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The map label for this gene is fadE42 [H]

Identifier: 54026985

GI number: 54026985

Start: 5224956

End: 5226578

Strand: Reverse

Name: fadE42 [H]

Synonym: nfa50110

Alternate gene names: 54026985

Gene position: 5226578-5224956 (Counterclockwise)

Preceding gene: 54026986

Following gene: 54026982

Centisome position: 86.8

GC content: 69.44

Gene sequence:

>1623_bases
ATGCAGACTCATGAGGTCTTCAACCAGGTCCCGAACATCGTGCCCTTCGACGTCTCGCGCAATCCCGCGCTGCTCGAGGG
CCTGCACCGCGAGGGCGCGGGCTGGGCCGAGGCCGAGGTGCGCGAACTCGGCGCGCTCGCCGGCGGTGAGCGCGCGCAGG
AGTGGGGCAGGCTCGCCAACGAGTACCCGCCGGTCCTGCACACCCACGACCGCTACGGCCATCGCATCGACGAAGTCGAA
TTCCACCCGTACTGGCACGAACTCATGACGGTCGCCGTCGGCCACGGCCTGCACGCCGCCCCCTGGCTCGACGAACGCCC
CGGCGCGCACGTCGCCCGCGCCGCCAAGTTCTACACCTGGGGCGCCGCCGACGCCGGTCACATGTGTCCCATCTCGATGA
CCTACGCCGCCGTGCCCGCCCTGCGCCACAACCCCGAACTGGCCGCGAAGTACGAGCCGCTGCTCGGCTCCCGCGTCTAC
GATTTCGGCCTGCGCGAGCCCACCGGCAAGGCCGGACTCATCGCGGGCATGTCGATGACGGAGAAGCAGGGCGGCTCCGA
CGTGCGCGCCAACACCACCACCGCGACACCGCAGCCCGACGGCACCTACCGCATCGTCGGCCACAAGTGGTTCACCTCCG
CGCCGATGTCGGACATGTTCCTCACCCTGGCGCAAGCCCCCGGCGGCCTGTCCTGCTTCCTGCTGCCGCGCGTGCTGCCC
GACGGCACCCGCAACCCCATCCGCATCCAGCGCCTCAAGGACAAGCTCGGCAACAAGTCCAACGCCTCGTCGGAGATCGA
ATACGAGAACGCCACCGGCTGGCTCGTCGGCCCCGAAGGCCACGGCGTGAAGACCATCATCGAAATGGTCAACATGACCC
GCCTGGACTGCGTCATCGGTTCGGCCACCAACATGCGCCAGGCGACCGTGCACGCCGTGCACCACGCCCGGCACCGGGAA
GCGTTCGGCGCCAAGCTGATCGACCAGCCCGCCATGCGCAACGTCCTCGCCGACCTGGTGATCGAATCCGACGCCGCCAC
CACCGTCATGATGCGGCTGGCCGGCGCCACCGATCGCGCCGCCCACGACCCCGCCGAAGCGAACCTGCGCCGCATCGCCC
TCGCGGTCACCAAGTACTGGGTGTGCAAGCGCGCCCCCATGCTCACCGCCGAAGCCCTCGAATGCCTCGGCGGCAACGGC
TACGCCGAAGAATCCGGCATGCCCCGGCTCTACCGCGAGTCCCCCCTGATGTCGATCTGGGAAGGCTCCGGCAACGTCGC
CGCCCTCGACGCCCTGCGCGCCATGGGCCGCCAACCCGACACCGTCGCGGCCTACTTCGACGAGGTGAACAAGTCCCGCG
GCGACAACCCCCGCCTCGACGACGCCATCGACCGCGTCGGCAAGGAACTCGCCGACCTGTCCGACATCGAATACCGGGCC
CGGCGCGTGGTCGAACTCATGGCCCTGGTCTTGCAAGGCGCCCAGCTGGTGCGGCACGGACACCGCGCGGTGGCCGACGC
ATTCTGCGCCACCCGATTGGGGGATGACTGGGGAATCGCGTTCGGGACATTGCCGACCGGGGTCGACACCGAATCGATCA
TCGAGCGCGCGTTCGTGGAGTGA

Upstream 100 bases:

>100_bases
GAATCCGTCGTGCCCCAACTCGTCACCTTCGCCCGGCGCGCACTCGGTGTGCCGGAGCGGGCTCGCGCGGCCACGACCGC
GCCGGAAACAGGAGTGTCCG

Downstream 100 bases:

>100_bases
CTCGTCCTCGAGCCAACGCCGCAACCGGTGGCCTGCGCTACGGCCGGCATGTGGCAAGTGTCGGCCGGATGGTGTCGTTC
ACGCCAGATCAGCGAATTCG

Product: putative acyl-CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 540; Mature: 540

Protein sequence:

>540_residues
MQTHEVFNQVPNIVPFDVSRNPALLEGLHREGAGWAEAEVRELGALAGGERAQEWGRLANEYPPVLHTHDRYGHRIDEVE
FHPYWHELMTVAVGHGLHAAPWLDERPGAHVARAAKFYTWGAADAGHMCPISMTYAAVPALRHNPELAAKYEPLLGSRVY
DFGLREPTGKAGLIAGMSMTEKQGGSDVRANTTTATPQPDGTYRIVGHKWFTSAPMSDMFLTLAQAPGGLSCFLLPRVLP
DGTRNPIRIQRLKDKLGNKSNASSEIEYENATGWLVGPEGHGVKTIIEMVNMTRLDCVIGSATNMRQATVHAVHHARHRE
AFGAKLIDQPAMRNVLADLVIESDAATTVMMRLAGATDRAAHDPAEANLRRIALAVTKYWVCKRAPMLTAEALECLGGNG
YAEESGMPRLYRESPLMSIWEGSGNVAALDALRAMGRQPDTVAAYFDEVNKSRGDNPRLDDAIDRVGKELADLSDIEYRA
RRVVELMALVLQGAQLVRHGHRAVADAFCATRLGDDWGIAFGTLPTGVDTESIIERAFVE

Sequences:

>Translated_540_residues
MQTHEVFNQVPNIVPFDVSRNPALLEGLHREGAGWAEAEVRELGALAGGERAQEWGRLANEYPPVLHTHDRYGHRIDEVE
FHPYWHELMTVAVGHGLHAAPWLDERPGAHVARAAKFYTWGAADAGHMCPISMTYAAVPALRHNPELAAKYEPLLGSRVY
DFGLREPTGKAGLIAGMSMTEKQGGSDVRANTTTATPQPDGTYRIVGHKWFTSAPMSDMFLTLAQAPGGLSCFLLPRVLP
DGTRNPIRIQRLKDKLGNKSNASSEIEYENATGWLVGPEGHGVKTIIEMVNMTRLDCVIGSATNMRQATVHAVHHARHRE
AFGAKLIDQPAMRNVLADLVIESDAATTVMMRLAGATDRAAHDPAEANLRRIALAVTKYWVCKRAPMLTAEALECLGGNG
YAEESGMPRLYRESPLMSIWEGSGNVAALDALRAMGRQPDTVAAYFDEVNKSRGDNPRLDDAIDRVGKELADLSDIEYRA
RRVVELMALVLQGAQLVRHGHRAVADAFCATRLGDDWGIAFGTLPTGVDTESIIERAFVE
>Mature_540_residues
MQTHEVFNQVPNIVPFDVSRNPALLEGLHREGAGWAEAEVRELGALAGGERAQEWGRLANEYPPVLHTHDRYGHRIDEVE
FHPYWHELMTVAVGHGLHAAPWLDERPGAHVARAAKFYTWGAADAGHMCPISMTYAAVPALRHNPELAAKYEPLLGSRVY
DFGLREPTGKAGLIAGMSMTEKQGGSDVRANTTTATPQPDGTYRIVGHKWFTSAPMSDMFLTLAQAPGGLSCFLLPRVLP
DGTRNPIRIQRLKDKLGNKSNASSEIEYENATGWLVGPEGHGVKTIIEMVNMTRLDCVIGSATNMRQATVHAVHHARHRE
AFGAKLIDQPAMRNVLADLVIESDAATTVMMRLAGATDRAAHDPAEANLRRIALAVTKYWVCKRAPMLTAEALECLGGNG
YAEESGMPRLYRESPLMSIWEGSGNVAALDALRAMGRQPDTVAAYFDEVNKSRGDNPRLDDAIDRVGKELADLSDIEYRA
RRVVELMALVLQGAQLVRHGHRAVADAFCATRLGDDWGIAFGTLPTGVDTESIIERAFVE

Specific function: May help to prevent alkylation damage by protecting DNA and destroying alkylating agents [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI76496475, Length=375, Percent_Identity=23.7333333333333, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI4557235, Length=375, Percent_Identity=23.7333333333333, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI4557233, Length=286, Percent_Identity=25.5244755244755, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI226958414, Length=273, Percent_Identity=24.5421245421245, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI226958412, Length=273, Percent_Identity=24.5421245421245, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI4501859, Length=287, Percent_Identity=24.0418118466899, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI4557231, Length=274, Percent_Identity=24.8175182481752, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI187960098, Length=274, Percent_Identity=24.8175182481752, Blast_Score=70, Evalue=7e-12,
Organism=Escherichia coli, GI87082384, Length=530, Percent_Identity=45.6603773584906, Blast_Score=428, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI86563383, Length=479, Percent_Identity=29.8538622129436, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI86563381, Length=479, Percent_Identity=29.8538622129436, Blast_Score=189, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17538396, Length=274, Percent_Identity=26.6423357664234, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17508101, Length=265, Percent_Identity=27.1698113207547, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI71985184, Length=270, Percent_Identity=23.7037037037037, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17506239, Length=288, Percent_Identity=25, Blast_Score=82, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI71985192, Length=225, Percent_Identity=24.8888888888889, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17569725, Length=266, Percent_Identity=23.6842105263158, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281363737, Length=306, Percent_Identity=23.8562091503268, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21356377, Length=266, Percent_Identity=23.3082706766917, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21355753, Length=365, Percent_Identity=21.0958904109589, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24646207, Length=283, Percent_Identity=25.7950530035336, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24666513, Length=294, Percent_Identity=23.8095238095238, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M [H]

EC number: NA

Molecular weight: Translated: 59114; Mature: 59114

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTHEVFNQVPNIVPFDVSRNPALLEGLHREGAGWAEAEVRELGALAGGERAQEWGRLAN
CCHHHHHHHCCCCEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHH
EYPPVLHTHDRYGHRIDEVEFHPYWHELMTVAVGHGLHAAPWLDERPGAHVARAAKFYTW
HCCCCEECCHHHCCCCCCEEECHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHEEC
GAADAGHMCPISMTYAAVPALRHNPELAAKYEPLLGSRVYDFGLREPTGKAGLIAGMSMT
CCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHCHHHCCHHHHCCCCCCCCCCCEEECCCHH
EKQGGSDVRANTTTATPQPDGTYRIVGHKWFTSAPMSDMFLTLAQAPGGLSCFLLPRVLP
HCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHCCCCCCEEEEHHHHCC
DGTRNPIRIQRLKDKLGNKSNASSEIEYENATGWLVGPEGHGVKTIIEMVNMTRLDCVIG
CCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHEEC
SATNMRQATVHAVHHARHREAFGAKLIDQPAMRNVLADLVIESDAATTVMMRLAGATDRA
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCC
AHDPAEANLRRIALAVTKYWVCKRAPMLTAEALECLGGNGYAEESGMPRLYRESPLMSIW
CCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCEEE
EGSGNVAALDALRAMGRQPDTVAAYFDEVNKSRGDNPRLDDAIDRVGKELADLSDIEYRA
CCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RRVVELMALVLQGAQLVRHGHRAVADAFCATRLGDDWGIAFGTLPTGVDTESIIERAFVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MQTHEVFNQVPNIVPFDVSRNPALLEGLHREGAGWAEAEVRELGALAGGERAQEWGRLAN
CCHHHHHHHCCCCEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHH
EYPPVLHTHDRYGHRIDEVEFHPYWHELMTVAVGHGLHAAPWLDERPGAHVARAAKFYTW
HCCCCEECCHHHCCCCCCEEECHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHEEC
GAADAGHMCPISMTYAAVPALRHNPELAAKYEPLLGSRVYDFGLREPTGKAGLIAGMSMT
CCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHCHHHCCHHHHCCCCCCCCCCCEEECCCHH
EKQGGSDVRANTTTATPQPDGTYRIVGHKWFTSAPMSDMFLTLAQAPGGLSCFLLPRVLP
HCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHCCCCCCEEEEHHHHCC
DGTRNPIRIQRLKDKLGNKSNASSEIEYENATGWLVGPEGHGVKTIIEMVNMTRLDCVIG
CCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHEEC
SATNMRQATVHAVHHARHREAFGAKLIDQPAMRNVLADLVIESDAATTVMMRLAGATDRA
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCC
AHDPAEANLRRIALAVTKYWVCKRAPMLTAEALECLGGNGYAEESGMPRLYRESPLMSIW
CCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCEEE
EGSGNVAALDALRAMGRQPDTVAAYFDEVNKSRGDNPRLDDAIDRVGKELADLSDIEYRA
CCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RRVVELMALVLQGAQLVRHGHRAVADAFCATRLGDDWGIAFGTLPTGVDTESIIERAFVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961409; 7610040; 9278503 [H]