Click here to switch to the map view.

The map label for this gene is uppS [C]

Identifier: 54026792

GI number: 54026792

Start: 5032523

End: 5033311

Strand: Reverse

Name: uppS [C]

Synonym: nfa48180

Alternate gene names: 54026792

Gene position: 5033311-5032523 (Counterclockwise)

Preceding gene: 54026795

Following gene: 54026790

Centisome position: 83.59

GC content: 68.82

Gene sequence:

>789_bases
TTGGTCGCCGTGGAGTTTCGGAACCGGGTGCGTGGCCTGCCGTACCGCATCTACGAGGCCCGGCTGGTCAAGCAGCTGGC
CGGCAGACAACATCCCCGCCATGTGGCGGTGATGTGCGACGGTAACCGACGCTGGGCCCGGGAGAACGGTTTCACCGACG
TCAGCCACGGGCACCGGGTGGGTGCGCTGAAGATCGCCGAACTGGTCGAATGGTGCTCGCAGGCGGGCATCGAGATGGTC
ACCGTCTACCTGCTCTCGACGGAGAACCTGCAGCGCGACCCGGAGGAGCTCGAGACCCTCTTCGAGGTCATCACCGACGT
GGTCGAGGAACTGTCCGCACCCGAGCGCGACTGGAGCGTGCGCATCGTCGGCTCGCTCGACGGCTTCCCCGAACTGATCG
CCAAACGCATGCGCACCGCCGCCGAGCAGACCGAGGGCAGGCGCGGCGTGCACGTCAACGTGGCGGTCGGCTACGGCGGG
CGCCAGGAGATCGCCGACGCGGTCCGCTCGCTGGTGCGCCAGGAGATCGCGGCCGGGGAGACCGGCGAGGACCTGGTGCA
GTCGATCACCGTCAACGCCATCGGCCAGCACCTGTACACCTCCGGCCAGCCCGACCCGGACCTGGTCATCCGCACCTCCG
GCGAGCAGCGGCTCTCGGGTTTCCTGCTGTGGCAGAGCGCCTACTCCGAGATCTGGTTCACCGAGGTGTACTGGCCGGAG
TTCCGGCGCGTGGACTTCCTGCGCGCCCTGCGCGACTACGCGGCACGGCACCGGCGATTCGGCGTGTGA

Upstream 100 bases:

>100_bases
AGACCGGTGAGTAACCTACGGTACCGTAGGTTTGGGCGGGTAACCACTCCTCCACGGGGTAACGCAGTCGCTGCCGGTTT
CACAGTGACGAGGCGTACTG

Downstream 100 bases:

>100_bases
GGCAGCGCCTTCCGTGCCGCGGCGCCCCGGCGGCGGTCAGAGCTTGCGCAGGCGCAACCGGTTGATGCTGTGGTCGGCGT
CCTTGCGCAGCACCAGCGTC

Product: putative undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: (2Z,6E)-farnesyl diphosphate synthase; Z-FPP synthase; Z-isoprenyl diphosphate synthase [H]

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MVAVEFRNRVRGLPYRIYEARLVKQLAGRQHPRHVAVMCDGNRRWARENGFTDVSHGHRVGALKIAELVEWCSQAGIEMV
TVYLLSTENLQRDPEELETLFEVITDVVEELSAPERDWSVRIVGSLDGFPELIAKRMRTAAEQTEGRRGVHVNVAVGYGG
RQEIADAVRSLVRQEIAAGETGEDLVQSITVNAIGQHLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEIWFTEVYWPE
FRRVDFLRALRDYAARHRRFGV

Sequences:

>Translated_262_residues
MVAVEFRNRVRGLPYRIYEARLVKQLAGRQHPRHVAVMCDGNRRWARENGFTDVSHGHRVGALKIAELVEWCSQAGIEMV
TVYLLSTENLQRDPEELETLFEVITDVVEELSAPERDWSVRIVGSLDGFPELIAKRMRTAAEQTEGRRGVHVNVAVGYGG
RQEIADAVRSLVRQEIAAGETGEDLVQSITVNAIGQHLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEIWFTEVYWPE
FRRVDFLRALRDYAARHRRFGV
>Mature_262_residues
MVAVEFRNRVRGLPYRIYEARLVKQLAGRQHPRHVAVMCDGNRRWARENGFTDVSHGHRVGALKIAELVEWCSQAGIEMV
TVYLLSTENLQRDPEELETLFEVITDVVEELSAPERDWSVRIVGSLDGFPELIAKRMRTAAEQTEGRRGVHVNVAVGYGG
RQEIADAVRSLVRQEIAAGETGEDLVQSITVNAIGQHLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEIWFTEVYWPE
FRRVDFLRALRDYAARHRRFGV

Specific function: Generates Z-farnesyl diphosphate (Z-FPP) from isopentenyl pyrophosphate (IPP). Z-FPP is the precursor of decaprenyl diphosphate, which has a central role in the biosynthesis of the mycobacterial cell wall [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family. Z-FPP synthase subfamily [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=232, Percent_Identity=34.4827586206897, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI45580738, Length=232, Percent_Identity=34.4827586206897, Blast_Score=135, Evalue=3e-32,
Organism=Escherichia coli, GI1786371, Length=231, Percent_Identity=38.0952380952381, Blast_Score=154, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI71993029, Length=227, Percent_Identity=33.0396475770925, Blast_Score=138, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6319474, Length=217, Percent_Identity=33.1797235023041, Blast_Score=127, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6323748, Length=229, Percent_Identity=27.9475982532751, Blast_Score=94, Evalue=2e-20,
Organism=Drosophila melanogaster, GI18857969, Length=230, Percent_Identity=36.0869565217391, Blast_Score=140, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.68 [H]

Molecular weight: Translated: 29865; Mature: 29865

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAVEFRNRVRGLPYRIYEARLVKQLAGRQHPRHVAVMCDGNRRWARENGFTDVSHGHRV
CEEEEHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHCCCCCCCCCCCCC
GALKIAELVEWCSQAGIEMVTVYLLSTENLQRDPEELETLFEVITDVVEELSAPERDWSV
HHHHHHHHHHHHHHCCHHEEHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEE
RIVGSLDGFPELIAKRMRTAAEQTEGRRGVHVNVAVGYGGRQEIADAVRSLVRQEIAAGE
EEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCC
TGEDLVQSITVNAIGQHLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEIWFTEVYWPE
CHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHEECCCH
FRRVDFLRALRDYAARHRRFGV
HHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVAVEFRNRVRGLPYRIYEARLVKQLAGRQHPRHVAVMCDGNRRWARENGFTDVSHGHRV
CEEEEHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHCCCCCCCCCCCCC
GALKIAELVEWCSQAGIEMVTVYLLSTENLQRDPEELETLFEVITDVVEELSAPERDWSV
HHHHHHHHHHHHHHCCHHEEHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEE
RIVGSLDGFPELIAKRMRTAAEQTEGRRGVHVNVAVGYGGRQEIADAVRSLVRQEIAAGE
EEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCC
TGEDLVQSITVNAIGQHLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEIWFTEVYWPE
CHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHEECCCH
FRRVDFLRALRDYAARHRRFGV
HHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]