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The map label for this gene is lrp [H]

Identifier: 54026447

GI number: 54026447

Start: 4639171

End: 4639611

Strand: Reverse

Name: lrp [H]

Synonym: nfa44740

Alternate gene names: 54026447

Gene position: 4639611-4639171 (Counterclockwise)

Preceding gene: 54026449

Following gene: 54026443

Centisome position: 77.05

GC content: 67.57

Gene sequence:

>441_bases
GTGGACACGCTGGATCGGGCAATAGTCGAGGAGTTGGAGCGTGACGGCCGCCTCACCAACGTGGAGCTGGCCGCCCGCGT
CGGTCTCACCCCCGGCCCCTGCCTGCGCCGCGTGCACCGGTTGGAGGCGGCGGGCGTCATCCGTGGCTACCGCGCCGTCG
TGGATCCGGAGCGCCTCGGCCGCGCCTTCGAGGTGCTGCTCGACCTCTCGCTCGAAAGCCACGACGCCCGCACCACCGAG
CATTTCGAGACCACCATGCGCGGCTTCGCCGAGGTGCGCGAATTGCGCAGGCTCTTCGGCACTCCCGACTATTTCGTGCG
CGTCGCCGTCGCCGACCTCACCGCCTACGAGCGCTTCCTCAGCAGGCATGTGATGACGATCCCGAAGGTCGAGCGGGTGG
TTTCCCGTTTCACCATGAAGACCGTCAAGCAGTTGGACTGA

Upstream 100 bases:

>100_bases
CCTTTCCGGTGAGTGGGATGCCTCTCCATCCTCTCGCACGGACCGAGCAGTTTGATTGCTGGAATTGCGCTGACGTCCGG
GATCGGCGCAATATTCTCCC

Downstream 100 bases:

>100_bases
CCGCGACGCCCAGCGACAGCGCGGCAAGGAATTTCGGCCCGCCGGGCTGGTAAAAGGTGTCCATCTCGCGGATGGTGAAG
CCGGCCGCGCGGATCAGCCG

Product: putative transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 146; Mature: 146

Protein sequence:

>146_residues
MDTLDRAIVEELERDGRLTNVELAARVGLTPGPCLRRVHRLEAAGVIRGYRAVVDPERLGRAFEVLLDLSLESHDARTTE
HFETTMRGFAEVRELRRLFGTPDYFVRVAVADLTAYERFLSRHVMTIPKVERVVSRFTMKTVKQLD

Sequences:

>Translated_146_residues
MDTLDRAIVEELERDGRLTNVELAARVGLTPGPCLRRVHRLEAAGVIRGYRAVVDPERLGRAFEVLLDLSLESHDARTTE
HFETTMRGFAEVRELRRLFGTPDYFVRVAVADLTAYERFLSRHVMTIPKVERVVSRFTMKTVKQLD
>Mature_146_residues
MDTLDRAIVEELERDGRLTNVELAARVGLTPGPCLRRVHRLEAAGVIRGYRAVVDPERLGRAFEVLLDLSLESHDARTTE
HFETTMRGFAEVRELRRLFGTPDYFVRVAVADLTAYERFLSRHVMTIPKVERVVSRFTMKTVKQLD

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=144, Percent_Identity=37.5, Blast_Score=112, Evalue=7e-27,
Organism=Escherichia coli, GI87081742, Length=143, Percent_Identity=33.5664335664336, Blast_Score=93, Evalue=6e-21,
Organism=Escherichia coli, GI1790182, Length=148, Percent_Identity=28.3783783783784, Blast_Score=63, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 16770; Mature: 16770

Theoretical pI: Translated: 8.51; Mature: 8.51

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTLDRAIVEELERDGRLTNVELAARVGLTPGPCLRRVHRLEAAGVIRGYRAVVDPERLG
CCHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHH
RAFEVLLDLSLESHDARTTEHFETTMRGFAEVRELRRLFGTPDYFVRVAVADLTAYERFL
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
SRHVMTIPKVERVVSRFTMKTVKQLD
HHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDTLDRAIVEELERDGRLTNVELAARVGLTPGPCLRRVHRLEAAGVIRGYRAVVDPERLG
CCHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHH
RAFEVLLDLSLESHDARTTEHFETTMRGFAEVRELRRLFGTPDYFVRVAVADLTAYERFL
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
SRHVMTIPKVERVVSRFTMKTVKQLD
HHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]