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The map label for this gene is etfA [H]

Identifier: 54026249

GI number: 54026249

Start: 4430778

End: 4431734

Strand: Reverse

Name: etfA [H]

Synonym: nfa42780

Alternate gene names: 54026249

Gene position: 4431734-4430778 (Counterclockwise)

Preceding gene: 54026250

Following gene: 54026247

Centisome position: 73.6

GC content: 70.95

Gene sequence:

>957_bases
ATGGCTGAAGTACTCGTGCTCGTCGAGCACGCCGACGGTGCGATCAAGAAGGTCAGCACCGAACTGCTCACCGCCGCCCG
CACCCTGGGCAGCCCGGCCGCCGTCGTGCTTGGCGCGCCCGGCACCGGCGACAAGCTCGCCGACGCGCTGACCGCCGCGG
GCGCCGAGAAGATCTACATCGCCGAGTCCGACGATGTGGAGAACTACCTGGTGACCCCGAAGGTCGACGTGCTCGCCGGC
CTCGTCGAGTCGGTCTCCCCGGCCGCCGTCATCGTGGCCGCCTCCGCCGAGGGCAAGGAGGTGTCGGGCCGCCTCGCCGC
CCGCATCGGCTCCGGCCTGCTCGTCGACGTCATCGGCGTGAACGCCGACGGCTCGGCCGTGCACTCCATCTTCGGTGGCG
CCTTCACCGTCGAGGCCAAGGCCAACGGCGACGTGCCGGTCATCTCGGTGCGCCCCGGCGCCATCGAGGCCGTCGCGCAG
CAGGGCGCGGGCGAGAAGGTCACCGTCGAGGTGCCCGCGCAGGAGGAGGGCGTGGTCAAGGTGACCGCGCGCGAGCCCGT
CGTCGCCGGTGACCGCCCCGAGCTCACCGAGGCGAACATCGTCGTCTCCGGTGGCCGCGGCGTCGGTTCCGCCGACAACT
TCTCCGTGGTCGAGGAGCTGGCCGACTCGCTCGGCGCGGCCGTGGGCGCCTCCCGCGCCGCCGTCGACTCCGGCTACTAC
CCGGGTCAGTTCCAGGTCGGCCAGACCGGTAAGACGGTCTCCCCGCAGCTGTACATCGCGCTGGGCATCTCCGGCGCCAT
CCAGCACCGCGCGGGCATGCAGACCTCGAAGACCATCGTCGCGGTCAACAAGGACGAGGAAGCCCCGATCTTCGAGATCG
CGGACTACGGCATCGTCGGCGACCTGTTCAACGTCGCCCCGCAGCTGACCGAGGCCATCAAGTCCCACAAGGGCTGA

Upstream 100 bases:

>100_bases
CGAAGGCGACGGCGGCACCAAGATCGCCCAGTACCTGGTCGGCCAGAAGATCATCTGATCCGCGCCACATCGGACTGAGA
CTTCCTAGGAGAGAACACAA

Downstream 100 bases:

>100_bases
GCCTCCAGCCCTGTGCGCAATGCCCGGCCGGTTCCCCGGCCGGGCATTGTCGTTTCCTCAGGCCGTGTGCAGGGCGGAGA
GGAGGGTGTCCAGGATGGGG

Product: putative electron transfer flavoprotein subunit alpha

Products: NA

Alternate protein names: Alpha-ETF; Electron transfer flavoprotein large subunit; ETFLS [H]

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MAEVLVLVEHADGAIKKVSTELLTAARTLGSPAAVVLGAPGTGDKLADALTAAGAEKIYIAESDDVENYLVTPKVDVLAG
LVESVSPAAVIVAASAEGKEVSGRLAARIGSGLLVDVIGVNADGSAVHSIFGGAFTVEAKANGDVPVISVRPGAIEAVAQ
QGAGEKVTVEVPAQEEGVVKVTAREPVVAGDRPELTEANIVVSGGRGVGSADNFSVVEELADSLGAAVGASRAAVDSGYY
PGQFQVGQTGKTVSPQLYIALGISGAIQHRAGMQTSKTIVAVNKDEEAPIFEIADYGIVGDLFNVAPQLTEAIKSHKG

Sequences:

>Translated_318_residues
MAEVLVLVEHADGAIKKVSTELLTAARTLGSPAAVVLGAPGTGDKLADALTAAGAEKIYIAESDDVENYLVTPKVDVLAG
LVESVSPAAVIVAASAEGKEVSGRLAARIGSGLLVDVIGVNADGSAVHSIFGGAFTVEAKANGDVPVISVRPGAIEAVAQ
QGAGEKVTVEVPAQEEGVVKVTAREPVVAGDRPELTEANIVVSGGRGVGSADNFSVVEELADSLGAAVGASRAAVDSGYY
PGQFQVGQTGKTVSPQLYIALGISGAIQHRAGMQTSKTIVAVNKDEEAPIFEIADYGIVGDLFNVAPQLTEAIKSHKG
>Mature_317_residues
AEVLVLVEHADGAIKKVSTELLTAARTLGSPAAVVLGAPGTGDKLADALTAAGAEKIYIAESDDVENYLVTPKVDVLAGL
VESVSPAAVIVAASAEGKEVSGRLAARIGSGLLVDVIGVNADGSAVHSIFGGAFTVEAKANGDVPVISVRPGAIEAVAQQ
GAGEKVTVEVPAQEEGVVKVTAREPVVAGDRPELTEANIVVSGGRGVGSADNFSVVEELADSLGAAVGASRAAVDSGYYP
GQFQVGQTGKTVSPQLYIALGISGAIQHRAGMQTSKTIVAVNKDEEAPIFEIADYGIVGDLFNVAPQLTEAIKSHKG

Specific function: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) [H]

COG id: COG2025

COG function: function code C; Electron transfer flavoprotein, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ETF alpha-subunit/fixB family [H]

Homologues:

Organism=Homo sapiens, GI4503607, Length=314, Percent_Identity=42.0382165605096, Blast_Score=228, Evalue=6e-60,
Organism=Homo sapiens, GI189181759, Length=270, Percent_Identity=43.7037037037037, Blast_Score=213, Evalue=1e-55,
Organism=Escherichia coli, GI1787990, Length=278, Percent_Identity=32.7338129496403, Blast_Score=138, Evalue=4e-34,
Organism=Escherichia coli, GI1786226, Length=233, Percent_Identity=35.6223175965665, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI87082157, Length=236, Percent_Identity=32.2033898305085, Blast_Score=81, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17506929, Length=315, Percent_Identity=37.7777777777778, Blast_Score=197, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6325261, Length=327, Percent_Identity=36.085626911315, Blast_Score=178, Evalue=1e-45,
Organism=Drosophila melanogaster, GI17136898, Length=309, Percent_Identity=39.8058252427184, Blast_Score=207, Evalue=7e-54,
Organism=Drosophila melanogaster, GI24652801, Length=309, Percent_Identity=39.8058252427184, Blast_Score=207, Evalue=7e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001308
- InterPro:   IPR014730
- InterPro:   IPR014731
- InterPro:   IPR018206
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01012 ETF; PF00766 ETF_alpha [H]

EC number: NA

Molecular weight: Translated: 32058; Mature: 31927

Theoretical pI: Translated: 4.35; Mature: 4.35

Prosite motif: PS00696 ETF_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEVLVLVEHADGAIKKVSTELLTAARTLGSPAAVVLGAPGTGDKLADALTAAGAEKIYI
CCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCCEEEE
AESDDVENYLVTPKVDVLAGLVESVSPAAVIVAASAEGKEVSGRLAARIGSGLLVDVIGV
ECCCCCCCEEECCCHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHCCCEEEEEEEE
NADGSAVHSIFGGAFTVEAKANGDVPVISVRPGAIEAVAQQGAGEKVTVEVPAQEEGVVK
CCCCHHHHHHCCCEEEEEECCCCCEEEEEECCCHHHHHHHCCCCCEEEEECCCCCCCEEE
VTAREPVVAGDRPELTEANIVVSGGRGVGSADNFSVVEELADSLGAAVGASRAAVDSGYY
EEECCCEECCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHCCCCC
PGQFQVGQTGKTVSPQLYIALGISGAIQHRAGMQTSKTIVAVNKDEEAPIFEIADYGIVG
CCEEEECCCCCCCCCEEEEEEECCHHHHHHCCCCCCCEEEEECCCCCCCEEEEECCCHHH
DLFNVAPQLTEAIKSHKG
HHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AEVLVLVEHADGAIKKVSTELLTAARTLGSPAAVVLGAPGTGDKLADALTAAGAEKIYI
CEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCCEEEE
AESDDVENYLVTPKVDVLAGLVESVSPAAVIVAASAEGKEVSGRLAARIGSGLLVDVIGV
ECCCCCCCEEECCCHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHCCCEEEEEEEE
NADGSAVHSIFGGAFTVEAKANGDVPVISVRPGAIEAVAQQGAGEKVTVEVPAQEEGVVK
CCCCHHHHHHCCCEEEEEECCCCCEEEEEECCCHHHHHHHCCCCCEEEEECCCCCCCEEE
VTAREPVVAGDRPELTEANIVVSGGRGVGSADNFSVVEELADSLGAAVGASRAAVDSGYY
EEECCCEECCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHCCCCC
PGQFQVGQTGKTVSPQLYIALGISGAIQHRAGMQTSKTIVAVNKDEEAPIFEIADYGIVG
CCEEEECCCCCCCCCEEEEEEECCHHHHHHCCCCCCCEEEEECCCCCCCEEEEECCCHHH
DLFNVAPQLTEAIKSHKG
HHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]