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The map label for this gene is iscS [H]

Identifier: 54026239

GI number: 54026239

Start: 4421531

End: 4422682

Strand: Reverse

Name: iscS [H]

Synonym: nfa42680

Alternate gene names: 54026239

Gene position: 4422682-4421531 (Counterclockwise)

Preceding gene: 54026245

Following gene: 54026238

Centisome position: 73.45

GC content: 72.48

Gene sequence:

>1152_bases
ATGCTGCCCGCCGCCATCGAGGCGATGACGGCTGCGATGGCCCGGCCCGGCAACGCCTCCTCGGTGCACGGCTCCGGCCG
CGCCGCCCGTCGCATGCTGGAGGAGGCGCGCGAGTCGATCGCGGCGAATCTGGGCGCCCGGCCCTCGGAGGTCGTGTTCA
CCTCCGGTGGTACCGAGAGCGACAACCTCGCCGTCAAGGGCATCTACTGGGCCCGTCGTGACGCCGATCCGCGCCGCGTG
CGCATCCTGACCAGCGCCGTCGAGCACCACGCCGTGATCGACGCGGTCGAATGGCTCGAGCAGCACGAGGGCGCCCGGGT
GACCTGGCTGCCGGTCGACGCGCAGGGCCTGGTCTCGCCGCGCACGCTGCGCGCCGCGCTCGACGAGCACGCCGACGAGG
TCGCGCTGATCTCGATCATGTGGGCCAACAACGAGGTCGGCACCATCGAGCCGATCCACGAACTGGCCGCGGTGGCACAG
GAATTCGGCATCCCGATGCACAGTGACGCCATCCAGGCCGCCGCTCAGCTGCCGATCGACTTCGGGGCGAGCGGGCTGGC
GGCCGCCAGCTTCGCCGGCCACAAGGTCGGCGGCCCGCACGGCGTCGGCGTGCTGTTGCTGGGCAGGCAGGTGCCCTGCG
TGCCGCTGTTGCACGGTGGCGGCCACGAGCGCGATCTGCGCTCGGGCACCTCCGATACGCCCGCCGCCGTGGGCTTGGCC
GCGGCCCTGGACGTCACGGTCGCCGAACTGCCCGCCAAGACCGCCGAGCTGATCGCGTTGCGGGACGAGTTGATCGCCGG
TGTGCTGGCCGCCGTACCCGATGCCGTGCTCAACGGCCCGGCGGGCCAGGGCCGGCTGCCCGGCAACGCGCACTTCACCT
TCGCCGGTTGCGAGGGTGACTCACTGCTGATGCTGCTGGACGCGGCCGGGATCGAATGCTCGACGGGTTCGGCCTGCACG
GCCGGGGTGGCGACACCCAGCCACGTGTTGATCGCGATGGGCGTGCAGCCGTGGGTGGCGCGCGGGTCGCTGCGTTTCTC
GCTCGGCCACACCTCGACGCGCGCCGACGTGCGGGCCCTGCTCGAGGTGTTGCCCCAGGTGGTGGAGCGGGCCAGGGCGG
CTGGTCTCGCCGGTGCGAAAGGTGGTGTGTGA

Upstream 100 bases:

>100_bases
CGGCGGCTATCCTTTGATGGTCATGAAGTCGGCTTATTCGGGTCCGGTCACCGGTGCTGCGCCCCAGACGGTCTACCTCG
ATCATGCGGCCACCACACCG

Downstream 100 bases:

>100_bases
TGCGGGTTCTCGCGGCGATGAGCGGTGGCGTCGACTCGGCCGTCGCGGCGGCGCGCGCCGTCGACGCCGGACACGACGTG
GTCGGCGTGCACCTGGCGCT

Product: putative aminotransferase

Products: NA

Alternate protein names: NifS protein homolog [H]

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MLPAAIEAMTAAMARPGNASSVHGSGRAARRMLEEARESIAANLGARPSEVVFTSGGTESDNLAVKGIYWARRDADPRRV
RILTSAVEHHAVIDAVEWLEQHEGARVTWLPVDAQGLVSPRTLRAALDEHADEVALISIMWANNEVGTIEPIHELAAVAQ
EFGIPMHSDAIQAAAQLPIDFGASGLAAASFAGHKVGGPHGVGVLLLGRQVPCVPLLHGGGHERDLRSGTSDTPAAVGLA
AALDVTVAELPAKTAELIALRDELIAGVLAAVPDAVLNGPAGQGRLPGNAHFTFAGCEGDSLLMLLDAAGIECSTGSACT
AGVATPSHVLIAMGVQPWVARGSLRFSLGHTSTRADVRALLEVLPQVVERARAAGLAGAKGGV

Sequences:

>Translated_383_residues
MLPAAIEAMTAAMARPGNASSVHGSGRAARRMLEEARESIAANLGARPSEVVFTSGGTESDNLAVKGIYWARRDADPRRV
RILTSAVEHHAVIDAVEWLEQHEGARVTWLPVDAQGLVSPRTLRAALDEHADEVALISIMWANNEVGTIEPIHELAAVAQ
EFGIPMHSDAIQAAAQLPIDFGASGLAAASFAGHKVGGPHGVGVLLLGRQVPCVPLLHGGGHERDLRSGTSDTPAAVGLA
AALDVTVAELPAKTAELIALRDELIAGVLAAVPDAVLNGPAGQGRLPGNAHFTFAGCEGDSLLMLLDAAGIECSTGSACT
AGVATPSHVLIAMGVQPWVARGSLRFSLGHTSTRADVRALLEVLPQVVERARAAGLAGAKGGV
>Mature_383_residues
MLPAAIEAMTAAMARPGNASSVHGSGRAARRMLEEARESIAANLGARPSEVVFTSGGTESDNLAVKGIYWARRDADPRRV
RILTSAVEHHAVIDAVEWLEQHEGARVTWLPVDAQGLVSPRTLRAALDEHADEVALISIMWANNEVGTIEPIHELAAVAQ
EFGIPMHSDAIQAAAQLPIDFGASGLAAASFAGHKVGGPHGVGVLLLGRQVPCVPLLHGGGHERDLRSGTSDTPAAVGLA
AALDVTVAELPAKTAELIALRDELIAGVLAAVPDAVLNGPAGQGRLPGNAHFTFAGCEGDSLLMLLDAAGIECSTGSACT
AGVATPSHVLIAMGVQPWVARGSLRFSLGHTSTRADVRALLEVLPQVVERARAAGLAGAKGGV

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=374, Percent_Identity=36.6310160427808, Blast_Score=232, Evalue=5e-61,
Organism=Homo sapiens, GI156713448, Length=399, Percent_Identity=32.8320802005013, Blast_Score=171, Evalue=1e-42,
Organism=Escherichia coli, GI48994898, Length=377, Percent_Identity=37.1352785145889, Blast_Score=216, Evalue=1e-57,
Organism=Escherichia coli, GI1787970, Length=369, Percent_Identity=27.9132791327913, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1789175, Length=384, Percent_Identity=28.6458333333333, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI25143064, Length=377, Percent_Identity=36.8700265251989, Blast_Score=226, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI17533177, Length=325, Percent_Identity=28.6153846153846, Blast_Score=128, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6319831, Length=355, Percent_Identity=36.6197183098592, Blast_Score=210, Evalue=3e-55,
Organism=Drosophila melanogaster, GI20129463, Length=376, Percent_Identity=37.5, Blast_Score=225, Evalue=5e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010240
- InterPro:   IPR017772
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 39406; Mature: 39406

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPAAIEAMTAAMARPGNASSVHGSGRAARRMLEEARESIAANLGARPSEVVFTSGGTES
CCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCC
DNLAVKGIYWARRDADPRRVRILTSAVEHHAVIDAVEWLEQHEGARVTWLPVDAQGLVSP
CCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCH
RTLRAALDEHADEVALISIMWANNEVGTIEPIHELAAVAQEFGIPMHSDAIQAAAQLPID
HHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCC
FGASGLAAASFAGHKVGGPHGVGVLLLGRQVPCVPLLHGGGHERDLRSGTSDTPAAVGLA
CCCCCHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEECCCCCCCHHHCCCCCCCHHHHHH
AALDVTVAELPAKTAELIALRDELIAGVLAAVPDAVLNGPAGQGRLPGNAHFTFAGCEGD
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCEEEEECCCCC
SLLMLLDAAGIECSTGSACTAGVATPSHVLIAMGVQPWVARGSLRFSLGHTSTRADVRAL
CEEEEEECCCCEECCCCCCCCCCCCCCCEEEEECCCCHHHCCCEEEEECCCCHHHHHHHH
LEVLPQVVERARAAGLAGAKGGV
HHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MLPAAIEAMTAAMARPGNASSVHGSGRAARRMLEEARESIAANLGARPSEVVFTSGGTES
CCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCC
DNLAVKGIYWARRDADPRRVRILTSAVEHHAVIDAVEWLEQHEGARVTWLPVDAQGLVSP
CCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCH
RTLRAALDEHADEVALISIMWANNEVGTIEPIHELAAVAQEFGIPMHSDAIQAAAQLPID
HHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCC
FGASGLAAASFAGHKVGGPHGVGVLLLGRQVPCVPLLHGGGHERDLRSGTSDTPAAVGLA
CCCCCHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEECCCCCCCHHHCCCCCCCHHHHHH
AALDVTVAELPAKTAELIALRDELIAGVLAAVPDAVLNGPAGQGRLPGNAHFTFAGCEGD
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCEEEEECCCCC
SLLMLLDAAGIECSTGSACTAGVATPSHVLIAMGVQPWVARGSLRFSLGHTSTRADVRAL
CEEEEEECCCCEECCCCCCCCCCCCCCCEEEEECCCCHHHCCCEEEEECCCCHHHHHHHH
LEVLPQVVERARAAGLAGAKGGV
HHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10930739 [H]