCTTCGGTGACCGCCGCAAGGCTCAGCTGGCCGACATCGCCATCCTGA
CCGGTGGCGAGGTCATCAGCGAAGAGGTCGGCCTCTCGCTGGAGACCGCGGGCATCGAGCTGCTCGGCCAGGCTCGCAAG
GTCGTCGTGACCAAGGACGAGACCACCATCGTCGAGGGCGCGGGCGACGCCGAGGCGATCAAGGGCCGGGTCGCGCAGAT
CCGCACCGAGATCGAGAACTCCGACTCCGACTACGACCGCGAGAAGCTGCAGGAGCGGCTGGCCAAGCTGGCCGGCGGCG
TGGCCGTCATCAAGGCGGGCGCGGCCACCGAGGTCGAGCTCAAGGAGCGCAAGCACCGCATCGAGGACGCCGTCCGCAAC
GCGAAGGCCGCCGTCGAGGAGGGCATCGTCGCCGGTGGTGGCGTGGCCCTGCTGCAGGCCGCCCCGGCCCTGGACGAGCT
GAAGCTGACCGGTGACGAGGCCACCGGCGCGAACATCGTGCGCGTCGCTCTCTCGGCTCCGCTGAAGCAGATCGCCTTCA
ACGCCGGCCTCGAGCCCGGCGTGGTCGCCGAGAAGGTCTCGAACCTGGAGGCCGGCCACGGCCTGAACGCCGACTCGGGC
GAGTACGAGGACCTGCTGGCCGCCGGCGTCGCCGACCCGGTCAAGGTCACCCGCTCGGCGCTGCAGAACGCGGCCTCCAT
CGCGGCCCTGTTCCTCACCACCGAGGCCGTCGTCGCCGACAAGCCGGAGAAGGCCGCCGCTCCCGCCGGCGACCCGACCG
GTGGCATGGGCGGCATGGACTTCTGA

Upstream 100 bases:

>100_bases
CGTCCGTCGCGGGCACCGCACCTGGCCAGCGTACCTGGGACGACCCAACCTGCGGTCGTCCTGCGTGTCAGCCATCCACA
TGGAGGATCTCAACAACGCC

Downstream 100 bases:

>100_bases
GTCCCGCCGCACGGCAACACCTTTGAGAGAACCCGAGAGCCGGGCCACCGTCGGTGGCCCGGCTCTCGGCCGTTCCGGCC
CGGCATACCCGGCCCGCCGG

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Heat shock protein 60; Protein Cpn60 [H]

Number of amino acids: Translated: 541; Mature: 540

Protein sequence:

>541_residues
MAKTIAYDEEARRGLERGLNSLADAVKVTLGPKGRNVVLEKKWGAPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKT
DDVAGDGTTTATVLAQALVREGLRNVAAGANPLGLKRGIEKAVEAVTAKLLDTAKEVETKEQIAATAGISAGDASIGELI
AEAMDKVGKEGVITVEESNTFGLQLELTEGMRFDKGYISGYFVTDPERQEAVLEDPYILLVGSKVSTVKDLLPLLEKVIQ
AGKPLLIIAEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAQLADIAILTGGEVISEEVGLSLETAGIELLGQARK
VVVTKDETTIVEGAGDAEAIKGRVAQIRTEIENSDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVRN
AKAAVEEGIVAGGGVALLQAAPALDELKLTGDEATGANIVRVALSAPLKQIAFNAGLEPGVVAEKVSNLEAGHGLNADSG
EYEDLLAAGVADPVKVTRSALQNAASIAALFLTTEAVVADKPEKAAAPAGDPTGGMGGMDF

Sequences:

>Translated_541_residues
MAKTIAYDEEARRGLERGLNSLADAVKVTLGPKGRNVVLEKKWGAPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKT
DDVAGDGTTTATVLAQALVREGLRNVAAGANPLGLKRGIEKAVEAVTAKLLDTAKEVETKEQIAATAGISAGDASIGELI
AEAMDKVGKEGVITVEESNTFGLQLELTEGMRFDKGYISGYFVTDPERQEAVLEDPYILLVGSKVSTVKDLLPLLEKVIQ
AGKPLLIIAEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAQLADIAILTGGEVISEEVGLSLETAGIELLGQARK
VVVTKDETTIVEGAGDAEAIKGRVAQIRTEIENSDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVRN
AKAAVEEGIVAGGGVALLQAAPALDELKLTGDEATGANIVRVALSAPLKQIAFNAGLEPGVVAEKVSNLEAGHGLNADSG
EYEDLLAAGVADPVKVTRSALQNAASIAALFLTTEAVVADKPEKAAAPAGDPTGGMGGMDF
>Mature_540_residues
AKTIAYDEEARRGLERGLNSLADAVKVTLGPKGRNVVLEKKWGAPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTD
DVAGDGTTTATVLAQALVREGLRNVAAGANPLGLKRGIEKAVEAVTAKLLDTAKEVETKEQIAATAGISAGDASIGELIA
EAMDKVGKEGVITVEESNTFGLQLELTEGMRFDKGYISGYFVTDPERQEAVLEDPYILLVGSKVSTVKDLLPLLEKVIQA
GKPLLIIAEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAQLADIAILTGGEVISEEVGLSLETAGIELLGQARKV
VVTKDETTIVEGAGDAEAIKGRVAQIRTEIENSDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVRNA
KAAVEEGIVAGGGVALLQAAPALDELKLTGDEATGANIVRVALSAPLKQIAFNAGLEPGVVAEKVSNLEAGHGLNADSGE
YEDLLAAGVADPVKVTRSALQNAASIAALFLTTEAVVADKPEKAAAPAGDPTGGMGGMDF

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=530, Percent_Identity=46.9811320754717, Blast_Score=469, Evalue=1e-132,
Organism=Homo sapiens, GI31542947, Length=530, Percent_Identity=46.9811320754717, Blast_Score=469, Evalue=1e-132,
Organism=Homo sapiens, GI5453607, Length=544, Percent_Identity=22.4264705882353, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI5453603, Length=571, Percent_Identity=24.3432574430823, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI38455427, Length=122, Percent_Identity=31.9672131147541, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1790586, Length=528, Percent_Identity=59.6590909090909, Blast_Score=599, Evalue=1e-172,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=47.6370510396975, Blast_Score=471, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI193210679, Length=240, Percent_Identity=45, Blast_Score=188, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI17564182, Length=546, Percent_Identity=23.2600732600733, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323288, Length=525, Percent_Identity=50.4761904761905, Blast_Score=493, Evalue=1e-140,
Organism=Saccharomyces cerevisiae, GI6322524, Length=183, Percent_Identity=28.4153005464481, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24641193, Length=525, Percent_Identity=47.8095238095238, Blast_Score=471, Evalue=1e-133,
Organism=Drosophila melanogaster, GI24641191, Length=525, Percent_Identity=47.8095238095238, Blast_Score=471, Evalue=1e-133,
Organism=Drosophila melanogaster, GI45550936, Length=524, Percent_Identity=45.4198473282443, Blast_Score=446, Evalue=1e-125,
Organism=Drosophila melanogaster, GI45550132, Length=524, Percent_Identity=45.4198473282443, Blast_Score=446, Evalue=1e-125,
Organism=Drosophila melanogaster, GI45550935, Length=524, Percent_Identity=45.4198473282443, Blast_Score=446, Evalue=1e-125,
Organism=Drosophila melanogaster, GI17864606, Length=523, Percent_Identity=41.1089866156788, Blast_Score=394, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24584129, Length=538, Percent_Identity=35.6877323420074, Blast_Score=301, Evalue=1e-81,
Organism=Drosophila melanogaster, GI19921262, Length=538, Percent_Identity=35.6877323420074, Blast_Score=301, Evalue=1e-81,
Organism=Drosophila melanogaster, GI24645179, Length=512, Percent_Identity=22.0703125, Blast_Score=70, Evalue=5e-12,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 56408; Mature: 56277

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKTIAYDEEARRGLERGLNSLADAVKVTLGPKGRNVVLEKKWGAPTITNDGVSIAKEIE
CCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCCCHHHHHCC
LEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLRNVAAGANPLGLKRGIE
CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
KAVEAVTAKLLDTAKEVETKEQIAATAGISAGDASIGELIAEAMDKVGKEGVITVEESNT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCC
FGLQLELTEGMRFDKGYISGYFVTDPERQEAVLEDPYILLVGSKVSTVKDLLPLLEKVIQ
EEEEEEECCCCEECCCCEEEEEECCCCHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHH
AGKPLLIIAEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAQLADIAILTGGEVIS
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHEEEEECCHHHH
EEVGLSLETAGIELLGQARKVVVTKDETTIVEGAGDAEAIKGRVAQIRTEIENSDSDYDR
HHHCCEEEHHHHHHHCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCH
EKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVRNAKAAVEEGIVAGGGVALLQA
HHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
APALDELKLTGDEATGANIVRVALSAPLKQIAFNAGLEPGVVAEKVSNLEAGHGLNADSG
CCCHHHEEECCCCCCCCHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCC
EYEDLLAAGVADPVKVTRSALQNAASIAALFLTTEAVVADKPEKAAAPAGDPTGGMGGMD
CHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCC
F
C
>Mature Secondary Structure 
AKTIAYDEEARRGLERGLNSLADAVKVTLGPKGRNVVLEKKWGAPTITNDGVSIAKEIE
CCCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCCCHHHHHCC
LEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLRNVAAGANPLGLKRGIE
CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
KAVEAVTAKLLDTAKEVETKEQIAATAGISAGDASIGELIAEAMDKVGKEGVITVEESNT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCC
FGLQLELTEGMRFDKGYISGYFVTDPERQEAVLEDPYILLVGSKVSTVKDLLPLLEKVIQ
EEEEEEECCCCEECCCCEEEEEECCCCHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHH
AGKPLLIIAEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAQLADIAILTGGEVIS
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHEEEEECCHHHH
EEVGLSLETAGIELLGQARKVVVTKDETTIVEGAGDAEAIKGRVAQIRTEIENSDSDYDR
HHHCCEEEHHHHHHHCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCH
EKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVRNAKAAVEEGIVAGGGVALLQA
HHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
APALDELKLTGDEATGANIVRVALSAPLKQIAFNAGLEPGVVAEKVSNLEAGHGLNADSG
CCCHHHEEECCCCCCCCHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCC
EYEDLLAAGVADPVKVTRSALQNAASIAALFLTTEAVVADKPEKAAAPAGDPTGGMGGMD
CHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCC
F
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA