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The map label for this gene is caiC [H]

Identifier: 54026712

GI number: 54026712

Start: 4948684

End: 4950453

Strand: Reverse

Name: caiC [H]

Synonym: nfa47380

Alternate gene names: 54026712

Gene position: 4950453-4948684 (Counterclockwise)

Preceding gene: 54026713

Following gene: 54026711

Centisome position: 82.22

GC content: 71.58

Gene sequence:

>1770_bases
GTGACCACCCAGACCCGCACCACGGTCGGCCTGCTCGATCTCGCCCGTGCCCTGCCCGGCATGGCCCTCGACGCCCCGGT
CATGGCGCGCAACGCCCTCGGCATGCTCACCGGGCCCGGCGCCAAGGCATCGGTCGGGCTGTTCTTCCAGCGCACCGCGC
ACCGGCACCCGCACCGCGTCTTCCTGCGCTTCGAGGGCGCCGCCTACACCTACCGGGAGGCCAACGCCGAGGTGAACCGG
TACGCGGCGGTGCTGTCCGGGCGCGGGGTCGGCCGCGGCGACGTGGTCGGGGTACTGATGACCAACCGGCCCGAGACGCT
GTTCGTGGTGCTGGCGACGGTGAAGCTCGGCGCCACCGTCGGCCTGCTCAACCACAACCAGCGCGAGAAGGTGCTCGCGC
ACAGCTTCGGCCTGCTCGACAGCGTGCTGAACGTGGTCGGCGCCGAATGCCGGGAGGCGCTCGAGTCGCTGCCCGAGCCG
CTGCCGAACGTCCTGGCCGCCGAGGAACTGCACGAGGCCGCCCGCGGCGCCGAGGCGAGCGATCCGGCGGTCTGCGCCGA
GATCACCGCGCGCGAACGGGCTTTCCTCATCTTCACCTCGGGCACCACCGGCCTGCCCAAGGCCAGCGTGATGACCCATC
ACCGCTGGGCCAAGAGCATGCACGGCCTCGGCGGTCTCGGAATCCGCTTGCGCGGCGACGACGTCATGTACTGCTGCCTG
CCGCTGTACCACAACAACGCCCTCACCGTCGCCCTCTCCGCGGTGCTCGCCGCCGGCGCGACCTACGCACTGGGCAGGCG
GTTCTCGGCGTCCGCGTTCTGGGACGAGGTGATCCGCGAACGCGCCACGGCGTTCATCTACATCGGGGAGCTGTGCCGGT
ACCTGCTGAACCAGCCGCCGCGGCCGACCGACCGGCAGCACCGGGTGCGGCTGGCCGTCGGCAACGGGCTGCGCCCGCAG
CTGTGGGACGAGTTCACCACCCGCTTCGGTATCGACCGGGTGGTCGAGTTCTACAGCGCCAGTGAGGCGCCCATCGCCTT
CGTCAACGCGTTCGGGGTGAGCCACACCGCCGGGTTCGGGCCGCTGCCCTACGCGATCGTGGAGTACGACGAGGAGACCG
GCGCCCCGCGCCGCGGCCCCGACGGCAGGTTGCGCCGGGTGCGCTCCGGCGGCGTCGGCCTGTTGCTGGCCAAGGTCACC
GGCAGGCAGCCCTTCGACGGCTACACCGACCGCGAGGCCACCGAGGCCAAACTGGTCCGGGATGCCTTCCGCCCCGGCGA
CGTGTGGTTCGACACCGGTGACCTGGTGCGCGATCAGGGCTGGTGGCACATCGCCTTCGTCGACCGGCTCGGCGACACCT
TCCGCTGGAAGGGCGAGAACGTCGCCACCACCGAGGTGGAGAACGCACTGGCCCACCACGATTCGATCGCCGAGGCCGTG
GTGTTCGGTGTCGACGTGCCCGGCGCCGACGGCAAGGCCGGCATGGCGGCGGTGACCCTGCACCCGGACGCCGAGTTCGA
CGGCCGCGGGCTCGCCCGGGTCGCCTACGAGCAGTTGCCTTCCTACGCGGTGCCGCTGTTCGTGCGGGTCGTGCCCGAGC
TGGAGCAGACCTCGACCTTCAAGAGCCGCAAGGTGGAACTGCGCAAGCAGGGCTACCAGCCGGACGAGCACAGCGAGCTG
TACGTGCTGGCCGGACGGACCGACGGCTACGTGCCCGCCTACGACGACTACCCCGCCGAGGTGGCGGCCGGGCGCGCGCC
GAAGAACTGA

Upstream 100 bases:

>100_bases
CTTCGCCGCACTGTGCCGGGCCGAACGGGGGAGTGCCGCGGCGTCCTGAGGGAATCCGGATGAGCAGCAGACAACGGCAC
ACCCCGAGGAGACCACAGAC

Downstream 100 bases:

>100_bases
TCGGGGCCCTCGGTACAGTCGTGGTCATGTTCAGCCCGCCCGCAGCGCCGCTGCCCACCCTGTGCGGCAAGCCGGTCGCG
ACGGACCGGGCGCTGGTGAT

Product: long-chain-acyl-CoA synthetase

Products: D-carnitinyl-CoA; crotonobetainyl-CoA; L-carnitinyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 589; Mature: 588

Protein sequence:

>589_residues
MTTQTRTTVGLLDLARALPGMALDAPVMARNALGMLTGPGAKASVGLFFQRTAHRHPHRVFLRFEGAAYTYREANAEVNR
YAAVLSGRGVGRGDVVGVLMTNRPETLFVVLATVKLGATVGLLNHNQREKVLAHSFGLLDSVLNVVGAECREALESLPEP
LPNVLAAEELHEAARGAEASDPAVCAEITARERAFLIFTSGTTGLPKASVMTHHRWAKSMHGLGGLGIRLRGDDVMYCCL
PLYHNNALTVALSAVLAAGATYALGRRFSASAFWDEVIRERATAFIYIGELCRYLLNQPPRPTDRQHRVRLAVGNGLRPQ
LWDEFTTRFGIDRVVEFYSASEAPIAFVNAFGVSHTAGFGPLPYAIVEYDEETGAPRRGPDGRLRRVRSGGVGLLLAKVT
GRQPFDGYTDREATEAKLVRDAFRPGDVWFDTGDLVRDQGWWHIAFVDRLGDTFRWKGENVATTEVENALAHHDSIAEAV
VFGVDVPGADGKAGMAAVTLHPDAEFDGRGLARVAYEQLPSYAVPLFVRVVPELEQTSTFKSRKVELRKQGYQPDEHSEL
YVLAGRTDGYVPAYDDYPAEVAAGRAPKN

Sequences:

>Translated_589_residues
MTTQTRTTVGLLDLARALPGMALDAPVMARNALGMLTGPGAKASVGLFFQRTAHRHPHRVFLRFEGAAYTYREANAEVNR
YAAVLSGRGVGRGDVVGVLMTNRPETLFVVLATVKLGATVGLLNHNQREKVLAHSFGLLDSVLNVVGAECREALESLPEP
LPNVLAAEELHEAARGAEASDPAVCAEITARERAFLIFTSGTTGLPKASVMTHHRWAKSMHGLGGLGIRLRGDDVMYCCL
PLYHNNALTVALSAVLAAGATYALGRRFSASAFWDEVIRERATAFIYIGELCRYLLNQPPRPTDRQHRVRLAVGNGLRPQ
LWDEFTTRFGIDRVVEFYSASEAPIAFVNAFGVSHTAGFGPLPYAIVEYDEETGAPRRGPDGRLRRVRSGGVGLLLAKVT
GRQPFDGYTDREATEAKLVRDAFRPGDVWFDTGDLVRDQGWWHIAFVDRLGDTFRWKGENVATTEVENALAHHDSIAEAV
VFGVDVPGADGKAGMAAVTLHPDAEFDGRGLARVAYEQLPSYAVPLFVRVVPELEQTSTFKSRKVELRKQGYQPDEHSEL
YVLAGRTDGYVPAYDDYPAEVAAGRAPKN
>Mature_588_residues
TTQTRTTVGLLDLARALPGMALDAPVMARNALGMLTGPGAKASVGLFFQRTAHRHPHRVFLRFEGAAYTYREANAEVNRY
AAVLSGRGVGRGDVVGVLMTNRPETLFVVLATVKLGATVGLLNHNQREKVLAHSFGLLDSVLNVVGAECREALESLPEPL
PNVLAAEELHEAARGAEASDPAVCAEITARERAFLIFTSGTTGLPKASVMTHHRWAKSMHGLGGLGIRLRGDDVMYCCLP
LYHNNALTVALSAVLAAGATYALGRRFSASAFWDEVIRERATAFIYIGELCRYLLNQPPRPTDRQHRVRLAVGNGLRPQL
WDEFTTRFGIDRVVEFYSASEAPIAFVNAFGVSHTAGFGPLPYAIVEYDEETGAPRRGPDGRLRRVRSGGVGLLLAKVTG
RQPFDGYTDREATEAKLVRDAFRPGDVWFDTGDLVRDQGWWHIAFVDRLGDTFRWKGENVATTEVENALAHHDSIAEAVV
FGVDVPGADGKAGMAAVTLHPDAEFDGRGLARVAYEQLPSYAVPLFVRVVPELEQTSTFKSRKVELRKQGYQPDEHSELY
VLAGRTDGYVPAYDDYPAEVAAGRAPKN

Specific function: Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI227499619, Length=564, Percent_Identity=39.0070921985816, Blast_Score=371, Evalue=1e-103,
Organism=Homo sapiens, GI40807357, Length=570, Percent_Identity=37.5438596491228, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI62865631, Length=548, Percent_Identity=37.4087591240876, Blast_Score=337, Evalue=3e-92,
Organism=Homo sapiens, GI13325055, Length=548, Percent_Identity=37.4087591240876, Blast_Score=337, Evalue=3e-92,
Organism=Homo sapiens, GI38524616, Length=564, Percent_Identity=35.8156028368794, Blast_Score=333, Evalue=3e-91,
Organism=Homo sapiens, GI13325057, Length=573, Percent_Identity=37.347294938918, Blast_Score=315, Evalue=1e-85,
Organism=Homo sapiens, GI13236579, Length=510, Percent_Identity=39.2156862745098, Blast_Score=310, Evalue=3e-84,
Organism=Homo sapiens, GI227499621, Length=549, Percent_Identity=35.7012750455373, Blast_Score=306, Evalue=4e-83,
Organism=Homo sapiens, GI187761345, Length=402, Percent_Identity=27.363184079602, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI187761343, Length=402, Percent_Identity=27.363184079602, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI221142682, Length=510, Percent_Identity=26.8627450980392, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1788107, Length=560, Percent_Identity=22.5, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI145693145, Length=539, Percent_Identity=23.191094619666, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17551278, Length=576, Percent_Identity=32.9861111111111, Blast_Score=304, Evalue=1e-82,
Organism=Caenorhabditis elegans, GI115534440, Length=550, Percent_Identity=33.6363636363636, Blast_Score=300, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI32563687, Length=525, Percent_Identity=22.8571428571429, Blast_Score=73, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6319515, Length=519, Percent_Identity=32.7552986512524, Blast_Score=269, Evalue=1e-72,
Organism=Drosophila melanogaster, GI28573631, Length=574, Percent_Identity=35.3658536585366, Blast_Score=328, Evalue=5e-90,
Organism=Drosophila melanogaster, GI20130353, Length=574, Percent_Identity=35.3658536585366, Blast_Score=328, Evalue=7e-90,
Organism=Drosophila melanogaster, GI45552801, Length=547, Percent_Identity=35.2833638025594, Blast_Score=326, Evalue=3e-89,
Organism=Drosophila melanogaster, GI45550496, Length=547, Percent_Identity=35.2833638025594, Blast_Score=325, Evalue=4e-89,
Organism=Drosophila melanogaster, GI24583465, Length=543, Percent_Identity=34.4383057090239, Blast_Score=315, Evalue=5e-86,
Organism=Drosophila melanogaster, GI24583463, Length=543, Percent_Identity=34.4383057090239, Blast_Score=315, Evalue=5e-86,
Organism=Drosophila melanogaster, GI281364798, Length=543, Percent_Identity=34.4383057090239, Blast_Score=315, Evalue=5e-86,
Organism=Drosophila melanogaster, GI18859661, Length=446, Percent_Identity=24.4394618834081, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24581924, Length=361, Percent_Identity=26.0387811634349, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24656500, Length=439, Percent_Identity=23.4624145785877, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: 6.3.2.- [C]

Molecular weight: Translated: 64281; Mature: 64149

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTQTRTTVGLLDLARALPGMALDAPVMARNALGMLTGPGAKASVGLFFQRTAHRHPHRV
CCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHCCCEEECCCCCCHHHHHHHHHCCCCCCEE
FLRFEGAAYTYREANAEVNRYAAVLSGRGVGRGDVVGVLMTNRPETLFVVLATVKLGATV
EEEECCCEEEEECCCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEEEHHHHCCEE
GLLNHNQREKVLAHSFGLLDSVLNVVGAECREALESLPEPLPNVLAAEELHEAARGAEAS
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCC
DPAVCAEITARERAFLIFTSGTTGLPKASVMTHHRWAKSMHGLGGLGIRLRGDDVMYCCL
CCCHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCEEEEEE
PLYHNNALTVALSAVLAAGATYALGRRFSASAFWDEVIRERATAFIYIGELCRYLLNQPP
EEECCCHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHEEEEHHHHHHHHHCCCC
RPTDRQHRVRLAVGNGLRPQLWDEFTTRFGIDRVVEFYSASEAPIAFVNAFGVSHTAGFG
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCC
PLPYAIVEYDEETGAPRRGPDGRLRRVRSGGVGLLLAKVTGRQPFDGYTDREATEAKLVR
CCCEEEEEECHHCCCCCCCCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHH
DAFRPGDVWFDTGDLVRDQGWWHIAFVDRLGDTFRWKGENVATTEVENALAHHDSIAEAV
HHCCCCCEEECCCCHHHCCCCEEEEEHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHH
VFGVDVPGADGKAGMAAVTLHPDAEFDGRGLARVAYEQLPSYAVPLFVRVVPELEQTSTF
EEECCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCHHHHHHH
KSRKVELRKQGYQPDEHSELYVLAGRTDGYVPAYDDYPAEVAAGRAPKN
HHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHCCCCCCC
>Mature Secondary Structure 
TTQTRTTVGLLDLARALPGMALDAPVMARNALGMLTGPGAKASVGLFFQRTAHRHPHRV
CCCCCHHHHHHHHHHHCCCCCCCCCHHHHHCCCEEECCCCCCHHHHHHHHHCCCCCCEE
FLRFEGAAYTYREANAEVNRYAAVLSGRGVGRGDVVGVLMTNRPETLFVVLATVKLGATV
EEEECCCEEEEECCCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEEEHHHHCCEE
GLLNHNQREKVLAHSFGLLDSVLNVVGAECREALESLPEPLPNVLAAEELHEAARGAEAS
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCC
DPAVCAEITARERAFLIFTSGTTGLPKASVMTHHRWAKSMHGLGGLGIRLRGDDVMYCCL
CCCHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCEEEEEE
PLYHNNALTVALSAVLAAGATYALGRRFSASAFWDEVIRERATAFIYIGELCRYLLNQPP
EEECCCHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHEEEEHHHHHHHHHCCCC
RPTDRQHRVRLAVGNGLRPQLWDEFTTRFGIDRVVEFYSASEAPIAFVNAFGVSHTAGFG
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCC
PLPYAIVEYDEETGAPRRGPDGRLRRVRSGGVGLLLAKVTGRQPFDGYTDREATEAKLVR
CCCEEEEEECHHCCCCCCCCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHH
DAFRPGDVWFDTGDLVRDQGWWHIAFVDRLGDTFRWKGENVATTEVENALAHHDSIAEAV
HHCCCCCEEECCCCHHHCCCCEEEEEHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHH
VFGVDVPGADGKAGMAAVTLHPDAEFDGRGLARVAYEQLPSYAVPLFVRVVPELEQTSTF
EEECCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCHHHHHHH
KSRKVELRKQGYQPDEHSELYVLAGRTDGYVPAYDDYPAEVAAGRAPKN
HHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Coenzyme A; D-carnitine; Coenzyme A; crotono-betaine; L-carnitine [C]

Specific reaction: Coenzyme A + D-carnitine = D-carnitinyl-CoA Coenzyme A + crotono-betaine = crotonobetainyl-CoA Coenzyme A + L-carnitine = L-carnitinyl-CoA [C]

General reaction: Ligases; Forming Carbon-Sulfur Bonds; Acid-Thiol Ligases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA