Click here to switch to the map view.

The map label for this gene is mutM [H]

Identifier: 54026994

GI number: 54026994

Start: 5234919

End: 5235788

Strand: Reverse

Name: mutM [H]

Synonym: nfa50200

Alternate gene names: 54026994

Gene position: 5235788-5234919 (Counterclockwise)

Preceding gene: 54026995

Following gene: 54026989

Centisome position: 86.96

GC content: 70.69

Gene sequence:

>870_bases
GTGCCCGAGCTACCCGAAGTGGAGGCGCTGGCCCAGTTCCTGCGCGAACACGCCGTCGGCGCGGTGGTGGGGCGAGTCGA
TGTGGCCGCGCTGAGCGCGGTGAAGACCTTCGACCCGCCGGTCACCGCGCTGTCCGGCCGCGACGTCAGCGGCGCGGCAC
GCTGGGGCAAGTTCCTCGGCATGGACTGTTCGGGGCTGTGGCTGATCACGCATCTGTCCCGCGGCGGCTGGCTGCGCTGG
ATCGACGAACCCAACCCGAATCCACCCAAGCCCGGCGGCAAGAGCCCGCTGGCGCTGCGGGTGCACTTCTTCACCCCCGA
GGGCGCCACACCCGCGTTCGACCTCACCGAGGCGGGCACCAAAAAGCGTCTGGCCGTCTACGTGGTCGACGATCCCAAGC
TGGTCCCCGGTATCGCCCGGCTCGGGCCCGACGCGCTCGAGGTGAGCGAACCCCAGTTCGCCGAACTCCTGCACGGCACC
TCGCAGCGGCTCAAGACCGCGCTGGTGGATCAGGCGCTGCTCGCGGGCATCGGCAACGCCTACTCCGACGAGATCCTGCA
CACCGCCAAGATCTCGCCGTTCGCCAACACCAAGACCCTGCCCGCCGAGAAGATCGCCGAACTCTACGCGGCGATGCGCG
CCGTGCTCACCGACGCGGTGCAGCGCTCGGTGGGGCAGGACGCGGCCCGGCTCAAGGGCGAGAAACGCTCGGGCATGCGG
GTGCACGCCCGCACCGGCCAGCCCTGCCCGGTGTGCGGGGACACCGTGCGCGAGGTCTCCTACGCCGAACGGTCGTTCCA
GTACTGCCCCACCTGCCAGACCGGCGGGAAGGTGCTCGCCGACCGGCGCATGTCGCGGCTGCTCAAGTGA

Upstream 100 bases:

>100_bases
GGTCCGGGCGCGGCTGCGGGACCGCAAGGGCTGGATCATGGACATCTACCTGCTGCGTCGTAGCCCGGGGAATGTCGGTG
CGGCCGGGTAGCCTGGCGAT

Downstream 100 bases:

>100_bases
GCGGGTTGCGTGCGCTGGGCGGTTGAGTCGAACTCAGCGGCCGCTGGACCGTGCGTGGCCTGAGCGGGTGAGCAGGCGGG
CGCCGATCAGGTCAGGGTCG

Product: putative formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MPELPEVEALAQFLREHAVGAVVGRVDVAALSAVKTFDPPVTALSGRDVSGAARWGKFLGMDCSGLWLITHLSRGGWLRW
IDEPNPNPPKPGGKSPLALRVHFFTPEGATPAFDLTEAGTKKRLAVYVVDDPKLVPGIARLGPDALEVSEPQFAELLHGT
SQRLKTALVDQALLAGIGNAYSDEILHTAKISPFANTKTLPAEKIAELYAAMRAVLTDAVQRSVGQDAARLKGEKRSGMR
VHARTGQPCPVCGDTVREVSYAERSFQYCPTCQTGGKVLADRRMSRLLK

Sequences:

>Translated_289_residues
MPELPEVEALAQFLREHAVGAVVGRVDVAALSAVKTFDPPVTALSGRDVSGAARWGKFLGMDCSGLWLITHLSRGGWLRW
IDEPNPNPPKPGGKSPLALRVHFFTPEGATPAFDLTEAGTKKRLAVYVVDDPKLVPGIARLGPDALEVSEPQFAELLHGT
SQRLKTALVDQALLAGIGNAYSDEILHTAKISPFANTKTLPAEKIAELYAAMRAVLTDAVQRSVGQDAARLKGEKRSGMR
VHARTGQPCPVCGDTVREVSYAERSFQYCPTCQTGGKVLADRRMSRLLK
>Mature_288_residues
PELPEVEALAQFLREHAVGAVVGRVDVAALSAVKTFDPPVTALSGRDVSGAARWGKFLGMDCSGLWLITHLSRGGWLRWI
DEPNPNPPKPGGKSPLALRVHFFTPEGATPAFDLTEAGTKKRLAVYVVDDPKLVPGIARLGPDALEVSEPQFAELLHGTS
QRLKTALVDQALLAGIGNAYSDEILHTAKISPFANTKTLPAEKIAELYAAMRAVLTDAVQRSVGQDAARLKGEKRSGMRV
HARTGQPCPVCGDTVREVSYAERSFQYCPTCQTGGKVLADRRMSRLLK

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=285, Percent_Identity=28.4210526315789, Blast_Score=87, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 31160; Mature: 31029

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: PS01242 ZF_FPG_1 ; PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVEALAQFLREHAVGAVVGRVDVAALSAVKTFDPPVTALSGRDVSGAARWGKFLG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHC
MDCSGLWLITHLSRGGWLRWIDEPNPNPPKPGGKSPLALRVHFFTPEGATPAFDLTEAGT
CCCCCEEEEEEECCCCEEEECCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCC
KKRLAVYVVDDPKLVPGIARLGPDALEVSEPQFAELLHGTSQRLKTALVDQALLAGIGNA
CCEEEEEEECCCCHHCHHHHCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
YSDEILHTAKISPFANTKTLPAEKIAELYAAMRAVLTDAVQRSVGQDAARLKGEKRSGMR
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCCE
VHARTGQPCPVCGDTVREVSYAERSFQYCPTCQTGGKVLADRRMSRLLK
EEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
PELPEVEALAQFLREHAVGAVVGRVDVAALSAVKTFDPPVTALSGRDVSGAARWGKFLG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHC
MDCSGLWLITHLSRGGWLRWIDEPNPNPPKPGGKSPLALRVHFFTPEGATPAFDLTEAGT
CCCCCEEEEEEECCCCEEEECCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCC
KKRLAVYVVDDPKLVPGIARLGPDALEVSEPQFAELLHGTSQRLKTALVDQALLAGIGNA
CCEEEEEEECCCCHHCHHHHCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
YSDEILHTAKISPFANTKTLPAEKIAELYAAMRAVLTDAVQRSVGQDAARLKGEKRSGMR
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCCE
VHARTGQPCPVCGDTVREVSYAERSFQYCPTCQTGGKVLADRRMSRLLK
EEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA