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The map label for this gene is echA19 [C]

Identifier: 54026662

GI number: 54026662

Start: 4892815

End: 4893609

Strand: Reverse

Name: echA19 [C]

Synonym: nfa46890

Alternate gene names: 54026662

Gene position: 4893609-4892815 (Counterclockwise)

Preceding gene: 54026669

Following gene: 54026661

Centisome position: 81.27

GC content: 72.08

Gene sequence:

>795_bases
ATGAGCGAGAACAAGGCGACCCGATTGGACCGTGAGACCACCGAGGCCGGCGCCGAGGTCGCGATCCTGACCCTGGCCAA
CCCGCCGCTGAACCTGTTCGACCAGGCCATGTTCGACGGCCTGGTCGCCGACATCGCGGCGCTGACCGCCGCGCCGCCGC
GGGCGGTGCTGTTGCGCGCGGAGGGCAAGGTCGTCTCCGGTGGTGTCGACGTGCACGTGTTCGACGGGCTGAGCACCGAG
CAGGGCGCCGCGCTGTGGCAGCGGCTGTTCGACGAGATCATCCACCCCATCGAGGCGCTGCCGTGCCCGGTGTTGTTCGC
CGCGCACGGGCTCACTCTCACCGCCGCGTTCGAGATCGCGCTGGCCTGCGACATCATTCTGGCCGCGCCCAAGGCCAAGT
TCGGTCTGGTGGAGACCGTGGTCGGGCTGACCCCGTCGATGGGCGGGCCGCAGCGGTTGGCCGAGCGGGCGGGCTCGGGC
CGCGCGCGCGAGTTCGTGATGACCGCCGACCTCTACGACGCCGCCACGATGGCCGACTGGGGCGTGGTCAACTACGTGCA
CGACGATCTGGATCCGGCCGCGCGGGCGCTGGCGCACAAGCTGGCCGACGGCCCGACGCGCGCGCACGCGGCGACCAAGC
AGATCATCGCGGCGTGGCGCTCCGGCGGCGTCGCACACGCCGACGCGGTGACCCCGAAGGTCTCCGGCGTGCTGTTCGAC
ACCGAGGACCTGCGCGGCGGCGTGCGCAGCTTCCTGGAGAACGGGCCGGGCAAGGCGACCTACACCGGCCGCTGA

Upstream 100 bases:

>100_bases
GAGCCCGGTGCTTCCGAAGAGACCGGTGTCGCCGACGAGCTTCGTGTTTCCGCCTCGCTCACTCTCCCAGTGTCGCAGAC
GCACCGCTTAGGCTGCTGCA

Downstream 100 bases:

>100_bases
CGGGGACCCGCCGGAGGGACACAGTCCGACAACAACACCGCGCGATTGTGATCCGCGTCATATAGTGCAGGGGCCTGCTG
GCTCTAGGCACGCGGAGGAC

Product: putative enoyl-CoA hydratase/isomerase family protein

Products: NA

Alternate protein names: 3-hydroxypropionyl-CoA dehydratase [H]

Number of amino acids: Translated: 264; Mature: 263

Protein sequence:

>264_residues
MSENKATRLDRETTEAGAEVAILTLANPPLNLFDQAMFDGLVADIAALTAAPPRAVLLRAEGKVVSGGVDVHVFDGLSTE
QGAALWQRLFDEIIHPIEALPCPVLFAAHGLTLTAAFEIALACDIILAAPKAKFGLVETVVGLTPSMGGPQRLAERAGSG
RAREFVMTADLYDAATMADWGVVNYVHDDLDPAARALAHKLADGPTRAHAATKQIIAAWRSGGVAHADAVTPKVSGVLFD
TEDLRGGVRSFLENGPGKATYTGR

Sequences:

>Translated_264_residues
MSENKATRLDRETTEAGAEVAILTLANPPLNLFDQAMFDGLVADIAALTAAPPRAVLLRAEGKVVSGGVDVHVFDGLSTE
QGAALWQRLFDEIIHPIEALPCPVLFAAHGLTLTAAFEIALACDIILAAPKAKFGLVETVVGLTPSMGGPQRLAERAGSG
RAREFVMTADLYDAATMADWGVVNYVHDDLDPAARALAHKLADGPTRAHAATKQIIAAWRSGGVAHADAVTPKVSGVLFD
TEDLRGGVRSFLENGPGKATYTGR
>Mature_263_residues
SENKATRLDRETTEAGAEVAILTLANPPLNLFDQAMFDGLVADIAALTAAPPRAVLLRAEGKVVSGGVDVHVFDGLSTEQ
GAALWQRLFDEIIHPIEALPCPVLFAAHGLTLTAAFEIALACDIILAAPKAKFGLVETVVGLTPSMGGPQRLAERAGSGR
AREFVMTADLYDAATMADWGVVNYVHDDLDPAARALAHKLADGPTRAHAATKQIIAAWRSGGVAHADAVTPKVSGVLFDT
EDLRGGVRSFLENGPGKATYTGR

Specific function: Plays a role in autotrophic carbon fixation via the 3- hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the reversible dehydration of 3-hydroxypropionyl-CoA to form acryloyl- CoA, and the reversible dehydration of (S)-3-hydroxybutyryl-CoA to form crot

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=239, Percent_Identity=25.9414225941423, Blast_Score=72, Evalue=7e-13,
Organism=Escherichia coli, GI1787659, Length=258, Percent_Identity=27.5193798449612, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI87082183, Length=236, Percent_Identity=24.5762711864407, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788682, Length=137, Percent_Identity=35.036496350365, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI221142681, Length=118, Percent_Identity=37.2881355932203, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787660, Length=241, Percent_Identity=28.2157676348548, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17540714, Length=181, Percent_Identity=33.7016574585635, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24653139, Length=191, Percent_Identity=33.5078534031414, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI20129971, Length=267, Percent_Identity=25.0936329588015, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24653477, Length=267, Percent_Identity=25.0936329588015, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.116 [H]

Molecular weight: Translated: 27716; Mature: 27585

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSENKATRLDRETTEAGAEVAILTLANPPLNLFDQAMFDGLVADIAALTAAPPRAVLLRA
CCCCCHHHCCCHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
EGKVVSGGVDVHVFDGLSTEQGAALWQRLFDEIIHPIEALPCPVLFAAHGLTLTAAFEIA
CCEEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHH
LACDIILAAPKAKFGLVETVVGLTPSMGGPQRLAERAGSGRAREFVMTADLYDAATMADW
HHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHH
GVVNYVHDDLDPAARALAHKLADGPTRAHAATKQIIAAWRSGGVAHADAVTPKVSGVLFD
HHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEECCCCCCCCCEEEEC
TEDLRGGVRSFLENGPGKATYTGR
HHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SENKATRLDRETTEAGAEVAILTLANPPLNLFDQAMFDGLVADIAALTAAPPRAVLLRA
CCCCHHHCCCHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
EGKVVSGGVDVHVFDGLSTEQGAALWQRLFDEIIHPIEALPCPVLFAAHGLTLTAAFEIA
CCEEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHH
LACDIILAAPKAKFGLVETVVGLTPSMGGPQRLAERAGSGRAREFVMTADLYDAATMADW
HHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHH
GVVNYVHDDLDPAARALAHKLADGPTRAHAATKQIIAAWRSGGVAHADAVTPKVSGVLFD
HHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEECCCCCCCCCEEEEC
TEDLRGGVRSFLENGPGKATYTGR
HHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA