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The map label for this gene is recQ [H]

Identifier: 54026456

GI number: 54026456

Start: 4646436

End: 4648301

Strand: Reverse

Name: recQ [H]

Synonym: nfa44830

Alternate gene names: 54026456

Gene position: 4648301-4646436 (Counterclockwise)

Preceding gene: 54026457

Following gene: 54026455

Centisome position: 77.2

GC content: 70.31

Gene sequence:

>1866_bases
GTGGATCACCCCGACGCCTTCTCGCCCGCCACCGACGCCCCCTCCGGGGCCGGAATCGGTGCGGCACAAGAGGTTCTGCG
GCGCGTCTTCGGGTACGACAGCTTCCGCGGCGACCAGGCGGCCATCGTCGAGCACGTCATCGGCGGTGGCGACGCCCTGG
TGCTGATGCCGACCGGCGGCGGCAAGTCGCTGTGCTACCAGGTGCCCGCCCTGGTGCGGCCCGGTGTCGGGGTGGTGGTC
TCGCCGCTCATCGCGTTGATGCAGGACCAGGTCGACGCCCTGTCCGCGCTGGGCGTGCGCGCCGGCTTCCTCAACTCCAC
CCAGTTCCCCGACGAGCGCGCCACCGTCGAGGCGCAGTTCCTGGCCGGGGAGCTCGACCTGCTCTACCTCGCCCCGGAGC
GGCTGCGGCTGGAGTCCACCGCACGACTGCTCGACCGTGGCACGGTCGCGTTGTTCGCCATCGACGAGGCGCACTGCGTC
GCGCAGTGGGGCCACGACTTCCGCCCCGACTACCTGGCGCTGTCGATGCTGCACGAGCGCTGGCCGGACGTGCCGCGCAT
CGCGCTCACCGCCACCGCCACCGAGAAGACCCGCGACGAGATCATCCACCGGCTCGACCTCGGGTCGGCGCGCCGCTTCG
TCGCCAGCTTCGACCGGCCCAACATCCAGTACCGCATCGAGCCGAAGAACCGCGCCGAGCGGCAACTGCTCGATTTCATC
CGCACCGAGCACCCCGGCGACGCGGGCATCGTGTACTGCCTCTCGCGCAACTCCGTGGAGAAGACCGCCGCCTTCCTGAA
CGAGAACGGCATCGGGGCGGTGCCGTATCACGCTGGCCTGGACAACCGCACCCGCGCGGCGAACCAGTCCCGGTTCCTGC
GCGAGGACGGCCTCGTGGTGGTCGCCACCATCGCCTTCGGCATGGGTATCGACAAGCCGGACGTCCGCTTCGTTGCCCAT
CTCGACCTGCCCAAATCGGTGGAGGGCTACTACCAGGAGACCGGTCGCGCGGGCCGCGACGGACTGCCCGCGACCGCGTG
GATGGTCTACGGCCTCAACGACGTGGTGCAGCAGCGCAAACTCATCGACTCCTCCGAGGGCGACGCCGCGCACCGCAGGC
AGTTGCAGCTGCATCTGGACGCGATGCTCGCGCTGTGTGAAACCGTGGACTGTCGCCGTGCGCAACTGCTGGCCTACTTC
GGTCAGCACGGCACCGGCTGCGGCAACTGCGACACCTGCCTGACTCCACCCGAGTCCTGGGACGGCACCGTGGCTGCCCA
GAAACTGCTCTCGGCGGTGCTGCGGCTCGACCGGGAACGTGGCCAGGCCTTCGGCGCGGGCCACGTGCTCGACATCCTGC
TCGGCAAGAAGAACCCCAAGGTGCTGCAGTACGACCACCACGAACTGACGGTGTTCGGTGTCGGTGCCGATCTGCGCGAC
ACCGAGTGGCGCGGCGTGGTGCGACAACTCCTGGCACAGGGGTTGCTCGCGGTGCGCGGCGACTACGGGGTGCTGACGCT
CACCCCGGCCAGCGAGGAGGTGCTCTTCGGCGGCCGCAAGGTGATGTTGCGGCGCGAACCCGAGCGCCCGGTCAAGCAGG
CGCGCGGCGGTAAGTCCGCGCGCGCGGTGGTCGCCGATCTGCCCGCCGCCGACGTGCCGGTGTTCGAGAAGCTGCGCGAA
TGGCGGGCCGCCACGGCCAAGGAACAGGGGGTGCCCGCCTACGTCGTCTTCCACGACGCGACGCTGCGCGAGATCGCCGC
GCGCAAGCCGACCACGCTGGCCGAGCTCGGCGGCGTCGGCGGCGTCGGCGAGAACAAGCTGGCCAAGTACGGTCAGCAGG
TGCTCGACGTGCTCGCCGCCGCATGA

Upstream 100 bases:

>100_bases
AGTGAGCGAGTTGTCCACCTGTGGACAACTCGGGGTGTGAGCCGGGAAACGGACGCCGTCCGGGGCGCGGGTGTCGGGCG
GCGCTCGTAGGATGGGCCGC

Downstream 100 bases:

>100_bases
GGGCGGCGGCGTGGCCCCGGAGCGCGGGACAGGCCAGGATGGGCGAGGATGTGCGGAACGTCGACGGGTGGAGGGCCGGG
GATGAGTGAGGCACAGGGCA

Product: putative helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 621; Mature: 621

Protein sequence:

>621_residues
MDHPDAFSPATDAPSGAGIGAAQEVLRRVFGYDSFRGDQAAIVEHVIGGGDALVLMPTGGGKSLCYQVPALVRPGVGVVV
SPLIALMQDQVDALSALGVRAGFLNSTQFPDERATVEAQFLAGELDLLYLAPERLRLESTARLLDRGTVALFAIDEAHCV
AQWGHDFRPDYLALSMLHERWPDVPRIALTATATEKTRDEIIHRLDLGSARRFVASFDRPNIQYRIEPKNRAERQLLDFI
RTEHPGDAGIVYCLSRNSVEKTAAFLNENGIGAVPYHAGLDNRTRAANQSRFLREDGLVVVATIAFGMGIDKPDVRFVAH
LDLPKSVEGYYQETGRAGRDGLPATAWMVYGLNDVVQQRKLIDSSEGDAAHRRQLQLHLDAMLALCETVDCRRAQLLAYF
GQHGTGCGNCDTCLTPPESWDGTVAAQKLLSAVLRLDRERGQAFGAGHVLDILLGKKNPKVLQYDHHELTVFGVGADLRD
TEWRGVVRQLLAQGLLAVRGDYGVLTLTPASEEVLFGGRKVMLRREPERPVKQARGGKSARAVVADLPAADVPVFEKLRE
WRAATAKEQGVPAYVVFHDATLREIAARKPTTLAELGGVGGVGENKLAKYGQQVLDVLAAA

Sequences:

>Translated_621_residues
MDHPDAFSPATDAPSGAGIGAAQEVLRRVFGYDSFRGDQAAIVEHVIGGGDALVLMPTGGGKSLCYQVPALVRPGVGVVV
SPLIALMQDQVDALSALGVRAGFLNSTQFPDERATVEAQFLAGELDLLYLAPERLRLESTARLLDRGTVALFAIDEAHCV
AQWGHDFRPDYLALSMLHERWPDVPRIALTATATEKTRDEIIHRLDLGSARRFVASFDRPNIQYRIEPKNRAERQLLDFI
RTEHPGDAGIVYCLSRNSVEKTAAFLNENGIGAVPYHAGLDNRTRAANQSRFLREDGLVVVATIAFGMGIDKPDVRFVAH
LDLPKSVEGYYQETGRAGRDGLPATAWMVYGLNDVVQQRKLIDSSEGDAAHRRQLQLHLDAMLALCETVDCRRAQLLAYF
GQHGTGCGNCDTCLTPPESWDGTVAAQKLLSAVLRLDRERGQAFGAGHVLDILLGKKNPKVLQYDHHELTVFGVGADLRD
TEWRGVVRQLLAQGLLAVRGDYGVLTLTPASEEVLFGGRKVMLRREPERPVKQARGGKSARAVVADLPAADVPVFEKLRE
WRAATAKEQGVPAYVVFHDATLREIAARKPTTLAELGGVGGVGENKLAKYGQQVLDVLAAA
>Mature_621_residues
MDHPDAFSPATDAPSGAGIGAAQEVLRRVFGYDSFRGDQAAIVEHVIGGGDALVLMPTGGGKSLCYQVPALVRPGVGVVV
SPLIALMQDQVDALSALGVRAGFLNSTQFPDERATVEAQFLAGELDLLYLAPERLRLESTARLLDRGTVALFAIDEAHCV
AQWGHDFRPDYLALSMLHERWPDVPRIALTATATEKTRDEIIHRLDLGSARRFVASFDRPNIQYRIEPKNRAERQLLDFI
RTEHPGDAGIVYCLSRNSVEKTAAFLNENGIGAVPYHAGLDNRTRAANQSRFLREDGLVVVATIAFGMGIDKPDVRFVAH
LDLPKSVEGYYQETGRAGRDGLPATAWMVYGLNDVVQQRKLIDSSEGDAAHRRQLQLHLDAMLALCETVDCRRAQLLAYF
GQHGTGCGNCDTCLTPPESWDGTVAAQKLLSAVLRLDRERGQAFGAGHVLDILLGKKNPKVLQYDHHELTVFGVGADLRD
TEWRGVVRQLLAQGLLAVRGDYGVLTLTPASEEVLFGGRKVMLRREPERPVKQARGGKSARAVVADLPAADVPVFEKLRE
WRAATAKEQGVPAYVVFHDATLREIAARKPTTLAELGGVGGVGENKLAKYGQQVLDVLAAA

Specific function: DNA helicase [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4557365, Length=639, Percent_Identity=35.6807511737089, Blast_Score=374, Evalue=1e-103,
Organism=Homo sapiens, GI148612816, Length=422, Percent_Identity=40.7582938388626, Blast_Score=285, Evalue=9e-77,
Organism=Homo sapiens, GI14591902, Length=459, Percent_Identity=35.2941176470588, Blast_Score=282, Evalue=6e-76,
Organism=Homo sapiens, GI14591904, Length=459, Percent_Identity=35.2941176470588, Blast_Score=282, Evalue=6e-76,
Organism=Homo sapiens, GI51242943, Length=394, Percent_Identity=40.8629441624365, Blast_Score=267, Evalue=2e-71,
Organism=Homo sapiens, GI51242947, Length=394, Percent_Identity=40.8629441624365, Blast_Score=266, Evalue=4e-71,
Organism=Homo sapiens, GI169218196, Length=683, Percent_Identity=29.5754026354319, Blast_Score=262, Evalue=6e-70,
Organism=Homo sapiens, GI110735439, Length=689, Percent_Identity=29.7532656023222, Blast_Score=262, Evalue=7e-70,
Organism=Homo sapiens, GI284005309, Length=359, Percent_Identity=37.3259052924791, Blast_Score=190, Evalue=3e-48,
Organism=Homo sapiens, GI20149629, Length=321, Percent_Identity=22.4299065420561, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI48994977, Length=607, Percent_Identity=44.9752883031301, Blast_Score=499, Evalue=1e-142,
Organism=Escherichia coli, GI1787605, Length=334, Percent_Identity=24.8502994011976, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI25145561, Length=650, Percent_Identity=35.0769230769231, Blast_Score=336, Evalue=2e-92,
Organism=Caenorhabditis elegans, GI71987997, Length=406, Percent_Identity=39.4088669950739, Blast_Score=295, Evalue=4e-80,
Organism=Caenorhabditis elegans, GI71987993, Length=406, Percent_Identity=39.4088669950739, Blast_Score=295, Evalue=5e-80,
Organism=Caenorhabditis elegans, GI32564293, Length=673, Percent_Identity=29.8662704309064, Blast_Score=278, Evalue=5e-75,
Organism=Caenorhabditis elegans, GI17552866, Length=413, Percent_Identity=37.772397094431, Blast_Score=256, Evalue=3e-68,
Organism=Caenorhabditis elegans, GI17555296, Length=331, Percent_Identity=22.9607250755287, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323844, Length=559, Percent_Identity=34.7048300536673, Blast_Score=344, Evalue=2e-95,
Organism=Saccharomyces cerevisiae, GI6321360, Length=343, Percent_Identity=23.0320699708455, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24646066, Length=636, Percent_Identity=35.5345911949685, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24664226, Length=436, Percent_Identity=39.2201834862385, Blast_Score=278, Evalue=8e-75,
Organism=Drosophila melanogaster, GI62472181, Length=436, Percent_Identity=39.2201834862385, Blast_Score=275, Evalue=8e-74,
Organism=Drosophila melanogaster, GI24664230, Length=436, Percent_Identity=39.2201834862385, Blast_Score=275, Evalue=8e-74,
Organism=Drosophila melanogaster, GI21358123, Length=366, Percent_Identity=35.5191256830601, Blast_Score=206, Evalue=3e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 67579; Mature: 67579

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHPDAFSPATDAPSGAGIGAAQEVLRRVFGYDSFRGDQAAIVEHVIGGGDALVLMPTGG
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEECCC
GKSLCYQVPALVRPGVGVVVSPLIALMQDQVDALSALGVRAGFLNSTQFPDERATVEAQF
CCHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCEEEEE
LAGELDLLYLAPERLRLESTARLLDRGTVALFAIDEAHCVAQWGHDFRPDYLALSMLHER
ECCCEEEEEECHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHCCCCCCCHHHHHHHHHHH
WPDVPRIALTATATEKTRDEIIHRLDLGSARRFVASFDRPNIQYRIEPKNRAERQLLDFI
CCCCCCEEEEECCCHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHH
RTEHPGDAGIVYCLSRNSVEKTAAFLNENGIGAVPYHAGLDNRTRAANQSRFLREDGLVV
HCCCCCCCCEEEEECCCCHHHHHHHHCCCCCEECCCCCCCCCCHHHHHHHHHHHHCCCEE
VATIAFGMGIDKPDVRFVAHLDLPKSVEGYYQETGRAGRDGLPATAWMVYGLNDVVQQRK
EEEEHHHCCCCCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCHHHHHHHCHHHHHHHHH
LIDSSEGDAAHRRQLQLHLDAMLALCETVDCRRAQLLAYFGQHGTGCGNCDTCLTPPESW
HHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
DGTVAAQKLLSAVLRLDRERGQAFGAGHVLDILLGKKNPKVLQYDHHELTVFGVGADLRD
CCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHEECCCCCCEEEECCCEEEEEEECCCCCC
TEWRGVVRQLLAQGLLAVRGDYGVLTLTPASEEVLFGGRKVMLRREPERPVKQARGGKSA
CHHHHHHHHHHHHHHHEECCCCCEEEECCCCCCHHCCCEEEEEECCCCCHHHHHCCCCCC
RAVVADLPAADVPVFEKLREWRAATAKEQGVPAYVVFHDATLREIAARKPTTLAELGGVG
CEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHCCCCHHHHHCCCC
GVGENKLAKYGQQVLDVLAAA
CCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDHPDAFSPATDAPSGAGIGAAQEVLRRVFGYDSFRGDQAAIVEHVIGGGDALVLMPTGG
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEECCC
GKSLCYQVPALVRPGVGVVVSPLIALMQDQVDALSALGVRAGFLNSTQFPDERATVEAQF
CCHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCEEEEE
LAGELDLLYLAPERLRLESTARLLDRGTVALFAIDEAHCVAQWGHDFRPDYLALSMLHER
ECCCEEEEEECHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHCCCCCCCHHHHHHHHHHH
WPDVPRIALTATATEKTRDEIIHRLDLGSARRFVASFDRPNIQYRIEPKNRAERQLLDFI
CCCCCCEEEEECCCHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHH
RTEHPGDAGIVYCLSRNSVEKTAAFLNENGIGAVPYHAGLDNRTRAANQSRFLREDGLVV
HCCCCCCCCEEEEECCCCHHHHHHHHCCCCCEECCCCCCCCCCHHHHHHHHHHHHCCCEE
VATIAFGMGIDKPDVRFVAHLDLPKSVEGYYQETGRAGRDGLPATAWMVYGLNDVVQQRK
EEEEHHHCCCCCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCHHHHHHHCHHHHHHHHH
LIDSSEGDAAHRRQLQLHLDAMLALCETVDCRRAQLLAYFGQHGTGCGNCDTCLTPPESW
HHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
DGTVAAQKLLSAVLRLDRERGQAFGAGHVLDILLGKKNPKVLQYDHHELTVFGVGADLRD
CCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHEECCCCCCEEEECCCEEEEEEECCCCCC
TEWRGVVRQLLAQGLLAVRGDYGVLTLTPASEEVLFGGRKVMLRREPERPVKQARGGKSA
CHHHHHHHHHHHHHHHEECCCCCEEEECCCCCCHHCCCEEEEEECCCCCHHHHHCCCCCC
RAVVADLPAADVPVFEKLREWRAATAKEQGVPAYVVFHDATLREIAARKPTTLAELGGVG
CEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHCCCCHHHHHCCCC
GVGENKLAKYGQQVLDVLAAA
CCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]