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The map label for this gene is norA [H]

Identifier: 54026425

GI number: 54026425

Start: 4620495

End: 4621781

Strand: Reverse

Name: norA [H]

Synonym: nfa44520

Alternate gene names: 54026425

Gene position: 4621781-4620495 (Counterclockwise)

Preceding gene: 54026426

Following gene: 54026424

Centisome position: 76.76

GC content: 72.88

Gene sequence:

>1287_bases
GTGAGCGGCTGTACCAGGTCGGGCAGCCGCGGGCTGCCCGGCGAGATCAAGGTACTGGTCGGCGCGGCGTTCGTCATCGC
GCTCGGCTTCGGCCTCGTCGCGCCCGTGCTGCCGCAGTTCGCGCGCAGCTTCGGCGTCGGCATGGCGGCCGCGTCGGCCA
TCGTCAGCGCCTTCGCGCTCATGCGGCTGCTGTTCGCGCCGTTCAGCGGGCAGCTGGTGCAGAAGCTGGGGGAGCGCTGG
GTCTACCTCGGCGGCCTGCTGATCGTCGCGATCTCCACCGGCGCCAGCGCGTTCTCCCAGACCTACTGGCAGCTGCTGGT
GCTGCGCTCGCTCGGCGGCATCGGCTCCACCATGTTCACGGTGTCGTCGCTGGCGCTGGTGATCCGGCTCTCGCCGGTCG
AGCAGCGCGGCCGGGTGTCGGGACTGTGGTCGACCAGCTTCCTGATCGGCTCGGTCAGCGGCCCGCTCGTCGGCGGCGCA
CTGGCCGGACTCGGCCTGCGCGCCCCCTTCCTCATCTATGCCGCCGCCCTGCTGGTGGCCTCCGGCATCGTCTACGTGAG
CCTGCGCCATTCGCAGCCCATCGCCGCCGAGAGCGGCAGCGACCTGCCCGTGCTCACCTTCCGGCAGGGCCTGGCAAAAC
CCGCCTACCCCGCGCTGCTGTGGACGCACTTCGCCAACGGCGCGGCCGTGTTCGGCGTGCGGATGGCGTTCGTGCCGCTC
ATCGTGGTCGAGGTGCTGGCCCAGCCGCCCGGCATGGCGGGCGTGGCGCTCACCGCGTTCGCCGCGGGCAACGTGGCCGT
GCTGTTCGCGTCCGGCCGCTTGTCGGACCGATTCGGCCGCCGCCCGTTCCTCATCGCCGGCGCCCTGGTGTGCGGCATCG
GCACCGTCTCGATCGGCTTCGCCCCCGACCTGATCTGGCTGCTGGCCGCCTCCGTGGTGGCGGGCCTCGGTTCCGGCATG
CTCACCCCCAGCGAGCAGGCGGCCCTGGCCGACATCATCGGCGCGAAGGCCCGCGGCGGCCCCATGCTGGCCGGCTTCCA
GATGTCCGCCGACCTCGGCACCGTGCTCGGCCCCGTCCTCATCGGCGCCGTCGTCGAGGCCACCTCCTACGGCGTCGGCC
TGTCCATCACCGGATCCCTGCTGTTCGCCGCCGCCGCCATCTGGCTGTTCGTCCCCGAGACCCTCGCCCGCCCGGCCACC
CGCACCGAACCACCGGCCGTCCCCGACGACGACGCCGAATATCAGCTGGCCCACCGCGCCGCCGAGGACGACACCGACCG
TCGCTGA

Upstream 100 bases:

>100_bases
AGGACAAGTACAAGATCTACGCCGAGTCGTTCCAGGGCCCCGAGCACCTCGCCCAGGTCCAGGCCGCCGCCGAGGAGATG
GTGGGCAAGGCGCTCCAGCC

Downstream 100 bases:

>100_bases
CCGCGGGCCCCAGCACTCGAGGCAGAGTAGGGGCGTGAGCGAACCGCGCCCGAACTACACCCCGCGCCCGATGTCGAACA
CCACGACCTTCGCCCTCGGC

Product: putative transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MSGCTRSGSRGLPGEIKVLVGAAFVIALGFGLVAPVLPQFARSFGVGMAAASAIVSAFALMRLLFAPFSGQLVQKLGERW
VYLGGLLIVAISTGASAFSQTYWQLLVLRSLGGIGSTMFTVSSLALVIRLSPVEQRGRVSGLWSTSFLIGSVSGPLVGGA
LAGLGLRAPFLIYAAALLVASGIVYVSLRHSQPIAAESGSDLPVLTFRQGLAKPAYPALLWTHFANGAAVFGVRMAFVPL
IVVEVLAQPPGMAGVALTAFAAGNVAVLFASGRLSDRFGRRPFLIAGALVCGIGTVSIGFAPDLIWLLAASVVAGLGSGM
LTPSEQAALADIIGAKARGGPMLAGFQMSADLGTVLGPVLIGAVVEATSYGVGLSITGSLLFAAAAIWLFVPETLARPAT
RTEPPAVPDDDAEYQLAHRAAEDDTDRR

Sequences:

>Translated_428_residues
MSGCTRSGSRGLPGEIKVLVGAAFVIALGFGLVAPVLPQFARSFGVGMAAASAIVSAFALMRLLFAPFSGQLVQKLGERW
VYLGGLLIVAISTGASAFSQTYWQLLVLRSLGGIGSTMFTVSSLALVIRLSPVEQRGRVSGLWSTSFLIGSVSGPLVGGA
LAGLGLRAPFLIYAAALLVASGIVYVSLRHSQPIAAESGSDLPVLTFRQGLAKPAYPALLWTHFANGAAVFGVRMAFVPL
IVVEVLAQPPGMAGVALTAFAAGNVAVLFASGRLSDRFGRRPFLIAGALVCGIGTVSIGFAPDLIWLLAASVVAGLGSGM
LTPSEQAALADIIGAKARGGPMLAGFQMSADLGTVLGPVLIGAVVEATSYGVGLSITGSLLFAAAAIWLFVPETLARPAT
RTEPPAVPDDDAEYQLAHRAAEDDTDRR
>Mature_427_residues
SGCTRSGSRGLPGEIKVLVGAAFVIALGFGLVAPVLPQFARSFGVGMAAASAIVSAFALMRLLFAPFSGQLVQKLGERWV
YLGGLLIVAISTGASAFSQTYWQLLVLRSLGGIGSTMFTVSSLALVIRLSPVEQRGRVSGLWSTSFLIGSVSGPLVGGAL
AGLGLRAPFLIYAAALLVASGIVYVSLRHSQPIAAESGSDLPVLTFRQGLAKPAYPALLWTHFANGAAVFGVRMAFVPLI
VVEVLAQPPGMAGVALTAFAAGNVAVLFASGRLSDRFGRRPFLIAGALVCGIGTVSIGFAPDLIWLLAASVVAGLGSGML
TPSEQAALADIIGAKARGGPMLAGFQMSADLGTVLGPVLIGAVVEATSYGVGLSITGSLLFAAAAIWLFVPETLARPATR
TEPPAVPDDDAEYQLAHRAAEDDTDRR

Specific function: Involved in quinolone resistance. May constitute a membrane-associated active efflux pump of hydrophilic quinolones [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI42476325, Length=345, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1787291, Length=404, Percent_Identity=25.990099009901, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004734
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43879; Mature: 43748

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGCTRSGSRGLPGEIKVLVGAAFVIALGFGLVAPVLPQFARSFGVGMAAASAIVSAFAL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
MRLLFAPFSGQLVQKLGERWVYLGGLLIVAISTGASAFSQTYWQLLVLRSLGGIGSTMFT
HHHHHCCCCCHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHHHHHCCCCHHHHH
VSSLALVIRLSPVEQRGRVSGLWSTSFLIGSVSGPLVGGALAGLGLRAPFLIYAAALLVA
HHHHHHHEEECCHHHCCCCCCEEHHHHHEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHH
SGIVYVSLRHSQPIAAESGSDLPVLTFRQGLAKPAYPALLWTHFANGAAVFGVRMAFVPL
CCEEEEEEECCCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHH
IVVEVLAQPPGMAGVALTAFAAGNVAVLFASGRLSDRFGRRPFLIAGALVCGIGTVSIGF
HHHHHHHCCCCCCHHHHHHHCCCCEEEEEECCCCHHHHCCCCHHHHHHHHHHHHHHCCCC
APDLIWLLAASVVAGLGSGMLTPSEQAALADIIGAKARGGPMLAGFQMSADLGTVLGPVL
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCEEECEEECCHHHHHHHHHH
IGAVVEATSYGVGLSITGSLLFAAAAIWLFVPETLARPATRTEPPAVPDDDAEYQLAHRA
HHHHHHHHHCCCCEEHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCHHHHHHHH
AEDDTDRR
CCCCCCCC
>Mature Secondary Structure 
SGCTRSGSRGLPGEIKVLVGAAFVIALGFGLVAPVLPQFARSFGVGMAAASAIVSAFAL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
MRLLFAPFSGQLVQKLGERWVYLGGLLIVAISTGASAFSQTYWQLLVLRSLGGIGSTMFT
HHHHHCCCCCHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHHHHHCCCCHHHHH
VSSLALVIRLSPVEQRGRVSGLWSTSFLIGSVSGPLVGGALAGLGLRAPFLIYAAALLVA
HHHHHHHEEECCHHHCCCCCCEEHHHHHEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHH
SGIVYVSLRHSQPIAAESGSDLPVLTFRQGLAKPAYPALLWTHFANGAAVFGVRMAFVPL
CCEEEEEEECCCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHH
IVVEVLAQPPGMAGVALTAFAAGNVAVLFASGRLSDRFGRRPFLIAGALVCGIGTVSIGF
HHHHHHHCCCCCCHHHHHHHCCCCEEEEEECCCCHHHHCCCCHHHHHHHHHHHHHHCCCC
APDLIWLLAASVVAGLGSGMLTPSEQAALADIIGAKARGGPMLAGFQMSADLGTVLGPVL
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCEEECEEECCHHHHHHHHHH
IGAVVEATSYGVGLSITGSLLFAAAAIWLFVPETLARPATRTEPPAVPDDDAEYQLAHRA
HHHHHHHHHCCCCEEHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCHHHHHHHH
AEDDTDRR
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA