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The map label for this gene is proC [H]

Identifier: 54027151

GI number: 54027151

Start: 5475550

End: 5476371

Strand: Reverse

Name: proC [H]

Synonym: nfa51770

Alternate gene names: 54027151

Gene position: 5476371-5475550 (Counterclockwise)

Preceding gene: 54027152

Following gene: 54027150

Centisome position: 90.95

GC content: 70.68

Gene sequence:

>822_bases
ATGACGAGAATTGCGGTGATCGGTGGAGGCCGGATCGGGGAGGCGTTGATCGCCGGGCTGCTCGAATCCGGCCGGGCGAG
CAAGGACCTGGTGGTCGTCGAGACCCACCAGGACCGGGCCGAGCTGGTGGCGAGCCGATTCGGGGTGCGGGTCACCGCGG
AGGTCGCCGATGCCGCCATCGGCGCCGACCTGCTGGTGATCGCGGTGAAGCCCGGCGATGTCGACACCGTGCTGACCCAG
CTGGGCAAGGCCGAGCTGAACGCGGGCGACGTCGACCAGGTGCTGGTCTCGCTGGCCGCGGGTGTGCCGACCGCTCGGCT
GGAGGCCAAGATGCCCGCCGGGTTCCCGGTCGTGCGGGTCATGCCGAACACCCCGATGCTGGTCGGGCAGGGCATGATCG
TGCTCGCGCCGGGCCGCTACACCAAGCCGAGCCAGCTCGAGCTGGTCACCGAGGTGCTCGGCACCGTCGGCAAGGTGGTC
ACGGTCGCGGAGTCGCAGATGGACGCGGTGACCGCGGTGTCCGGCTCCGGTCCCGCCTATTTCTTCCTGGTCGTCGAGGC
CATGATCGATGCGGCCGTCAGCCTCGGCCTGTCCCGCGACATCGCGACCGATCTGGTGGTGCAGACGATGGTCGGCTCGG
CCGCGTTGCTGGACGAGGCAGAGCAGAGCGCGGTGGAATTGCGCGCCGCGGTGACCTCGCCCGCGGGCACCACCGCGGCG
GCCCTTCGCGAGCTCGAGCGCGCAGGAGTACGCTCGGCATTCCTGGAGGCTTTGCACGCGGCGAAGGAGCGTTCGGCCGA
ACAGGGCGCGTCGGCGGAGTGA

Upstream 100 bases:

>100_bases
ACCAGCTCGTGCTCGACAGCACCGGCGCGGTGGTCGCCCAGAGCAGGCAACTCGCACTGCTGCCACAGCCGAGGGACGGA
CGAGGCTAGCCTTTAGGGCC

Downstream 100 bases:

>100_bases
CCACGGTATGAATCCGGCGTGAGCGGCTGATTTCTCACACCCGTCGCAGTAATCCCACTGGTCCCGCTAAGCTTCAAGGA
GCACGTGCGTGTCTGTTCCG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 273; Mature: 272

Protein sequence:

>273_residues
MTRIAVIGGGRIGEALIAGLLESGRASKDLVVVETHQDRAELVASRFGVRVTAEVADAAIGADLLVIAVKPGDVDTVLTQ
LGKAELNAGDVDQVLVSLAAGVPTARLEAKMPAGFPVVRVMPNTPMLVGQGMIVLAPGRYTKPSQLELVTEVLGTVGKVV
TVAESQMDAVTAVSGSGPAYFFLVVEAMIDAAVSLGLSRDIATDLVVQTMVGSAALLDEAEQSAVELRAAVTSPAGTTAA
ALRELERAGVRSAFLEALHAAKERSAEQGASAE

Sequences:

>Translated_273_residues
MTRIAVIGGGRIGEALIAGLLESGRASKDLVVVETHQDRAELVASRFGVRVTAEVADAAIGADLLVIAVKPGDVDTVLTQ
LGKAELNAGDVDQVLVSLAAGVPTARLEAKMPAGFPVVRVMPNTPMLVGQGMIVLAPGRYTKPSQLELVTEVLGTVGKVV
TVAESQMDAVTAVSGSGPAYFFLVVEAMIDAAVSLGLSRDIATDLVVQTMVGSAALLDEAEQSAVELRAAVTSPAGTTAA
ALRELERAGVRSAFLEALHAAKERSAEQGASAE
>Mature_272_residues
TRIAVIGGGRIGEALIAGLLESGRASKDLVVVETHQDRAELVASRFGVRVTAEVADAAIGADLLVIAVKPGDVDTVLTQL
GKAELNAGDVDQVLVSLAAGVPTARLEAKMPAGFPVVRVMPNTPMLVGQGMIVLAPGRYTKPSQLELVTEVLGTVGKVVT
VAESQMDAVTAVSGSGPAYFFLVVEAMIDAAVSLGLSRDIATDLVVQTMVGSAALLDEAEQSAVELRAAVTSPAGTTAAA
LRELERAGVRSAFLEALHAAKERSAEQGASAE

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=265, Percent_Identity=32.0754716981132, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI21361454, Length=269, Percent_Identity=33.8289962825279, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI24797097, Length=271, Percent_Identity=34.6863468634686, Blast_Score=137, Evalue=8e-33,
Organism=Homo sapiens, GI24797095, Length=271, Percent_Identity=34.6863468634686, Blast_Score=137, Evalue=9e-33,
Organism=Escherichia coli, GI1786585, Length=264, Percent_Identity=35.2272727272727, Blast_Score=144, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI17569021, Length=273, Percent_Identity=34.0659340659341, Blast_Score=149, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17540664, Length=283, Percent_Identity=29.6819787985866, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320861, Length=286, Percent_Identity=26.9230769230769, Blast_Score=94, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21358587, Length=267, Percent_Identity=34.8314606741573, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24647700, Length=167, Percent_Identity=39.5209580838323, Blast_Score=120, Evalue=9e-28,
Organism=Drosophila melanogaster, GI24648116, Length=281, Percent_Identity=33.0960854092527, Blast_Score=119, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27951; Mature: 27819

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRIAVIGGGRIGEALIAGLLESGRASKDLVVVETHQDRAELVASRFGVRVTAEVADAAI
CCEEEEEECCHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHCCEEEHHHHHHHC
GADLLVIAVKPGDVDTVLTQLGKAELNAGDVDQVLVSLAAGVPTARLEAKMPAGFPVVRV
CCCEEEEEECCCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHCCCCCCCCCEEEE
MPNTPMLVGQGMIVLAPGRYTKPSQLELVTEVLGTVGKVVTVAESQMDAVTAVSGSGPAY
CCCCCEEECCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCH
FFLVVEAMIDAAVSLGLSRDIATDLVVQTMVGSAALLDEAEQSAVELRAAVTSPAGTTAA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
ALRELERAGVRSAFLEALHAAKERSAEQGASAE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TRIAVIGGGRIGEALIAGLLESGRASKDLVVVETHQDRAELVASRFGVRVTAEVADAAI
CEEEEEECCHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHCCEEEHHHHHHHC
GADLLVIAVKPGDVDTVLTQLGKAELNAGDVDQVLVSLAAGVPTARLEAKMPAGFPVVRV
CCCEEEEEECCCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHCCCCCCCCCEEEE
MPNTPMLVGQGMIVLAPGRYTKPSQLELVTEVLGTVGKVVTVAESQMDAVTAVSGSGPAY
CCCCCEEECCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCH
FFLVVEAMIDAAVSLGLSRDIATDLVVQTMVGSAALLDEAEQSAVELRAAVTSPAGTTAA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
ALRELERAGVRSAFLEALHAAKERSAEQGASAE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]