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The map label for this gene is kbl [C]

Identifier: 54026294

GI number: 54026294

Start: 4481163

End: 4482584

Strand: Reverse

Name: kbl [C]

Synonym: nfa43230

Alternate gene names: 54026294

Gene position: 4482584-4481163 (Counterclockwise)

Preceding gene: 54026295

Following gene: 54026292

Centisome position: 74.45

GC content: 73.07

Gene sequence:

>1422_bases
GTGAGCGAGTCCGCCCGCGAGTTGGCGCGCAAGTTGTTGTCCGCCGGCGGCGCCGCCGCGGGAGCGCCCCCCACCGGCGG
GCCGGGCAGGCCGGGGTCGGGCGTGCCCGCCGCGGCCCCCGCGCGCCCCGCCGCCACTCCGGGACGGCCGGGCGGCACGG
CGGCCCGTCCCCGCCGCGGCCCCGGCAAGCAGTTCGCCGACCACCCCGAGGTGGCCGCGACCGTGGCCAAGCAGGCCGCG
ATCGACAAGCTCTACGGCGACAGCGACATGCCCAATCCGCTGTTCCTGGTGCGGTCGGGCCCCAACGACGCCACGATCCG
TGCCGACGATCGTGACCTGATCAACTTCAGCGCCTACAACTACCTCGGCCTGGCCAACCATCCCCGGGTGGTGCGCGGCG
CGAAGGAGGCGCTCGACCGCTACGGCGCGTCCGCCTCGGCCAGCCGCATCATCGCCGGGGAGATCCCGCTCTACCGTGAG
CTGGAGGCCAGGCTGGCCGCACTCTACGGTGTCGGCGACGCCATGATCACCACCAGCGGCTACCTCACCAACGCGGGCGC
GCTCGGCTTCCTGCTGCGCGAGGGCGACGTGGCGGTGTGCGATGCGCTGATCCACGGCAGCGTGGTCTCGGGGACACAAT
GGTCGGGGTGCCGCCGGATCACCTTCCGGCACAACGATCCCGACGCGCTGCGCGCCGTCCTGCGGATGTCGCGCGCGGGC
TTCGACCGCGCCCTGGTGGTGCTGGAGGGGCACTACAGCATGGACGGCACCGTCGGCCGGGTCGACGAACTGGCCGCCGT
GGCACGGGAATACGACTGTGCCGTGATGGTCGACGAGGCGCACTCGTTCGGCGTGTTCGGCGACCGTGGCCACGGCATCC
GCGAGCACTACCGGATGCCCGCCGACGCGGTGGACATCTGGATGGGCACGCTGTCGAAGGCGCTGGGCAGTTGCGGCGGG
TTCCTGGCCGCCGACGCCGACCTCATCCGCGCGATGAAGGCCGCGGCACCGGGCATCGCGATGCTGACCGGCGGGCCCGC
ACCGGCCGCGATTGGCGCCGCGCTGGCCGCGCTCGACGTGCTCGCGGACGAACCCGAGCGCCTGACCCGCCTGTGGGCCA
ACGCGAAACAGTTCACCGCGCTGCTCACCGAACGCGGCCTCGACCTGGGCAGCTCGGAGGGCACGCCGATCTGCCCGGTG
ATCGTGCCCGGTGAGGTGCGCTCCGGATTCGTCTCCTCCTACCTGCTGCAGCGCGGGGTGTACGCGGGCAACATCTCCGC
GCCCGCGGTGCCCGCCGGTCAGGAGCGGCTGCGGTTCTTCCTCACCAGCGAACACACAGACGAGCAGCTGGTCACCGCGG
CGGATCTGCTCGCCGAGGCCATCGGTCACGCGCGGCACCTGCCCGACCCGACCGTGCAGTAG

Upstream 100 bases:

>100_bases
CGGTAGCGCCGGGGCCGAACGGCGGGACACCCGATCCGGACGGCGCGGCGGTGGCGCCGAACGGTGCGGCGGACGCAGCG
GCCCCCGCGGAGGTGCGGTC

Downstream 100 bases:

>100_bases
TGCGAGAGCCCGGCCGGGCCCTGTTCCCCCCTCCTGGATCAGGGACCGGCCGGGCTGGAACAAACCATCCCTCGGGGGTC
TTGACAGGGGCTTACAGAGC

Product: putative 2-amino-3-ketobutyrate CoA ligase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MSESARELARKLLSAGGAAAGAPPTGGPGRPGSGVPAAAPARPAATPGRPGGTAARPRRGPGKQFADHPEVAATVAKQAA
IDKLYGDSDMPNPLFLVRSGPNDATIRADDRDLINFSAYNYLGLANHPRVVRGAKEALDRYGASASASRIIAGEIPLYRE
LEARLAALYGVGDAMITTSGYLTNAGALGFLLREGDVAVCDALIHGSVVSGTQWSGCRRITFRHNDPDALRAVLRMSRAG
FDRALVVLEGHYSMDGTVGRVDELAAVAREYDCAVMVDEAHSFGVFGDRGHGIREHYRMPADAVDIWMGTLSKALGSCGG
FLAADADLIRAMKAAAPGIAMLTGGPAPAAIGAALAALDVLADEPERLTRLWANAKQFTALLTERGLDLGSSEGTPICPV
IVPGEVRSGFVSSYLLQRGVYAGNISAPAVPAGQERLRFFLTSEHTDEQLVTAADLLAEAIGHARHLPDPTVQ

Sequences:

>Translated_473_residues
MSESARELARKLLSAGGAAAGAPPTGGPGRPGSGVPAAAPARPAATPGRPGGTAARPRRGPGKQFADHPEVAATVAKQAA
IDKLYGDSDMPNPLFLVRSGPNDATIRADDRDLINFSAYNYLGLANHPRVVRGAKEALDRYGASASASRIIAGEIPLYRE
LEARLAALYGVGDAMITTSGYLTNAGALGFLLREGDVAVCDALIHGSVVSGTQWSGCRRITFRHNDPDALRAVLRMSRAG
FDRALVVLEGHYSMDGTVGRVDELAAVAREYDCAVMVDEAHSFGVFGDRGHGIREHYRMPADAVDIWMGTLSKALGSCGG
FLAADADLIRAMKAAAPGIAMLTGGPAPAAIGAALAALDVLADEPERLTRLWANAKQFTALLTERGLDLGSSEGTPICPV
IVPGEVRSGFVSSYLLQRGVYAGNISAPAVPAGQERLRFFLTSEHTDEQLVTAADLLAEAIGHARHLPDPTVQ
>Mature_472_residues
SESARELARKLLSAGGAAAGAPPTGGPGRPGSGVPAAAPARPAATPGRPGGTAARPRRGPGKQFADHPEVAATVAKQAAI
DKLYGDSDMPNPLFLVRSGPNDATIRADDRDLINFSAYNYLGLANHPRVVRGAKEALDRYGASASASRIIAGEIPLYREL
EARLAALYGVGDAMITTSGYLTNAGALGFLLREGDVAVCDALIHGSVVSGTQWSGCRRITFRHNDPDALRAVLRMSRAGF
DRALVVLEGHYSMDGTVGRVDELAAVAREYDCAVMVDEAHSFGVFGDRGHGIREHYRMPADAVDIWMGTLSKALGSCGGF
LAADADLIRAMKAAAPGIAMLTGGPAPAAIGAALAALDVLADEPERLTRLWANAKQFTALLTERGLDLGSSEGTPICPVI
VPGEVRSGFVSSYLLQRGVYAGNISAPAVPAGQERLRFFLTSEHTDEQLVTAADLLAEAIGHARHLPDPTVQ

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977442, Length=352, Percent_Identity=32.6704545454545, Blast_Score=173, Evalue=4e-43,
Organism=Homo sapiens, GI83977440, Length=352, Percent_Identity=32.6704545454545, Blast_Score=172, Evalue=8e-43,
Organism=Homo sapiens, GI83977444, Length=352, Percent_Identity=32.6704545454545, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI119220554, Length=403, Percent_Identity=28.287841191067, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI7657118, Length=365, Percent_Identity=31.2328767123288, Blast_Score=168, Evalue=9e-42,
Organism=Homo sapiens, GI284448556, Length=348, Percent_Identity=31.0344827586207, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI4758668, Length=376, Percent_Identity=28.1914893617021, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI4502025, Length=341, Percent_Identity=32.5513196480938, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI40316939, Length=341, Percent_Identity=32.5513196480938, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI5454084, Length=287, Percent_Identity=28.9198606271777, Blast_Score=128, Evalue=9e-30,
Organism=Escherichia coli, GI1790046, Length=355, Percent_Identity=34.3661971830986, Blast_Score=197, Evalue=9e-52,
Organism=Escherichia coli, GI1786993, Length=340, Percent_Identity=29.7058823529412, Blast_Score=126, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI71994529, Length=363, Percent_Identity=30.0275482093664, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI32566772, Length=371, Percent_Identity=28.5714285714286, Blast_Score=169, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17560912, Length=354, Percent_Identity=28.5310734463277, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17560914, Length=354, Percent_Identity=28.5310734463277, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71982625, Length=392, Percent_Identity=24.4897959183673, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71982617, Length=352, Percent_Identity=25, Blast_Score=117, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320267, Length=352, Percent_Identity=28.125, Blast_Score=160, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6320438, Length=370, Percent_Identity=27.8378378378378, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6323954, Length=271, Percent_Identity=25.830258302583, Blast_Score=97, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24662918, Length=366, Percent_Identity=31.6939890710383, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI17137420, Length=458, Percent_Identity=30.7860262008734, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI17136286, Length=378, Percent_Identity=29.6296296296296, Blast_Score=165, Evalue=6e-41,
Organism=Drosophila melanogaster, GI24653280, Length=326, Percent_Identity=26.3803680981595, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24653276, Length=326, Percent_Identity=26.3803680981595, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24653278, Length=326, Percent_Identity=26.3803680981595, Blast_Score=127, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR010962
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 49402; Mature: 49271

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESARELARKLLSAGGAAAGAPPTGGPGRPGSGVPAAAPARPAATPGRPGGTAARPRRG
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PGKQFADHPEVAATVAKQAAIDKLYGDSDMPNPLFLVRSGPNDATIRADDRDLINFSAYN
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCEEEECCCCEEEECCCC
YLGLANHPRVVRGAKEALDRYGASASASRIIAGEIPLYRELEARLAALYGVGDAMITTSG
CCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCEEECCC
YLTNAGALGFLLREGDVAVCDALIHGSVVSGTQWSGCRRITFRHNDPDALRAVLRMSRAG
CEECCCHHEEEEECCCHHHHHHHHHCCEECCCCCCCEEEEEEECCCHHHHHHHHHHHHCC
FDRALVVLEGHYSMDGTVGRVDELAAVAREYDCAVMVDEAHSFGVFGDRGHGIREHYRMP
CCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHHCCC
ADAVDIWMGTLSKALGSCGGFLAADADLIRAMKAAAPGIAMLTGGPAPAAIGAALAALDV
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHH
LADEPERLTRLWANAKQFTALLTERGLDLGSSEGTPICPVIVPGEVRSGFVSSYLLQRGV
HHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCC
YAGNISAPAVPAGQERLRFFLTSEHTDEQLVTAADLLAEAIGHARHLPDPTVQ
CCCCCCCCCCCCCHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SESARELARKLLSAGGAAAGAPPTGGPGRPGSGVPAAAPARPAATPGRPGGTAARPRRG
CHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PGKQFADHPEVAATVAKQAAIDKLYGDSDMPNPLFLVRSGPNDATIRADDRDLINFSAYN
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCEEEECCCCEEEECCCC
YLGLANHPRVVRGAKEALDRYGASASASRIIAGEIPLYRELEARLAALYGVGDAMITTSG
CCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCEEECCC
YLTNAGALGFLLREGDVAVCDALIHGSVVSGTQWSGCRRITFRHNDPDALRAVLRMSRAG
CEECCCHHEEEEECCCHHHHHHHHHCCEECCCCCCCEEEEEEECCCHHHHHHHHHHHHCC
FDRALVVLEGHYSMDGTVGRVDELAAVAREYDCAVMVDEAHSFGVFGDRGHGIREHYRMP
CCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHHCCC
ADAVDIWMGTLSKALGSCGGFLAADADLIRAMKAAAPGIAMLTGGPAPAAIGAALAALDV
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHH
LADEPERLTRLWANAKQFTALLTERGLDLGSSEGTPICPVIVPGEVRSGFVSSYLLQRGV
HHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCC
YAGNISAPAVPAGQERLRFFLTSEHTDEQLVTAADLLAEAIGHARHLPDPTVQ
CCCCCCCCCCCCCHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA